Publications

Featured Publications

Morules But Not Squamous Differentiation are a Reliable Indicator of CTNNB1 (ß-catenin) Mutations in Endometrial Carcinoma and Precancers

Niu S, Lucas E, Molberg K, Strickland A, Wang Y, Carrick K, Rivera-Colon G, Gwin K, SoRelle JA, Castrillon DH, Zheng W, Chen H, 2022 Jul Am J Surg Pathol

Endometrial stromal tumors: Diagnostic updates and challenges.

Niu S, Zheng W, 2022 Jan Semin Diagn Pathol

The Prognostic Values of HPV Genotypes and Tumor PD-L1 Expression in Patients With HPV-associated Endocervical Adenocarcinoma.

Zhou F, Chen H, Li M, Strickland AL, Zheng W, Zhang X, 2022 03 Am J Surg Pathol 3 46 300-308

Reliable Identification of Endometrial Precancers Through Combined Pax2, ß-Catenin, and Pten Immunohistochemistry

Aguilar M, Chen H, Rivera-Colon G, Niu S, Carrick K, Gwin K, Cuevas IC, Sahoo SS, Li HD, Zhang S, Zheng W, Lucas E, Castrillon DH, 2021 Sep Am J Surg Pathol

Navigating through perplex morphologic changes after exogenous hormone usage.

Chang RJ, Rivera-Colon G, Chen H, Niu S, Carrick K, Lucas E, Gwin K, Zheng W, 2021 Oct Semin Diagn Pathol

The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiation.

Sun D, Qin Z, Xu Y, Xiao Q, Xu Y, Bai M, Li W, Liu Y, Zheng W, Zhang Z, 2021 Nov Cancer Lett

Tumoral Morphologic Features From Cervical Biopsies That Are Predictive of a Negligible Risk for Nodal Metastasis and Tumor Recurrence in Usual-type Cervical Adenocarcinomas: A Multi-institutional Study.

Wang Y, Chang RJ, Luo RZ, Yu J, Zhang X, Yang X, Quddus MR, Li L, Yang W, Liu A, Jiang Q, Zhao R, Zhu H, Zhou F, Wang Y, Sheng X, Liu LL, Wen YL, Banet N, Sung CJ, Qi Y, Bi R, Li M, Wang Y, Li J, Lin W, Wang Y, Rivera G, Chen H, Holloway SB, Fadare O, Liu J, Wang J, Lea J, Kong B, Zheng W, 2021 Nov Am J Surg Pathol

High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.

Zhang C, Zheng W, 2021 Nov Semin Diagn Pathol

Serial genomic analysis of endometrium supports the existence of histologically indistinct endometrial cancer precursors.

Aguilar M, Zhang H, Zhang M, Cantarell B, Sahoo SS, Li HD, Cuevas IC, Lea J, Miller DS, Chen H, Zheng W, Gagan J, Lucas E, Castrillon DH, 2021 Jan J Pathol

Tumor Necrotic Debris and High Nuclear Grade: Newly Identified High-risk Factors for Early-stage Endocervical Adenocarcinoma.

Holloway SB, Colon GR, Zheng W, Lea JS, 2021 04 Am J Clin Oncol 4 44 162-168

LASS2 mediates Nrf2-driven progestin resistance in endometrial cancer.

Yang B, Hu M, Fu Y, Sun D, Zheng W, Liao H, Zhang Z, Chen X, 2021 Am J Transl Res 3 13 1280-1289

PD-L1 Expression in Endometrial Serous Carcinoma and Its Prognostic Significance.

Zhang T, Liu Q, Zhu Y, Zhang S, Peng Q, Strickland AL, Zheng W, Zhou F, 2021 Cancer Manag Res 13 9157-9165

Specific Biomarker Expression Patterns in the Diagnosis of Residual and Recurrent Endometrial Precancers After Progestin Treatment: A Longitudinal Study.

Chen H, Lucas E, Strickland AL, Carrick K, Gwin K, Castrillon DH, Rivera-Colon G, Niu S, Molberg KH, Zheng W, 2020 Oct Am. J. Surg. Pathol. 10 44 1429-1439

PD-L1 Expression and CD8+ Tumor-infiltrating Lymphocytes in Different Types of Tubo-Ovarian Carcinoma and Their Prognostic Value in High-grade Serous Carcinoma.

Chen H, Molberg K, Strickland AL, Castrillon DH, Carrick K, Jiang Q, Niu S, Rivera-Colon G, Gwin K, Hinson S, Lea J, Miller DS, Zheng W, Lucas E, 2020 May Am. J. Surg. Pathol.

Cervical Adenocarcinoma: Histopathologic Features From Biopsies to Predict Tumor Behavior.

