Research
Our lab develops optical technologies for minimally and non-invasive bedside measurement of microvascular blood flow and oxygen saturation, allowing continuous assessment of aerobic metabolism. We utilize diffuse optical and correlation spectroscopies to continuously investigate brain and spinal cord health during critical care.
Current projects:
Monitoring cerebral hemodynamics during pediatric extracorporeal circulatory support
Developing minimally invasive tools and techniques to monitor the central nervous system
Collaborators: Lakshmi Raman, M.D., Ethan Sanford, M.D., Chasity Custer, M.D. (UTSW/Children’s Health Center), Ann Stowe, Ph.D. (University of Kentucky), Jonathan Fisher, Ph.D. (NYMC), Imad Khan, M.D., Regina Choe, Ph.D. (University of Rochester), Zhenpeng Qin, Ph.D. (UT Dallas), Robert Bachoo, M.D. (UTSW)
- Funding: NIH-NINDS, McDermott Chair (UTSW), Women's Auxiliary (Children's Medical Center Foundation)
- Previous funding: NIH-NIBIB, The Hartwell Foundation, NIH-N
Meet the Principal Investigator
Dr. David Busch
Dr. Busch is an associate professor in the Department of Anesthesiology and Pain Management, Neurology, and Biomedical Engineering. His work translates tools and techniques from the physical sciences to solve pressing clinical problems, primarily in monitoring the brain and spinal cord. Much of his research utilizes minimally and non-invasive diffuse optical tools which enable continuous, long-term measurements of the central nervous system. Dr. Busch’s work has been funded by the Fulbright Commission, the Institute of International Education Whitaker Fellowship, the NIH, the McDermott Chair, the Women's Auxiliary, the Thrasher Research Foundation, and the Hartwell Foundation.
Meet the Team
Dr. Margherita Tabet
Dr. Tabet is a medical doctor functioning as a postdoctoral research fellow at the University of Texas Southwestern Medical Center. She is working to understand how skin melanin content can affect pulse oximetry while directly contributing to projects continuously monitoring critical care patients.
Nikhitha Mule
Dr. Mule is a postdoctoral researcher at the University of Texas Southwestern Medical Center. Her research involves developing, validating, and applying diffuse optical techniques for noninvasive monitoring of tissue physiology in clinical studies in neurocritical care.
Compact hybrid near-infrared and speckle contrast optical spectroscopy device
Quiroga A, Verma M, Fornasier M, Beslija F, Frisk LK, Chetia S, Yaqub MA, Beato JM, Fernadez J, Bosch V, Menino X, Senciales D, Garcia C, Acaine O, Sifuentes JC, Dave S, Cheruku S, Choi C, Lahsaei P, Tabet M, Weldon-Carroll R, Olson D, Little W, Busch DR, Durduran T 2025 Dec
Stute K, Gossé LK, Montero-Hernandez S, Perkins GA, Yücel MA, Cutini S, Durduran T, Ehlis AC, Ferrari M, Gervain J, Mesquita RC, Orihuela-Espina F, Quaresima V, Scholkmann F, Tachtsidis I, Torricelli A, Wabnitz H, Yodh AG, Carp SA, Dehghani H, Fang Q, Fantini S, Hoshi Y, Niu H, Obrig H, Klein F, Artemenko C, Bajracharya A, Barth B, Bartkowski C, Borot L, Bulgarelli C, Busch DR, Chojak M, DeFreitas JM, Diprossimo L, Dresler T, Eken A, Elsherif MM, Emberson LL, Exner A, Ferdous TR, Fiske A, Forbes SH, Gemignani J, Gerloff C, Guérin SM, Guevara E, de Hamilton AF, Hosseini SM, Jain D, Kerr-German AN, Kong H, Kroczek A, Longhurst JK, Lührs M, MacLennan RJ, Mehler DM, Meidenbauer KL, Moreau D, Mutlu MC, Orti R, Paranawithana I, Pinti P, Jounghani AR, Reindl V, Ross NA, Sanchez-Alonso S, Seidel-Marzi O, Shukla M, Usama SA, Talati M, Vergotte G, Yaqub MA, Yu CC, Zainodini H
