INTERNAL MEDICINE RESEARCH
Research
The Vongpatanasin lab studies neural control of blood pressure and the influence of nutrition and various hormones on the autonomic control of blood pressure in humans. Our laboratory has performed autonomic studies in both normal healthy subjects and patients with hypertension or autonomic dysfunction.
Clinical Studies
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.
The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase accumulation of amyloid-beta protein in the brain and affect memory and thinking ability in older adults. However, it is inconclusive whether lowering blood pressure reduces brain amyloid-beta protein and improves brain function.
The investigators hypothesize that treating high blood pressure alters brain pulsatility, which in turn reduces accumulation of amyloid-beta protein in the brain and improves brain structure and function.
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health & Hospital System.
Lab Members
Wanpen Vongpatanasin, M.D.
Professor, Department of Internal Medicine
Director, UTSW Hypertension Section and Hypertension Fellowship Program
Attending Physician, internal medicine and cardiology, Parkland Memorial Hospital and Zale Lipshy Pavilion — William P. Clements Jr. University Hospital
Featured Publications
Kim HK, Ishizawa R, Fukazawa A, Wang Z, Bezan Petric U, Chang Hu M, Smith SA, Mizuno M, Vongpatanasin W,
2022 Jun
Hypertension
101161HYPERTENSIONAHA12219177
Gonzalez-Gonzalez MA, Romero K, Beitter J, Lloyd D, Lam DV, Hernandez-Reynoso AG, Kanneganti A, Kim HK, Bjune CK, Smith S, Vongpatanasin W, Romero-Ortega MI,
2022
Front Neurosci
16
726467
Choudhry NK, Kronish IM, Vongpatanasin W, Ferdinand KC, Pavlik VN, Egan BM, Schoenthaler A, Houston Miller N, Hyman DJ,
2021 Oct
Hypertension
HYP0000000000000203
Hearon CM, Howden EJ, Fu Q, Yoo JK, Dias KA, Roberts-Reeves MA, Samels M, Sarma S, Nesbitt S, Vongpatanasin W, Goldstein DS, Addo T, Levine BD,
2021 03
Am J Hypertens
Rader F, Franklin SS, Mirocha J, Vongpatanasin W, Haley RW, Victor RG,
2019 Sep
Hypertension
HYPERTENSIONAHA11913542
High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.
Peri-Okonny PA, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W 2019 Jan Circulation
Lodhi HA, Peri-Okonny PA, Schesing K, Phelps K, Ngo C, Evans H, Arbique D, Price AL, Vernino S, Phillips L, Mitchell JH, Smith SA, Yano Y, Das SR, Wang T, Vongpatanasin W,
2019 Apr
J Am Heart Assoc
7
8
e010161
Pierdomenico SD, Pierdomenico AM, Coccina F, Clement DL, De Buyzere ML, De Bacquer DA, Ben-Dov IZ, Vongpatanasin W, Banegas JR, Ruilope LM, Thijs L, Staessen JA
2018 Oct
Hypertension
4
72
862-869
Vongpatanasin W, Ayers C, Lodhi H, Das SR, Berry JD, Khera A, Victor RG, Lin FC, Viera AJ, Yano Y, de Lemos JA
2018 Dec
Hypertension
6
72
1312-1319
Yano Y, Neeland IJ, Ayers C, Peshock R, Berry JD, Lloyd-Jones DM, Greenland P, Mitchell GF, Vongpatanasin W
2017 May
Hypertension
Mizuno M, Mitchell JH, Crawford S, Huang CL, Maalouf NM, Hu MC, Moe OW, Smith SA, Vongpatanasin W
2016 May
Am. J. Physiol. Regul. Integr. Comp. Physiol.
ajpregu.00124.2016
Aldosterone and Salt Loading Independently Exacerbate the Exercise Pressor Reflex in Rats.
Mizuno M, Downey RM, Mitchell JH, Auchus RJ, Smith SA, Vongpatanasin W 2015 Jul HypertensionTherapeutic drug monitoring facilitates blood pressure control in resistant hypertension.
Brinker S, Pandey A, Ayers C, Price A, Raheja P, Arbique D, Das SR, Halm EA, Kaplan NM, Vongpatanasin W 2014 Mar J. Am. Coll. Cardiol. 8 63 834-5Resistant hypertension: a review of diagnosis and management.
Vongpatanasin W 2014 Jun JAMA 21 311 2216-24
Kontak AC, Victor RG, Vongpatanasin W
2013 Jan
Hypertension
Price A, Raheja P, Wang Z, Arbique D, Adams-Huet B, Mitchell JH, Victor RG, Thomas GD, Vongpatanasin W
2013 Apr
Hypertension
Raheja P, Price A, Wang Z, Arbique D, Adams-Huet B, Auchus RJ, Vongpatanasin W
2012 Jun
Vongpatanasin W, Thomas GD, Schwartz R, Cassis LA, Osborne-Lawrence S, Hahner L, Gibson LL, Black S, Samols D, Shaul PW
2007 Feb
Circulation
8
115
1020-8
Menon DV, Wang Z, Fadel PJ, Arbique D, Leonard D, Li JL, Victor RG, Vongpatanasin W
2007 Aug
J. Am. Coll. Cardiol.
7
50
626-33
Cocaine stimulates the human cardiovascular system via a central mechanism of action.
Vongpatanasin W, Mansour Y, Chavoshan B, Arbique D, Victor RG 1999 Aug Circulation 5 100 497-502
Vongpatanasin W, Hillis LD, Lange RA
1996 Aug
N. Engl. J. Med.
6
335
407-16
Contact Us
Department of Internal Medicine, Division of Cardiology
5323 Harry Hines Blvd.
Suite H4.110
Dallas, Texas 75309-8586
(214) 648-3180