Publications for Mark Henkemeyer

Featured Publications

Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.

Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES, 2021 Mar Proc Natl Acad Sci U S A 10 118

EphB2 receptor cell-autonomous forward signaling mediates auditory memory recall and learning-driven spinogenesis.

Talebian A, Henkemeyer M, 2019 Commun Biol 2 372

EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells.

Mimche PN, Lee CM, Mimche SM, Thapa M, Grakoui A, Henkemeyer M, Lamb TJ, 2018 02 Sci Rep 1 8 2532

Autonomous and non-autonomous roles for ephrin-B in interneuron migration.

Talebian A, Britton R, Ammanuel S, Bepari A, Sprouse F, Birnbaum SG, Szabó G, Tamamaki N, Gibson J, Henkemeyer M 2017 Sep Dev. Biol.

A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.

Xu NJ, Sun S, Gibson JR, Henkemeyer M 2011 Nov Nat. Neurosci. 11 14 1421-9

Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues.

Dravis C, Henkemeyer M 2011 Jul Dev. Biol. 1 355 138-51

EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche.

Catchpole T, Henkemeyer M 2011 Aug J. Neurosci. 32 31 11472-83

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning.

Xu NJ, Henkemeyer M 2009 Mar Nat. Neurosci. 3 12 268-76

Ephrins in reverse, park and drive.

Cowan CA, Henkemeyer M, 2002 Jul Trends Cell Biol 7 12 339-46

The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.

Cowan CA, Henkemeyer M 2001 Sep Nature 6852 413 174-9

Nuk controls pathfinding of commissural axons in the mammalian central nervous system.

Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R 1996 Jul Cell 1 86 35-46

Abnormalities in cortical interneuron subtypes in ephrin-B mutant mice.

Talebian A, Britton R, Henkemeyer M, 2018 07 Eur J Neurosci 2 48 1803-1817

Eph receptor interclass cooperation is required for the regulation of cell proliferation.

Jurek A, Genander M, Kundu P, Catchpole T, He X, Strååt K, Sabelström H, Xu NJ, Pettersson S, Henkemeyer M, Frisén J, 2016 Oct Exp Cell Res 1 348 10-22

Ephrin Bs and canonical Reelin signalling.

Pohlkamp T, Xiao L, Sultana R, Bepari A, Bock HH, Henkemeyer M, Herz J 2016 Nov Nature 7630 539 E4-E6

EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure.

Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Greenberg ME, Henkemeyer M, Cowan CW, 2016 Apr Dev Neurobiol 4 76 405-20

Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour.

Zhu XN, Liu XD, Sun S, Zhuang H, Yang JY, Henkemeyer M, Xu NJ 2016 Nat Commun 7 11096

EphB4 forward signalling regulates lymphatic valve development.

Zhang G, Brady J, Liang WC, Wu Y, Henkemeyer M, Yan M, 2015 Apr Nat Commun 6 6625

Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.

Raft S, Andrade LR, Shao D, Akiyama H, Henkemeyer M, Wu DK, 2014 Jun Dev Biol 1 390 51-67

EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding.

Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Dravis C, Kwan KY, Šestan N, Greenberg ME, Henkemeyer M, Cowan CW, 2014 Feb Proc Natl Acad Sci U S A 6 111 2188-93

Ephrin-B2 Reverse Signaling Increases a5?1 Integrin Mediated Fibronectin Deposition and Reduces Distal Lung Compliance.

Bennett KM, Afanador MD, Lal CV, Xu H, Persad E, Legan SK, Chenaux G, Dellinger M, Savani RC, Dravis C, Henkemeyer M, Schwarz MA 2013 Jun Am. J. Respir. Cell Mol. Biol.

EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak.

Srivastava N, Robichaux MA, Chenaux G, Henkemeyer M, Cowan CW, 2013 Jan Mol Cell Neurosci 52 106-16

Reelin induces EphB activation.

Bouché E, Romero-Ortega MI, Henkemeyer M, Catchpole T, Leemhuis J, Frotscher M, May P, Herz J, Bock HH 2013 Apr Cell Res. 4 23 473-90

Ephrin reverse signaling in axon guidance and synaptogenesis.

Xu NJ, Henkemeyer M, 2012 Feb Semin Cell Dev Biol 1 23 58-64

Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection.