2025 Apr
Neurophotonics
12
27801
Olson DM, Nairon EB, Riskey LM, Salter A, Busch DR
2025 Mar
American Journal of Critical Care
34
129-136
Khan IR, Dar IA, Johnson TW, Loose E, Xu YY, Santiago E, Donohue KL, Marinescu MA, Gosev I, Schifitto G, Maddox RK, Busch DR, Choe R, Selioutski O
2024 Nov
Journal of Clinical Neurophysiology
41
597-605
Mireles M, Jiménez-Valerio G, Morales-Dalmau J, Johansson JD, Martínez-Lozano M, Vidal-Rosas EE, Navarro-Pérez V, Busch DR, Casanovas O, Durduran T, Vilches C
2024 Oct
Biomedical Optics Express
15
5773-5789
Dar IA, Khan IR, Johnson TW, Helmy SM, Cardona JI, Escobar S, Selioutski O, Marinescu MA, Zhang CT, Proctor AR, AbdAllah N, Busch DR, Maddox RK, Choe R
2024 Oct
PloS one
19
Nairon EB, Joseph J, Kamal A, Busch DR, Olson DM
2024 May
Critical Care Explorations
6
E1089
Tabet M, Custer C, Khan IR, Sanford E, Sharma J, Choe R, Singh S, Sirsi D, Olson DM, Morriss MC, Raman L, Busch DR
2024 Mar
ASAIO Journal
70
167-176
Dar IA, Khan IR, Maddox RK, Marinescu MA, Busch DR, Choe R
2024
Neuroinflammation and Autoregulation During Pediatric Extracorporeal Life Support
Tabet M, McAtee AM, Custer C, Sanford E, Weldon-Carroll RC, Sharma J, Abioye A, Sirsi D, Singh S, Morriss MC, Turchan-Cholewo JT, Olson DW, Raman L, Stowe AM, Busch DR 2024Compact, multiwavelength, multidistance speckle contrast spectroscopy (SCOS) for the critical care
Quiroga A, Verma M, Beslija F, Frisk LK, Chetia S, Senciales D, Yaqub MA, Tabet M, Weldon-Carroll RC, Little W, Dave S, Cheruku S, Choi C, Lahsaei P, Olson DW, Busch DR, Durduran T 2024Neuroinflammation and Autoregulation During Pediatric Extracorporeal Life Support
Tabet M, McAtee AM, Custer C, Sanford E, Weldon-Carroll RC, Sharma J, Abioye A, Sirsi D, Singh S, Morriss MC, Turchan-Cholewo JT, Olson DW, Raman L, Stowe AM, Busch DR 2024Compact, multiwavelength, multidistance speckle contrast spectroscopy (SCOS) for the critical care
Quiroga A, Verma M, Beslija F, Frisk LK, Chetia S, Senciales D, Yaqub MA, Tabet M, Weldon-Carroll RC, Little W, Dave S, Cheruku S, Choi C, Lahsaei P, Olson DW, Busch DR, Durduran T 2024
Custer C, Singh S, Sanford E, Nandy K, Raman L, Busch DR, Morriss MC
2023 Nov
ASAIO Journal
69
E460-E462
Sanford EL, Akorede R, Miller I, Morriss MC, Nandy K, Raman L, Busch DR
2023 Jul
ASAIO Journal
69
E315-E321
Lynch JM, Mavroudis CD, Ko TS, Jacobwitz M, Busch DR, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Yodh AG, Licht DJ
2022 Dec
Seminars in thoracic and cardiovascular surgery
34
1275-1284
Wang L, Cochran JM, Ko T, Baker WB, Abramson K, He L, Busch DR, Kavuri V, Linn RL, Parry S, Yodh AG, Schwartz N
2022 Sep
Nature Biomedical Engineering
6
1017-1030
Padawer-Curry JA, Volk LE, Mavroudis CD, Ko TS, Morano VC, Busch DR, Rosenthal TM, Melchior RW, Shade BC, Schiavo KL, Boorady TW, Schmidt AL, Andersen KN, Breimann JS, Jahnavi J, Mensah-Brown KG, Yodh AG, Mascio CE, Kilbaugh TJ, Licht DJ, White BR, Baker WB
