Our lab develops optical technologies for minimally and non-invasive bedside measurement of microvascular blood flow and oxygen saturation, allowing continuous assessment of aerobic metabolism. We utilize diffuse optical and correlation spectroscopies to investigate continuous, quantitative brain and spinal cord health during critical care.
Monitoring cerebral hemodynamics during pediatric extracorporeal circulatory support
Developing minimally invasive tools and techniques to monitor the central nervous system
Collaborators: Lakshmi Raman M.D., Ethan Sanford M.D. (Children’s Health Center), Thomas Floyd M.D. (UTSW), Ann Stowe Ph.D. (University of Kentucky), Jonathan Fisher Ph.D. (NYMC), Imad Khan M.D., Regina Choe Ph.D. (University of Rochester)
- Funding: NIH-NINDS, NIH-NIBIB, McDermott Chair (UTSW), Women's Auxiliary (Children's Medical Center Foundation)
- Previous funding: Hartwell Foundation
Meet the Principal Investigator
Dr. David Busch
Dr. Busch is an assistant professor in the Department of Anesthesiology and Pain Management, with a secondary appointment in Neurology and Neurotherapeutics. His work translates tools and techniques from the physical sciences to solve pressing clinical problems, primarily in monitoring the brain and spinal cord. Much of his research utilizes minimally and non-invasive diffuse optical tools which enable continuous, long-term measurements of the central nervous system. Dr. Busch’s work has been funded by the Fulbright Commission, the Institute of International Education Whitaker Fellowship, the NIH, the McDermott Chair, the Women's Auxiliary, the Thrasher Research Foundation, and the Hartwell Foundation.
Meet the Team
Dr. Margherita Tabet
Dr. Tabet is a medical doctor functioning as a postdoctoral research fellow at the University of Texas Southwestern Medical Center. She is working to understand how skin melanin content can affect pulse oximetry while directly contributing to projects continuously monitoring critical care patients.
RyanCole Weldon-Carroll is a graduate of Southern Methodist University, where he graduated with a degree in Electrical Engineering with a Biomedical Specialization on the Premed Track with minors in Chemistry, Biology, and Math. He is improving monitoring technologies which focus on aspects from spinal cord blood flow to cerebral hemodynamics.
Jayesh Sharma is a Neuroscience graduate from the University of Southern California. He is working towards bridging clinical care with advanced biometrics predicting and improving patient outcomes.
Bill Zhang is a medical student attending the University of Texas Southwestern. He is working on examining blood biomarkers as a predictive factor in critical care patient outcomes.
Summer Morris is a medical student attending the University of Texas Southwestern. She directly works on monitoring critical care patients and managing the information databases paired with our clinical research.
Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring.Busch DR, Lin W, Goh CC, Gao F, Larson N, Wahl J, Bilfinger TV, Yodh AG, Floyd TF, 2021 PLoS One 5 16 e0251271
Detection of Brain Hypoxia Based on Noninvasive Optical Monitoring of Cerebral Blood Flow with Diffuse Correlation Spectroscopy.Busch DR, Balu R, Baker WB, Guo W, He L, Diop M, Milej D, Kavuri V, Amendolia O, St Lawrence K, Yodh AG, Kofke WA 2018 Jul Neurocrit Care
Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest.Busch DR, Rusin CG, Miller-Hance W, Kibler K, Baker WB, Heinle JS, Fraser CD, Yodh AG, Licht DJ, Brady KM 2016 Sep Biomed Opt Express 9 7 3461-3470
Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome.Busch DR, Lynch JM, Winters ME, McCarthy AL, Newland JJ, Ko T, Cornaglia MA, Radcliffe J, McDonough JM, Samuel J, Matthews E, Xiao R, Yodh AG, Marcus CL, Licht DJ, Tapia IE 2016 Jan Sleep 1 39 209-16
Association of ongoing cerebral oxygen extraction during deep hypothermic circulatory arrest with post-operative brain injury.Lynch JM, Mavroudis CD, Ko TS, Jacobwitz M, Busch DR, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Yodh AG, Licht DJ, 2021 Sep Semin Thorac Cardiovasc Surg
Performance Assessment of a Commercial Continuous-Wave Near-Infrared Spectroscopy Tissue Oximeter for Suitability for Use in an International, Multi-Center Clinical Trial.Cortese L, Zanoletti M, Karadeniz U, Pagliazzi M, Yaqub MA, Busch DR, Mesquida J, Durduran T, 2021 Oct Sensors (Basel) 21 21
Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine.Padawer-Curry JA, Volk LE, Mavroudis CD, Ko TS, Morano VC, Busch DR, Rosenthal TM, Melchior RW, Shade BC, Schiavo KL, Boorady TW, Schmidt AL, Andersen KN, Breimann JS, Jahnavi J, Mensah-Brown KG, Yodh AG, Mascio CE, Kilbaugh TJ, Licht DJ, White BR, Baker WB, 2021 May Pediatr Res
Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data.Cochran JM, Leproux A, Busch DR, O'Sullivan TD, Yang W, Mehta RS, Police AM, Tromberg BJ, Yodh AG, 2021 Feb J Biomed Opt 2 26
Blood flow response to orthostatic challenge identifies signatures of the failure of static cerebral autoregulation in patients with cerebrovascular disease.Gregori-Pla C, Mesquita RC, Favilla CG, Busch DR, Blanco I, Zirak P, Frisk LK, Avtzi S, Maruccia F, Giacalone G, Cotta G, Camps-Renom P, Mullen MT, Martí-Fàbregas J, Prats-Sánchez L, Martínez-Domeño A, Kasner SE, Greenberg JH, Zhou C, Edlow BL, Putt ME, Detre JA, Yodh AG, Durduran T, Delgado-Mederos R, 2021 Apr BMC Neurol 1 21 154
Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units.Mesquida J, Caballer A, Cortese L, Vila C, Karadeniz U, Pagliazzi M, Zanoletti M, Pacheco AP, Castro P, García-de-Acilu M, Mesquita RC, Busch DR, Durduran T, 2021 11 Crit Care 1 25 381
Asymmetric, dynamic adaptation in prefrontal cortex during dichotic listening tasks.Fisher JAN, Gumenchuk I, Rogovin OS, Yodh AG, Busch DR, 2020 Oct Neurophotonics 4 7 045008
Towards detection of brain injury using multimodal non-invasive neuromonitoring in adults undergoing extracorporeal membrane oxygenation.Dar IA, Khan IR, Maddox RK, Selioutski O, Donohue KL, Marinescu MA, Prasad SM, Quazi NH, Donlon JS, Loose EA, Ramirez GA, Ren J, Majeski JB, Abramson K, Durduran T, Busch DR, Choe R, 2020 Nov Biomed Opt Express 11 11 6551-6569
Noninvasive optical measurement of microvascular cerebral hemodynamics and autoregulation in the neonatal ECMO patient.Busch DR, Baker WB, Mavroudis CD, Ko TS, Lynch JM, McCarthy AL, DuPont-Thibodeau G, Buckley EM, Jacobwitz M, Boorady TW, Mensah-Brown K, Connelly JT, Yodh AG, Kilbaugh TJ, Licht DJ, 2020 12 Pediatr Res 6 88 925-933
Multi-Site Optical Monitoring of Spinal Cord Ischemia during Spine Distraction.Busch DR, Lin W, Cai C, Cutrone A, Tatka J, Kovarovic BJ, Yodh AG, Floyd TF, Barsi J, 2020 09 J Neurotrauma 18 37 2014-2022
Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Cochran JM, Busch DR, Lin L, Minkoff DL, Schweiger M, Arridge S, Yodh AG 2019 Jan J Biomed Opt 5 24 1-11
Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke.Gregori-Pla C, Blanco I, Camps-Renom P, Zirak P, Serra I, Cotta G, Maruccia F, Prats-Sánchez L, Martínez-Domeño A, Busch DR, Giacalone G, Martí-Fàbregas J, Durduran T, Delgado-Mederos R 2019 Feb J. Neurol.
