Substance use, particularly the use of stimulants and opioids in the fourth wave of the opioid epidemic, are a major public health problem. Research is needed to develop new substance use disorder treatments and to determine how to best broadly disseminate the treatments that are currently available and effective.
As a key leader in the field of mood disorders, Dr. Madhukar Trivedi serves as the Principal Investigator of the National Institute on Drug Abuse (NIDA) sponsored Clinical Trials Network (CTN) Big SouthWest Node that researches novel interventions aimed at improving outcomes for substance use disorders.
Mood Disorders Research
Committed to the delivery of evidence-based treatment.
For more than two decades, Dr. Madhukar Trivedi and his colleagues at UT Southwestern have conducted cutting-edge research to improve the treatment of depression and mood disorders. Housed within the Department of Psychiatry at UT Southwestern Medical Center, our center has one of the strongest programs in the nation for mood disorders research and treatment.
Innovatively Increasing PCP Prescribing of Buprenorphine: Measurement Based Care and Integrated Electronic Solution (MBC4OUD)
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Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone:Improving the Real-World Effectiveness of Injection Naltrexone for Opioid Use Disorder (SWIFT)
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The use of respective Transcranial Magnetic Stimulation (rTMS) for Stimulant Use Disorders (STIMULUS)
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Randomized, Placebo-Controlled Trial of Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)
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Strategies to Enhance Recruitment and Retention of Black Individuals Into Clinical Trials for Substance Use Disorders (I-DREM)
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Randomized, Double-blind, Placebo-controlled Trial of Monthly Injectable Buprenorphine for Methamphetamine Use Disorder (MURB)
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Remote Methadone Ingestion Surveillance Trial (RMIST)
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Driving Change in Diagnosis, Prevention, and Treatment
To better understand the areas of greatest impact, we have identified and partnered with schools, community organizations, and healthcare systems on initiatives to improve the diagnosis and treatment of mood disorders and enhance suicide prevention efforts.
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Prioritizing Mental Health
Self-monitoring involves keeping a personal record of your moods and behaviors in order to track trends over time. This allows individuals to observe how their mental state changes and provides concrete data to show how they are progressing, and which symptom profiles need attention.
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Sharing Insights
On our Brainstorm podcast, we decode the science of mood disorders through discussions with a leading expert in the field, Dr. Madhukar Trivedi. We’re here to change the way we think and talk about depression, in an accessible, approachable way.
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Solving Depression, Saving Tomorrows
Be part of the great impact we're having on science and medical care across the globe.
Continued advancements come through tireless pursuit, and our Center's faculty and staff understand that the commitment we renew each day is built upon a foundation of scholarship and a network of like-minded organizations. By sharing our findings worldwide, we strive to improve patient care and further the research momentum of our fellow scientists. Made possible by public grants and philanthropic investments, these programs provide civic and health partners with resources and tools to better prevent, identify, and treat depression in individuals of all ages.