The recent completion of the sequence of the entire Drosophila genome is providing abundant new molecular probes to investigate these processes. Most recently we have become interested in the molecular signaling mechanisms mediating the detection and perception of volatile pheromones. A recent postdoctoral fellow, Dr. PingXi Xu, was awarded the $25,000 Eppendorf Prize in Neuroscience in 2005 for his work in this area.
Professor
Departments of Pharmacology and Neuroscience
Phone: 214-648-1650
Fax: 214-648-1801
Email
B.S., University of Utah, 1982
M.D., University of Utah College of Medicine, 1986
Ph.D. (Biology, Neuroscience), University of California at San Diego, under Dr. Charles Zuker
PEPR fellowship, UTSW, 1993-1995
Assistant Professor, UTSW, 1996-2004
Associate Professor, UTSW, 2004-2011
Professor, UTSW, 2011-present
Parks, A., Tran, T., Gutierrez, L., Stojanik, C., Plyler, J., Thomson, G. A., Bohm, R. A., Scheuerman, E., Smith, D.P., Atkinson, N.S. (2021) Alcohol-induced aggression in Drosophila Addiction Biology. e13045. DOI: 10.1111/adb.13045.
Poudel, S., Guo, H., Smith. D. P. (2021) PKC98E Regulates Odorant Responses in Drosophila melanogaster. J. Neurosci. 41(18): 3948-3957.
Parks, A., Tran, T., Scheuerman, E., Smith, D., Atkinson, N. (2020) Alcohol Potentiates a Pheromone Signal in Flies eLife, 2020;9:e59853. DOI: http://doi.org/10.7554/elife.59853
Scheuermann, E. A., Smith, D.P. (2019) Odor-Specific Deactivation Defects in a Drosophila Odorant-Binding Protein Mutant. Genetics 213(3):897-909. PMICID:PMC6827369.
Guo, H., Kunwar, K. and Smith, D. P. (2019) Multiple Channels of DEET Repellency in Drosophila. Pest Management Science 76(3):880-887. PMC7015792
Guo, H., Smith, D. P. (2017) Odorant receptor desensitization in Insects J. Exp. Neuro. 11: 1-5. PMCID: PMC5751911.
Pitts, S., Pelser, E. Meeks, J, Smith, D. (2016) Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila PLOS One 11(9): e0162761. PMCID: PMC5019410.
Ha, T.-S., Xia, R., Zhang, H., Jin, X., and Smith, D. P. (2014) A lipid flippase modulates olfactory receptor expression and odorant sensitivity in Drosophila. PNAS USA (2014);111(21):7831-6. doi: 10.1073/pnas.1401938111.
Li, Q., Ha, T. S., Okuwa, S., Smith, D. P., Volkan, P. C. (2013) Combinatorial rules of precursor specification underlying olfactory neuron diversity. Current Biology 23: 2481-2490. PMID: 24268416.
Ronderos, D. and Smith, D. P. (2014) A farnesol-activated odorant receptor mediates oviposition behavior in Drosophila. J. Neuroscience 34: 3959-3968. PMID 24623773, PMCID:PMC3951695.
Ronderos, D. and Smith, D.P. (2009). Activation of the T1 neuronal circuit is necessary and sufficient to induce sexually dimorphic behaviors in Drosophila. J. Neuroscience, 30(7) 2595-2599.
Ronderos, D.S. and Smith, D.P. (2009). Diverse signaling mechanisms mediate volatile odorant detection in Drosophila. Fly, 3:4 1-8.
Laughlin, J.D., Ha, T.S., Jones, D.M.N., and Smith, D.P. (2008). Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein. Cell, 133: 1255-1265.
Jin, X, Ha, T.S. and Smith, D.P. (2008). SNMP is a signaling component required for pheromone sensitivity in Drosophila. PNAS USA, 105:10996-1001.
Ha, T-S and Smith D.P. (2006). A pheromone receptor mediates 11-cis vaccenyl acetate responses in Drosophila. J. Neurosci, 26:8727-8733.
Xu, P.-X., Atkinson, R., Jones, D.M.N. and Smith, D.P. (2005). Drosophila OBP LUSH is required for Activity in Pheromone-Sensitive Neurons. Neuron, 45: 193-200.
Shanbhag, S.R., Smith, D.P., and Steinbrecht, R.A. (2005). Three odorant binding proteins are co-expressed in sensilla trichodea of Drosophila melanogaster. Arthropod Structure and Development, 34: 153-165.
Liu, Q., Rand, T. A., Kalidas, S., Du, F., Kim, H.-E., Smith, D.P., Wang, X-D. (2003). R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science, 301: 1921-1925.
Elmore, T., Ignell, R. Carlson, J.R.R. and Smith, D.P. (2003). Odorant Receptor Mutants Reveal Peripheral Coding Mechanisms in Drosophila J. Neuroscience, 23: 9906-9912.
Xu, P.-X. and Smith, D.P. (2003). Identification of an Atypical Odorant Binding Protein Family in the Genome of Anopheles gambiae. Insect Molecular Biology, 12: 549-560.
Kruse, S. W., Zhao, R., Smith, D.P. and Jones, D.N.M. (2003). Structure of a specific alcohol-binding site defined by the Drosophila protein LUSH. Nature Structural Biology, 10: 694-700.
Kalidas, S. and Smith, D.P. (2002). Novel Genomic cDNA Hybrids Produce Effective RNA Interference in Adult Drosophila. Neuron, 33:1-8.
Shanbhag, S.R., Hekmat-Scafe, D., Kim, M. S., Park, S.K., Carlson, J.R., Pikielny, C., Smith, D.P., Steinbrecht, R.A. (2001). Expression mosaic of Odorant-Binding Proteins in Drosophila Olfactory Organs. Microscopy Research and Techniques, 55:297-306.
Galindo, K. and Smith, D.P. (2001). A Large Family of Divergent Odorant-Binding Proteins Expressed in Gustatory and Olfactory Sensilla. Genetics, 159: 1059-1072.
Elmore, T. and Smith, D.P. (2001). Putative Drosophila Odor Receptor OR43b Localizes to Dendrites of Olfactory Neurons. Insect Biochemistry and Molecular Biology 31:791-798.
Coral G. Warr, Leslie B. Vosshall, Hubert O. Amrein, John R. Carlson, Qian Gao, and Dean P. Smith (2000). A Unified Nomenclature System for the Drosophila Odorant Receptors. Cell 102, 145-146.
Elmore, T., Rodrigues, A., Smith, D.P. (1998). dRGS7 encodes a Drosophila homolog of EGL-10 and vertebrate RGS7. DNA and Cell Science 17: 983-989.
Kim, M.-S., Repp, A., Smith, D.P. (1998). LUSH mediates chemosensory responses to alcohols in Drosophila. Genetics 150: 711-721.
Phone: 214-648-1650
Fax: 214-648-1801
Email