Vongpatanasin Lab | UT Southwestern, Dallas, Texas

Research

The Vongpatanasin lab studies neural control of blood pressure and the influence of nutrition and various hormones on the autonomic control of blood pressure in humans. Our laboratory has performed autonomic studies in both normal healthy subjects and patients with hypertension or autonomic dysfunction.

Clinical Studies

Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity (PHOS-VEX)

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

Learn more about this study (clinicaltrials.gov)

Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid and Tau in Older Adults (IPAT)

The IPAT study is a 2-arm open-label randomized controlled trial to assess the effects of intensive pharmacological reduction of high blood pressure (SBP) on brain amyloid and tau protein deposition (Alzheimer’s Disease pathology) in older adults who are at high risk for AD and related dementias, that is, those who have high blood pressure, family history of dementia, or subjective memory complaints. Furthermore, IPAT will examine effects of intensive blood pressure lowering on brain volume, perfusion, and neural network connectivity using magnetic resonance imaging (MRI) and cognitive performance.

Learn more about this study at the IPAT Study website.

Preventing Cognitive Decline by Reducing BP Target Trial (PCOT)

The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health & Hospital System.

Learn more about this study (clinicaltrials.gov)

Lab Members

Wanpen Vongpatanasin, M.D.

Professor, Department of Internal Medicine

Director, UTSW Hypertension Section and Hypertension Fellowship Program

Attending Physician, internal medicine and cardiology, Parkland Memorial Hospital and Zale Lipshy Pavilion — William P. Clements Jr. University Hospital

Email Dr. Vongpatanasin

Han Kyul Kim, Ph.D.

Instructor

John Giacona, Ph.D., PA-C

Assistant Professor

Brooke Bates

Clinical Research Assistant I

Ashley Murillo, BSN, RN

Research Nurse

Featured Publications

Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats.

Kim HK, Ishizawa R, Fukazawa A, Wang Z, Bezan Petric U, Chang Hu M, Smith SA, Mizuno M, Vongpatanasin W, 2022 Jun Hypertension 101161HYPERTENSIONAHA12219177

Renal Nerve Activity and Arterial Depressor Responses Induced by Neuromodulation of the Deep Peroneal Nerve in Spontaneously Hypertensive Rats.

Gonzalez-Gonzalez MA, Romero K, Beitter J, Lloyd D, Lam DV, Hernandez-Reynoso AG, Kanneganti A, Kim HK, Bjune CK, Smith S, Vongpatanasin W, Romero-Ortega MI, 2022 Front Neurosci 16 726467

Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association.

Choudhry NK, Kronish IM, Vongpatanasin W, Ferdinand KC, Pavlik VN, Egan BM, Schoenthaler A, Houston Miller N, Hyman DJ, 2021 Oct Hypertension HYP0000000000000203

Evidence of reduced efferent renal sympathetic innervation after chemical renal denervation in humans.

Hearon CM, Howden EJ, Fu Q, Yoo JK, Dias KA, Roberts-Reeves MA, Samels M, Sarma S, Nesbitt S, Vongpatanasin W, Goldstein DS, Addo T, Levine BD, 2021 03 Am J Hypertens

Superiority of Out-of-Office Blood Pressure for Predicting Hypertensive Heart Disease in Non-Hispanic Black Adults.

Rader F, Franklin SS, Mirocha J, Vongpatanasin W, Haley RW, Victor RG, 2019 Sep Hypertension HYPERTENSIONAHA11913542

High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.

Peri-Okonny PA, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W 2019 Jan Circulation

Usefulness of Blood Pressure Variability Indices Derived From 24-Hour Ambulatory Blood Pressure Monitoring in Detecting Autonomic Failure.

Lodhi HA, Peri-Okonny PA, Schesing K, Phelps K, Ngo C, Evans H, Arbique D, Price AL, Vernino S, Phillips L, Mitchell JH, Smith SA, Yano Y, Das SR, Wang T, Vongpatanasin W, 2019 Apr J Am Heart Assoc 7 8 e010161

Prognostic Value of Masked Uncontrolled Hypertension.

Pierdomenico SD, Pierdomenico AM, Coccina F, Clement DL, De Buyzere ML, De Bacquer DA, Ben-Dov IZ, Vongpatanasin W, Banegas JR, Ruilope LM, Thijs L, Staessen JA 2018 Oct Hypertension 4 72 862-869

Diagnostic Thresholds for Blood Pressure Measured at Home in the Context of the 2017 Hypertension Guideline.

Vongpatanasin W, Ayers C, Lodhi H, Das SR, Berry JD, Khera A, Victor RG, Lin FC, Viera AJ, Yano Y, de Lemos JA 2018 Dec Hypertension 6 72 1312-1319

Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension: The Dallas Heart Study.

Yano Y, Neeland IJ, Ayers C, Peshock R, Berry JD, Lloyd-Jones DM, Greenland P, Mitchell GF, Vongpatanasin W 2017 May Hypertension

High Dietary Phosphate Intake Induces Hypertension and Augments Exercise Pressor Reflex Function in Rats.

Mizuno M, Mitchell JH, Crawford S, Huang CL, Maalouf NM, Hu MC, Moe OW, Smith SA, Vongpatanasin W 2016 May Am. J. Physiol. Regul. Integr. Comp. Physiol. ajpregu.00124.2016

Aldosterone and Salt Loading Independently Exacerbate the Exercise Pressor Reflex in Rats.

Mizuno M, Downey RM, Mitchell JH, Auchus RJ, Smith SA, Vongpatanasin W 2015 Jul Hypertension

Therapeutic drug monitoring facilitates blood pressure control in resistant hypertension.

Brinker S, Pandey A, Ayers C, Price A, Raheja P, Arbique D, Das SR, Halm EA, Kaplan NM, Vongpatanasin W 2014 Mar J. Am. Coll. Cardiol. 8 63 834-5

Resistant hypertension: a review of diagnosis and management.

Vongpatanasin W 2014 Jun JAMA 21 311 2216-24

Dexmedetomidine as a Novel Countermeasure for Cocaine-Induced Central Sympathoexcitation in Cocaine-Addicted Humans.

Kontak AC, Victor RG, Vongpatanasin W 2013 Jan Hypertension

Differential Effects of Nebivolol Versus Metoprolol on Functional Sympatholysis in Hypertensive Humans.

Price A, Raheja P, Wang Z, Arbique D, Adams-Huet B, Mitchell JH, Victor RG, Thomas GD, Vongpatanasin W 2013 Apr Hypertension

Spironolactone Prevents Chlorthalidone-Induced Sympathetic Activation and Insulin Resistance in Hypertensive Patients.

Raheja P, Price A, Wang Z, Arbique D, Adams-Huet B, Auchus RJ, Vongpatanasin W 2012 Jun Hypertension

C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice.

Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, Gibson LL, Black S, Samols D, Shaul PW 2007 Feb Circulation 8 115 1020-8

Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans.

Menon DV, Wang Z, Fadel PJ, Arbique D, Leonard D, Li JL, Victor RG, Vongpatanasin W 2007 Aug J. Am. Coll. Cardiol. 7 50 626-33

Cocaine stimulates the human cardiovascular system via a central mechanism of action.

Vongpatanasin W, Mansour Y, Chavoshan B, Arbique D, Victor RG 1999 Aug Circulation 5 100 497-502

Prosthetic heart valves.

Vongpatanasin W, Hillis LD, Lange RA 1996 Aug N. Engl. J. Med. 6 335 407-16