About Us

Advancing Research in Mood Disorders

Continued advancements come through tireless pursuit, and our Center's faculty and staff understand that the commitment we renew each day is built upon a foundation of scholarship and a network of like-minded organizations. By sharing our findings worldwide, we strive to improve patient care and further the research momentum of our fellow scientists. Made possible by public grants and philanthropic investments, these programs provide civic and health partners with resources and tools to better prevent, identify, and treat depression in individuals of all ages.

Mood Disorders Research

Solving Depression, Saving Tomorrows

Built on a quarter-century of research in mood disorders, the Center for Depression Research and Clinical Care (CDRC) was established in 2015 to realize a future free from the burden of depression. In the last seven years, our Center has demonstrated its impact in lives changed. We have led research into new treatments, including brain and blood tests, for depression and suicide. 

    A future free from the burden of depression.

    • Transform the diagnosis and treatment of depression and bipolar disorder
    • Revolutionize our understanding of the biological causes of depression and bipolar disorder
    • Accelerate scientific discovery
    • Disseminate new findings to real practice
    1. Promote resilience
    2. Map brain pathology over time
    3. Create a biosignature
    4. Move to personalized treatment

    Mood Disorders Network/ Pediatric Mood Disorders Network

    • Comprised of clinical and community members to address gaps in the screening, diagnosis, treatment, and management of depression and other mood disorders.

    • The Pediatric Mood Disorder Network was established in 2017 with the goal of collaborating with clinical and community members to address gaps in the treatment of depression.

    Risk & Resilience Network

    • Comprised of local schools, colleges, and youth community organizations with a focus on preventing depression and suicide through education and engagement.

    • The Risk and Resilience Network team supports youth-serving organizations with programs that help mood and anxiety in adolescents through resilience building and mental health education.

    Our path to success is based on 5 core objectives:

    1. Partner with the community to make depression treatment mainstream.
    2. Teach resilience to empower prevention.
    3. Train the trainers.
    4. Blend patient experience with data and metrics to guide treatment and progress.
    5. Develop biomarkers to improve existing treatments and create new ones.
    Dr. Madhukar Trivedi

    Meet the Director

    Madhukar Trivedi, M.D., is a Professor in the Department of Psychiatry at UT Southwestern Medical Center. He serves as Chief of the Division of Mood Disorders and the founding Director of the Center for Depression Research and Clinical Care, where he holds the Betty Jo Hay Distinguished Chair in Mental Health and the Julie K. Hersh Chair for Depression Research and Clinical Care. He specializes in treating depression.


    • Published over 500 chapters and papers in journals
    • Principal Investigator in clinical trials funded through the National Institute of Mental Health (NIMH) and the Texas Department of Mental Health
    • Developed the established benchmarks now used for treating depression and other mood disorders
    Mood Disorders Research

    Meet Our Faculty

    The CDRC has faculty members with expertise in neuroimaging, cognitive and behavioral phenotyping, biospecimens, exercise, biostatistics, genetics, adolescent behaviors, research, novel treatments, and addiction.

    Through scientific research and rigorous peer review, we have expanded our understanding of depression.

    Mood Disorders Research

    Treatment Resistant Depression Clinic

    The Center for Depression Research and Clinical Care (CDRC) at UT Southwestern Medical Center is nationally recognized for its cutting edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

    Mood Disorders Research

    Partnering with community to make depression treatment mainstream.

    Educating About Mental Health

    Programs available through the Risk and Resilience Network will allow adolescents to learn and develop life-long coping and resilience skills that are shown to help teens and young adults avoid high risk and self-destructive behavior that can lead to poor academic achievement, substance abuse, more severe psychiatric conditions, and even suicide.

    Find out more
    YAM Trainers Team

    Cultivating Wellness

    Building resilience through adopting powerful tools for mental wellbeing is an important part of what we strive for at the CDRC. Understanding the importance of developing habits that encourage positive feelings builds on our work in preventing and treating mood disorders. In an interview with Gardenuity, Dr. Trivedi discusses the 5 ways gardening can reduce depression and anxiety.

    Find out more
    Dr. Trivedi interview with Gardenuity

    Measuring for Better Treatment

    Measurement-based care is an important aspect of our work and focuses on making depression the 6th vital sign physicians monitor during primary care visits. The VitalSign6 program is one of the CDRC's longest running programs, and their goal is to make incorporating measurement-based care into primary care and pediatric clinics easy for clinicians.

    Find out more
    VitalSign6 Texas Tech rollout

    Power Through Partnerships

    Be part of the great impact we're having on science and medical care across the globe.

    The Center for Depression Research and Clinical Care has one vision: a future free from the burden of depression. More than a center, we are a community of committed faculty and staff, collaborators, clinicians, research participants, and community partners, as well as, the donors and advocates who are critical to our mission.