2022 May
Pediatric Research
91
1374-1382
Sanford E, Akorede R, Miller I, Contreras G, Swalley N, Morriss MC, Raman L, Busch DR
2022
Optics InfoBase Conference Papers
Cortese L, De Oliveira LB, Bernardes Delazari LE, Buckley EM, Busch DR, Caballer A, Carbajal Robles V, Castro P, Cavallaro Barauna Lima AL, Cheruku S, Chiscano L, Choi C, Dave S, Do Nascimento B, Dos Santos Roceto Ratti L, Eiras Falcão AL, Espinal C, Fernández S, Ferrer R, Font F, Forti RM, De Acilu MG, Grasselli G, Gruartmoner G, Guzzardella A, Jabeen I, Karadeniz U, Lahsaei P, Lívio Emídio G, Marin Corral J, Matas A, Mesquita RC, Mera A, De Oca Hernández FJ, Myers T, Nogales S, Olson D, Pagliazzi M, Parada Guzmán M, Parrilla-Gómez FJ, Pérez Pacheco A, Pérez Terán P, Picazo Moreno L, Pineda Vázquez D, Quiroga Soto AF, Quispe Siccha RM, Romero D, Santillán Aguayo E, Serra I, Serrano Loyola R, Téllez A, Utino Taniguchi L, Vilà C, Weinmann M, Zanella A, Zanoletti M, Mesquida J, Durduran T
2022
Optics InfoBase Conference Papers
Author Collaboration tH, Mesquida J, Caballer A, Cortese L, Vila C, Karadeniz U, Pagliazzi M, Zanoletti M, Pacheco AP, Castro P, García-de-Acilu M, Mesquita RC, Busch DR, Durduran T, Pagliazzi M, Cortese L, Zanoletti M, Karadeniz U, Mesquida J, Caballer A, Nogales S, Espinal C, Gruartmoner G, Terán PP, Vilà C, Picazo L, Ferrer R, De Acilu MG, Chiscano L, Mera A, Castro P, Téllez A, Fernández S, Matas A, Fuentes F, Serra I, Romero D, Font F, Myers T, Busch DR, Dave S, Cheruku S, Choi C, Lahsaei P, Olson DW, Pacheco AP, Quispe Siccha RM, Liceaga E, De Oca Hernández FJ, Besen BA, Taniguchi LU
2021 Dec
Critical Care
25
Gregori-Pla C, Mesquita RC, Favilla CG, Busch DR, Blanco I, Zirak P, Frisk LK, Avtzi S, Maruccia F, Giacalone G, Cotta G, Camps-Renom P, Mullen MT, Martí-Fàbregas J, Prats-Sánchez L, Martínez-Domeño A, Kasner SE, Greenberg JH, Zhou C, Edlow BL, Putt ME, Detre JA, Yodh AG, Durduran T, Delgado-Mederos R
2021 Dec
BMC Neurology
21
Cortese L, Zanoletti M, Karadeniz U, Pagliazzi M, Yaqub MA, Busch DR, Mesquida J, Durduran T
2021 Nov
Sensors
21
Busch DR, Lin W, Goh CC, Gao F, Larson N, Wahl J, Bilfinger TV, Yodh AG, Floyd TF
2021 May
PloS one
16
Cochran JM, Leproux A, Busch DR, O'Sullivan TD, Yang W, Mehta RS, Police AM, Tromberg BJ, Yodh AG
2021 Feb
Journal of biomedical optics
26
Cortese L, de Oliveira LB, Barcelona M, Bernardes Delazari LE, Besen BA, Busch DR, Caballer A, Robles VC, Castro P, Cavallaro Barauna Lima AL, Cheruku S, Chiscano L, Choi C, Mesquita RC, Dave S, dos Santos Roceto Ratti L, Eiras Falcão AL, Espinal C, Fernández S, Ferrer R, Font F, de Acilu MG, Gruartmoner G, Karadeniz U, Lahsaei P, Emídio GL, Corral JM, Matas A, Forti RM, Mera A, De Oca Hernández FJ, Myers T, Nogales S, Olson D, Pagliazzi M, Guzmán MP, Pacheco AP, Terán PP, Picazo L, Vázquez DP, Soto AF, Siccha RM, Romero D, Aguayo ES, Serra I, Loyola RS, Téllez A, Taniguchi LU, Vilà C, Zanoletti M, Mesquida J, Durduran T
2021