Perfusion Enhancement with Respiratory Impedance After Stroke (PERI-Stroke).Favilla CG, Forti RM, Zamzam A, Detre JA, Mullen MT, Yodh AG, Kasner SE, Busch DR, Baker WB, Mesquita RC, Kung D, Messé SR, 2019 10 Neurotherapeutics 4 16 1296-1303
Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury.Baker WB, Balu R, He L, Kavuri VC, Busch DR, Amendolia O, Quattrone F, Frangos S, Maloney-Wilensky E, Abramson K, Mahanna Gabrielli E, Yodh AG, Andrew Kofke W, 2019 08 J Cereb Blood Flow Metab 8 39 1469-1485
Evaluation of a New Catheter for Simultaneous Intracranial Pressure Monitoring and Cerebral Spinal Fluid Drainage: A Pilot Study.Olson DM, Atem F, Busch DR, 2019 08 Neurocrit Care 1 31 225-226
Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable Gate Array.Lin W, Busch DR, Goh CC, Barsi J, Floyd TF, 2019 IEEE Access 7 122503-122512
Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine.Ko TS, Mavroudis CD, Baker WB, Morano VC, Mensah-Brown K, Boorady TW, Schmidt AL, Lynch JM, Busch DR, Gentile J, Bratinov G, Lin Y, Jeong S, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Xiao R, Gaynor JW, Yodh AG, Kilbaugh TJ, Licht DJ 2018 Oct J. Cereb. Blood Flow Metab. 271678X18809828
Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment.Cochran JM, Busch DR, Leproux A, Zhang Z, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue B, Jiang S, Kaufman PA, Chung SH, Schnall M, Snyder BS, Hylton N, Carp SA, Isakoff SJ, Mankoff D, Tromberg BJ, Yodh AG 2018 Oct J Biomed Opt 2 24 1-11
Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults.He L, Baker WB, Milej D, Kavuri VC, Mesquita RC, Busch DR, Abramson K, Jiang JY, Diop M, St Lawrence K, Amendolia O, Quattrone F, Balu R, Kofke WA, Yodh AG 2018 Oct Neurophotonics 4 5 045006
Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease.Lynch JM, Ko T, Busch DR, Newland JJ, Winters ME, Mensah-Brown K, Boorady TW, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Spray TL, Yodh AG, Naim MY, Licht DJ 2018 May J. Thorac. Cardiovasc. Surg.
Laser safety in fiber-optic monitoring of spinal cord hemodynamics: a preclinical evaluation.Busch DR, Davis J, Kogler A, Galler RM, Parthasarathy AB, Yodh AG, Floyd TF 2018 Jun J Biomed Opt 6 23 1-9
Effects of Exercise Training on Calf Muscle Oxygen Extraction and Blood Flow in Patients with Peripheral Artery Disease.Baker WB, Li Z, Schenkel SS, Chandra M, Busch DR, Englund EK, Schmitz KH, Yodh AG, Floyd TF, Mohler ER 2017 Oct J. Appl. Physiol. jap.00585.2017
Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy.Cochran JM, Chung SH, Leproux A, Baker WB, Busch DR, DeMichele AM, Tchou J, Tromberg BJ, Yodh AG 2017 Jun Phys Med Biol 12 62 4637-4653
Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects.Baker WB, Parthasarathy AB, Gannon KP, Kavuri VC, Busch DR, Abramson K, He L, Mesquita RC, Mullen MT, Detre JA, Greenberg JH, Licht DJ, Balu R, Kofke WA, Yodh AG 2017 Aug J. Cereb. Blood Flow Metab. 8 37 2691-2705
Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry.Ban HY, Schweiger M, Kavuri VC, Cochran JM, Xie L, Busch DR, Katrašnik J, Pathak S, Chung SH, Lee K, Choe R, Czerniecki BJ, Arridge SR, Yodh AG 2016 Jul Med Phys 7 43 4383
Scoring system for periventricular leukomalacia in infants with congenital heart disease.McCarthy AL, Winters ME, Busch DR, Gonzalez-Giraldo E, Ko TS, Lynch JM, Schwab PJ, Xiao R, Buckley EM, Vossough A, Licht DJ 2015 Sep Pediatr. Res. 3 78 304-9
Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures.Chung SH, Feldman MD, Martinez D, Kim H, Putt ME, Busch DR, Tchou J, Czerniecki BJ, Schnall MD, Rosen MA, DeMichele A, Yodh AG, Choe R 2015 May Breast Cancer Res. 17 72
Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts.Baker WB, Parthasarathy AB, Ko TS, Busch DR, Abramson K, Tzeng SY, Mesquita RC, Durduran T, Greenberg JH, Kung DK, Yodh AG 2015 Jul Neurophotonics 3 2 035004
Time to surgery and preoperative cerebral hemodynamics predict postoperative white matter injury in neonates with hypoplastic left heart syndrome.Lynch JM, Buckley EM, Schwab PJ, McCarthy AL, Winters ME, Busch DR, Xiao R, Goff DA, Nicolson SC, Montenegro LM, Fuller S, Gaynor JW, Spray TL, Yodh AG, Naim MY, Licht DJ 2014 Nov J. Thorac. Cardiovasc. Surg. 5 148 2181-8
Noninvasive optical quantification of cerebral venous oxygen saturation in humans.Lynch JM, Buckley EM, Schwab PJ, Busch DR, Hanna BD, Putt ME, Licht DJ, Yodh AG 2014 Feb Acad Radiol 2 21 162-7
