Benjamin Chen Lab

Our goal is to further delineate the mechanisms of DNA-PKcs in DNA damage repair, cell cycle checkpoints, chromosomal stability maintenance, and carcinogenesis.

Our research focus has been on the biology of the DNA-dependent protein kinase (DNA-PK), composed of the DNA-binding Ku70/80 heterodimer and the large catalytic subunit DNA-PKcs, the key regulator of the non-homolog end-joining (NHEJ) pathway for DNA double-strand break (DSB) repair.

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Meet the Principal Investigator

Benjamin Chen, Ph.D.

Benjamin Chen, Ph.D.

Principal Investigator/Associate Professor
Radiation Oncology
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Research Interest

  • Genomic Instability and Cancer Development
  • Radiation Biology and DNA Damage Repair
  • Tissue Stem Cell
UT Southwestern Profile
DNA Fiber

DNA Fiber
A technique used to visualize DNA replication.

DNA-PKcs and Mitosis

DNA-PKcs and Mitosis
DNA-PKcs phosphorylation occurs at both centrosomes and kinetochores during mitosis, and depletion of DNA-PKcs delays mitosis due to impaired spindle formation and chromosomal misalignment.

DNA Fiber
DNA-PKcs and Mitosis

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Benjamin Chen, Ph.D.

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Hypocellularity (comparison of 7 sections)