Publications

Journal Publication

First authors are boldfaced. *indicates corresponding authors.

• Punwani S, Larson PEZ, Laustsen C, VanderMeulen J, Ardenkjær-Larsen JH, Autry AW, Bankson JA, Bernard J, Bok R, Bertelsen LB, Che J, Chen AP, Chowdhury R, Comment A, Cunningham CH, Dang D, Gallagher FA, Gaunt A, Gong Y, Gordon JW, Grimmer A, Grist J, Hansen ES, Lerche MH, Hesketh RL, Hoeverner JB, Hsieh CY, Keshari KR, Kozerke S, Lanz T, Mayer D, McLean M, Park JM, Slater J, Tyler D, Vanderheyden JL, von Morze C, Zaccagna F, Zaha V, Xu D, Vigneron D, HP 13C MRI Consensus Group. Consensus Recommendations for Hyperpolarized [1‐13C]pyruvate MRI Multi-center Human Studies. Magnetic Resonance in Medicine. 2025 Apr; In Press.
• Gottwald W, Nagel L, Skinner JG, Grashei M, Sühnel S, Setzer N, Eisenreich W, McLean MA, Gallagher FA, Park JM, Ahmadova Z, Gierse M, Karaali S, Knecht S, Schwartz I, Heid I, Topping GJ, van Heijster FHA, Schilling F*. Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry. npj Imaging. 2025 Apr; In Press.
• Park JM*, Lin SH, Baxter JD, Harrison CE, Leary J, Mozingo C, Liticker J, Malloy CR*, Jin ES*. Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver. Metabolism. 2025 Jan;165:156151.
• Lin SH, Ma J, Park JM*. Volumetric patch-based super-resolution reconstruction of hyperpolarized 13C cardiac MRI. IEEE Access. 2024 Nov;12:164315-164324.
• Huynh MT, Erfani Z, Al Nemri S, Chirayil S, Kovács Z*, Park JM*. Enhanced solubility and polarization of 13C-fumarate with meglumine allows for in vivo detection of gluconeogenic metabolism in kidneys. ACS Applied Materials & Interfaces. 2024 Jul;16(29):37435-37444.
• Huynh MT, Erfani Z, Kovács Z, Park JM*. Hyperpolarized [2-13C, 3-2H3]pyruvate detects hepatic gluconeogenesis in vivo. ACS Sensors. 2024 Jun;9(6):2801-2805.
• Zaidi M, Ma J, Thomas BP, Peña S, Harrison CE, Chen J, Lin SH, Derner K, Baxter JD, Liticker J, Malloy CR, Bartnik-Olson B, Park JM*. Functional activation of pyruvate dehydrogenase in human brain using hyperpolarized [1-13C]pyruvate. Magnetic Resonance in Medicine. 2024 May;91(5):1822-1833.
• Zhu M, Jhajharia A, Josan S, Park JM, Yen YF, Pfefferbaum A, Hurd RE, Spielman DM, Mayer D*. Investigating the origin of the 13C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13C]pyruvate injection. NMR in Biomedicine. 2024 Jan;37(3):e5073.
• Hackett EP, Chen J, Ingle L, Al Nemri S, Barshikar S, Pinho MC, Plautz EJ, Bartnik-Olson B, Park JM*. Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-13C]pyruvate. Magnetic Resonance in Medicine. 2023 Dec;90(6):2432–2442.
• Chen J, Singh TK, Al Nemri S, Zaidi M, Billingsley KL*, Park JM*. Hyperpolarized [1-13C]acetyl-L-carnitine probes TCA cycle activity in vivo. ACS Sensors. 2023 Aug;8(8):2927-2932.
• Park H, Chen J, Dimitrov IE, Park JM*, Wang Q*. Design and characterization of hyperpolarized 15N-BBCP as a H2O2-sensing probe. ACS Sensors. 2022 Oct;7(10):2928-2933. Link
• Ma J, Pinho MC, Harrison CE, Chen J, Sun C, Hackett EP, Liticker J, Ratnakar J, Reed GD, Chen AP, Sherry AD, Malloy CR, Wright SM, Madden CJ, Park JM*. Dynamic 13C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans. Magnetic Resonance in Medicine. 2022 Mar;87(3):1136-1149.