Blood flow reduction in breast tissue due to mammographic compression.Busch DR, Choe R, Durduran T, Friedman DH, Baker WB, Maidment AD, Rosen MA, Schnall MD, Yodh AG 2014 Feb Acad Radiol 2 21 151-61
Optically measured microvascular blood flow contrast of malignant breast tumors.Choe R, Putt ME, Carlile PM, Durduran T, Giammarco JM, Busch DR, Jung KW, Czerniecki BJ, Tchou J, Feldman MD, Mies C, Rosen MA, Schnall MD, DeMichele A, Yodh AG 2014 PLoS ONE 6 9 e99683
Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics.Busch DR, Choe R, Durduran T, Yodh AG 2013 Jul PET Clin 3 8
Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions.Mesquita RC, Schenkel SS, Minkoff DL, Lu X, Favilla CG, Vora PM, Busch DR, Chandra M, Greenberg JH, Detre JA, Yodh AG 2013 Jul Biomed Opt Express 7 4 978-94
Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy.Busch DR, Choe R, Rosen MA, Guo W, Durduran T, Feldman MD, Mies C, Czerniecki BJ, Tchou J, Demichele A, Schnall MD, Yodh AG 2013 Jan Biomed Opt Express 1 4 105-21
Early postoperative changes in cerebral oxygen metabolism following neonatal cardiac surgery: effects of surgical duration.Buckley EM, Lynch JM, Goff DA, Schwab PJ, Baker WB, Durduran T, Busch DR, Nicolson SC, Montenegro LM, Naim MY, Xiao R, Spray TL, Yodh AG, Gaynor JW, Licht DJ 2013 Jan J. Thorac. Cardiovasc. Surg. 1 145 196-203, 205.e1; discussion 203-5
Computer aided automatic detection of malignant lesions in diffuse optical mammography.Busch DR, Guo W, Choe R, Durduran T, Feldman MD, Mies C, Rosen MA, Schnall MD, Czerniecki BJ, Tchou J, DeMichele A, Putt ME, Yodh AG 2010 Apr Med Phys 4 37 1840-9
Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography.Choe R, Konecky SD, Corlu A, Lee K, Durduran T, Busch DR, Pathak S, Czerniecki BJ, Tchou J, Fraker DL, Demichele A, Chance B, Arridge SR, Schweiger M, Culver JP, Schnall MD, Putt ME, Rosen MA, Yodh AG 2009 Mar-Apr J Biomed Opt 2 14 024020
Determination of the optical properties of two-layer turbid media by use of a frequency-domain hybrid monte carlo diffusion model.Alexandrakis G, Busch DR, Faris GW, Patterson MS 2001 Aug Appl Opt 22 40 3810-21
Dept. of Anesthesiology and Pain Management
5323 Harry Hines Blvd
Dallas, Texas 75390
Join Our Lab
Non- and minimally-invasive diffuse optical tissue monitoring
A postdoctoral position is available in the laboratory of David R. Busch, Ph. D. in the Departments of Anesthesiology and Pain Management & Neurology and Neurotherapeutics at UT Southwestern Medical Center. This laboratory, new to UTSW, focuses on the development and translation of diffuse optical and correlation spectroscopic instrumentation to monitor the central nervous system.
Candidates must hold a Ph.D. in physics, biomedical engineering, bioengineering, or a similar field. A solid record of publication is required to demonstrate writing and technical expertise. Candidates with experience in the development of fiber optic probes, diffuse optics (DCS/DOT/DOS), tissue optics, and clinical translation are preferred. Previous work in an operating theater or intensive care unit is helpful.
The fellow will be focused on the translation of diffuse optics into the surgical and critical care setting. This work is performed in close collaboration with enthusiastic clinical collaborators. Current projects include non-invasive monitoring of cerebral hemodynamics during extracorporeal membrane oxygenation (Prof. Lakshmi Raman, Children’s Medical Center, PI: Busch, Hartwell Foundation) and minimally invasive monitoring of the spinal cord in animal models (Prof. Thomas Floyd, UTSW, PI: Floyd, NIH U01). The fellow will be expected and encouraged to develop new lines of research, collecting pilot data for their future independent research careers, within the general themes of the lab.
This lab and our collaborators are committed to the professional development of the members, making this position a valuable preparation for those interested in academic, industrial, or entrepreneurial careers. The position has no mandatory teaching or administrative duties.
The initial appointment is for 12 months with the possibility of renewal. Compensation will be commensurate with experience and includes competitive benefits.
Interested individuals should send a CV, statement of interests, expected date of availability, and a list of three references to:
David R. Busch, Ph. D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9068