We study the impact of disease-related hypoxic stress with aging upon synaptic plasticity, white matter connectivity, and cognitive performance.


  • Cell-specific molecular phenotyping of HIF and HIF controlled transcription within the brain with aging employing advanced cell separation techniques.
  • Behavioral phenotyping of the impact of HIF decline with aging using cell and or regional specific knockout/knockdown approaches to model the impact of HIF decline with aging upon cognitive performance.
  • High-resolution ex-vivo MRI phenotyping of brain-related morphological and connectivity changes due to HIF decline.