Monday May 16, 2022

Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury

Moderators: Brendan McGuire, MD (UAB) and William M. Lee, MD (UTSW)

Time Presentation Title Speaker
8:00-8:10 am  Welcome and Introduction  Brendan McGuire, MD 
8:10-8:35 am  Acute Liver Failure and ALFSG  William M. Lee, MD 
8:35-9:00 am  Mechanisms of Liver Injury  Lily Dara, MD 
9:00-9:20 am  Clinical Phenotypes of ALF  Raj Reddy, MD 
9:20-9:40 am  Acetaminophen: current status  Laura James, MD, PhD 
9:40 -10:00 am  Histopathology of ALF  David Kleiner, MD 
10-10:15 am  Discussion  


Session 2: Liver Regeneration and Response to Injury

Moderators: Adrian Reuben, MD (MUSC) and David Kleiner, MD (NCI)

Time Presentation Title Speaker
10:30-10:50 am  Overview of Basic Regenerative Mechanisms  Sanjeev Gupta, MD 
10:50-11:10 am  Immunologic Basis of Liver Injury/Response  Evangelos Triantafyllou MD, UK 
11:10-11:30 am  Pathogenesis of HBV ALF: host/viral factors  Patrizia Farci, MD 
11:30-11:50 pm  Wnt Signaling and Regeneration  Udayan Apte, PhD
11:50-12:10 pm  Pathophysiology of cerebral edema   Chris Rose, PhD
12:10-12:20 pm  Discussion  

Lunch Break – Visit Posters

Session 3: Genomics of Liver Injury

Moderators: Jorge Rakela, MD (Mayo Clinic) and Tony Bass, MD (UCSF)

Time Presentation Title Speaker
1:10-1:30pm Viral Discovery in ALF Charles Chiu, MD
1:30-1:50 pm Genomics and Viral Liver Injury Emmanuel Jouanguy, MD
1:50-2:10 pm Genomics of Drug-Induced Liver Injury Paola Nicoletti, PhD 
2:10-2:30 pm  Biomarkers in ALF Jorge Rakela, MD
2:30-2:45 pm  Discussion  


Session 4: Diagnosis and Evaluation of ALF

Moderators: Bob Fontana, MD (Michigan) and Dan Ganger, MD (Northwestern)

Time Presentation Title Speaker
3:00-3:20 pm Natural History of ALF TBD, MD 
3:20-3:40 pm Causality: Determining Etiology in ALF Daniel Ganger, MD
3:40-4:10 pm Prognostic Indices: Determining Outcomes David Koch, MD
4:10-4:30 pm Methacetin Breath Test/Other Prognostic Tools Robert J. Fontana, MD
4:30-4:50 pm Discussion  

Tuesday May 17, 2022  

Session 5: Complications of ALF: Riding Out the Storm

Moderators: Iris Liou, MD (Univ. of Washington) and Bilal Hameed, MD (UCSF) 

Time Presentation Title Speaker
8:00-8:30 am Critical Care of ALF: Overview Dean Karvellas, MD 
8:30-8:50 am Hemostasis in ALF: Is There a Coagulopathy? Todd Stravitz, MD
8:50-9:10 am The Decision to List for Transplant  Shannan Tujios, MD
9:10-9:30 am Outcomes of Transplantation: SRTR/ALFSG Justin Parekh, MD
9:30-9:45 am Discussion  


Session 6: Liver Support, Transplantation, and the Future

Moderator: Anne Larson, MD (Univ. of Washington) and Buddy Sussman, MD (Baylor Houston)

Time Presentation Title Speaker
10:00-10:20 am Liver support machines: Current status Scott Nyberg, MD
10:20-10:40 am Designing Clinical Trials in an Orphan Disease Valerie Durkalski, PhD 
10:40-11:00 am Pediatric ALF: Current Status Estella Alonso, MD
11:00-11:20 am Is ALF Going Away? An Epidemiologist’s View Babak Orandi, MD
11:20-11:40 am New agents for liver recovery Lars Zender, MD
11:40-11:55 am Discussion  
11:55-12:00 pm Final Words William M. Lee, MD


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