We're interested in cellular mechanisms maintaining genome stability and their impact on human diseases, including cancer and neurodegenerative disorders.
More specifically, our research focuses on these topics:
- DNA mismatch repair in neurodegenerative diseases
- Mechanistic studies of DNA mismatch repair
- Targeting DNA mismatch repair factors in cancer therapy
Histone mark H3K36me3 recruits MutSα to replicating chromatin
Lead author: Feng Li
Reconstitution of human mismatch repair in a defined system
Lead authors: Yanbin Zhang and Fenghua Yuan
dMMR facilitates immunotherapy by activating immune signaling
Lead author: Junhong Guan
Meet the PI
Guo-Min Li, Ph.D.
Professor, Director of the Reece A. Overcash, Jr. Center for Research on Colon Cancer
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