Publications

Featured Publications

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma.

Saha J, Bae J, Wang SY, Lu H, Chappell LJ, Gopal P, Davis AJ, 2021 Aug Nucleic Acids Res

Human RecQ Helicases in DNA Double-Strand Break Repair.

Lu H, Davis AJ, 2021 Front Cell Dev Biol 9 640755

Mechanism of efficient double-strand break repair by a long non-coding RNA.

Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA, 2020 Oct Nucleic Acids Res

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.

Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, 2020 Dec Cancer Cell

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response.

Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ, 2019 Aug Nucleic Acids Res.

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

Lu H, Shamanna RA, de Freitas JK, Okur M, Khadka P, Kulikowicz T, Holland PP, Tian J, Croteau DL, Davis AJ, Bohr VA 2017 Dec Nat Commun 1 8 2039

All Publications

Mechanism of efficient double-strand break repair by a long non-coding RNA.

Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA, 2020 Dec Nucleic Acids Res

HORMAD1 is a negative prognostic indicator in lung adenocarcinoma and specifies resistance to oxidative and genotoxic stress.

Nichols BA, Oswald NW, McMillan EA, McGlynn K, Yan J, Kim MS, Saha J, Mallipeddi PL, LaDuke SA, Villalobos PA, Rodriguez-Canales J, Wistuba II, Posner BA, Davis AJ, Minna JD, MacMillan JB, Whitehurst AW 2018 Sep Cancer Res.

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair.

Mohamad O, Sishc BJ, Saha J, Pompos A, Rahimi A, Story MD, Davis AJ, Kim DWN 2017 Jun Cancers (Basel) 6 9

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer.

Sishc BJ, Davis AJ 2017 Jul Cancers (Basel) 7 9

Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner.

Saha J, Wang SY, Davis AJ 2017 Meth. Enzymol. 591 97-118

Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks.

Davis AJ, Wang SY, Chen DJ, Chen BPC 2017 Methods Mol. Biol. 1599 277-285

Unsolved mystery: the role of BRCA1 in DNA end-joining.

Saha J, Davis AJ 2016 May J. Radiat. Res.

Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.

Mori E, Davis AJ, Hasegawa M, Chen DJ 2016 Jun Biochem. Biophys. Res. Commun.

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase.

Lee KJ, Saha J, Sun J, Fattah KR, Wang SC, Jakob B, Chi L, Wang SY, Taucher-Scholz G, Davis AJ, Chen DJ 2015 Dec Nucleic Acids Res.

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.

Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP 2015 Nat Commun 6 8325

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle.

Davis AJ, Chi L, So S, Lee KJ, Mori E, Fattah K, Yang J, Chen DJ 2014 Sep Nucleic Acids Res.

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway.

Davis AJ, Chen BP, Chen DJ 2014 Mar DNA Repair (Amst.)

Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after ?-irradiation and bleomycin treatment.

Abdisalaam S, Davis AJ, Chen DJ, Alexandrakis G 2014 Jan Nucleic Acids Res. 1 42 e5

Complex DSBs: A need for resection.

Davis AJ, Chen DJ 2014 Cell Cycle 24 13 3796-7

The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation.

Davis AJ, Lee KJ, Chen DJ 2013 Jun J. Biol. Chem. 26 288 18776

DNA double strand break repair via non-homologous end-joining.

Davis AJ, Chen DJ 2013 Jun Transl Cancer Res 3 2 130-143

The amino-terminal region of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is required for its DNA double-strand break-mediated activation.

Davis AJ, Lee KJ, Chen DJ 2013 Jan J. Biol. Chem.

A role for protein phosphatase 4 in regulating non-homologous end-joining.

Davis AJ, Chen DJ 2012 Oct Cell Cycle 19 11 3534-5

Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.

Shao Z, Davis AJ, Fattah KR, So S, Sun J, Lee KJ, Harrison L, Yang J, Chen DJ 2012 Mar DNA Repair (Amst.) 3 11 310-6

Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.

Sun J, Lee KJ, Davis AJ, Chen DJ 2012 Feb J. Biol. Chem. 7 287 4936-45

Involvement of the nuclear proteasome activator PA28? in the cellular response to DNA double-strand breaks.

Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y 2011 Dec Cell Cycle 24 10 4300-10

B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X 2010 Sep J. Biol. Chem. 39 285 29863-73

Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.

Davis AJ, So S, Chen DJ 2010 Jul Cell Cycle 13 9 2529-36

A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining.

Davis AJ, Chen DJ 2010 Aug Cell Cycle 16 9 3147-8

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.

So S, Davis AJ, Chen DJ 2009 Dec J. Cell Biol. 7 187 977-90

Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.

Davis AJ, Yan Z, Martinez B, Mumby MC 2008 Jun J. Biol. Chem. 23 283 16104-14

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.

Silverstein AM, Barrow CA, Davis AJ, Mumby MC 2002 Apr Proc. Natl. Acad. Sci. U.S.A. 7 99 4221-6