Trivedi Lab

Our vision is a future free from the burden of depression.

The Center for Depression Research and Clinical Care (CDRC) is a nationally recognized center of excellence in the research and treatment of mood disorders, including depression and bipolar disorder.

Our research brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

Built on a quarter-century of research in mood disorders, the CDRC was established in 2015 to realize a future free from the burden of depression. Our team has lead research into new treatments, including brain and blood tests, for depression and suicide. We have established evidence-based programs that transform our ability to prevent, diagnose, and treat depression. Critically, we have built networks and established research-driven programs that extend our reach to adolescents; addressing youth depression and suicide with mental health promotion and resilience training that encourages a conversation long overdue. We have witnessed the difference our efforts make for people with mental disorders and their families. Such results speak to the value of the work to which we have dedicated ourselves.

Meet the Director

Dr. Trivedi Professional Photo

Founding Director

For more than two decades, Dr. Madhukar Trivedi and his colleagues at UT Southwestern Medical Center have conducted cutting-edge research to improve the treatment of depression.

Recent News & Discoveries

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Season 2 of the CDRC's Brainstorm Podcast Series

Season 2, episode 1: CDRC's own, Kathryn Forbes interviews Dr. Madhukar Trivedi and three special guests—a clinical psychologist, a pediatrician, and a minister—about adolescent risk and the protective factors that can prevent mood disorders and promote mental health and well-being in adolescents.

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Unraveling the relationship between gut microbes and brain health

The role of the microbiome in intestinal and systemic health has garnered close attention among researchers for many years. Now evidence is mounting that this collection of microorganisms in the human gut can also impact a person’s neurological and emotional health, according to a recent perspective article in Science by neuroscientist Jane Foster, Ph.D., Professor of Psychiatry.

Drs. Ayvaci and Chin Fatt presenting

CDRC presents for Suicide Prevention Awareness Month

AFSP Project Leaders, Dr. Ayvaci and Dr. Chin Fatt, lead discussion on youth suicide as part of a series of activities to increase awareness.

Medscape's InDiscussion Podcast Series

Dr. Trivedi hosts Medscape's InDiscussion Podcast series on Major Depressive Disorder.

In this episode, Dr. Trivedi discusses the role and future of psychedelics for the treatment of major depressive disorder with Dr. Greg Fonzo.

Stay Engaged

Meet the Team

The CDRC has faculty members with expertise in neuroimaging, cognitive and behavioral phenotyping, biospecimens, biostatistics, genetics, adolescent behaviors, novel treatments and addiction.

Learn More About Us
YAM Trainers Team

Explore Our Initiatives

To better understand the areas of greatest impact, we have identified and partnered with schools, community organizations, and healthcare systems on initiatives to improve the diagnosis and treatment of mood disorders and enhance suicide prevention efforts.

Learn About Our Work
Drs. Andy Keller and Madhukar Trivedi

Learn About Our Community

The CDRC is always striving to build bridges to better mental health and wellbeing for our community in Texas and beyond.

Accomplishing this means addressing the particular needs and levels of community involvement that make success possible.

Learn About Our Collaborations
Drs. Ayvaci and Chin Fatt presenting