Publications

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

Sriramulu S, Thoidingjam S, Chen WM, Hassan O, Siddiqui F, Brown SL, Movsas B, Green MD, Davis AJ, Speers C, Walker E, Nyati S 2024 Dec Journal of Experimental and Clinical Cancer Research 43

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors

Hu Q, Espejo Valle-Inclán J, Dahiya R, Guyer A, Mazzagatti A, Maurais EG, Engel JL, Lu H, Davis AJ, Cortés-Ciriano I, Ly P 2024 Dec Nature communications 15

Current trends and future perspectives in hadron therapy: radiobiology

Story MD, Davis AJ, Sishc BJ 2024 Sep Health and Technology 14 867-872

AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer

Marquez-Palencia M, Herrera LR, Parida PK, Ghosh S, Kim K, Das NM, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, Diegeler S, Aguilera TA, Peng Y, Lewis CM, Arteaga CL, Hanker AB, Whitehurst AW, Lorens JB, Brekken RA, Davis AJ, Malladi S 2024 Mar Cancer research 84 675-687

The cancer testes antigen, HORMAD1, limits genomic instability in cancer cells by protecting stalled replication forks

Herrera LR, Johnson RA, McGlynn K, Gibbs ZA, Davis AJ, Whitehurst AW 2023 Nov Journal of Biological Chemistry 299

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining

Head PS, Kapoor-Vazirani P, Nagaraju GP, Zhang H, Rath SK, Luong NC, Haji-Seyed-Javadi R, Sesay F, Wang SY, Duong DM, Daddacha W, Minten EV, Song B, Danelia D, Liu X, Li S, Ortlund EA, Seyfried NT, Smalley DM, Wang Y, Deng X, Dynan WS, El-Rayes B, Davis AJ, Yu DS 2023 Aug Nucleic acids research 51 7972-7987

ATM phosphorylates the FATC domain of DNA-PKcsat threonine 4102 to promote non-homologous end joining

Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen PB, Davis AJ 2023 Jul Nucleic acids research 51 6770-6783

DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism

Chen WM, Chiang JC, Shang Z, Palchik G, Newman C, Zhang Y, Davis AJ, Lee H, Chen PB 2023 Mar EMBO Journal 42

DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks

Lu H, Guan J, Wang SY, Li G, Bohr VA, Davis AJ 2022 Jun Nucleic acids research 50 5635-5651

Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells

Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE 2022 Mar Biotechnology and Bioengineering 119 963-982

Evaluation of the Response of HNSCC Cell Lines to γ-Rays and 12C Ions: Can Radioresistant Tumors Be Identified and Selected for 12C Ion Radiotherapy?

Ding L, Sishc BJ, Polsdofer E, Yordy JS, Facoetti A, Ciocca M, Saha D, Pompos A, Davis AJ, Story MD 2022 Feb Frontiers in Oncology 12

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma

Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ 2021 Sep Nucleic acids research 49 9836-9850

Human RecQ Helicases in DNA Double-Strand Break Repair

Lu H, Davis AJ 2021 Feb Frontiers in Cell and Developmental Biology 9

Erratum: Mechanism of efficient double-strand break repair by a long non-coding RNA (Nucleic Acids Research (2020) 48:19 (10953-10972) DOI: 10.1093/nar/gkaa784)

Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA 2021 Jan Nucleic acids research 49 1199-1200

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM 2021 Jan Cancer Cell 39 109-121.e5

Mechanism of efficient double-strand break repair by a long non-coding RNA

Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA 2020 Nov Nucleic acids research 48 10953-10972

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ 2019 Oct Nucleic acids research 47 9467-9479

HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress

Nichols BA, Oswald NW, McMillan EA, McGlynn K, Yan J, Kim MS, Saha J, Mallipeddi PL, LaDuke SA, Villalobos PA, Rodriguez-Canales J, Wistuba II, Posner BA, Davis AJ, Minna JD, MacMillan JB, Whitehurst AW 2018 Nov Cancer research 78 6196-6208

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

Lu H, Shamanna RA, de Freitas JK, Okur M, Khadka P, Kulikowicz T, Holland PP, Tian J, Croteau DL, Davis AJ, Bohr VA 2017 Dec Nature communications 8

