Chen (Zhijian "James") Lab

Chen Lab's research revolves around the common theme of cell signaling and host defense

We are broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself.  In particular, we are fascinated by how a cell detects harmful or foreign insults and mounts an appropriate response to restore homeostasis.

Meet the Team

Zhijian "James" Chen, Ph.D.

Zhijian "James" Chen, Ph.D.

Howard Hughes Medical Institute
George L. MacGregor Distinguished Chair in Biomedical Science
Professor, Department of Molecular Biology
Member of National Academy of Sciences

Information about Dr. Chen's education and honors can be found via the link below.

Recent News & Discoveries

Phosphorylation article

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

Science 347: aaa2630

Lead Author: Siqi Liu

Dr. Chen with NAS President Podolsky and Dr. Olson

Zhijian "James" Chen is elected to the National Academy of Sciences

President Podolsky (left) and Dr. Olson (right), Chairman of Molecular Biology, celebrate his election during a reception.

Dr. Chen with NAS President Podolsky and Dr. Olson

Functional prions in innate immune signaling

Xin's paper on prion-like polymerization of MAVS and ASC in cell signaling was recently published by Cell.

Get Involved

Collaborate with Us

Reach out to us for more information on getting involved with our research.

Get in Touch
Tumor inoculation flowchart