Guo-Min Li Lab

We're interested in cellular mechanisms maintaining genome stability and their impact on human diseases, including cancer and neurodegenerative disorders.

More specifically, our research focuses on these topics: 

  • DNA mismatch repair in neurodegenerative diseases
  • Mechanistic studies of DNA mismatch repair
  • Targeting DNA mismatch repair factors in cancer therapy
DNA Mismatch

Histone mark H3K36me3 recruits MutSα to replicating chromatin

Lead author: Feng Li

DNA Mismatch and Repair

Reconstitution of human mismatch repair in a defined system

Lead authors: Yanbin Zhang and Fenghua Yuan

Mechanism of Mismatch Repair

Mechanism of Mismatch Repair

Lead authors: Janice Ortega and Grace Lee

Meet the PI

Guo-Min Li, Ph.D.

Guo-Min Li, Ph.D.

Professor, Director of the Reece A. Overcash, Jr. Center for Research on Colon Cancer

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