• Ma J, Malloy CR, Peña S, Harrison CE, Ratnakar J, Zaha VG, Park JM*. Dual-phase imaging of cardiac metabolism using hyperpolarzed [1-13C]pyruvate. Magnetic Resonance in Medicine. 2022 Jan;87(1):302-311.
• Chen J, LaGue E, Li J, Yang C, Hackett EP, Mendoza M, Alger JR, DeBerardinis RJ, Corbin IR, Billingsley KL*, Park JM*. Profiling carbohydrate metabolism in liver and hepatocellular carcinoma with 13C-glycerate probes. Analysis & Sensing. 2021 Nov;1(4):195-202.
• Singh J, Suh EH, Sharma G, Chen J, Hackett EP, Wen X, Sherry AD, Khemtong C, Malloy CR, Park JM, Kovács Z*. 13C-labeled diethyl ketoglutarate derivatives as hyperpolarized probes of 2-ketoglutarate dehydrogenase activity. Analysis & Sensing. 2021 Nov;1(4):156-160.
• Park JM, Josan S, Hurd RE, Graham J, Havel P, Bendahan D, Mayer D, Chung Y, Spielman DM, Jue T*. Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle. Pflügers Archiv: European Journal of Physiology. 2021 Nov; 473:1761-1773.
• Park JM*, Harrison CE, Ma J, Chen J, Ratnakar J, Zun Z, Liticker J, Reed GD, Chhabra A, Haller R, Jue T, Malloy CR. Hyperpolarized MR spectroscopy depicts in-vivo effect of exercise on pyruvate metabolism in human skeletal muscle. Radiology. 2021 Sep;300(3):626-632.
• Ma J, Chen J, Reed GD, Hackett EP, Harrison CE, Ratnakar J, Schulte RF, Zaha VG, Malloy CR, Park JM*. Cardiac T2* measurement of hyperpolarized 13C metabolites using metabolite-selective multi-echo spiral imaging. Magnetic Resonance in Medicine. 2021 Sep;86(3):1494-1504.
• Hackett EP, Shah B, Cheng B, LaGue E, Vemireddy V, Mendoza M, Bachoo RM, Billingsley KL, Chopra R*, Park JM*. Probing cerebral metabolism with hyperpolarized 13C imaging after opening the blood-brain barrier with focused ultrasound. ACS Chemical Neuroscience. 2021 Aug;12(15):2820-2828.
• Reed GD*, Ma J, Park JM, Schulte RF, Harrison CE, Chen AP, Peña S, Baxter JD, Derner K, Tai M, Raza J, Liticker J, Hall RG, Sherry AD, Zaha VG, Malloy CR. Characterization and compensation of f0 inhomogeneity artifact in spiral hyperpolarized 13C imaging of the human heart. Magnetic Resonance in Medicine. 2021 Jul;86(1):157-166.
• Chen J, Patel TR, Pinho MC, Choi C, Harrison CE, Baxter JD, Derner K, Peña S, Liticker J, Raza J, Hall RG, Reed GD, Cai C, Hatanpaa KJ, Bankson JA, Bachoo RM, Malloy CR, Mickey BE*, Park JM*. Preoperative imaging of glioblastoma patients using hyperpolarized 13C pyruvate. Neuro-Oncology Advances. 2021 Jun;3(1):vdab092.
• Chen J, Hackett EP, Kovács Z, Malloy CR, Park JM*. Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1-13C]-L-lactate. Magnetic Resonance in Medicine. 2021 Mar; 85(3):1175-1182.
• Ma J, Park JM*. Super-resolution hyperpolarized 13C imaging of human brain using patchbased algorithm. Tomography. 2020 Dec;6(4):343-355.
• Suh EH, Park JM, Lumata L, Sherry AD, Kovács Z*. Hyperpolarized 15N-labeled, deuterated tris(2-pyridylmethyl)amine as an MRI sensor of freely available Zn2+ in tissues. Communications Chemistry. 2020 Dec;185(3):1-8.
