BraNiC (Brain Networks in Coma) Lab

Research

The BraNiC lab is dedicated to developing advanced methods for assessing the potential for brain function recovery after severe brain injuries. We use non-invasive assessments of neuronal and cerebrovascular function in the intensive care unit to characterize physiological impairments in patients with traumatic and non-traumatic coma. Current research projects include:

  • Electroencephalography (EEG) derived brain network dynamics for prediction of coma recovery
  • Influence of acute cerebrovascular dysfunction on EEG and fMRI-based network dynamics and clinical recovery in disorders of consciousness
  • Predictive modeling using clinical data and time series analyses
brain EEG image with labels of frontal cortex, perietal, occipital, temporal cortex, striatum, thalamus

Meet the PI

headshot of Dr. Kartavya Sharma, dark haired man in dk blue suit, white shirt, and plaid tie

Kartavya Sharma, M.D.

Kartavya Sharma, M.D., received his medical degree at AIIMS, New Delhi, where his research in Velayudhan Mohan Kumar's lab revealed a novel role for the rat perirhinal cortex in male rat sexual behavior. As a neurology resident at UT Southwestern, working in Shuxin Li's lab, he investigated potential pharmacotherapies to promote axon regeneration after optic nerve and spinal cord injuries. Following a Neurocritical Care fellowship in at Johns Hopkins University, his work has focused on quantifying recovery potential following severe brain injuries.

He published the first quantitative meta-analysis of serum neuron-specific enolase thresholds for predicting anoxic brain injury outcomes and quantified bromocriptine's efficacy in reducing neurogenic fever in hospitalized patients. Since joining the UT Southwestern Neurology faculty in 2020, his ongoing TRC4 grant-funded research explores the effects of cerebrovascular dysfunction on EEG and fMRI-derived brain network dynamics in severe traumatic brain injuries.

Lab Members

Zachary Armstrong

Graduate Student

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Jill Morales

Clinical Research Coordinator

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Alumni

Leah Chandy, M.S.

Tabarak Mian, M.D.

Antonio Guerra, B.S.

Valeria Perez, Pharm. D.

Yash Sharma, B.S.

Merin John, M.D.

Publications

Contact Information

  • Kartavya Sharma
  • UT Southwestern Neurology - NE Neuro Critical Care CS05424
  • 214-648-4775, 214-648-5080
  • Email