Featured Publications
Inhibition of mRNA nuclear export promotes SARS-CoV-2 pathogenesis.
Mei M, Cupic A, Miorin L, Ye C, Cagatay T, Zhang K, Patel K, Wilson N, McDonald WH, Crossland NA, Lo M, Rutkowska M, Aslam S, Mena I, Martinez-Sobrido L, Ren Y, García-Sastre A, Fontoura BMA, 2024 May Proc Natl Acad Sci U S A 22 121 e2314166121Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex.
Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Haddad C, Gao S, Esparza M, Cagatay T, Batten K, El Zahed SS, Arnaoutov A, Zhong H, Shay JW, Tolbert BS, Dasso M, Lynch KW, García-Sastre A, Fontoura BMA, 2023 Apr Nat Commun 1 14 2304
Gao S, Esparza M, Dehghan I, Aksenova V, Zhang K, Batten K, Ferretti MB, Begg BE, Cagatay T, Shay JW, García-Sastre A, Goldsmith EJ, Chen ZJ, Dasso M, Lynch KW, Cobb MH, Fontoura BMA,
2022 Jun
Proc Natl Acad Sci U S A
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119
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Viral-host interactions during splicing and nuclear export of influenza virus mRNAs.
Esparza M, Bhat P, Fontoura BM, 2022 Jul Curr Opin Virol 55 101254
White K, Esparza M, Liang J, Bhat P, Naidoo J, McGovern BL, Williams MAP, Alabi BR, Shay J, Niederstrasser H, Posner B, García-Sastre A, Ready J, Fontoura BMA,
2021 Jul
J Med Chem
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.
Zhang K, Miorin L, Makio T, Dehghan I, Gao S, Xie Y, Zhong H, Esparza M, Kehrer T, Kumar A, Hobman TC, Ptak C, Gao B, Minna JD, Chen Z, García-Sastre A, Ren Y, Wozniak RW, Fontoura BMA, 2021 Feb Sci Adv 6 7Chemical intervention of influenza virus mRNA nuclear export.
Esparza M, Mor A, Niederstrasser H, White K, White A, Zhang K, Gao S, Wang J, Liang J, Sho S, Sakthivel R, Sathe AA, Xing C, Muñoz-Moreno R, Shay JW, García-Sastre A, Ready J, Posner B, Fontoura BMA, 2020 Apr PLoS Pathog. 4 16 e1008407Viral-induced alternative splicing of host genes promotes influenza replication.
Thompson MG, Dittmar M, Mallory MJ, Bhat P, Ferretti MB, Fontoura BM, Cherry S, Lynch KW, 2020 12 Elife 9SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A, 2020 11 Proc Natl Acad Sci U S A 45 117 28344-28354Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway.
Aksenova V, Smith A, Lee H, Bhat P, Esnault C, Chen S, Iben J, Kaufhold R, Yau KC, Echeverria C, Fontoura B, Arnaoutov A, Dasso M, 2020 09 Nat Commun 1 11 4577
Liu Z, Yan M, Liang Y, Liu M, Zhang K, Shao D, Jiang R, Li L, Wang C, Nussenzveig DR, Zhang K, Chen S, Zhong C, Mo W, Fontoura BMA, Zhang L,
2019 Mar
Neuron
Structural basis for influenza virus NS1 protein block of mRNA nuclear export.
Zhang K, Xie Y, Muñoz-Moreno R, Wang J, Zhang L, Esparza M, García-Sastre A, Fontoura BMA, Ren Y, 2019 Jul Nat MicrobiolDEAD-box ATPases are global regulators of phase-separated organelles.
Hondele M, Sachdev R, Heinrich S, Wang J, Vallotton P, Fontoura BMA, Weis K, 2019 Aug NatureInfluenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting.
Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, Shao D, Anantharaman A, García-Sastre A, Conrad NK, Fontoura BMA 2018 Sep J. Virol.Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing.
Thompson MG, Muñoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara MR, Mallory MJ, Zhang K, García-Sastre A, Fontoura BMA, Lynch KW 2018 Jun Nat Commun 1 9 2407Editorial overview: The cell nucleus: Dynamic interplay of shape and function.
Dasso M, Fontoura BMA 2018 Jun Curr. Opin. Cell Biol. 52 iv-vi
Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA
2018 Dec
Proc. Natl. Acad. Sci. U.S.A.
Kuss-Duerkop SK, Wang J, Mena I, White K, Metreveli G, Sakthivel R, Mata MA, Muñoz-Moreno R, Chen X, Krammer F, Diamond MS, Chen ZJ, García-Sastre A, Fontoura BMA
2017 Sep
PLoS Pathog.
9
13
e1006635
Dasso M, Fontoura BM
2016 Sep
Cell
6
166
1364-6
Influenza virus mRNA trafficking through host nuclear speckles.
Mor A, White A, Zhang K, Thompson M, Esparza M, Muñoz-Moreno R, Koide K, Lynch KW, García-Sastre A, Fontoura BM 2016 Nat Microbiol 7 1 16069Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo.
Moreira TG, Zhang L, Shaulov L, Harel A, Kuss SK, Williams J, Shelton J, Somatilaka B, Seemann J, Yang J, Sakthivel R, Nussenzveig DR, Faria AM, Fontoura BM 2015 Sci Rep 5 17655
Mor A, White MA, Fontoura BM
2014 Feb
Curr. Opin. Cell Biol.
