Publications

Bhave M., Mettlen M., Wang X.and Schmid S.L. 2020. Early and nonredundant functions of dynamin isoforms in clathrin-mediated endocytosis. Mol Biol Cell.

Chen Z., Mino R.E., Mettlen M., Michaely P., Bhave M., Reed D.K.and Schmid S.L. 2020. Wbox2: A clathrin terminal domain-derived peptide inhibitor of clathrin-mediated endocytosis. J Cell Biol.

Chen Z.and Schmid S.L. 2020. Evolving models for assembling and shaping clathrin-coated pits. J Cell Biol.

Lakoduk A.M., Kadlecova Z.and Schmid S.L. 2020. A functionally neutral single chain antibody to measure beta-1 integrin uptake and recycling. Traffic.

Mino R.E., Chen Z., Mettlen M.and Schmid S.L. 2020. An internally eGFP-tagged alpha-adaptin is a fully functional and improved fiduciary marker for clathrin-coated pit dynamics. Traffic.

Wang X., Chen Z., Mettlen M., Noh J., Schmid S.L.and Danuser G. 2020. DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis. Elife.

Xiao G.Y.and Schmid S.L. 2020. FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking. PLoS Biol.

Lakoduk A.M., Roudot P., Mettlen M., Grossman H.M., Schmid S.L.and Chen P.H. 2019. Mutant p53 amplifies a dynamin-1/APPL1 endosome feedback loop that regulates recycling and migration. J Cell Biol.

Richardson L.A., Schmid S.L., Bhandoola A., Harly C., Hedenstrom A., Laub M.T., Mace G.M., Sengupta P., Stock A.M., Read A.F., Malik H.S., Estelle M., Lowell S.and Kimmelman J. 2019. The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months. PLoS Biol.

Schmid S.L. 2019. A nostalgic look back 40 years after the discovery of receptor-mediated endocytosis. Mol Biol Cell.

Ramachandran R.and Schmid S.L. 2018. The dynamin superfamily. Curr Biol.

Xiao G.Y., Mohanakrishnan A.and Schmid S.L. 2018. Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis. Proc Natl Acad Sci U S A.

Srinivasan S., Burckhardt C.J., Bhave M., Chen Z., Chen P.H., Wang X., Danuser G. and S.L. Schmid. 2018 A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells. PloS Biol.

Mettlen M., Chen P.H., Srinivasan S., Danuser G. and S.L. Schmid. 2018 Regulation of Clathrin-Mediated Endocytosis. Annu Rev. Biochem.

Mohanakrishnan A., Tran T.V.M., Kumar M., Chen H., Posner B.A. and S.L. Schmid. 2017 A highly-sensitive high throughput assay for dynamin's basal GTPase activity. PlosOne.

Chen P.H., Bendris N., Hsiao Y.J., Reis C.R., Mettlen M., Chen H.Y., Yu S.L. and S.L. Schmid. 2017 Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis. Dev. Cell.

Reis C.R., Chen P.H., Bendris N. and S.L. Schmid. 2017 TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation. PNAS.

Kadlecova Z., Spielman S.J., Loerke D., Mohanakrishnan A., Reed D.K. and S.L. Schmid. 2017 Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2. J. Cell Biol.

Bendris N and S.L. Schmid. 2017 Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9. Trends Cell Biol.

Elkin S.R., Oswald N.W., Reed D.K., Mettlen M., McMillan J.B., and S.L. Schmid. 2016 Ikarugamycin: a natural product inhibitor of clathrin-mediated endocytosis. Traffic.

Bendris N., Stearns C.J., Reis C.R., Rodriguez-Canales J., Liu H., Witkiewicz A.W., and S.L. Schmid. 2016 Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells. J. Cell Sci.

Bendris N., Williams K.C., Reis C.R., Welf E.S., Chen P.H., Lemmers B., Hahne M., Leong H.S., and S.L. Schmid. 2016 SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases. Mol. Biol. Cell.

Srinivasan S., Dharmarajan V., Reed D.K., Griffin P.R., and S.L. Schmid. 2016 Identification and function of conformational dynamics in the multidomain GTPase dynamin. EMBO J.

Elkin S.R., Bendris N., Reis C.R., Zhou Y., Xie Y., Huffman K.E., Minna J.D., and S.L. Schmid. 2015. A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells Cancer Res,  75: 4640-50

Reis, C.R.,Chen, P.-H., Mettlen, M., Aguet, F., and S.L. Schmid. 2015. Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis in non-neuronal cells EMBO J, 34: 2131-46

Mattila, J-P, A. Shnyrova, A.C. Sundborger, E. Rodriguez Hortelano, M. Furhmans, S. Neumann, M. Muller, J.E. Hinshaw, S.L. Schmid* and V.A. Frolov*. 2015. A hemifission intermediate links two mechanistically distinct stages of membrane fission Nature, 524: 109-13

Shnyrova, A.V., P. V. Bashkirov, S.A. Akimov, T.J. Pucadyil, J. Zimmerberg, S L. Schmid and V.A. Frolov. 2013. Geometric catalysis of membrane fission driven by flexible dynamin rings. Science, 339:1433-36

Aguet, F., C. N. Antonescu, M. Mettlen, S.L. Schmid* and G. Danuser*. 2013. Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint. Dev. Cell 126: 279-91

Chappie, J.S., J.A. Mears, S. Fung, M. Leonard, S.L. Schmid, R.A. Milligan, J.E. Hinshaw and F. Dyda. 2011. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell 147:209-222

Liu, Y-W*, S. Neumann*, R. Ramachandran, S. M. Ferguson, T.J. Pucadyil and S.L. Schmid, 2011. Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc. Natl. Acad. Sci. 108:E234-42

Chappie, J.S., S. Acharya, M. Leonard, S.L. Schmid¹ and F. Dyda¹. 2010. G domain dimerization controls dynamin’s assembly-stimulated GTPase activity. Nature 465:435-40

Mettlen, M. D. Loerke, D. Yarar, G Danuser, S.L. Schmid. 2010. Cargo and adaptor specific mechanisms regulate clathrin mediated endocytosis. J. Cell Biol. 188:919-33