Meet the PI
Jonathan Cheng, M.D.
Jonathan Cheng, M.D., is an Associate Professor of Plastic Surgery at UT Southwestern Medical Center. He is a fellowship-trained hand surgeon with expertise in peripheral nerve reconstruction and microsurgery. Dr. Cheng's clinical practice has a specialized focus on brachial plexus and peripheral nerve repair, and he is the leader of the peripheral nerve and brachial plexus team clinic at Children's Health Children’s Medical Center Dallas.
His research interests in peripheral nerve regeneration and neural interfacing are well-matched with his clinical interests, as his research focus is on the development of real-world solutions to longstanding clinical challenges.
As a member of the UT Southwestern Biomedical Engineering Program, Dr. Cheng mentors Ph.D. doctoral candidates from UT Southwestern and its partner institutions (UT Arlington and UT Dallas).
The basic and translational research interests of Dr. Cheng include mechanistic investigations into peripheral nerve regeneration, neural interfacing for the control of robotic limbs, and bioelectronic medicines for the modulation of systemic disease. Our lab performs a comprehensive suite of outcome measures to assess peripheral nerve recovery and chronic neural interfacing in the research setting.
Current studies include:
- Long gap peripheral nerve regeneration – Translational therapies for peripheral nerve regeneration across a long nerve gap, rapid screening of novel small molecule drugs
- Fascicular targeting of peripheral nerve interfaces -
- Development of precise surgical techniques for placement of chronic peripheral nerve implants
- Design of implantable systems for chronic neural recording and stimulation
- Human trials to investigate the basic physiology of fascicular targeting
- Bioelectronic medicines – Biologically active neural implants for chronic interfacing of autonomic nerves
A bioelectric neural interface towards intuitive prosthetic control for amputees.Nguyen AT, Xu J, Jiang M, Luu DK, Wu T, Tam WK, Zhao W, Drealan MW, Overstreet CK, Zhao Q, Cheng J, Keefer E, Yang Z, 2020 Oct J Neural Eng
Percutaneous Fixation of Pediatric Fractures of the Proximal Phalanx Neck: A Novel Technique.Pientka WF, Cheng J, 2020 Nov Tech Hand Up Extrem Surg
Comparison of provocative manoeuvres in diagnosing thumb carpometacarpal joint arthritis.Mailey B, Naram A, Cheng J, 2019 Sep J Hand Surg Eur Vol 7 44 750-752
Fascicle specific targeting for selective peripheral nerve stimulation.Overstreet CK, Cheng J, Keefer EW, 2019 Nov J Neural Eng 6 16 066040
Oral Antibiotics Are Effective for the Treatment of Hand Osteomyelitis in Children.Kargel JS, Sammer DM, Pezeshk RA, Cheng J 2018 Aug Hand (N Y) 1558944718788666
Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction.Vasudevan S, Huang J, Botterman B, Matloub HS, Keefer E, Cheng J 2014 Aug Plast Reconstr Surg Glob Open 8 2 e201
MR neurography of the brachial plexus in adult and pediatric age groups: evolution, recent advances, and future directions.Mazal AT, Faramarzalian A, Samet JD, Gill K, Cheng J, Chhabra A, 2020 Jan Expert Rev Med Devices
In-Depth Look at the Anatomical Relationship of the Lesser Occipital Nerve, Great Auricular Nerve, and Spinal Accessory Nerve and Their Implication in Safety of Operations in the Posterior Triangle of the Neck.Amirlak B, Lu KB, Erickson CR, Sanniec K, Totonchi A, Peled ZM, Cheng JC, 2020 09 Plast Reconstr Surg 3 146 509-514
Diffusion-weighted imaging and diffusion tensor imaging as adjuncts to conventional MRI for the diagnosis and management of peripheral nerve sheath tumors: current perspectives and future directions.Mazal AT, Ashikyan O, Cheng J, Le LQ, Chhabra A 2018 Dec Eur Radiol
Asymmetric Sensory-Motor Regeneration of Transected Peripheral Nerves Using Molecular Guidance Cues.Anand S, Desai V, Alsmadi N, Kanneganti A, Nguyen DH, Tran M, Patil L, Vasudevan S, Xu C, Hong Y, Cheng J, Keefer E, Romero-Ortega MI 2017 Oct Sci Rep 1 7 14323
Magnetic resonance neurography in the management of peripheral trigeminal neuropathy: experience in a tertiary care centre.Cox B, Zuniga JR, Panchal N, Cheng J, Chhabra A 2016 Jan Eur Radiol
Clinical Impact of Magnetic Resonance Neurography in Patients with Brachial Plexus Neuropathies.Fisher S, Wadhwa V, Manthuruthil C, Cheng J, Chhabra A 2016 Aug Br J Radiol 20160503
An implantable, designed-for-human-use peripheral nerve stimulation and recording system for advanced prosthetics.Lachapelle JR, Bjune CK, Kindle AL, Czarnecki A, Burns JR, Grainger JE, Segura CA, Nugent BD, Sriram TS, Parks PD, Keefer E, Cheng J 2016 08 Conf Proc IEEE Eng Med Biol Soc 2016 1794-1797
An Association between Carpal Tunnel Syndrome and Migraine Headaches-National Health Interview Survey, 2010.Law HZ, Amirlak B, Cheng J, Sammer DM 2015 Mar Plast Reconstr Surg Glob Open 3 3 e333
Peripheral neuropathy: surgical approaches simplified for the imagers.Kao DS, Cheng J 2015 Apr Semin Musculoskelet Radiol 2 19 121-9
Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces.Desai VH, Anand S, Tran M, Kanneganti A, Vasudevan S, Seifert JL, Cheng J, Keefer EW, Romero-Ortega MI 2014 Aug Conf Proc IEEE Eng Med Biol Soc 2014 1973-6
Evaluation of the scratch collapse test in peroneal nerve compression.Gillenwater J, Cheng J, Mackinnon SE 2011 Oct Plast. Reconstr. Surg. 4 128
Discussion: Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective study.Cheng J 2010 Sep Plast. Reconstr. Surg. 3 126
Topographic mapping of the superior transverse scapular ligament: a cadaver study to facilitate suprascapular nerve decompression.Weinfeld AB, Cheng J, Nath RK, Basaran I, Yuksel E, Rose JE 2002 Sep Plast. Reconstr. Surg. 3 110
The effects of increased gravity and microgravity on cardiac morphology.Goldstein MA, Cheng J, Schroeter JP 1998 Jun Aviat Space Environ Med 6 Suppl 69