Cortese L, de Oliveira LB, Barcelona M, Delazari LE, Besen BA, Busch DR, Caballer A, Robles VC, Castro P, Barauna Lima AL, Cheruku S, Chiscano L, Choi C, Mesquita RC, Dave S, dos Santos Roceto Ratti L, Eiras Falcão AL, Espinal C, Fernández S, Ferrer R, Font F, de Acilu MG, Gruartmoner G, Karadeniz U, Lahsaei P, Lívio Emídio G, Marin Corral J, Matas A, Menezes Forti R, Mera A, de Oca Hernández FJ, Myers T, Nogales S, Olson D, Pagliazzi M, Parada Guzmán M, Pérez Pacheco A, Pérez Terán P, Picazo L, Pineda Vázquez D, Quiroga Soto AF, Quispe Siccha RM, Romero D, Santillán Aguayo E, Serra I, Serrano Loyola R, Téllez A, Utino Taniguchi L, Vilà C, Zanoletti M, Mesquida J, Durduran T
2021
Optics InfoBase Conference Papers
Busch DR, Baker WB, Mavroudis CD, Ko TS, Lynch JM, McCarthy AL, DuPont-Thibodeau G, Buckley EM, Jacobwitz M, Boorady TW, Mensah-Brown K, Connelly JT, Yodh AG, Kilbaugh TJ, Licht DJ
2020 Dec
Pediatric Research
88
925-933
Dar IA, Khan IR, Maddox RK, Selioutski O, Donohue KL, Marinescu MA, Prasad SM, Quazi NH, Donlon JS, Loose EA, Ramirez GA, Ren J, Majeski JB, Abramson K, Durduran T, Busch DR, Choe R
2020 Nov
Biomedical Optics Express
11
6551-6569
Multi-Site Optical Monitoring of Spinal Cord Ischemia during Spine Distraction
Busch DR, Lin W, Cai C, Cutrone A, Tatka J, Kovarovic BJ, Yodh AG, Floyd TF, Barsi J 2020 Sep Journal of neurotrauma 37 2014-2022
Ko TS, Mavroudis CD, Baker WB, Morano VC, Mensah-Brown K, Boorady TW, Schmidt AL, Lynch JM, Busch DR, Gentile J, Bratinov G, Lin Y, Jeong S, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Xiao R, Gaynor JW, Yodh AG, Kilbaugh TJ, Licht DJ
2020 Jan
Journal of Cerebral Blood Flow and Metabolism
40
187-203
Dar IA, Khan IR, Maddox RK, Prasad SM, Selioutski O, Donohue KL, Abramson K, Yodh AG, Durduran T, Busch DR, Choe R
2020
Perfusion Enhancement with Respiratory Impedance After Stroke (PERI-Stroke)
Favilla CG, Forti RM, Zamzam A, Detre JA, Mullen MT, Yodh AG, Kasner SE, Busch DR, Baker WB, Mesquita RC, Kung D, Messé SR 2019 Oct Neurotherapeutics 16 1296-1303
Olson DW, Atem F, Busch DR
2019 Aug
Neurocritical Care
31
225-226
Baker WB, Balu R, He L, Kavuri VC, Busch DR, Amendolia O, Quattrone F, Frangos S, Maloney-Wilensky E, Abramson K, Mahanna Gabrielli E, Yodh AG, Andrew Kofke W
2019 Aug
Journal of Cerebral Blood Flow and Metabolism
39
1469-1485
Cochran JM, Busch DR, Lin L, Minkoff DL, Schweiger M, Arridge S, Yodh AG
2019 May
Journal of biomedical optics
24
Special Section Guest Editorial: Celebration of the Britton Chance Legacy
Li LZ, Busch D, Yodh AG 2019 May Journal of biomedical optics 24
Gregori-Pla C, Blanco I, Camps-Renom P, Zirak P, Serra I, Cotta G, Maruccia F, Prats-Sánchez L, Martínez-Domeño A, Busch DR, Giacalone G, Martí-Fàbregas J, Durduran T, Delgado-Mederos R
2019 Apr
Journal of neurology
266
990-997
Busch DR, Balu R, Baker WB, Guo W, He L, Diop M, Milej D, Kavuri V, Amendolia O, St. Lawrence K, Yodh AG, Kofke WA
2019 Feb
Neurocritical Care
30
72-80
Cochran JM, Busch DR, Leproux A, Zhang Z, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue B, Jiang S, Kaufman PA, Chung SH, Schnall M, Snyder BS, Hylton N, Carp SA, Isakoff SJ, Mankoff D, Tromberg BJ, Yodha AG
2019 Jan
Journal of biomedical optics
24
Diffuse Correlation Spectroscopy Analysis Implemented on a Field Programmable Gate Array
Lin W, Busch DR, Goh CC, Barsi J, Floyd TF 2019 IEEE Access 7 122503-122512Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults
