Shuang Liang, Ph.D.

Publications by Shuang Liang, Ph.D.

Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.
Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E, J Biol Chem. 2019 Aug 16;294(33):12359-12369.

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.
Zhong F, Liang S, Zhong Z#, Trends Immunol. 2019 Dec;40(12):1120-1133.

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T#, Brenner DA# Gastroenterology 2018 Nov

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
Zhong Z*, Liang S*, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M Nature 2018 Aug 560 7717 198-203

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.
Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA Hepatol Commun 2017 12 1 10 1043-1057

TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice.
Yang L*, Miura K*, Zhang B*, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E Cell Mol Gastroenterol Hepatol 2017 May 3 3 469-483 

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.
Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T J. Clin. Invest. 2017 Mar

Promising Therapy Candidates for Liver Fibrosis.
Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T Front Physiol 2016 7 47

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.
Liang S#, Kisseleva T, Brenner# DA Front Physiol 2016 7 17

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Zhong Z*, Umemura A*, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M Cell 2016 Feb 164 5 896-910

Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells.
Sobol A*, Galluzzo P*, Liang S, Rambo B, Skucha S, Weber MJ, Alani S, Bocchetta M J. Cell. Physiol. 2015 May 230 5 1064-74

Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes.
Zhang B, Roh YS, Liang S, Liu C, Naiki M, Masuda K, Seki E PLoS ONE 2014 9 12 e114071

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis
Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E J. Clin. Invest. 2014 Jul

Novel fate-tracing strategies show that hepatic stellate cells mediate fibrosis in vivo.
Liang S, Zhong Z, Seki E Gastroenterology 2014 Jun 146 7 1823-5

TRPM2 links oxidative stress to NLRP3 inflammasome activation.
Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L Nat Commun 2013 4 1611

Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment.
Liang S*, Galluzzo P*, Sobol A, Skucha S, Rambo B, Bocchetta M Genes Cancer 2012 Feb 3 2 141-51

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.
Eliasz S, Liang S, Chen Y, De Marco MA, Machek O, Skucha S, Miele L, Bocchetta M Oncogene 2010 Apr 29 17 2488-98

* Co-first author
# Corresponding author 

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