Cerebral Autoregulation, Brain Perfusion, and Neurocognitive outcomes after Traumatic Brain Injury (CAPCOG-TBI)

The focus of this study is to determine whether neurodegeneration and cognitive outcomes change after a year following a moderate to severe traumatic brain injury (TBI). We would like to know if cerebral blood flow (CBF) regulation remains altered during the chronic stage in TBI survivors and if CBF regulation is associated with brain functional integrity. 

The study is funded by The National Institute of Health- Research Project Grant (R01) and is a 5-year observational study that will be enrolling from 2024-2027. 

As of March 18th, 2026, 82 patients were enrolled, 40 completed 3-month Follow-up, 25 completed 6-month Follow-up, and 26 completed 12 month follow up.

Resources

Find helpful information below in English and Spanish.

General Information (En Español)

Support Groups

  • Brain Injury Network
    View the ongoing list of active groups in the DFW area.
  • Texas Health and Human Services
    View the interactive map to find a group near you.
  • Dallas Acquired Brain Injury Support Group for Survivors & Family
    First Tuesday of each month | 1 p.m. - 2:30 p.m.
    Email us for in-person meeting location or Zoom link.
  • Growing Forward- Brain Injury Support Community
    Meeting Time: Every Monday | 6:30pm CT
    Location: Virtually
    Email us for the zoom link.
  • TBI Support Group
    3rd Tuesday of each month | 6:00pm-7:00pm CT
    Location: Baylor Scott & White - Fort Worth
    6601 Harris Pkwy
    Fort Worth, TX 76132
    Contact: (817) 738-9866
  • DFW Concussion Support Group 
    Meeting Time: First Saturday of each month | 10:00am - 11:30am CT
    Location: Arborlawn United Methodist Church
    5001 Briarhaven Road
    Fort Worth, TX 76109
    Contact: (214) 718-7464
  • Young Women’s Brain Injury Support Group
    Meeting Time: 1st Thursday of each month | 12:00pm-1:00pm CT
    Location: Virtually
    Contact: 214-718-7464

Our Team

Principal Investigators

Rong Zang, Ph.D.

Professor
Department of Neurology, UTSW
Cognitive & Memory Disorders, Biomedical Engineering, and Internal Medicine

View faculty profile

David Zhu, Ph.D.

Professor
Department of Neuroscience, MSU
Radiology, Psychology, Electrical & Computer Engineering and Biomedical Engineering

Key Personnel

Danilo Cardim, Ph.D.

Research Instructor

Department of Neuroscience, UT Southwestern

Jill Morales

Clinical Research Coordinator
Department of Neurology, UT Southwestern

Javier Sigala Salazar, MPH

Bilingual Research Associate
Institute for Exercise and Environmental Medicine

Shotaro Saito, Ph.D

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Chris Reagin, B.S.N, R.N

Research Nurse
Institute for Exercise and Environmental Medicine

John Ashley, Ph.D.

Postdoctoral Research Fellow
Institute for Exercise and Environmental Medicine

Anna Tomlinson, DNP, APRN, AGACNP-BC

Nurse Practitioner
Institute for Exercise and Environmental Medicine

Margaret (Meg) McGregor, B.S.

Research Associate
Institute for Exercise and Environmental Medicine

Contact Us

  • UT Southwestern CAPCOG-TBI Study
  • 469-431-4316
  • Email