Wolf Lab

Wolf Lab research focuses on the roles of urinary proteins Uromodulin and Mucin-1 in health and disease.

We study the physiological roles of both proteins on metabolism and nephrolithiasis, and develop new state-of-the-art therapies to treat autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by Uromodulin mutations.

Meet the Principal Investigator

Matthias T. Wolf, M.D.

Matthias T. Wolf, M.D.

Associate Professor

Department of Pediatrics

Cell and Molecular Biology

Dr. Matthias Wolf is a Pediatric Nephrologist at UT Southwestern and Children’s Medical Center Dallas.

Recent News & Discoveries

urinary Mucin-1 protein

Mucin-1 is secreted in the urine and kidney stone formers have lower urinary Mucin-1 protein

We study the effects of urinary Uromodulin and Mucin-1 on renal calcium absorption and the effect on calcium-containing kidney stone formation by modifying the calcium channel TRPV5.

Urinary Uromodulin

Urinary Uromodulin modifies tubular magnesium transport

We investigate the effects of urinary Uromodulin and Mucin-1 on renal magnesium homeostasis and the consequences on metabolic disorders.

Uromodulin secretion

HTS assay identifies small molecules to increase mutant Uromodulin secretion

We developed a cell-culture based HTS assay which allows us to find new targeted therapies to enhance secretion of mutant Uromodulin and ameliorate apoptosis is cells expressing mutant Uromodulin.

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We are looking for dynamic, diverse, and motivated researchers to join our team.

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metabolic cage

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low mg conditions