He L, Baker WB, Milej D, Kavuri VC, Mesquita RC, Busch DR, Abramson K, Jiang JY, Diop M, Lawrence KS, Amendolia O, Quattrone F, Balu R, Kofke WA, Yodha AG 2018 Oct Neurophotonics 5
Lynch JM, Ko T, Busch DR, Newland JJ, Winters ME, Mensah-Brown K, Boorady TW, Xiao R, Nicolson SC, Montenegro LM, Gaynor JW, Spray TL, Yodh AG, Naim MY, Licht DJ
2018 Oct
Journal of Thoracic and Cardiovascular Surgery
156
1657-1664
Laser safety in fiber-optic monitoring of spinal cord hemodynamics: A preclinical evaluation
Busch DR, Davis J, Kogler A, Galler RM, Parthasarathy AB, Yodh AG, Floyd TF 2018 Jun Journal of biomedical optics 23
Baker WB, Parthasarathy AB, He L, Kavuri VC, Diop M, Milej D, Busch DR, Gannon KP, Mullen MT, Detre JA, Licht DJ, Lawrence KS, Balu R, Kofke WA, Yodh AG
2018
Pilot study of blood flow markers during neoadjuvant chemotherapy
Cochran JM, Chung SH, Leproux A, Baker WB, Busch DR, Tromberg BJ, Yodh AG 2018Noninvasive continuous optical monitoring of absolute cerebral blood flow in adult human subjects
He L, Baker W, Milej D, Kavuri V, Busch D, Diop M, Lawrence KS, Balu R, Andrew Kofke W, Yodh AG 2018
Ko TS, Mavroudis CD, Baker WB, Morano V, Mensah-Brown K, Boorady T, Lynch JM, Busch DR, Schmidt AL, Gentile J, Bratinov G, Lin Y, Jeong S, Melchior RW, Rosenthal TM, Schiavo KL, Shade BC, Xiao R, Yodh AG, Kilbaugh TJ, Licht DJ
2018
Continuous and minimally invasive measurement of blood flow in the spinal cord
Busch DR, Lin W, Cutrone A, Kovarovic BJ, Tatka J, Goh CC, Yodh AG, Barsi J, Floyd TF 2018Development of a continuous, axially-resolved, optical monitor of spinal cord blood flow
Busch DR, Gao F, Goh CC, Lin W, Yodh AG, Floyd TF 2018Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days
Cochran JM, Busch DR, Leproux A, Tromberg BJ, Yodh AG 2018Optical quantification of placenta oxygenation with ultrasound integrated frequency-domain NIRS
Wang L, Ko T, He L, Kavuri V, Parthasarathy A, Baker W, Busch D, Cochran J, Abramson K, Acker A, Yodh AG, Schwartz N 2018
Baker WB, Li Z, Schenkel SS, Chandra M, Busch DR, Englund EK, Schmitz KH, Yodh AG, Floyd TF, Mohler ER
2017 Dec
Journal of applied physiology
123
1599-1609
Baker WB, Parthasarathy AB, Gannon KP, Kavuri VC, Busch DR, Abramson K, He L, Mesquita RC, Mullen MT, Detre JA, Greenberg JH, Licht DJ, Balu R, Kofke WA, Yodh AG
2017 Aug
Journal of Cerebral Blood Flow and Metabolism
37
2691-2705
Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy
Cochran JM, Chung SH, Leproux A, Baker WB, Busch DR, Demichele AM, Tchou J, Tromberg BJ, Yodh AG 2017 May Physics in medicine and biology 62 4637-4653
Busch DR, Lin W, Cutrone A, Kovarovic BJ, Tatka J, Yodh AG, Barsi J, Floyd TF
2017
Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest
Busch DR, Rusin CG, Miller-Hance W, Kibler K, Baker WB, Heinle JS, Fraser CD, Yodh AG, Licht DJ, Brady KM 2016 Sep Biomedical Optics Express 7 3461-3470
Ban HY, Schweiger M, Kavuri VC, Cochran JM, Xie L, Busch DR, Katrašnik J, Pathak S, Chung SH, Lee K, Choe R, Czerniecki BJ, Arridge SR, Yodh AG
2016 Jul
Medical physics
43
4383-4395
Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
Baker WB, Ko TS, Xiao W, Parthasarathy AB, Busch DR, Licht DJ, Yodh AG 2016 Apr 3
