Stone Chen Lab

The Stone Chen Lab investigates the molecular mechanisms linking membrane signaling to cytoskeletal dynamics and their roles in human disease. Our current research centers on protein assemblies pivotal to actin polymerization and endosomal trafficking, such as the WAVE and WASH complexes, as well as the CCC-Retriever and Retromer complexes. These systems coordinate essential cellular processes such as migration, adhesion, metabolism, immune activation, and neural development.

We combine biochemical, biophysical, computational, and structural approaches, and collaborate widely with biologists and clinicians to uncover how these molecular systems drive cellular function and contribute to disease.