Chenaux G, Henkemeyer M, 2011 Nov Eur J Neurosci 10 34 1620-33

Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents.

Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Xiong LZ, Song XJ 2011 Jul Cancer Res. 13 71 4392-402

Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping.

Thakar S, Chenaux G, Henkemeyer M 2011 Nat Commun 2 431

EphB signaling controls lineage plasticity of adult neural stem cell niche cells.

Nomura T, Göritz C, Catchpole T, Henkemeyer M, Frisén J 2010 Dec Cell Stem Cell 6 7 730-43

Epithelial dynamics of pancreatic branching morphogenesis.

Villasenor A, Chong DC, Henkemeyer M, Cleaver O 2010 Dec Development 24 137 4295-305

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

Genander M, Halford MM, Xu NJ, Eriksson M, Yu Z, Qiu Z, Martling A, Greicius G, Thakar S, Catchpole T, Chumley MJ, Zdunek S, Wang C, Holm T, Goff SP, Pettersson S, Pestell RG, Henkemeyer M, Frisén J 2009 Nov Cell 4 139 679-92

EphB2 and EphB3 forward signalling are required for palate development.

Risley M, Garrod D, Henkemeyer M, McLean W, 2009 Mar-Apr Mech Dev 3-4 126 230-9

An in vivo mouse model of long-term potentiation at synapses between primary afferent C-fibers and spinal dorsal horn neurons: essential role of EphB1 receptor.

Liu WT, Han Y, Li HC, Adams B, Zheng JH, Wu YP, Henkemeyer M, Song XJ, 2009 Jun Mol Pain 5 29

Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice.

Han Y, Song XS, Liu WT, Henkemeyer M, Song XJ 2008 Mol Pain 4 60

Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation.

Aoto J, Ting P, Maghsoodi B, Xu N, Henkemeyer M, Chen L 2007 Jul J. Neurosci. 28 27 7508-19

EphB2 and ephrin-B2 regulate the ionic homeostasis of vestibular endolymph.

Dravis C, Wu T, Chumley MJ, Yokoyama N, Wei S, Wu DK, Marcus DC, Henkemeyer M, 2007 Jan Hear Res 1-2 223 93-104

EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.

Chumley MJ, Catchpole T, Silvany RE, Kernie SG, Henkemeyer M 2007 Dec J. Neurosci. 49 27 13481-90

B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus.

Armstrong JN, Saganich MJ, Xu NJ, Henkemeyer M, Heinemann SF, Contractor A, 2006 Mar J Neurosci 13 26 3474-81

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.

Holmberg J, Genander M, Halford MM, Annerén C, Sondell M, Chumley MJ, Silvany RE, Henkemeyer M, Frisén J 2006 Jun Cell 6 125 1151-63

Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain.

Mendes SW, Henkemeyer M, Liebl DJ, 2006 Jan J Neurosci 3 26 882-92

EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord.

Kadison SR, Mäkinen T, Klein R, Henkemeyer M, Kaprielian Z, 2006 Aug J Neurosci 35 26 8909-14

Distinct roles for ephrinB3 in the formation and function of hippocampal synapses.

Rodenas-Ruano A, Perez-Pinzon MA, Green EJ, Henkemeyer M, Liebl DJ, 2006 Apr Dev Biol 1 292 34-45

Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth.

Benson MD, Romero MI, Lush ME, Lu QR, Henkemeyer M, Parada LF 2005 Jul Proc. Natl. Acad. Sci. U.S.A. 30 102 10694-9

GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.

Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M, 2005 Jul Nat Neurosci 7 8 906-15

EphB receptor tyrosine kinases control morphological development of the ventral midbrain.

Altick AL, Dravis C, Bowdler T, Henkemeyer M, Mastick GS, 2005 Apr Mech Dev 4 122 501-12

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.

Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB 2004 May Nat. Neurosci. 5 7 501-9

Abnormal hippocampal axon bundling in EphB receptor mutant mice.

Chen ZY, Sun C, Reuhl K, Bergemann A, Henkemeyer M, Zhou R, 2004 Mar J Neurosci 10 24 2366-74

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.

Dravis C, Yokoyama N, Chumley MJ, Cowan CA, Silvany RE, Shay J, Baker LA, Henkemeyer M 2004 Jul Dev. Biol. 2 271 272-90

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.

Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M 2004 Jul Dev. Biol. 2 271 263-71

Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.

Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, Gale NW, Holt CE, Mason CA, Henkemeyer M 2003 Sep Neuron 6 39 919-35

Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.

Henkemeyer M, Itkis OS, Ngo M, Hickmott PW, Ethell IM 2003 Dec J. Cell Biol. 6 163 1313-26

Eph receptor deficiencies lead to altered cochlear function.

Howard MA, Rodenas-Ruano A, Henkemeyer M, Martin GK, Lonsbury-Martin BL, Liebl DJ, 2003 Apr Hear Res 1-2 178 118-30

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.

Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP, 2002 Sep Proc Natl Acad Sci U S A 19 99 12327-32

Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP.

Contractor A, Rogers C, Maron C, Henkemeyer M, Swanson GT, Heinemann SF, 2002 Jun Science 5574 296 1864-9

EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping.

Hindges R, McLaughlin T, Genoud N, Henkemeyer M, O'Leary D 2002 Aug Neuron 3 35 475-87

Eph receptors tingle the spine.

Henkemeyer M, Frisén J, 2001 Sep Neuron 6 31 876-7

Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1.

Rossi DJ, Londesborough A, Korsisaari N, Pihlak A, Lehtonen E, Henkemeyer M, Mäkelä TP, 2001 Jun EMBO J 11 20 2844-56

Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline.

Yokoyama N, Romero MI, Cowan CA, Galvan P, Helmbacher F, Charnay P, Parada LF, Henkemeyer M 2001 Jan Neuron 1 29 85-97

Crystal structure of an Eph receptor-ephrin complex.

Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB 2001 Dec 20-27 Nature 6866 414 933-8

EphB2 guides axons at the midline and is necessary for normal vestibular function.

Cowan CA, Yokoyama N, Bianchi LM, Henkemeyer M, Fritzsch B, 2000 May Neuron 2 26 417-30

Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.

Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M, 2000 Mar Development 6 127 1231-41

Role of p120 Ras-GAP in directed cell movement.

Kulkarni SV, Gish G, van der Geer P, Henkemeyer M, Pawson T, 2000 Apr J Cell Biol 2 149 457-70

Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.

Himanen JP, Henkemeyer M, Nikolov DB, 1998 Dec Nature 6710 396 486-91

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

Saxton TM, Henkemeyer M, Gasca S, Shen R, Rossi DJ, Shalaby F, Feng GS, Pawson T, 1997 May EMBO J 9 16 2352-64

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T, 1997 Jul EMBO J 13 16 3877-88

Receptor tyrosine kinase signaling in vascular development.

Merenmies J, Parada LF, Henkemeyer M 1997 Jan Cell Growth Differ. 1 8 3-10

Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.

van der Geer P, Henkemeyer M, Jacks T, Pawson T, 1997 Apr Mol Cell Biol 4 17 1840-7

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands.

Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T 1996 Oct Nature 6602 383 722-5

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T, 1996 Nov EMBO J 22 15 6035-49

Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.

Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD, 1996 Jul Neuron 1 17 9-19

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.

Henkemeyer M, Rossi DJ, Holmyard DP, Puri MC, Mbamalu G, Harpal K, Shih TS, Jacks T, Pawson T, 1995 Oct Nature 6551 377 695-701

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

Yamaguchi TP, Harpal K, Henkemeyer M, Rossant J, 1994 Dec Genes Dev 24 8 3032-44

Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.

Henkemeyer M, Marengere LE, McGlade J, Olivier JP, Conlon RA, Holmyard DP, Letwin K, Pawson T, 1994 Apr Oncogene 4 9 1001-14

Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways.

Pawson T, Olivier P, Rozakis-Adcock M, McGlade J, Henkemeyer M, 1993 Jun Philos Trans R Soc Lond B Biol Sci 1293 340 279-85

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T, 1993 Apr Cell 1 73 179-91

A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization.

Henkemeyer M, West SR, Gertler FB, Hoffmann FM, 1990 Nov Cell 5 63 949-60

Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells.

Holland GD, Henkemeyer MJ, Kaehler DA, Hoffmann FM, Risser R 1990 May J. Virol. 5 64 2226-35

The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development.

Henkemeyer MJ, Gertler FB, Goodman W, Hoffmann FM 1987 Dec Cell 5 51 821-8