The role of the core non-homologous end joining factors in carcinogenesis and cancer

Sishc BJ, Davis AJ 2017 Jul Cancers 9

Carbon ion radiotherapy: A review of clinical experiences and preclinical research, with an emphasis on DNA damage/repair

Mohamad O, Sishc BJ, Saha J, Pompos A, Rahimi A, Story MD, Davis AJ, Kim DW 2017 Jun Cancers 9

Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner

Saha J, Wang SY, Davis AJ 2017 97-118

Imaging of fluorescently tagged ATM kinase at the sites of DNA double strand breaks

Davis AJ, Wang SY, Chen DJ, Chen BP 2017 277-285

Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance

Mori E, Davis AJ, Hasegawa M, Chen DJ 2016 Aug Biochemical and Biophysical Research Communications 477 235-240

Unsolved mystery: The role of BRCA1 in DNA end-joining

Saha J, Davis AJ 2016 Aug Journal of radiation research 57 i18-i24

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

Lee KJ, Saha J, Sun J, Fattah KR, Wang SC, Jakob B, Chi L, Wang SY, Taucher-Scholz G, Davis AJ, Chen DJ 2015 Dec Nucleic acids research 44 1732-1745

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP 2015 Oct Nature communications 6

ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels

Story MD, Davis AJ 2015 Breast Diseases 26 297-299

Complex DSBs: A need for resection

Davis AJ, Chen DJ 2014 Dec Cell Cycle 13 3796-3797

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle

Davis AJ, Chi L, So S, Lee KJ, Mori E, Fattah K, Yang J, Chen DJ 2014 Oct Nucleic acids research 42 11487-11501

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

Davis AJ, Chen BP, Chen DJ 2014 May DNA repair 17 21-29

Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment

Abdisalaam S, Davis AJ, Chen DJ, Alexandrakis G 2014 Jan Nucleic acids research 42 e5

The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation (Journal of Biological Chemistry (2013) 288, (7037-7046))

Davis AJ, Lee KJ, Chen DJ 2013 Jun Journal of Biological Chemistry 288 18776

DNA double strand break repair via non-homologous end-joining

Davis AJ, Chen DJ 2013 Jun Translational Cancer Research 2 130-143

The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation

Davis AJ, Lee KJ, Chen DJ 2013 Mar Journal of Biological Chemistry 288 7037-7046

A role for protein phosphatase 4 in regulating non-homologous end-joining

Davis AJ, Chen DJ 2012 Oct Cell Cycle 11 3535

Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination

Shao Z, Davis AJ, Fattah KR, So S, Sun J, Lee KJ, Harrison L, Yang J, Chen DJ 2012 Mar DNA repair 11 310-316

Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex

Sun J, Lee KJ, Davis AJ, Chen DJ 2012 Feb Journal of Biological Chemistry 287 4936-4945

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks

Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, Van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y 2011 Dec Cell Cycle 10 4300-4310

B55α PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X 2010 Sep Journal of Biological Chemistry 285 29863-29873

A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining

Davis AJ, Chen DJ 2010 Aug Cell Cycle 9 3151-3155

Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks

Davis AJ, So S, Chen DJ 2010 Jul Cell Cycle 9 2529-2536

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites (Journal of Cell Biology (2009) 187, 7 (977-990))

So S, Davis AJ, Chen DJ 2010 Feb Journal of Cell Biology 188 443

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

So S, Davis AJ, Chen DJ 2009 Dec Journal of Cell Biology 187 977-990

Protein Phosphatase 2A

Silverstein AM, Davis AJ, Bielinski VA, Esplin ED, Mahmood NA, Mumby MC 2009 Jan 2 1353-1365

Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit

Davis AJ, Yan Z, Martinez B, Mumby MC 2008 Jun Journal of Biological Chemistry 283 16104-16114

Protein Phosphatase 2A

Silverstein AM, Davis AJ, Bielinski VA, Esplin ED, Mahmood NA, Mumby MC 2003 Nov 2-3 405-415

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

Silverstein AM, Barrow CA, Davis AJ, Mumby MC 2002 Apr Proceedings of the National Academy of Sciences of the United States of America 99 4221-4226