Our question: how do cancer cells proliferate?
We study the metabolic regulation of cancer cell proliferation with a focus on the following areas:
- Understanding how metabolites regulate mitochondria function.
- Characterizing metabolites as signaling molecules in cells.
- Understanding the allosteric effects of metabolites on immune suppression.
Our approach: from bench to bedside, guided by clinical questions.
We use a combination cell culture, biochemistry, molecular and cell biology, and mass spectrometry assays to interrogate metabolic signaling in cells.