Guidelines and Expert Consensus Statements

We have helped shape clinical practice through guidelines, white papers, and expert consensus statements. These publications provide frameworks for biomarker development, risk stratification, and treatment recommendations. They also highlight gaps in care and propose research agendas to advance the field.

Singal AG, Llovet J, Yarchoan M, Mehta N, Heimbach J, Dawson L, Jou J, Kulik L, Agopian V, Marrero JA, Mendiratta-Lala M, Brown D, Rilling W, Goyal L, Wei A, Taddei T. AASLD Guidance on Prevention, Diagnosis, and Treatment of Hepatocellular Carcinoma. Hepatology 2023.
Singal AG, Hoshida Y, Pinato DJ, Marrero JA, Nault J-C, Paradis V, Tayob N, Sherman, M, Lim YS, Feng Z, Lok AS, Rinaudo J, Srivastava S, Llovet J, Villaneuva A. International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma. Gastroenterology 2021; 160(7): 2572-84.
Singal AG, Quirk L, Boike J, Chernyak V, Feng Z, Guimarqo G, Kanwal F, Ioannou G, Manes S, Marrero J, Mehta N, Pillai A, Shaheen N, Shaukat A, Sirlin C, Verna E, Wani S, Woods A, Yang JD, Parikh ND. Value of HCC surveillance in a landscape of emerging surveillance options: Perspectives of a multi-stakeholder modified Delphi panel. Hepatology 2025
Singal AG, Lok AS, Feng Z, Kanwal F, Parikh ND. Conceptual Model for the Hepatocellular Carcinoma Screening Continuum: Current Status and Research Agenda. Clinical Gastroenterology and Hepatology 2022; 20(1): 9-18.
Singal AG, Sanduzzi-Zamparelli M, Nahon P, Ronot M, Hoshida Y, Rich N, Reig M, Vilgrain V, Marrero J, Llovet JM, Parikh ND, Villanueva A. International Liver Cancer Association (ILCA) White Paper on Hepatocellular Carcinoma Risk Stratification and Surveillance. J Hepatology 2023; 79(1): 226-239.
Singal AG, Kanwal G, Llovet J. Global Trends in Hepatocellular Carcinoma Epidemiology: Implications for Screening, Prevention, and Therapy. Nature Reviews Clinical Oncology 2023; 20(12): 864-884.
McMahon B, Cohen C, Brown R, El-Serag H, Ioannou G, Lok A, Roberts L, Singal AG, Block T. Opportunities to Address Gaps in Early Detection and Improve Outcomes of Liver Cancer. JNCI Spectrum 2023; 7(3): pkad034.
Reig M, Forner A, Rimola J, Ferrer-Fabrega J, Burrel M, Garcia-Criado A, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. Journal of Hepatology 2022; 76(3): 681-93.
Singal AG, Kudo M, Bruix J. Breakthroughs in hepatocellular carcinoma therapies. Clinical Gastroenterology and Hepatology 2023; 21(8): 2135-2149.
Parikh ND, Tayob N, Singal AG. Blood-based biomarkers for hepatocellular carcinoma screening: Approaching the end of the ultrasound era? J. Hepatology 2023; 78(1): 207-216