Publications

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd September 2005 19 829-840

Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase

Bao-Liang Song and Russell A. DeBose-Boyd July 2004 279 28798-28806

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.

DeBose-Boyd, R.A. 2008 18 609-21

Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain

Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A 2003 11 25-33

Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi

DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. 1999 99 703-712

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. September 2009 284 26778-88

Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.

Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X, 2022 Jul Nat Commun 1 13 4273

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1.

Elsabrouty R, Jo Y, Hwang S, Jun DJ, DeBose-Boyd RA, 2021 Nov Elife 10

Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol.

Schumacher MM, DeBose-Boyd RA, 2021 Jun Annu Rev Biochem 90 659-679

Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.

Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X, 2021 Aug Sci Adv 34 7

Schnyder Corneal Dystrophy-Associated UBIAD1 is Defective in MK-4 Synthesis and Resists Autophagy-Mediated Degradation.

Jun DJ, Schumacher MM, Hwang S, Kinch LN, Grishen NV, DeBose-Boyd RA, 2020 Mar J. Lipid Res.

Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency.

Jo Y, Kim SS, Garland K, Fuentes I, DiCarlo LM, Ellis JL, Fu X, Booth SL, Evers BM, DeBose-Boyd RA, 2020 Mar Elife 9

Schnyder corneal dystrophy-associated UBIAD1 Inhibits ER-associated degradation of HMG CoA reductase in mice.

Jo Y, Hamilton JS, Hwang S, Garland K, Smith GA, Su S, Fuentes I, Neelam S, Thompson BM, McDonald JG, DeBose-Boyd RA 2019 Feb Elife 8

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond.

DeBose-Boyd RA, Ye J 2018 Feb Trends Biochem. Sci.

UbiA Prenyltransferase Domain-Containing Protein-1 Modulates HMG CoA Reductase Degradation to Coordinate Synthesis of Sterol and Nonsterol Isoprenoids.

Schumacher MM, Jun DJ, Johnson BM, DeBose-Boyd RA 2017 Nov J. Biol. Chem.

Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.

Johnson BM, DeBose-Boyd RA 2017 Nov Semin. Cell Dev. Biol.

Significance and regulation of lipid metabolism.

DeBose-Boyd RA 2017 Dec Semin. Cell Dev. Biol.

Hypoxia-inducible factor-1a activates insig-2 transcription for degradation of HMG CoA reductase in the liver.

Hwang S, Nguyen AD, Jo Y, Engelking LJ, Brugarolas J, DeBose-Boyd RA 2017 Apr J. Biol. Chem.

Membrane Extraction of HMG CoA Reductase as Determined by Susceptibility of Lumenal Epitope to In Vitro Protease Digestion.

Morris LL, DeBose-Boyd RA 2017 Methods Mol. Biol. 1583 193-199

Contribution of accelerated degradation to feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase and cholesterol metabolism in liver.

Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA 2016 Apr J. Biol. Chem.

Geranylgeranyl-Regulated Transport of the Prenyltransferase UBIAD1 between Membranes of the ER and Golgi.

Schumacher MM, Jun DJ, Jo Y, Seeman J, DeBose-Boyd RA 2016 Apr J. Lipid Res.

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase.

Schumacher MM, Elsabrouty R, Seemann J, Jo Y, DeBose-Boyd RA 2015 Elife 4

Sequential actions of the AAA-ATPase VCP/p97 and the proteasome 19S regulatory particle in sterol-accelerated, ER-associated degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.

Morris LL, Hartman IZ, Jun DJ, Seemann J, DeBose-Boyd RA 2014 May J. Biol. Chem.

Sterol-Induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Membranes of Permeabilized Cells.

Elsabrouty R, Jo Y, Dinh TT, Debose-Boyd RA 2013 Sep Mol. Biol. Cell

Lipid-Regulated Degradation of HMG CoA Reductase and Insig-1 through Distinct Mechanisms in Insect Cells.

Faulkner RA, Nguyen AD, Jo Y, Debose-Boyd RA 2013 Feb J. Lipid Res.

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.

Jo Y, Hartman IZ, Debose-Boyd RA 2013 Feb Mol. Biol. Cell 3 24 169-83

Opening up new fronts in the fight against cholesterol.

Debose-Boyd RA, Horton JD 2013 Elife 2 e00663

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA 2011 Dec Proc. Natl. Acad. Sci. U.S.A. 51 108 20503-8

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Jo Y, Sguigna PV, DeBose-Boyd RA 2011 Apr J. Biol. Chem. 17 286 15022-31

Regulation of cholesterol and Fatty Acid synthesis.

Ye J, Debose-Boyd RA 2011 Cold Spring Harb Perspect Biol 7 3

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets.

Hartman IZ, Liu P, Zehmer JK, Luby-Phelps K, Jo Y, Anderson RG, DeBose-Boyd RA 2010 Jun J. Biol. Chem. 25 285 19288-98

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.

Jo Y, Debose-Boyd RA 2010 Jun Crit. Rev. Biochem. Mol. Biol. 3 45 185-98

Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.

Lee PC, DeBose-Boyd RA 2010 Jan J. Lipid Res. 1 51 192-201

Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.

Lee, P.C., Debose-Boyd, R.A. 2010 51 192-201

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets.

Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. 2010 285 19288-98

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.

Jo, Y., Debose-Boyd, R.A. 2010 45 185-98

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

Nguyen AD, Lee SH, DeBose-Boyd RA 2009 Sep J. Biol. Chem. 39 284 26778-88