Rivera-Colon G, Chen H, Niu S, Lucas E, Holloway S, Carrick K, Gwin K, Lea J, Zheng W, 2020 Feb Am. J. Surg. Pathol. 2 44 247-254

PD-L1 Expression in Endocervical Adenocarcinoma: Correlation With Patterns of Tumor Invasion, CD8+ Tumor-infiltrating Lymphocytes, and Clinical Outcomes.

Rivera-Colon G, Chen H, Molberg K, Niu S, Strickland AL, Castrillon DH, Carrick K, Gwin K, Lea J, Zheng W, Lucas E, 2020 Dec Am J Surg Pathol

De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection.

Beshnova D, Ye J, Onabolu O, Moon B, Zheng W, Fu YX, Brugarolas J, Lea J, Li B, 2020 Aug Sci Transl Med 557 12

Dedifferentiated Endometrioid Carcinomas with Neuroendocrine Differentiation: A Clinicopathological and Immunohistochemical Study of Three Cases.

Zhou F, Zhang X, Chen H, Zheng W, 2020 Cancer Manag Res 12 11623-11629

Loss of tubal ciliated cells as a risk for "ovarian" or pelvic serous carcinoma.

Tao T, Lin W, Wang Y, Zhang J, Chambers SK, Li B, Lea J, Wang Y, Wang Y, Zheng W, 2020 Am J Cancer Res 11 10 3815-3827

Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression.

Jiang Y, Chen X, Wei Y, Feng Y, Zheng W, Zhang Z, 2019 May Biomed. Pharmacother. 113 108712

Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.

Walker JL, Brady MF, Wenzel L, Fleming GF, Huang HQ, DiSilvestro PA, Fujiwara K, Alberts DS, Zheng W, Tewari KS, Cohn DE, Powell MA, Van Le L, Davidson SA, Gray HJ, Rose PG, Aghajanian C, Myers T, Alvarez Secord A, Rubin SC, Mannel RS, 2019 Jun J. Clin. Oncol. 16 37 1380-1390

Effect of Progestin Usage on the Interpretation of Cervical High-grade Squamous Intraepithelial Lesion.

Wang Y, Chen H, Jiang Q, Luo R, Zhou P, Wang Y, Zhao R, Fadare O, Zheng W, 2019 Apr Am. J. Surg. Pathol.

Extended HPV genotyping and its application in cervical cancer screening

Yiying Wang, Yue Wang, Beihua Kong, Wenxin Zheng 2019 28 79-81

Human Papillomavirus Genotyping in 1,088 Anal Cancer Precursor Cases: Expected and Unexpected Results

Yuxin Liu, Keith Sigel, Melissa Gitman, Tamara Kalir, William Westra, Wenxin Zheng, Michael M Gaisa 2019

Clinical significance of HPV genotyping and viral load in cervical cancer screening

Yue Wang, Yiying Wang, Xin Xie, Wenxin Zheng, Beihua Kong 2019 54 350-353

Tubal Origin of "Ovarian" Low-Grade Serous Carcinoma: A Gene Expression Profile Study.

Wang Y, Hong S, Mu J, Wang Y, Lea J, Kong B, Zheng W, 2019 J Oncol 2019 8659754

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism.

Bai M, Yang L, Liao H, Liang X, Xie B, Xiong J, Tao X, Chen X, Cheng Y, Chen X, Feng Y, Zhang Z, Zheng W 2018 Jun Oncogene

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway.

Wang Y, Wang Y, Zhang Z, Park JY, Guo D, Liao H, Yi X, Zheng Y, Zhang D, Chambers SK, Zheng W 2016 Jan Oncotarget

Fallopian tube secretory cell expansion: a sensitive biomarker for ovarian serous carcinogenesis.

Wang Y, Li L, Wang Y, Tang SN, Zheng W 2016 Am J Transl Res 1 8 230-8

Cytologic studies of the fallopian tube in patients undergoing salpingo-oophorectomy.

Chen H, Klein R, Arnold S, Chambers S, Zheng W 2016 Cancer Cell Int. 16 78

A proposed model for endometrial serous carcinogenesis.

Zheng W, Xiang L, Fadare O, Kong B 2011 Jan Am. J. Surg. Pathol. 1 35 e1-e14

Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer.

Sun D, Bai M, Jiang Y, Hu M, Wu S, Zheng W, Zhang Z, 2020 Am J Transl Res 7 12 3116-3132

Stigmasterol sensitizes endometrial cancer cells to chemotherapy by repressing Nrf2 signal pathway.

Liao H, Zhu D, Bai M, Chen H, Yan S, Yu J, Zhu H, Zheng W, Fan G, 2020 Cancer Cell Int 20 480

Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ.

