Wolf Lab research focuses on the roles of urinary proteins Uromodulin and Mucin-1 in health and disease.
We study the physiological roles of both proteins on metabolism and nephrolithiasis, and develop new state-of-the-art therapies to treat autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by Uromodulin mutations.
Meet the Principal Investigator
Matthias T. Wolf, M.D.
Department of Pediatrics
Cell and Molecular Biology
Dr. Matthias Wolf is a Pediatric Nephrologist at UT Southwestern and Children’s Medical Center Dallas.
Recent News & Discoveries
Mucin-1 is secreted in the urine and kidney stone formers have lower urinary Mucin-1 protein
We study the effects of urinary Uromodulin and Mucin-1 on renal calcium absorption and the effect on calcium-containing kidney stone formation by modifying the calcium channel TRPV5.
Urinary Uromodulin modifies tubular magnesium transport
We investigate the effects of urinary Uromodulin and Mucin-1 on renal magnesium homeostasis and the consequences on metabolic disorders.
HTS assay identifies small molecules to increase mutant Uromodulin secretion
We developed a cell-culture based HTS assay which allows us to find new targeted therapies to enhance secretion of mutant Uromodulin and ameliorate apoptosis is cells expressing mutant Uromodulin.
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