Publications

Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors

Shekhar S, Tracy C, Lidsky PV, Andino R, Wert KJ, Krämer H 2025 Dec Nature communications 16

Elevated PRDM13 Disrupts Photoreceptor Function and Survival in the Mammalian Retina

Nettesheim ER, Rowe AA, Yee T, Alshaikhsalama A, Cepica T, Dutt V, Virani SS, Wickersham G, Mahajan VB, Small KW, Wert KJ 2025 Aug Investigative Ophthalmology and Visual Science 66

Female sex hormones exacerbate retinal neurodegeneration

Rowe AA, Velasquez MJ, Aumeier JW, Reyes S, Yee T, Nettesheim ER, McDonald JG, Wert KJ 2025 Apr Science Advances 11

Murine Orchiectomy and Ovariectomy to Reduce Sex Hormone Production

Rowe AA, Issioui Y, Johnny B, Wert KJ 2023 Nov Journal of Visualized Experiments 2023

Human retina-in-a-dish: Unlocking the potential to study mechanisms of inherited retinal disease

Yee T, Wert KJ 2023 Sep Molecular Therapy Methods and Clinical Development 30 573-575

HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy

Kong Y, Liu PK, Li Y, Nolan ND, Quinn PM, Hsu CW, Jenny LA, Zhao J, Cui X, Chang YJ, Wert KJ, Sparrow JR, Wang NK, Tsang SH 2023 Feb EMBO Molecular Medicine 15

Long-term progression of retinal degeneration in a preclinical model of CLN7 Batten disease as a baseline for testing clinical therapeutics

Rowe AA, Chen X, Nettesheim ER, Issioui Y, Dong T, Hu Y, Messahel S, Kayani SN, Gray SJ, Wert KJ 2022 Nov EBioMedicine 85

Base and Prime Editing in the Retina—From Preclinical Research toward Human Clinical Trials

Yee T, Wert KJ 2022 Oct International journal of molecular sciences 23

Differential effects of obstructive sleep apnea on the corneal subbasal nerve plexus and retinal nerve fiber layer

Bussan KA, Stuard WL, Mussi N, Lee W, Whitson JT, Issioui Y, Rowe AA, Wert KJ, Robertson DM 2022 Jun PloS one 17

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa

Rowe AA, Patel PD, Gordillo R, Wert KJ 2021 Sep JCI Insight 6

Phenotypic variance in Calpain-5 retinal degeneration

Tang PH, Chemudupati T, Wert KJ, Folk JC, Mahajan MA, Tsang SH, Bassuk AG, Mahajan VB 2020 Jun American Journal of Ophthalmology Case Reports 18

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration

Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB 2020 Feb EBioMedicine 52

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials

Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan MA, Bassuk AG, Tsang SH, Mahajan VB 2019 Dec Human mutation 40 2377-2392

In vivo expression of mutant calpains in the eye using lentivirus

Wert KJ, Mahajan VB 2019 233-247

Insights into retinal development using live imaging in female carriers of choroideremia

Wert KJ, Bakall B, Bassuk AG, Tsang SH, Mahajan VB 2019 Ophthalmic Surgery Lasers and Imaging Retina 50 E158-E162

Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface

Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB 2018 Aug Free Radical Biology and Medicine 124 408-419

Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis

Bakthavatchalu V, Wert KJ, Feng Y, Mannion A, Ge Z, Garcia A, Scott KE, Caron TJ, Madden CM, Jacobsen JT, Victora G, Jaenisch R, Fox JG 2018 Mar PloS one 13

Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas

Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R 2018 Proceedings of the National Academy of Sciences of the United States of America 115 3924-3929

Molecular Criteria for Defining the Naive Human Pluripotent State

Theunissen TW, Friedli M, He Y, Planet E, O'Neil RC, Markoulaki S, Pontis J, Wang H, Iouranova A, Imbeault M, Duc J, Cohen MA, Wert KJ, Castanon R, Zhang Z, Huang Y, Nery JR, Drotar J, Lungjangwa T, Trono D, Ecker JR, Jaenisch R 2016 Oct Cell Stem Cell 19 502-515

Pathology and mechanism of eye diseases

Wert KJ, Kroeger H, Wu F, Tsang SH, Lin JH 2016 Oct 3-32

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos

Cohen MA, Wert KJ, Goldmann J, Markoulaki S, Buganim Y, Fu D, Jaenisch R 2016 Feb Proceedings of the National Academy of Sciences of the United States of America 113 1570-1575

Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy

Wert KJ, Mahajan VB, Zhang L, Yan Y, Li Y, Tosi J, Hsu CW, Nagasaki T, Janisch KM, Grant MB, Mahajan M, Bassuk AG, Tsang SH 2016 Signal Transduction and Targeted Therapy 1

A systematic approach to identify candidate transcription factors that control cell identity

D'Alessio AC, Fan ZP, Wert KJ, Baranov P, Cohen MA, Saini JS, Cohick E, Charniga C, Dadon D, Hannett NM, Young MJ, Temple S, Jaenisch R, Lee TI, Young RA 2015 Nov Stem Cell Reports 5 763-775

CAPN5 mutation in hereditary uveitis: The R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse model

Wert KJ, Bassuk AG, Wu WH, Gakhar L, Coglan D, Mahajan MA, Wu S, Yang J, Lin CS, Tsang SH, Mahajan VB 2015 Apr Human molecular genetics 24 4584-4598

Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina

Wert KJ, Skeie JM, Bassuk AG, Olivier AK, Tsang SH, Mahajan VB 2014 May Human molecular genetics 23 2665-2677

General pathophysiology in retinal degeneration

Wert KJ, Lin JH, Tsang SH 2014 Apr 53 33-43

Mid-stage intervention achieves similar efficacy as conventional early-stage treatment using gene therapy in a pre-clinical model of retinitis pigmentosa

Wert KJ, Sancho-Pelluz J, Tsang SH 2014 Jan Human molecular genetics 23 514-523

Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an American ophthalmological society thesis)

Tsang SH, Chan L, Tsai YT, Wu WH, Hsu CW, Yang J, Tosi J, Wert KJ, Davis RJ, Mahajan VB 2014 Transactions of the American Ophthalmological Society 112 103-115

General pathophysiology in retinal degeneration

Wert KJ, Lin JH, Tsang SH 2014 Developments in ophthalmology 53 33-43

Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa

Wert KJ, Davis RJ, Sancho-pelluz J, Nishina PM, Tsang SH 2013 Feb Human molecular genetics 22 558-567

Therapeutic margins in a novel preclinical model of retinitis pigmentosa

Davis RJ, Hsu CW, Tsai YT, Wert KJ, Sancho-Pelluz J, Lin CS, Tsang SH 2013 Journal of Neuroscience 33 13475-13483

Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye.

Wert KJ, Skeie JM, Davis RJ, Tsang SH, Mahajan VB 2012 Journal of visualized experiments : JoVE

Deoxygenation of aromatic ketones using transfer hydrogenolysis with Raney nickel in 2-propanol

Zuidema DR, Williams SL, Wert KJ, Bosma KJ, Smith AL, Mebane RC 2011 Synthetic Communications 41 2927-2931

Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa

Wang NK, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH 2010 Apr Transplantation 89 911-919

Novel method of reducing ketones using sodium hydroxide in isopropanol

Zuidema DR, Wert KJ, Williams SL, Chill ST, Holte KL, Kokes NK, Mebane RC 2010 Jan Synthetic Communications 40 1187-1191