Niu S, Molberg K, Thibodeaux J, Rivera-Colon G, Hinson S, Zheng W, Lucas E, 2019 May - Jun J Am Soc Cytopathol 3 8 141-148

Age cutoff for reporting of benign-appearing endometrial cells in Papanicolaou specimens; should it be raised? A 10-year retrospective study from a large county hospital.

Hinson S, Molberg K, Mir M, Flores M, Zheng W, Lucas E, 2019 Mar - Apr J Am Soc Cytopathol 2 8 78-83

Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients.

Zhang C, Yang Y, Chen R, Wei Y, Feng Y, Zheng W, Liao H, Zhang Z 2019 Am J Transl Res 1 11 269-279

Mismatch Repair Protein Expression in Endometrioid Intraepithelial Neoplasia/Atypical Hyperplasia: Should We Screen for Lynch Syndrome in Precancerous Lesions?

Lucas E, Chen H, Molberg K, Castrillon DH, Rivera Colon G, Li L, Hinson S, Thibodeaux J, Lea J, Miller DS, Zheng W 2018 Oct Int. J. Gynecol. Pathol.

Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature.

Zhang M, Lucas E, Xiong H, Liu S, Molberg K, Jiang Q, Zheng W 2018 May J Ovarian Res 1 11 44

Primary Ovarian Pregnancy: A Case Series and Analysis.

Wang Y, Chen H, Zhao M, Fadare O, Zheng W 2018 Jan Int. J. Gynecol. Pathol.

Targeted Molecular and Immunohistochemical Analyses of Endometrial Clear Cell Carcinoma Show that POLE Mutations and DNA Mismatch Repair Protein Deficiencies are Uncommon.

Baniak N, Fadare O, Köbel M, DeCoteau J, Parkash V, Hecht JL, Hanley KZ, Gwin K, Zheng W, Quick CM, Jarboe EA, Liang SX, Kinloch M 2018 Dec Am. J. Surg. Pathol.

Estrogen affects the negative feedback loop of PTENP1-miR200c to inhibit PTEN expression in the development of endometrioid endometrial carcinoma.

Chen R, Zhang M, Liu W, Chen H, Cai T, Xiong H, Sheng X, Liu S, Peng J, Wang F, Chen H, Lin W, Xu X, Zheng W, Jiang Q 2018 Dec Cell Death Dis 1 10 4

Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma.

Qiu C, Wang Y, Wang X, Zhang Q, Li Y, Xu Y, Jin C, Bu H, Zheng W, Yang X, Lu N, Kong B 2018 Apr Int. J. Oncol.

Female adnexal tumor of probable Wolffian origin (FATWO)

Elena Lucas and Wenxin Zheng 2018

The Significance of L1CAM Expression in Clear Cell Carcinoma of the Endometrium.

Fadare O, Roma AA, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Hecht JL, Parkash V, Wang XJ 2017 Sep Histopathology

Does a p53 "Wild-type" Immunophenotype Exclude a Diagnosis of Endometrial Serous Carcinoma?

Fadare O, Roma AA, Parkash V, Zheng W, Walavalkar V 2017 Sep Adv Anat Pathol

Pathological findings in explanted vaginal mesh.

Li L, Wang X, Park JY, Chen H, Wang Y, Zheng W 2017 Sep Hum. Pathol.

Gene expression profiles of ovarian low-grade serous carcinoma resemble those of fallopian tube epithelium.

Qiu C, Lu N, Wang X, Zhang Q, Yuan C, Yan S, Dongol S, Li Y, Sun X, Sun C, Zhang Z, Zheng W, Kong B 2017 Sep Gynecol. Oncol.

Clear Cell Renal Cell Carcinoma Metastatic to the Gynecologic Tract: A Clinicopathologic Analysis of 17 Cases.

Fadare O, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Rawish KR, Roma AA, Zheng W, Hecht JL, Parkash V, Osunkoya AO 2017 Nov Int. J. Gynecol. Pathol.

BRCA1 expression, proliferative and apoptotic activities in ovarian epithelial inclusions.

Wang Y, Wang Y, Wei L, Hong S, Zhao M, Zhang X, Zheng W 2017 Mar J Ovarian Res 1 10 12

Endometrial Carcinoma With Trophoblastic Components: Clinicopathologic Analysis of a Rare Entity.

Rawish KR, Buza N, Zheng W, Fadare O 2017 Jun Int. J. Gynecol. Pathol.

Malignant Female Adnexal Tumor of Probable Wolffian Origin: Case Report and Literature Review.

Hong S, Cui J, Li L, Buscema J, Liggins C, Zheng W 2017 Jul Int. J. Gynecol. Pathol.

Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-survivin pathway.

Fan R, Wang Y, Wang Y, Wei L, Zheng W 2017 Am J Transl Res 3 9 1483-1491

Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization.

