Trivedi Lab

Our vision is a future free from the burden of depression.

The Center for Depression Research and Clinical Care (CDRC) is a nationally recognized center of excellence in the research and treatment of mood disorders, including depression and bipolar disorder.

Real People. Real Research.

Built on a quarter-century of research in mood disorders, the CDRC was established in 2015 to realize a future free from the burden of depression. Our team has led research into new treatments, including brain and blood tests, for depression and suicide. We have established evidence-based programs that transform our ability to prevent, diagnose, and treat depression. Critically, we have built networks and established research-driven programs that extend our reach to adolescents; addressing youth depression and suicide with mental health promotion and resilience training that encourages a conversation long overdue. We have witnessed the difference our efforts make for people with mental disorders and their families. Such results speak to the value of the work to which we have dedicated ourselves.

Meet the Director

Dr. Trivedi Professional Photo

Founding Director

For more than two decades, Dr. Madhukar Trivedi and his colleagues at UT Southwestern Medical Center have conducted cutting-edge research to improve the treatment of depression.

Quote from Madhukar Trivedi, M.D.

Depression should be seen like any other kind of chronic disease, like diabetes or hypertension. Therefore, we have to always be on the hunt for better treatments.
Madhukar Trivedi, M.D. Founding Director Center for Depression Research and Clinical Care

Recent News & Discoveries

brainstorm podcast image

Season 2 of the CDRC's Brainstorm Podcast Series

Season 2, episode 1: CDRC's own, Kathryn Forbes interviews Dr. Madhukar Trivedi and three special guests—a clinical psychologist, a pediatrician, and a minister—about adolescent risk and the protective factors that can prevent mood disorders and promote mental health and well-being in adolescents.

presenter on stage

Unraveling the relationship between gut microbes and brain health

The role of the microbiome in intestinal and systemic health has garnered close attention among researchers for many years. Now evidence is mounting that this collection of microorganisms in the human gut can also impact a person’s neurological and emotional health, according to a recent perspective article in Science by neuroscientist Jane Foster, Ph.D., Professor of Psychiatry.

Drs. Ayvaci and Chin Fatt presenting

CDRC presents for Suicide Prevention Awareness Month

Our priorities at the CDRC include studying biomarkers related to youth suicide risk and more effective ways to treat suicidal ideation and behavior. American Foundation for Suicide Prevention (AFSP) Project Leaders, Dr. Ayvaci and Dr. Chin Fatt, lead discussions on youth suicide as part of a series of activities to increase awareness.

Medscape's InDiscussion Podcast Series

Dr. Trivedi hosts Medscape's InDiscussion Podcast series on Major Depressive Disorder.

Dr. Madhukar Trivedi hosts a 6-part podcast series on topics related to Major Depressive Disorder (MDD) with thought leaders in the field. In this episode, Dr. Trivedi discusses the role and future of psychedelics for the treatment of major depressive disorder with Dr. Greg Fonzo.

Stay Engaged

Meet the Team

The CDRC has faculty members with expertise in neuroimaging, cognitive and behavioral phenotyping, biospecimens, biostatistics, genetics, adolescent behaviors, novel treatments and addiction.

Find out more
YAM Trainers Team

Explore Our Initiatives

To better understand the areas of greatest impact, we have identified and partnered with schools, community organizations, and healthcare systems on initiatives to improve the diagnosis and treatment of mood disorders and enhance suicide prevention efforts.

Find out more
Drs. Andy Keller and Madhukar Trivedi

Learn About Our Community

The CDRC is always striving to build bridges to better mental health and wellbeing for our community in Texas and beyond. Accomplishing this means addressing the particular needs and levels of community involvement that make success possible.

Find out more
Drs. Ayvaci and Chin Fatt presenting

Depression Research Clinic

Email address:
Phone Number: 214-648-0158
Fax Number: 214-648-0167

Mailing Address
1440 Empire Central
Level 3 Mood Disorders
Dallas, TX 75247-9119

Physical Address
1440 Empire Central
Level 3 Mood Disorders
Dallas, TX 75247-9119

Fort Worth Depression Research Clinic

Email address:
Phone Number: 214-648-0158

Physical Address
400 W. Magnolia Ave.
Fort Worth, TX 76104

Solving Depression, Saving Tomorrows

Be part of the great impact we're having on science and medical care across the globe.

Continued advancements come through tireless pursuit, and our Center's faculty and staff understand that the commitment we renew each day is built upon a foundation of scholarship and a network of like-minded organizations. By sharing our findings worldwide, we strive to improve patient care and further the research momentum of our fellow scientists. Made possible by public grants and philanthropic investments, these programs provide civic and health partners with resources and tools to better prevent, identify, and treat depression in individuals of all ages.