Chemical Synthesis and Antifibrotic Properties of (±)-Cochlearol T, (±)-Ganocochlearin A, and (±)-Cochlearol Y
Badrinath N. Kakde, Sung Wan An, Yaashmin Shiny Jebaraj, Sudha Neelam, Matthias T. F. Wolf, and Uttam K. Tambar
Stereoselective Total Synthesis of Rhodocoranes I and J
Cooper A. Vincent, Vaishnavi N. Nair, and Uttam K. Tambar
Metabolic inflexibility promotes mitochondrial health during liver regeneration
Xun Wang, Cameron J. Menezes, Yuemeng Jia, Yi Xiao, Siva Sai Krishna Venigalla, Feng Cai, Meng-Hsiung Hsieh, Wen Gu, Liming Du, Jessica Sudderth, Dohun Kim, Spencer D. Shelton, Claire B. Llamas, Yu-Hsuan Lin, Min Zhu, Salma Merchant, Divya Bezwada, Sherwin Kelekar, Lauren G. Zacharias, Thomas P. Mathews, Gerta Hoxhaj, R. Max Wynn, Uttam K. Tambar, Ralph J. DeBerardinis, Hao Zhu, and Prashant Mishra
Academic-Industrial Collaborations: Merging Paths to Thrive
Hongli Bao, Karla Bravo-Altamirano, Zachary Buchan, Pablo J. Cabrera, Sarah J. Ryan, Joshua J. Roth, Fernando Sartillo-Piscil, Yasuhiro Sawai, Uttam K. Tambar, and Cayetana Zarate
Hypoxia-driven heterogeneous expression of α5 integrin in glioblastoma stem cells is linked to HIF-2α
Mélissa Messé, Chloé Bernhard, Sophie Foppolo, Lionel Thomas, Patrice Marchand, Christel Herold-Mende, Ahmed Idbaih, Horst Kessler, Nelly Etienne-Selloum, Charles Ochoa, Uttam K. Tambar, Mohamed Elati, Patrice Laquerriere, Natacha Entz-Werle, Sophie Martin, Damien Reita, Monique Dontenwill
Copper-Catalyzed Regiodivergent Internal Allylic Alkylations
Madhu Sudan Manna, Seok Yeol Yoo, Mohammed Sharique, Hyoju Choi, Bimal Pudasaini, Mu-Hyun Baik, and Uttam K. Tambar
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
Cooper A. Vincent, Alexia Ripa, Ludovic Troian-Gautier, and Uttam K. Tambar
Photocatalytic Sulfonyl Fluorination of Alkyl Organoboron Substrates
Cooper A. Vincent, Maria I. Chiriac, Ludovic Troian-Gautier, and Uttam K. Tambar
Catalytic Photochemical Enantioselective α-Alkylation with Pyridinium Salts
Santhivardhana Reddy Yetra, Nathan Schmitt, and Uttam K. Tambar
Photosensitized activation of diazonium derivatives for C–B bond formation
Alexia Ripak, Simon De Kreijger, Renato N. Sampaio, Cooper A. Vincent, Émilie Cauët, Ivan Jabin, Uttam K. Tambar, Benjamin Elias, and Ludovic Troian-Gautier
Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1
Melanie Rodriguez, Ashari Kannangara, Julita Chlebowicz, Radha Akella, Haixia He, Uttam K. Tambar, and Elizabeth J. Goldsmith
Synthesis of Amines via Coupling of Imines and Alkylarenes
Vaishnavi N. Nair and Uttam. K. Tambar
Recent Total Syntheses of Anthraquinone-Based Natural Products
Jackson A. Gartman and Uttam K. Tambar
Catalytic Rearrangements of Onium Ylides in Aromatic Systems
Vaishnavi N. Nair and Uttam. K. Tambar
Cycloadditions of Donor–Acceptor Cyclopropanes and -butanes using S=N-Containing Reagents: Access to Cyclic Sulfinamides, Sulfonamides, and Sulfinamidines
Gwyndaf A. Oliver, Maximilian N. Loch, André U. Augustin, Pit Steinbach, Mohammed Sharique, Uttam K. Tambar, Peter G. Jones, Christoph Bannwarth, and Daniel B. Werz
Synthesis of Cell-Permeable N-Acetylhexosamine-1-Phosphates
Badrinath N. Kakde, Emanuela Capota, Jennifer J. Kohler, and Uttam K. Tambar
Synthetic Studies of the Rubellin Natural Products: Development of a Stereoselective Strategy and Total Synthesis of (+)-Rubellin C
Jackson A. Gartman and Uttam K. Tambar