• Hackett EP, Pinho MC, Harrison CE, Reed GD, Liticker J, Raza J, Hall RG, Malloy CR, Barshikar S, Madden CJ, Park JM*. Imaging acute metabolic changes in patients with mild traumatic brain injury using hyperpolarized [1-13C]pyruvate. iScience. 2020 Dec;23(12):101885.
• Park JM, Reed GD, Liticker J, Putnam WC, Chandra A, Yaros K, Afzal A, MacNamara J, Raza J, Hall RG, Baxter JD, Derner K, Peña S, Kallem RR, Subramaniyan I, Edpuganti V, Harrison CE, Muthukumar A, Lewis C, Reddy S, Unni N, Klemow D, Syed S, Li H, Cole S, Froehlich T, Ayers C, de Lemos J, Malloy CR, Haley B, Zaha VG*. Effect of doxorubicin on myocardial bicarbonate production from pyruvate dehydrogenase in women with breast cancer. Circulation Research. 2020 Dec;127(12):1568-1570.
• Chen J, Hackett EP, Singh J, Kovács Z, Park JM*. Simultaneous assessment of intracellular and extracellular pH using hyperpolarized [1-13C]alanine ethyl ester. Analytical Chemistry. 2020 Sep;92(17):11681-11686.
• Stender S, Zaha VG, Malloy CR, Sudderth J, DeBerardinis RJ, Park JM*. Assessment of rapid hepatic glycogen synthesis in humans using dynamic 13C MR spectroscopy. Hepatology Communications. 2020 Jan;4(3):425-433.
• Bachawal S, Park JM, Valluru KS, Loft MD, Felt SA, Vilches-Moure JG, Saenz YF, Daniel B, Iagaru A, Sonn G, Cheng Z, Spielman DM, Willmann JK*. Multimodality hyperpolarized 13C MRS/PET/Multiparametric MR imaging for detection and image-guided biopsy of prostate cancer: first experience in a canine prostate cancer model. Molecular Imaging and Biology. 2019 Oct;21(5):861-870.
• Suh EH, Hackett EP, Wynn RM, Chuang DT, Zhang B, Luo W, Sherry AD, Park JM*. In vivo assessment of increased oxidization of branched-chain amino acids in glioblastoma. Scientific Reports. 2019 Jan;9:340.
• Lin G, Keshari KR, Park JM*. Cancer metabolism and tumor heterogeneity: imaging perspectives using MR imaging and spectroscopy. Contrast Media & Molecular Imaging. 2017 Oct;2017:6053879.
• Tee SS*, Park JM, Hurd RE, Brimacombe KR, Boxer MB, Massoud TF, Rutt BK, Spielman DM. PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose. Oncotarget. 2017 Jul;26;8(53):90959-90968.
• Park JM*, Wu M, Datta K, Liu SC, Castillo A, Lough H, Spielman DM*, Billingsley KL*. Hyperpolarized sodium 13C-glycerate as a probe for assessing glycolysis in vivo. Journal of the American Chemical Society. 2017 May;139(19):6629-6634.
• Park JM*, Khemtong C, Liu SC, Hurd RE, Spielman DM. In vivo assessment of intracellular redox-state in rat liver using hyperpolarized [1-13C]alanine. Magnetic Resonance in Medicine. 2017 May;77(5):1741-1748.
• Wibowo A, Park JM, Liu SC, Khosla C, Spielman DM*. Real-time in vivo detection of H2O2 using hyperpolarized 13C-thiourea. ACS Chemical Biology. 2017 Apr;12(7):1737-1742.
• Park JM*, Spielman DM, Josan S, Jang T, Merchant M, Hurd RE, Mayer D, Recht LD. Hyperpolarized 13C-lactate to 13C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment. NMR in Biomedicine. 2016 May;29(5):650-659.
