Featured Publications
Mechanism of efficient double-strand break repair by a long non-coding RNA.
Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA, 2020 Oct Nucleic Acids ResMLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, Zhang Y, Ortega J, Zhang J, Siteni S, Chen M, Gu L, Shay JW, Davis AJ, Chen ZJ, Fu YX, Li GM, 2020 Dec Cancer CellDNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response.
Lu H, Saha J, Beckmann PJ, Hendrickson EA, Davis AJ, 2019 Aug Nucleic Acids Res.All Publications
Mechanism of efficient double-strand break repair by a long non-coding RNA.
Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA, 2020 Dec Nucleic Acids ResThe Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer.
Sishc BJ, Davis AJ 2017 Jul Cancers (Basel) 7 9Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner.
Saha J, Wang SY, Davis AJ 2017 Meth. Enzymol. 591 97-118Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks.
Davis AJ, Wang SY, Chen DJ, Chen BPC 2017 Methods Mol. Biol. 1599 277-285Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance.
Mori E, Davis AJ, Hasegawa M, Chen DJ 2016 Jun Biochem. Biophys. Res. Commun.Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase.
Lee KJ, Saha J, Sun J, Fattah KR, Wang SC, Jakob B, Chi L, Wang SY, Taucher-Scholz G, Davis AJ, Chen DJ 2015 Dec Nucleic Acids Res.LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.
Liu XS, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R, Lunardi A, Pandolfi PP 2015 Nat Commun 6 8325BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle.
Davis AJ, Chi L, So S, Lee KJ, Mori E, Fattah K, Yang J, Chen DJ 2014 Sep Nucleic Acids Res.DNA double strand break repair via non-homologous end-joining.
Davis AJ, Chen DJ 2013 Jun Transl Cancer Res 3 2 130-143A role for protein phosphatase 4 in regulating non-homologous end-joining.
Davis AJ, Chen DJ 2012 Oct Cell Cycle 19 11 3534-5Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.
Shao Z, Davis AJ, Fattah KR, So S, Sun J, Lee KJ, Harrison L, Yang J, Chen DJ 2012 Mar DNA Repair (Amst.) 3 11 310-6Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.
Davis AJ, So S, Chen DJ 2010 Jul Cell Cycle 13 9 2529-36A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining.
Davis AJ, Chen DJ 2010 Aug Cell Cycle 16 9 3147-8Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
So S, Davis AJ, Chen DJ 2009 Dec J. Cell Biol. 7 187 977-90