Catalyst-Controlled Regiodivergence in Rearrangements of Indole-Based Onium Ylides
Vaishnavi N. Nair, Volga Kojasoy, Croix J. Laconsay, Dean J. Tantillo, and Uttam K. Tambar
A Trimethoprim Derivative Impedes Antibiotic Resistance Evolution
Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, Xiaoyu Wang, Furkan C. R. Toprak, DaNae R. Woodard, Andrew Y. Koh, Noelle S. Williams, Dominika Borek, Ali Rana Atilgan, John D. Hulleman, Canan Atilgan, Uttam Tambar, and Erdal Toprak
N-Heterocyclic Carbene Catalyzed Benzannulations: Mechanism and Synthetic Utility
Mohammed Sharique and Uttam K. Tambar
Total Synthesis of (+)-Rubellin C
Jackson A. Gartman and Uttam K. Tambar
N-Heterocyclic Carbene Based Catalytic Platform for Hauser-Kraus Annulations
Mohammed Sharique and Uttam K. Tambar
Photocatalyzed Diastereoselective Isomerization of Cinnamyl Chlorides to Cyclopropanes
Bin Xu, Ludovic Troian-Gautier, Ryan Dykstra, Robert Martin, Osvaldo Gutierrez, and Uttam K. Tambar
Lactate Production is a Prioritized Feature of Adipocyte Metabolism
James R. Krycer, Lake-Ee Quek, Deanne Francis, Daniel J. Fazakerley, Sarah D. Elkington, Alexis Diaz-Vegas, Kristen C. Cooke, Fiona C. Weiss, Xiaowen Duan, Sergey Kurdyukov, Ping-Xin Zhou, Uttam K. Tambar, Akiyoshi Hirayama, Satsuki Ikeda, Yushi Kamei, Tomoyoshi Soga, Gregory J. Cooney, and David E. James
Synthesis of Amines by Rearrangements (Updated Book Chapter)
Charles Ochoa and Uttam K. Tambar
Science of Synthesis 2020, 2, 315
Controllable, Sequential, and Stereoselective C-H Allylic Alkylation of Alkenes
Ling Qin, Mohammed Sharique, and Uttam K. Tambar
Remote Allylation of Unactivated C(sp3)-H Bonds Triggered by Photogenerated Amidyl Radicals
Bin Xu and Uttam K. Tambar
Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)-Lundurine A
Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens, and Uttam K. Tambar
Total Synthesis of Sparstalonin B via a Palladium-Catalyzed Aldehyde α-Arylation
Dalton Kim, Aaron Nash, Jef De Brabander Jr., and Uttam K. Tambar
Catalytic Allylic Oxidation of Internal Alkenes to a Multifunctional Chiral Building Block
Liela Bayeh, Phong Q. Le, and Uttam K. Tambar
![Copper-Catalyzed Enantioselective, Diastereoselective, and Regioselective [2,3]-Rearrangements of Iodonium Ylides](/sites/default/files/styles/coh_small/public/2022-11/xu_ACIE_2017.png?itok=d_t5Vh_J)
Copper-Catalyzed Enantioselective, Diastereoselective, and Regioselective [2,3]-Rearrangements of Iodonium Ylides
Bin Xu and Uttam K. Tambar
Copper-Catalyzed Aminothiolation of 1,3-Dienes via a Dihydrothiazine Intermediate
Christopher E. Sleet and Uttam K. Tambar
Catalytic Asymmetric Intermolecular Allylic Functionalization of Unactivated Internal Alkenes
Liela Bayeh and Uttam K. Tambar
Brønsted Acid Catalyzed Enantioselective Pericyclic Reactions
Christopher E. Sleet, Uttam K. Tambar, and Pradip Maity
![Copper-catalyzed [1,2]-rearrangements of allylic iodides and aryl diazoacetates](/sites/default/files/styles/coh_small/public/2022-11/xu_Tetrahedron_2017.jpg?itok=qGOPh64o)
Copper-Catalyzed [1,2]-Rearrangements of Allylic Iodides and Aryl α-Diazoacetates
Bin Xu, Jackson A. Gartman, and Uttam K. Tambar
A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis
Rhonda F. Souza, Liela Bayeh, Stuart J. Spechler, Uttam K. Tambar and Richard K. Bruick
Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD
