Variation in HCC tumor growth patterns and prognosis

Understanding tumor biology and growth patterns is essential for prognostication in HCC. Although HCC is associated with high mortality overall, we have shown there is significant heterogeneity in tumor doubling times and progression rates. There is therefore a need to better understand tumor biology to help tailor our treatment strategies, particularly in patients with hepatic impairment from underlying cirrhosis. We are conducting studies to identify imaging and blood-based predictors of differing biological behaviors.

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Rich NE, John BV, Parikh, ND, Rowe I, Mehta N, Khatri G, Thomas SM, Anis M, Mendiratta-Lala M, Hernandez C, Odewole M, Sundaram LT, Konjeti VR, Shetty S, Shah T, Zhu H, Yopp A, Hoshida Y, Yao FY, Marrero JA, Singal AG. Hepatocellular carcinoma demonstrates heterogeneous growth patterns in a multicenter cohort of patients with cirrhosis. Hepatology 2020; 72(5): 1654-65.
Seif El Dahan K, Daher D, Rich N, Nayak A, Ankoma-Sey C, Govolan R, Bhongade M, Molina E, Amador E, Pitts H, Jalal P, Kanwal F, Parikh ND, Singal AG. Causes of mortality among patients with early-stage hepatocellular carcinoma. Hepatology 2025
Rich NE, Phen S, Desai N, Mittal S, Yopp AC, Yang JD, Marrero JA, Iyengar P, Infante R, Singal AG. Cachexia is Prevalent in Patients with Hepatocellular Carcinoma and Associated with Worse Prognosis. Clinical Gastroenterology and Hepatology 2022; 20(5): E1157-E1169.