28C
28-35
Primate-specific miR-576-3p sets host defense signalling threshold.
Yarbrough ML, Zhang K, Sakthivel R, Forst CV, Posner BA, Barber GN, White MA, Fontoura BM 2014 Nat Commun 5 4963Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing.
Tsai PL, Chiou NT, Kuss S, García-Sastre A, Lynch KW, Fontoura BM 2013 Jun PLoS Pathog. 6 9 e1003460
Zhang L, Das P, Schmolke M, Manicassamy B, Wang Y, Deng X, Cai L, Tu BP, Forst CV, Roth MG, Levy DE, García-Sastre A, de Brabander J, Phillips MA, Fontoura BM
2012 Feb
J. Cell Biol.
3
196
315-26
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.
Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM 2011 Sep Nat Chem Biol 10 7 712?719Vesicular stomatitis virus inhibits mitotic progression and triggers cell death.
Chakraborty P, Seemann J, Mishra RK, Wei JH, Weil L, Nussenzveig DR, Heiber J, Barber GN, Dasso M, Fontoura BM 2009 Oct EMBO Rep. 10 10 1154-60Nucleoporin levels regulate cell cycle progression and phase-specific gene expression.
Chakraborty P, Wang Y, Wei JH, van Deursen J, Yu H, Malureanu L, Dasso M, Forbes DJ, Levy DE, Seemann J, Fontoura BM 2008 Nov Dev. Cell 5 15 657-67Influenza virus targets the mRNA export machinery and the nuclear pore complex.
Satterly N, Tsai PL, van Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BM 2007 Feb Proc. Natl. Acad. Sci. U.S.A. 6 104 1853-8
Faria AM, Levay A, Wang Y, Kamphorst AO, Rosa ML, Nussenzveig DR, Balkan W, Chook YM, Levy DE, Fontoura BM
2006 Mar
Immunity
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24
295-304
Faria PA, Chakraborty P, Levay A, Barber GN, Ezelle HJ, Enninga J, Arana C, van Deursen J, Fontoura BM
2005 Jan
Mol. Cell
1
17
93-102
Role of nucleoporin induction in releasing an mRNA nuclear export block.
Enninga J, Levy DE, Blobel G, Fontoura BM 2002 Feb Science 5559 295 1523-5UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages.
Zhang M, Mishra S, Sakthivel R, Fontoura BM, Nussenzweig V 2016 Jan PLoS Pathog. 1 12 e1005370
Yarbrough ML, Mata MA, Sakthivel R, Fontoura BM
2014 Feb
Traffic
2
15
127-40
SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.
Das P, Deng X, Zhang L, Roth MG, Fontoura BM, Phillips MA, De Brabander JK 2013 Jun ACS Med Chem Lett 6 4 517-521Nuclear imprisonment: viral strategies to arrest host mRNA nuclear export.
Kuss SK, Mata MA, Zhang L, Fontoura BM 2013 Viruses 7 5 1824-49
Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ, Fontoura BM, Ménard R, Dever TE, Nussenzweig V
2012 Mar
Proc. Natl. Acad. Sci. U.S.A.
10
109
3956-61
Yarbrough ML, White MA, Fontoura BM
2012 Dec
Mol. Cell
5
48
665-6
Ward SE, Kim HS, Komurov K, Mendiratta S, Tsai PL, Schmolke M, Satterly N, Manicassamy B, Forst CV, Roth MG, García-Sastre A, Blazewska KM, McKenna CE, Fontoura BM, White MA
2012
PLoS ONE
8
7
e39284
Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.
Zhang ZC, Satterly N, Fontoura BM, Chook YM 2011 Dec Mol. Biol. Cell 23 22 4657-68
Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V
2010 Jul
J. Exp. Med.
7
207
1465-74
The Nup107-160 complex and gamma-TuRC regulate microtubule polymerization at kinetochores.
Mishra RK, Chakraborty P, Arnaoutov A, Fontoura BM, Dasso M 2010 Feb Nat. Cell Biol. 2 12 164-9NFAR-1 and -2 modulate translation and are required for efficient host defense.
Pfeifer I, Elsby R, Fernandez M, Faria PA, Nussenzveig DR, Lossos IS, Fontoura BM, Martin WD, Barber GN 2008 Mar Proc. Natl. Acad. Sci. U.S.A. 11 105 4173-8Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite.
Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V 2007 Nov Cell 3 131 492-504Structure-based design of a pathway-specific nuclear import inhibitor.
Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM 2007 May Nat. Struct. Mol. Biol. 5 14 452-4The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly.
Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ 2006 Sep Mol. Biol. Cell 9 17 3806-18
Chakraborty P, Satterly N, Fontoura BM
2006 Aug
Methods
4
39
363-9
Viral interactions with the nuclear transport machinery: discovering and disrupting pathways.
Fontoura BM, Faria PA, Nussenzveig DR 2005 Feb IUBMB Life 2 57 65-72
Enninga J, Levay A, Fontoura BM
2003 Oct
Mol. Cell. Biol.
20
23
7271-84
The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR.
Fontoura BM, Dales S, Blobel G, Zhong H 2001 Mar Proc. Natl. Acad. Sci. U.S.A. 6 98 3208-13
Fontoura BM, Blobel G, Yaseen NR
2000 Oct
J. Biol. Chem.
40
275
31289-96
Fontoura BM, Blobel G, Matunis MJ
1999 Mar
J. Cell Biol.
6
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1097-112