Lynch JM, Ko T, Newland JJ, Winters ME, Busch DR, Nicolson SC, Montenegro LM, Yodh AG, Licht DJ
2016 Apr
3
Blood flow response to orthostatic challenges in health and diseased populations
Busch DR, Gregori-Pla C, Blanco I, Giovannella M, Favilla C, Lynch JM, Winters ME, Mensah-Brown KG, McCarthy AL, Detre J, Yodh AG, Licht DJ, Mesquita RC, Durduran T 2016 AprCerebral autoregulation during pediatric extracorporeal membrane oxygenation therapy
Busch DR, Du Pont-Thibodeau G, Mavroudis CD, McCarthy AL, Ko T, Winters ME, Newland JJ, Mensah-Brown K, Griffith KR, Lyncha JM, Schwab PJ, Buckleyf EM, Yodh AG, Licht DJ 2016 AprMultimodal structural priors for spatially-dense diffuse optical tomography of breast cancer
Cochran JM, Ban HY, Busch DR, Schweiger MJ, Kavuri VC, Pathak S, Arridge SR, Yodh AG 2016 Apr 3
Lynch JM, Ko T, Newland JJ, Winters ME, Busch DR, Nicolson SC, Montenegro LM, Yodh AG, Licht DJ
2016 Apr
Cerebral autoregulation during pediatric extracorporeal membrane oxygenation therapy
Busch DR, Du Pont-Thibodeauc G, Mavroudise CD, McCarthya AL, Kod T, Wintersa ME, Newlanda JJ, Mensah-Browna K, Griffitha KR, Lyncha JM, Schwaba PJ, Buckleyf EM, Yodhb AG, Lichta DJ 2016 Apr 3
Lynch JM, Ko T, Newland JJ, Winters ME, Busch DR, Nicolson SC, Montenegro LM, Yodh AG, Licht DJ
2016
Cerebral autoregulation during pediatric extracorporeal membrane oxygenation therapy
Busch DR, Pont-Thibodeau GD, Mavroudis CD, McCarthy AL, Ko T, Winters ME, Newland JJ, Mensah-Brown K, Griffith KR, Lynch JM, Schwab PJ, Buckley EM, Yodh AG, Licht DJ 2016Multimodal structural priors for spatially-dense diffuse optical tomography of breast cancer
Cochran JM, Ban HY, Busch DR, Schweiger MJ, Kavuri VC, Pathak S, Arridge SR, Yodh G 2016Cerebral blood flow response to hypercapnia in children with obstructive sleep apnea syndrome
Busch DR, Lynch JM, Winters ME, McCarthy AL, Newland JJ, Ko T, Cornaglia MA, Radcliffe J, McDonough JM, Samuel J, Matthews E, Xiao R, Yodh AG, Marcus CL, Licht DJ, Tapia IE 2016 Sleep 39 209-216Scoring system for periventricular leukomalacia in infants with congenital heart disease
McCarthy AL, Winters ME, Busch DR, Gonzalez-Giraldo E, Ko TS, Lynch JM, Schwab PJ, Xiao R, Buckley EM, Vossough A, Licht DJ 2015 Sep Pediatric Research 78 304-309Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
Baker WB, Parthasarathy AB, Ko TS, Busch DR, Abramson K, Tzeng SY, Mesquita RC, Durduran T, Greenberg JH, Kung DK, Yodh AG 2015 Jul Neurophotonics 2
Chung SH, Feldman MD, Martinez D, Kim H, Putt ME, Busch DR, Tchou J, Czerniecki BJ, Schnall MD, Rosen MA, DeMichele A, Yodh AG, Choe R
2015 May
Breast Cancer Research
17
Baker WB, Parthasarathy AB, Busch DR, Mesquita RC, Greenberg JH, Yodh AG
2015
Baker WB, Parthasarathy AB, Busch DR, Mesquita RC, Greenberg JH, Yodh AG
2014 Nov
Biomedical Optics Express
5
4053-4075
Lynch JM, Buckley EM, Schwab PJ, McCarthy AL, Winters ME, Busch DR, Xiao R, Goff DA, Nicolson SC, Montenegro LM, Fuller S, Gaynor JW, Spray TL, Yodh AG, Naim MY, Licht DJ
2014 Nov
Journal of Thoracic and Cardiovascular Surgery
148
2181-2188
Optically measured microvascular blood flow contrast of malignant breast tumors
