Publications

  1. The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3. (2024) Das A., Cheng H., Wang Y., Kinch L., Liang, G., Hong S., Hobbs H.H., Cohen J.C. Proc. Natl. Acad. Sci. USA. 121:No.6 DOI: 10.1073/pnas.2312291121. PMCID: PMC10861911. PMID: 24261825

  2. From nature’s loss to patient’s gain. (2024) Hobbs H.H., Cohen J.C., Horton J.D. Circulation 149:171-173, DOI: 10.1161/CIRCULATIONAHA.123.064498 PMCID: PMC10874118. PMID: 38227713

  3. Hepatic TM6SF2 is required for lipidation of VLDL in a pre-Golgi compartment in mice and rats. Luo F., Smagris E., Martin S., Vale G., McDonald J.G., Fletcher J.A., Burgess S.C., Hobbs H.H., Cohen J.C. (2022)  Cell Mol Gastroenterol Hepatol 13: 879-899.DOI: 10.1016/j.jcmgh.2021.12.008.  PMCID: PMC8804273. PMID: 34923175

  4. Molecular basis of cholesterol efflux via ABCG subfamily transporters. (2021) Sun Y., Wang J., Long T., Qi X., Donnelly L., Elghobashi-Meinhardt N., Esparza L.,  Cohen J.C., Xie X., Hobbs H.H., Li X. Proc Natl Acad Sci USA. 118:No.34 DOI: 10.1073/pnas.2110483118. PMCID: PMC8403869. PMID: 34404721

  5. ANGPTL8 has both endocrine and autocrine effects on substrate utilization. (2020) Oldoni F., Cheng H., Banfi, S., Gusarova, V., Cohen J.C., Hobbs H.H. JCI Insight: 5(17):e138777. DOI: 10.1172/jci.insight.138777. PMCID: PMC7526440. PMID: 32730227

  6. Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis. (2019) BasuRay S., Wang Y., Smagris E., Cohen J.C., Hobbs H.H. Proc. Natl. Acad. Sci. USA 116: 9521-9526. DOI: 10.1073/pnas.1901974116. PMCID: PMC6511016. PMID: 31019090

  7. PNPLA3, CGI-58, and inhibition of hepatic triglyceride hydrolysis in mice. (2019) Wang Y., Kory N., Cohen J.C., Hobbs H.H. Hepatology 69: 2427-2441. DOI: 10.1002/hep.30583. PMCID: PMC6563103. PMID: 30802989

  8. HSD17B13 and chronic liver disease in Blacks and Hispanics. (2018) Kozlitina J., Stender S., Hobbs H.H., Cohen J.C. N. Engl. J. Med. 379: 1876-1877. DOI: 10.1056/NEJMc1804027. PMID: 30403941

  9. Patatin-like phospholipase domain-containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets. Mitsche M.A., Hobbs H.H., Cohen J.C. (2018) J Biol Chem. 293: 6958-6968. DOI: 10.1074/jbc.RA118.002333. PMCID: PMC5936833. PMID: 29555681

  10. Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice. (2018) Banfi S., Gusarova V., Gromada J., Cohen J.C., Hobbs H.H. Proc. Natl. Acad. Sci. USA. 115: E1249-E1258. DOI: 10.1073/pnas.1717420115. PMCID: PMC5819435. PMID: 29358393

  11. Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. (2018) Stender S., Smagris E., Lauridsen B.K., Kofoed K.F., Nordestgaard B.G., Tybjærg-Hansen A., Pennacchio L.A., Dickel D.E., Cohen J.C., Hobbs H.H. Hepatology 67: 2182-2195. DOI: 10.1002/hep.29751. PMCID: PMC5991995. PMID: 29266543

  12. The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation. (2017) BasuRay S., Smagris E., Cohen J.C., Hobbs H.H. Hepatology 66: 1111-1124. DOI: 10.1002/hep.29273. PMCID: PMC5605398. PMID: 28520213

  13. Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci. (2017)  Stender S., Kozlitina J., Nordestgaard B.G., Tybjaerg-Hansen A., Hobbs H.H., Cohen J.C. Nat Genet. 49: 842-847. DOI: 10.1038/ng.3855. PMCID: PMC5562020. PMID: 28436986