Xiaofang Huo, Agoston T. Agoston, Kerry B. Dunbar, Daisha J. Cipher, Xi Zhang, Chunhua Yu, Edaire Cheng, Qiuyang Zhang, Thai H. Pham, Uttam K. Tambar, Richard K. Bruick, David H. Wang, Robert D. Odze, Stuart J. Spechler, Rhonda F. Souza
![Ligand-Controlled Regiodivergence in the Copper-Catalyzed [2,3]- and [1,2]-Rearrangements of Iodonium Ylides](/sites/default/files/styles/coh_small/public/2022-11/xu_JACS_2016.gif?itok=uxqS2OWL)
Ligand-Controlled Regiodivergence in the Copper-Catalyzed [2,3]- and [1,2]-Rearrangements of Iodonium Ylides
Bin Xu and Uttam K. Tambar
Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2
Thomas H. Scheuermann, Daniel Stroud, Christopher E. Sleet, Liela Bayeh, Cameron Shokri, Hanzhi Wang, Charles G. Caldwell, Jamie Longgood, John B. MacMillan, Richard K. Bruick, Kevin H. Gardner, and Uttam K. Tambar
Palladium-catalyzed cross-coupling of α-bromocarbonyls and allylic alcohols for the synthesis of α-aryl dicarbonyl compounds
Yang Yu and Uttam K. Tambar
Bis(phenylsulfonyl)sulfur Diimide
Liela Bayeh and Uttam K. Tambar
Regioselective and Diastereoselective Aminoarylation of 1,3-Dienes
Hongli Bao, Liela Bayeh, and Uttam K. Tambar
Synthesis of (±)-Amathaspiramide F
Arash Soheili, Carrie Johnson, and Uttam K. Tambar
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain -Ketoacid Dehydrogenase Kinase
Shih-Chia Tso, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Xiangbing, Qi, Kristen J. Skvorak, Kenneth Dorko, Amy L. Wallace, Lorraine K. Morlock, Brendan H. Lee, Susan M. Hutson, Stephen C. Strom, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, and David T. Chuang
Allylic Functionalization of Unactivated Olefins with Grignard Reagents
Hongli Bao, Liela Bayeh, and Uttam K. Tambar
Specific Inhibitors Targeting the ATP-Binding Pocket of Pyruvate Dehydrogenase Kinase
Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Cheng-Yang Wu, Jacinta L. Chuang, Ingrid Wernstedt-Asterholm, Lorraine K. Morlock, Philipp E. Scherer, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, and David T. Chuang
Brønsted Acid Catalyzed Enantioselective Indole Aza-Claisen Rearrangement Mediated by an Arene CH-O Interaction
Pradip Maity, Ryan Pemberton, Dean J. Tantillo, and Uttam K. Tambar
Catalytic Enantioselective Allylic Amination of Olefins for the Synthesis of ent-Sitagliptin
Hongli Bao, Liela Bayeh, and Uttam K. Tambar
![Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement](/sites/default/files/styles/coh_small/public/2022-11/soheili_OL_2013.gif?itok=KFJsKLzq)
Synthesis of (±)-Amathaspiramide F and Discovery of an Unusual Stereocontrolling Element for the [2,3]-Stevens Rearrangement
Arash Soheili and Uttam K. Tambar
![Stereoselective Synthesis of Functionalized Cyclic Amino Acid Derivatives via a [2,3]-Stevens Rearrangement and Ring-Closing Metathesis](/sites/default/files/styles/coh_small/public/2022-11/nash_OL_2013.gif?itok=Bp-Wi34_)
Stereoselective Synthesis of Functionalized Cyclic Amino Acid Derivatives via a [2,3]-Stevens Rearrangement and Ring-Closing Metathesis
Aaron Nash, Arash Soheili, and Uttam K. Tambar
Structure-based Design and Mechanisms of Allosteric Inhibitors for Mitochondrial Branched-chain -Ketoacid Dehydrogenase Kinase
Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, Jacinta L. Chuang, Lorraine K. Morlock, Amy L. Wallace, Kamran Ahmed, Sunil Laxman, Philippe M. Campeau, Brendan H. Lee, Susan M. Hutson, Benjamin P. Tu, Noelle S. Williams, Uttam K. Tambar, R. Max Wynn, and David T. Chuang
Development of Inhibitors of the PAS-B Domain of the HIF-2a Transcription Factor
Jamie L. Rogers, Liela Bayeh, Thomas H. Scheuermann, Jamie Longgood, Chuck Caldwell, Jason Key, Jacinth Naidoo, Lisa Melito, Cameron Shokri, Doug E. Frantz, Richard K. Bruick, Kevin H. Gardner, John B. MacMillan, and Uttam K. Tambar
Allosteric Inhibition of Hypoxia Inducible Factor-2 with Small Molecules
Thomas H. Scheuermann, Qiming Li, He-Wen Ma, Jason Key, Lei Zhang, Rui Chen, Joseph A. Garcia, Jacinth Naidoo, Jamie Longgood, Douglas E. Frantz, Uttam K. Tambar, Kevin H. Gardner, and Richard K. Bruick
![Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement](/sites/default/files/styles/coh_small/public/2022-11/bao_JACS_2012.gif?itok=lUgdAEnJ)
Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement
Hongli Bao and Uttam K. Tambar
![Tandem Catalytic Allylic Amination and [2,3]-Stevens Rearrangement of Tertiary Amines](/sites/default/files/styles/coh_small/public/2022-11/soheili_JACS_2011.gif?itok=yW86gZpD)
Tandem Catalytic Allylic Amination and [2,3]-Stevens Rearrangement of Tertiary Amines
Arash Soheili and Uttam K. Tambar
![Stereoselective [2,3]-Rearrangements of Amine N-Oxides](/sites/default/files/styles/coh_small/public/2022-11/bao_Synlett_2011.jpeg?itok=vuGmAt-W)
Stereoselective [2,3]-Rearrangements of Amine N-Oxides
Hongli Bao, Xiangbing Qi, and Uttam K. Tambar
Total Synthesis of (±)-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine
Xiangbing Qi, Hongli Bao, and Uttam K. Tambar
![Catalytic Enantioselective [2,3]-Rearrangements of Amine N-Oxides](/sites/default/files/styles/coh_small/public/2022-11/bao_JACS_2011.gif?itok=XPacAepO)
Catalytic Enantioselective [2,3]-Rearrangements of Amine N-Oxides
Hongli Bao, Xiangbing Qi, and Uttam K. Tambar
PhD and Postdoctoral Publications
Enantioselective (Formal) Aza-Diels-Alder Reactions with Non-Danishefsky-Type Dienes
Uttam K. Tambar, Sharon K. Lee, and James L. Leighton
Highly Enantioselective Formal Aza-Diels–Alder Reactions with Acylhydrazones and Danishefsky's Diene Promoted by a Silicon Lewis Acid
Sharon K. Lee, Uttam K. Tambar, Nicholas R. Perl, and James L. Leighton
The Direct Acyl-Alkylation of Arynes. Preparation of Methyl 2-(2-Acetylphenyl)Acetate
David C. Ebner, Uttam K. Tambar, and Brian M. Stoltz
Pd-Catalyzed Enantioselective Aerobic Oxidation of Secondary Alcohols: Applications to the Total Synthesis of Alkaloids
Shyam Krishnan, Jeffrey T. Bagdanoff, David C. Ebner, Yeeman K. Ramtohul, Uttam K. Tambar, and Brian M. Stoltz
The Development and Scope of a Versatile Tandem Stille-Oxa-Electrocyclization Reaction
Uttam K. Tambar, Taichi Kano, John F. Zepernick and Brian M. Stoltz
Convergent and Diastereoselective Synthesis of the Polycyclic Pyran Core of Saudin
Uttam K. Tambar, Taichi Kano, John F. Zepernick, and Brian M. Stoltz
A Convergent and Enantioselective Synthesis of (+)-Amurensinine via Selective C-H and C-C Bond Insertion Reactions
Uttam K. Tambar, David C. Ebner, and Brian M. Stoltz
Progress toward the Total Synthesis of Saudin: Development of a Tandem Stille-Oxa-Electrocyclization Reaction
Uttam K. Tambar, Taichi Kano, and Brian M. Stoltz
The Direct Acyl-Alkylation of Arynes
Uttam K. Tambar and Brian M. Stoltz