Choe R, Putt ME, Carlile PM, Durduran T, Giammarco JM, Busch DR, Jung KW, Czerniecki BJ, Tchou J, Feldman MD, Mies C, Rosen MA, Schnall MD, DeMichele A, Yodh AG 2014 Jun PloS one 9Noninvasive Optical Quantification of Cerebral Venous Oxygen Saturation in Humans
Lynch JM, Buckley EM, Schwab PJ, Busch DR, Hanna BD, Putt ME, Licht DJ, Yodh AG 2014 Feb Academic radiology 21 162-167Blood Flow Reduction in Breast Tissue due to Mammographic Compression
Busch DR, Choe R, Durduran T, Friedman DH, Baker WB, Maidment AD, Rosen MA, Schnall MD, Yodh AG 2014 Feb Academic radiology 21 151-161Introduction to the Special Issue. Britton Chance 100th Commemorative
Pogue BW, Busch D, Li LZ, Zhang H, Shieh DB 2014 Feb Academic radiology 21 137-138Toward noninvasive characterization of breast cancer and cancer metabolism with diffuse optics
Busch DR, Choe R, Durduran T, Yodh AG 2013 Jul PET Clinics 8 345-365
Ban HY, Busch DR, Pathak S, Moscatelli FA, Machida M, Schotland JC, Markel VA, Yodh AG
2013 Feb
Journal of biomedical optics
18
Buckley EM, Lynch JM, Goff DA, Schwab PJ, Baker WB, Durduran T, Busch DR, Nicolson SC, Montenegro LM, Naim MY, Xiao R, Spray TL, Yodh AG, Gaynor JW, Licht DJ
2013 Jan
Journal of Thoracic and Cardiovascular Surgery
145
196-205.e1
Mesquita RC, Schenkel SS, Minkoff DL, Lu X, Favilla CG, Vora PM, Busch DR, Chandra M, Greenberg JH, Detre JA, Yodh AG
2013
Biomedical Optics Express
4
978-994
Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy
Busch DR, Choe R, Rosen MA, Guo W, Durduran T, Feldman MD, Mies C, Czerniecki BJ, Tchou J, DeMichele A, Schnall MD, Yodh AG 2013 Biomedical Optics Express 4 105-121
Choe R, Durduran T, Busch DR, Chung SH, Pathak S, Ban HY, Foster EK, Averna TA, Buckley EM, Kim MN, Mies C, Rosen MA, Schnall MD, DeMichele A, Yodh AG
2012 Dec
BW3A.5
Microvascular blood flow changes in human breast during simulated mammography
Busch DR, Choe R, Durduran T, Bakera WB, Fostera EK, Averna TA, Friedman D, Rosen MA, Schnall MD, Yodha AG 2012 JM3A.13Computer aided monitoring of neoadjuvant chemotherapy for breast cancer
Busch DR, Guo W, Choe R, Durduran T, Feldman MD, Mies C, Czerniecki BJ, Tchou J, DeMichele A, Rosen MA, Schnall MD, Yodh AG 2012 BSu5A.7Microvascular blood flow changes in human breast during simulated mammography
Busch DR, Choe R, Durduran T, Baker WB, Foster EK, Averna TA, Friedman D, Rosen MA, Schnall MD, Yodh AG 2012 JM3A.13
Minkoff DL, Busch DR, Buckley EM, Durduran T, Licht DJ, Yodh AG
2010 Jun
Medical physics
37
3141
TU‐E‐201C‐07: Computer Aided Detection for Diffuse Optical Mammography
Busch DR, Guo W, Choe R, Durduran T, Pathak S, Putt ME, Schnall MD, Rosen MA, Yodh AG 2010 Jun Medical physics 37 3405-3406SU‐HH‐BRB‐08: Blood Flow and Volume Changes during Simulated Mammography
Busch DR, Minkoff DL, Choe R, Durduran T, Schnall MD, Rosen MA, Yodh AG 2010 Jun Medical physics 37 3331Computer aided automatic detection of malignant lesions in diffuse optical mammography
Busch DR, Guo W, Choe R, Durduran T, Feldman MD, Mies C, Rosen MA, Schnall MD, Czerniecki BJ, Tchou J, Demichele A, Putt ME, Yodh AG 2010 Medical physics 37 1840-1849Development of a frequency-domain multi-spectral breast diffuse optical tomography instrument
Ban HY, Konecky SD, Busch DR, Chung SH, Pathak S, Choe R, Yodh AG 2010
