Learning & Memory
Sun, X., Bernstein, M.J., Meng, M., Rao, S., Sørensen, A.T., Yao, L., Zhang, X., Anikeeva, P.O. & Lin, Y. Functionally Distinct Neuronal Ensembles Within the Memory Engram. Cell 181, 410-423 (2020).
Yelhekar, T.D., Meng, M., Doupe, J., & Lin, Y. All IEGs are not created equal – Molecular sorting within the memory engram. Book chapter for Engram: A Window Into the Memory Trace. Springer-Nature.
Weng, F.J., Garcia, R.I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., David, D., Garcia-Dominquez, D., Hung, M., Yelhekar, T.D., Sørensen, A.T., Xu, W., Chung, K., Castillo, P. & Lin, Y. Npas4 is a Critical Regulator of Learning-induced Plasticity at Mossy Fiber-CA3 Synapses During Contextual Memory Formation. Neuron 97, 1137-1152 (2018).
Ramamoorthi, K., French R.A., Belfort G.M., Fitzmaurice H.L., McKinney R.M., Neve, R.L., Otto, T. & Lin, Y. Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation. Science 334, 1669-75 (2011).
Sun, X. & Lin, Y. Npas4: Linking neuronal activity to neural circuit plasticity. Trends in Neurosciences 39, 64-75 (2016).
Neurodevelopment
Xue, J., Brawner, A.T., Thompson, J.R., Yelhekar, T.D., Newmaster, K.T., Qiu, Q., Cooper, Y.A., Yu, C.R., Ahmed-Braima, Y.H., Kim, Y. & Lin, Y. Spatiotemporal Mapping and Molecular Basis of Whole-brain Circuit Maturation. bioRxiv. doi: 10.1101/2024.01.03.572456 (2024).
Thompson, J.R. & Lin, Y. Nature and nurture converge in the nucleus to regulate activity-dependent neuronal development. Book chapter for Transcriptional Regulation by Neuronal Activity; To the nucleus and back; 2nd edition. Springer-Nature.
E/I Balance
Lin, Y., Bloodgood, B.L., Hauser, J.L., Lapan, A.D., Koon, A.K., Kim, T.K., Hu, L.S., Malik, A.N. and Greenberg, M.E. Activity-dependent regulation of inhibitory synapse development by Npas4. Nature 455, 1198-1204 (2008).
Ramamoorthi, K. & Lin Y. The contribution of GABAergic dysfunction to neurodevelopmental disorders. Trends in Molecular Medicine 17, 452-62 (2011).
Neurogenetic Tool Development
Sørensen, A.T., Cooper, Y.A., Weng, F.J., Young, A., Ramamoorthi, K., LaVerriere, E., Baratta, M., Hemberg, M., Maier, S.F., and Lin, Y. A robust activity marking system for exploring active neuronal ensembles. eLife 5, e13918 (2016).
Xue, J., Brawner, A.T., Thompson, J.R., Yelhekar, T.D., Newmaster, K.T., Qiu, Q., Cooper, Y.A., Yu, C.R., Ahmed-Braima, Y.H., Kim, Y. & Lin, Y. Spatiotemporal Mapping and Molecular Basis of Whole-brain Circuit Maturation. bioRxiv. doi: 10.1101/2024.01.03.572456 (2024).