Monday May 16, 2022
Session 1: Acute Liver Failure: Overview and Mechanisms of Liver Injury
Moderators: Brendan McGuire, MD (UAB) and William M. Lee, MD (UTSW)
| Time | Presentation Title | Speaker |
|---|---|---|
| 8:00-8:10 am | Welcome and Introduction | Brendan McGuire, MD |
| 8:10-8:35 am | Acute Liver Failure and ALFSG | William M. Lee, MD |
| 8:35-9:00 am | Mechanisms of Liver Injury | Lily Dara, MD |
| 9:00-9:20 am | Clinical Phenotypes of ALF | Raj Reddy, MD |
| 9:20-9:40 am | Acetaminophen: current status | Laura James, MD, PhD |
| 9:40 -10:00 am | Histopathology of ALF | David Kleiner, MD |
| 10-10:15 am | Discussion |
Break
Session 2: Liver Regeneration and Response to Injury
Moderators: Adrian Reuben, MD (MUSC) and David Kleiner, MD (NCI)
| Time | Presentation Title | Speaker |
|---|---|---|
| 10:30-10:50 am | Overview of Basic Regenerative Mechanisms | Sanjeev Gupta, MD |
| 10:50-11:10 am | Immunologic Basis of Liver Injury/Response | Evangelos Triantafyllou MD, UK |
| 11:10-11:30 am | Pathogenesis of HBV ALF: host/viral factors | Patrizia Farci, MD |
| 11:30-11:50 pm | Wnt Signaling and Regeneration | Udayan Apte, PhD |
| 11:50-12:10 pm | Pathophysiology of cerebral edema | Chris Rose, PhD |
| 12:10-12:20 pm | Discussion |
Lunch Break – Visit Posters
Session 3: Genomics of Liver Injury
Moderators: Jorge Rakela, MD (Mayo Clinic) and Tony Bass, MD (UCSF)
| Time | Presentation Title | Speaker |
|---|---|---|
| 1:10-1:30pm | Viral Discovery in ALF | Charles Chiu, MD |
| 1:30-1:50 pm | Genomics and Viral Liver Injury | Emmanuel Jouanguy, MD |
| 1:50-2:10 pm | Genomics of Drug-Induced Liver Injury | Paola Nicoletti, PhD |
| 2:10-2:30 pm | Biomarkers in ALF | Jorge Rakela, MD |
| 2:30-2:45 pm | Discussion |
Break
Session 4: Diagnosis and Evaluation of ALF
Moderators: Bob Fontana, MD (Michigan) and Dan Ganger, MD (Northwestern)
| Time | Presentation Title | Speaker |
|---|---|---|
| 3:00-3:20 pm | Natural History of ALF | TBD, MD |
| 3:20-3:40 pm | Causality: Determining Etiology in ALF | Daniel Ganger, MD |
| 3:40-4:10 pm | Prognostic Indices: Determining Outcomes | David Koch, MD |
| 4:10-4:30 pm | Methacetin Breath Test/Other Prognostic Tools | Robert J. Fontana, MD |
| 4:30-4:50 pm | Discussion |
Tuesday May 17, 2022
Session 5: Complications of ALF: Riding Out the Storm
Moderators: Iris Liou, MD (Univ. of Washington) and Bilal Hameed, MD (UCSF)
| Time | Presentation Title | Speaker |
|---|---|---|
| 8:00-8:30 am | Critical Care of ALF: Overview | Dean Karvellas, MD |
| 8:30-8:50 am | Hemostasis in ALF: Is There a Coagulopathy? | Todd Stravitz, MD |
| 8:50-9:10 am | The Decision to List for Transplant | Shannan Tujios, MD |
| 9:10-9:30 am | Outcomes of Transplantation: SRTR/ALFSG | Justin Parekh, MD |
| 9:30-9:45 am | Discussion |
Break
Session 6: Liver Support, Transplantation, and the Future
Moderator: Anne Larson, MD (Univ. of Washington) and Buddy Sussman, MD (Baylor Houston)
| Time | Presentation Title | Speaker |
|---|---|---|
| 10:00-10:20 am | Liver support machines: Current status | Scott Nyberg, MD |
| 10:20-10:40 am | Designing Clinical Trials in an Orphan Disease | Valerie Durkalski, PhD |
| 10:40-11:00 am | Pediatric ALF: Current Status | Estella Alonso, MD |
| 11:00-11:20 am | Is ALF Going Away? An Epidemiologist’s View | Babak Orandi, MD |
| 11:20-11:40 am | New agents for liver recovery | Lars Zender, MD |
| 11:40-11:55 am | Discussion | |
| 11:55-12:00 pm | Final Words | William M. Lee, MD |