Zhang L, Yang B, Zhang A, Zhou A, Yuan J, Wang Y, Sun L, Cao H, Wang J, Zheng W 2016 Apr J. Med. Virol.

Overexpression and oncogenic function of HMGA2 in endometrial serous carcinogenesis.

Wei L, Liu X, Zhang W, Wei Y, Li Y, Zhang Q, Dong R, Kwon JS, Liu Z, Zheng W, Kong B 2016 Am J Cancer Res 2 6 249-59

Are clear cell carcinomas of the ovary and endometrium phenotypically identical? A proteomic analysis

Fata CR, Seeley EH, Desouki MM, Du L, Gwin K, Hanley KZ, Hecht JL, Jarboe EA, Liang SX, Parkash V, Quick CM, Zheng W, Shyr Y, Caprioli RM, Fadare O 2015 Jun Hum. Pathol.

Ovarian serous carcinogenesis from tubal secretory cells.

Zhang W, Wei L, Li L, Yang B, Kong B, Yao G, Zheng W 2015 Jul Histol. Histopathol. 11645

Primary sources of pelvic serous cancer in patients with endometrial intraepithelial carcinoma.

Jia L, Yuan Z, Wang Y, Cragun JM, Kong B, Zheng W 2015 Jan Mod. Pathol. 1 28 118-27

Tubal origin of ovarian endometriosis and clear cell and endometrioid carcinoma.

Wang Y, Mang M, Wang Y, Wang L, Klein R, Kong B, Zheng W 2015 Am J Cancer Res 3 5 869-79

Flutamide and biomarkers in women at high risk for ovarian cancer: preclinical and clinical evidence.

Gruessner C, Gruessner A, Glaser K, AbuShahin N, Zhou Y, Laughren C, Wright H, Pinkerton S, Yi X, Stoffer J, Azodi M, Zheng W, Chambers SK 2014 Sep Cancer Prev Res (Phila) 9 7 896-905

IMP3 signatures of fallopian tube: a risk for pelvic serous cancers.

Wang Y, Wang Y, Li D, Li L, Zhang W, Yao G, Jiang Z, Zheng W 2014 Jul J Hematol Oncol 1 7 49

Tubal origin of ovarian endometriosis.

Yuan Z, Wang L, Wang Y, Zhang T, Li L, Cragun JM, Chambers SK, Kong B, Zheng W 2014 Aug Mod. Pathol. 8 27 1154-62

Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium.

Wang Y, Wang Y, Li J, Cragun J, Hatch K, Chambers SK, Zheng W 2013 Mar J Hematol Oncol 1 6 22

Secretory cell expansion with aging: risk for pelvic serous carcinogenesis.

Li J, Ning Y, Abushahin N, Yuan Z, Wang Y, Wang Y, Yuan B, Cragun JM, Chambers SK, Hatch K, Kong B, Zheng W 2013 Dec Gynecol. Oncol. 3 131 555-60

Tubal origin of ovarian low-grade serous carcinoma.

Chen C, Li J, Yao G, Chambers SK, Zheng W 2013 Dec Am J Clin Exp Obstet Gynecol 1 1 13-36

Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology.

Xiang L, Zheng W, Kong B 2012 Dec Gynecol. Oncol. 3 127 595-600

Endometrial serous carcinoma (uterine papillary serous carcinoma): precancerous lesions and the theoretical promise of a preventive approach.

Fadare O, Zheng W 2012 Am J Cancer Res 3 2 335-9

Fallopian tube as main source for ovarian and pelvic (non-endometrial) serous carcinomas.

Zheng W, Fadare O 2012 Int J Clin Exp Pathol 3 5 182-6

Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis.

Li J, Fadare O, Xiang L, Kong B, Zheng W 2012 J Hematol Oncol 5 8

Tubal origin of 'ovarian' low-grade serous carcinoma.

Li J, Abushahin N, Pang S, Xiang L, Chambers SK, Fadare O, Kong B, Zheng W 2011 Nov Mod. Pathol. 11 24 1488-99

Personal history of breast cancer as a significant risk factor for endometrial serous carcinoma in women aged 55 years old or younger.

Liang SX, Pearl M, Liang S, Xiang L, Jia L, Yang B, Fadare O, Schwartz PE, Chambers SK, Kong B, Zheng W 2011 Feb Int. J. Cancer 4 128 763-70

High levels of Nrf2 determine chemoresistance in type II endometrial cancer.

Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, Zhang DD 2010 Jul Cancer Res. 13 70 5486-96

Molecular identification of "latent precancers" for endometrial serous carcinoma in benign-appearing endometrium.

Zhang X, Liang SX, Jia L, Chen N, Fadare O, Schwartz PE, Kong B, Zheng W 2009 Jun Am. J. Pathol. 6 174 2000-6