• Yang S, Lee J, Joe E, Lee H, Choi YS, Park JM, Spielman DM, Song HT, Kim DH*. Metaboliteselective hyperpolarized 13C imaging using extended chemical shift displacement at 9.4T. Magnetic Resonance Imaging. 2016 May;34(4):535-540.
• Park JM, Josan S, Jang T, Merchant M, Watkins R, Hurd RE, Recht LD, Mayer D*, Spielman DM. Volumetric spiral chemical shift imaging of hyperpolarized [2-13C]pyruvate in a rat C6 glioma model. Magnetic Resonance in Medicine. 2016 Mar;75(3):973-984.
• Josan S*, Billingsley KL, Orduna J, Park JM, Luong R, Yu L, Hurd RE, Pfefferbaum A, Spielman DM, Mayer D. Assessing inflammatory liver injury in an acute CCl4 model using dynamic 3D metabolic imaging of hyperpolarized [1-13C]pyruvate. NMR in Biomedicine. 2015 Dec;28(12):1671-7.
• Park JM, Josan S, Mayer D, Hurd RE, Chung Y, Bendahan D, Spielman DM, Jue T*. Hyperpolarized 13C NMR observation of lactate kinetics in skeletal muscle. The Journal of Experimental Biology. 2015 Oct;218:3308-3318.
• Billingsley KL*, Park JM, Josan S, Hurd RE, Mayer D, Spielman-Sun E, Nishimura DG, Brooks JD, Spielman DM. The feasibility of assessing branched-chain amino acid metabolism in cellular models of prostate cancer with hyperpolarized [1-13C]-ketoisocaproate. Magnetic Resonance Imaging. 2014 Sep;32(7):791-795.
• Josan S*, Hurd RE, Park JM, Yen YF, Watkins R, Pfefferbaum A, Spielman DM, Mayer D. Dynamic metabolic imaging of hyperpolarized [2-13C]pyruvate using spiral CSI with alternating spectral band excitation. Magnetic Resonance in Medicine. 2014 Jun;71(6):2051-2058.
• Billingsley KL*, Josan S, Park JM, Tee SS, Hurd RE, Mayer D, Spielman DM. Hyperpolarized [1,4-13C]-diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging. NMR in Biomedicine. 2014 Mar;27(3):356-362.
• Josan S*, Park JM, Hurd RE, Yen YF, Pfefferbaum A, Spielman DM, Mayer D. In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-13C] and [2-13C]pyruvate. NMR in Biomedicine. 2013 Dec;26(12):1680-1687.
• Park JM*, Josan S, Yen YF, Grafendorfer T, Hurd RE, Spielman DM, Mayer D. Measuring mitochondrial metabolism in rat brain in vivo using MR spectroscopy of hyperpolarized [2-13C]pyruvate. NMR in Biomedicine. 2013 Oct;26(10):1197-1203.
• Josan S*, Hurd RE, Billingsley KL, Senadheera L, Park JM, Yen YF, Pfefferbaum A, Spielman DM, Mayer D. Effects of isoflurane anesthesia on hyperpolarized 13C metabolic measurements in rat brain. Magnetic Resonance in Medicine. 2013 Oct;70(4):1117-1124.
• Park JM*, Recht LD, Josan S, Jang T, Merchant M, Yen YF, Hurd RE, Spielman DM, Mayer D. Metabolic response of glioma to dichloroacetate measured by hyperpolarized 13C MR spectroscopic imaging. Neuro-Oncology. 2013 Apr;15(4):433-441.
• Park JM*, Josan S, Jang T, Merchant M, Yen YF, Hurd RE, Recht LD, Spielman DM, Mayer D. Metabolite kinetics in C6 rat glioma model using MR spectroscopic imaging of hyperpolarized [1-13C]pyruvate. Magnetic Resonance in Medicine. 2012 Dec;68(6):1886-1893.
• Mayer D*, Yen YF, Josan S, Park JM, Pfefferbaum A, Hurd RE, Spielman DM. Application of hyperpolarized [1-13C]lactate for the in vivo investigation of cardiac metabolism. NMR in Biomedicine. 2012 Oct;25(10):1119-1124.