Choe R, Konecky SD, Corlu A, Lee K, Durduran T, Busch DR, Pathak S, Czerniecki BJ, Tchou J, Fraker DL, Demichele A, Chance B, Arridge SR, Schweiger M, Culver JP, Schnall MD, Putt ME, Rosen MA, Yodh AG
2009
Journal of biomedical optics
14
Busch DR, Zhao C, Yu G, Choe R, Durduran T, Rosen M, Schnall MD, Yodh AG
2008
BSuE16
Busch DR, Zhao Z, Nioka S, Yodh AG, Schnall M, Chance B, Intes X
2006
Comparison of imaged ICG and Gd kinetics with a DOT-MRI instrument
Busch D, Intes X, Nioka S, Chance B 2006
Alexandrakis G, Busch DR, Faris GW, Patterson MS
2001 Aug
Applied Optics
40
3810-3821
Two-layer frequency domain property measurements-experiment and hybrid model
Busch DR, Faris GW, Alexandrakis G, Patterson MS 2001 401Two-layer frequency domain property measurementS-EXperi ment and hybrid model
Busch DR, Paris GW, Alexandrakis G, Patterson MS 2001
Faris GW, Alexandrakis G, Busch DR, Patterson MS
2001
Proceedings of SPIE - The International Society for Optical Engineering
4250
313-318
Contact Us
Dept. of Anesthesiology and Pain Management
5323 Harry Hines Blvd
Dallas, Texas 75390
Join Our Lab
Non- and minimally-invasive diffuse optical tissue monitoring
A postdoctoral position is available in the laboratory of David R. Busch, Ph. D. in the Departments of Anesthesiology and Pain Management & Neurology and Neurotherapeutics at UT Southwestern Medical Center. This laboratory, new to UTSW, focuses on the development and translation of diffuse optical and correlation spectroscopic instrumentation to monitor the central nervous system.
Candidates must hold a Ph.D. in physics, biomedical engineering, bioengineering, or a similar field. A solid record of publication is required to demonstrate writing and technical expertise. Candidates with experience in the development of fiber optic probes, diffuse optics (DCS/DOT/DOS), tissue optics, and clinical translation are preferred. Previous work in an operating theater or intensive care unit is helpful.
The fellow will be focused on the translation of diffuse optics into the surgical and critical care setting. This work is performed in close collaboration with enthusiastic clinical collaborators. Current projects include non-invasive monitoring of cerebral hemodynamics during extracorporeal membrane oxygenation (Prof. Lakshmi Raman, Children’s Medical Center, PI: Busch, Hartwell Foundation) and minimally invasive monitoring of the spinal cord in animal models. The fellow will be expected and encouraged to develop new lines of research, collecting pilot data for their future independent research careers, within the general themes of the lab.
This lab and our collaborators are committed to the professional development of the members, making this position a valuable preparation for those interested in academic, industrial, or entrepreneurial careers. The position has no mandatory teaching or administrative duties.
The initial appointment is for 12 months with the possibility of renewal. Compensation will be commensurate with experience and includes competitive benefits.
Interested individuals should send a CV, statement of interests, expected date of availability, and a list of three references to:
David R. Busch, Ph. D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9068