Nguyen T.P., Fang M., Kim J., Wang B., Lin E., Khivansara V., Barrows N., Rivera-Cancel G., Goralski M., Cervantes C.L., Xie S., Peterson J.M., Povedano J.M., Antczak M.I., Posner B.A., McFadden D.G., Ready J.M., De Brabander J.K., Nijhawan D. Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules. (2023) Cell Chem Biol. 2023 Aug 14:S2451-9456(23)00245-3. doi: 10.1016/j.chembiol.2023.07.017
Povedano J.M., Li V., Lake K.E., Bai X., Rallabandi R., Kim J.,Xie Y., De Brabander J.K., and McFadden D.G. TK216 targets microtubules in Ewing sarcoma cells. (2022) Cell Chem Biol. Aug 18;29(8):1325-1332.e4. doi: 10.1016/j.chembiol.2022.06.002.
Povedano J. M., Rallabandi R., Bai X., Ye X., Liou J., Chen H., Kim J., Xie Y., Posner B., Rice L., De Brabander J.K., and McFadden D.G. A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-Cancer Toxins. (2020) J Med Chem. DOI: 10.1021/acs.jmedchem.0c01482.
Povedano J.M., Liou J., Wei D., Srivatsav A., Kim J., Xie Y., Nijhawan D., and McFadden D.G. Engineering forward genetics into cultured cancer cells for chemical target identification. (2019) Cell Chem Biol. Jul 11; 26:1-7. PMID: 31303577
Povedano J. M., Martinez P., Serrano R., Tejera Á., Gómez-López G., Bobadilla M., Flores J.M., Bosch F., and Blasco M.A. Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres. (2018) eLife. Jan 30;7. pii: e31299. doi: 10.7554/eLife.31299.
Bär C., Povedano J. M., Serrano R., Popkes M., Benitez-Buelga C., Formentinin I., Bobadilla M., Bosch F., and Blasco M. A. Telomerase gene therapy rescues telomere length, bone marrow aplasia and survival in a mouse model of aplastic anemia. (2016) Blood. 127(14):1770-9. doi: 10.1182/blood-2015-08-667485.
Povedano J. M., Martinez P., Flores J. M., Mulero F., and Blasco M. A. Telomere dysfunction in lung alveolar type II cells is sufficient to trigger progressive pulmonary fibrosis in mice. (2015) Cell Rep. 12 (2), 286-99.