Harbour Lab
The Harbour Lab uses genomic technologies and genetically engineered human cells and mouse models to develop biomarkers and elucidate mechanisms of tumor evolution and metastasis in uveal melanoma and retinoblastoma.
Meet the PI
J. William Harbour, M.D.
Dr. Harbour is Professor and Chair of the Department of Ophthalmology at UT Southwestern Medical Center. He specializes in ocular oncology.
Dr. Harbour earned his medical degree at Johns Hopkins University and completed a residency in ophthalmology at the Wills Eye Hospital of Thomas Jefferson University. He received advanced training through a fellowship in vitreoretinal diseases and surgery at the Bascom Palmer Eye Institute of the University of Miami, a fellowship in ocular oncology at the University of California, San Francisco, and research training in molecular oncology at Washington University in St. Louis.
Certified by the American Board of Ophthalmology, he joined the UT Southwestern faculty in 2021.
Previously, Dr. Harbour held the Dr. Mark J. Daily, M.D., Endowed Chair at the Bascom Palmer Eye Institute, where he also served as Director of Ocular Oncology and Vice Chair for Translational Research. He also served as Associate Director for Basic Science at the Sylvester Comprehensive Cancer Center of the University of Miami.
Dr. Harbour’s clinical interests focus on ocular tumors such as uveal melanoma, retinoblastoma, and lymphoma. He has trained many residents and fellows and pioneered new surgical methods in fine needle biopsy, laser treatment, and brachytherapy of ocular tumors. He also has been awarded patents for innovations in genetic prognostic testing for uveal melanoma.
His research interests include the use of genetic and genomic technologies to better understand, diagnose, and treat eye cancers. His team discovered three of the most important genomic drivers of metastasis in uveal melanoma, as well as key genomic events in retinoblastoma. His contributions to the field have been recognized by the Association for Research in Vision and Ophthalmology’s Cogan Award and the Macula Society’s Paul Henkind and Rosenthal Awards, among many others.
Dr. Harbour has delivered more than 300 invited scientific lectures and published more than 200 peer-reviewed scientific articles and book chapters.
He is an Associate Editor for Melanoma Research and has served on the editorial boards of Archives of Ophthalmology, Translational Vision Science & Technology, Melanoma Management, Expert Review of Ophthalmology, and Faculty of 1000.
Dr. Harbour is a member of numerous professional organizations, including the Association of American Physicians, American Academy of Ophthalmology, American Association for Cancer Research, and American Association of Ophthalmic Oncologists and Pathologists, and he is the founder of the Collaborative Ocular Oncology Group.
Harbour Lab
Meet the Team
L. to r.: Mithalesh Singh, Ph.D. (Postdoc); Mahsa Sorouri, Ph.D. (Lab Manager); J. William Harbour, M.D.; and Jie Han, M.S. (Research Scientist)
Contact Us
- Harbour Lab
- The Harbour Lab is located on the 5th floor of ND (Pickens Biomedical Building) on North Campus.
- 6001 Forest Park Road Dallas, TX 75235 ND5.307 (5th floor, room 307)
Mechanisms of Tumor Progression in Eye Cancer
Uveal Melanoma
Over the past two decades, the Harbour Laboratory has made great strides in understanding uveal melanoma, the most common primary cancer of the eye. The lab found that uveal melanomas can be divided into two basic forms, based on gene expression profile, mutation status, and chromosomal alterations. Class 1 uveal melanomas have low metastatic risk, whereas class 2 uveal melanomas have high metastatic risk. Based on this discovery, the lab developed a clinical prognostic test based on a 15-gene signature that has been prospectively validated in multiple studies and is currently the standard of care for precision medicine in this cancer type. Further, the lab discovered that mutational inactivation of the tumor suppressor BAP1 accounts for the class 2 uveal melanoma tumor type, as well as a novel BAP1 familial cancer syndrome, which is transmitted in an autosomal dominant fashion and can include uveal and cutaneous melanoma, mesothelioma, renal cell carcinoma, meningioma, and other cancer types.
Recently, the lab discovered that the cancer-testis antigen PRAME can be aberrantly expressed in uveal melanoma, representing an independent prognostic factor in both class 1 and class 2 uveal melanomas. Further work in the lab has disclosed a functional role for PRAME in chromosomal instability, aneuploidy, and tumor progression.
Retinoblastoma
The Harbour Laboratory has established tumor samples and cell lines from a large number of primary human retinoblastoma samples and has undertaken an unprecedented scope and depth of genomic analysis that has disclosed a new understanding of retinoblastoma progression. The lab discovered ESRRG as one of the key drivers of retinoblastoma progression. This estrogen-related orphan receptor plays an essential role in retinal development, hypoxic adaptation, and retinoblastoma progression.
Research Directions
Major research directions in the lab include:
- Elucidate how BAP1 mutations and aberrant PRAME expression drive uveal melanoma progression, with a focus on how these genomic aberrations alter the tumor immune microenvironment.
- Elucidate how aberrant ESRRG expression and other recurrent genomic aberrations in retinoblastoma drive tumor progression, metastasis, and poor prognosis, with a focus on altered oxygen metabolism.
- Determine how to therapeutically disrupt key drivers of tumor progression in uveal melanoma and retinoblastoma.
Publications
Harbour JW, Correa ZM, Schefler AC, Mruthyunjaya P, Materin MA, Aaberg TA, Skalet AH, Reichstein DA, Weis E, Kim IK, Fuller TS, Demirci H, Piggott KD, Williams BK, Shildkrot E, Capone A, Oliver SC, Walter SD, Mason J, Char DH, Altaweel M, Wells JR, Duker JS, Hovland PG, Gombos DS, Tsai T, Javid C, Marr BP, Gao A, Decatur CL, Dollar JJ, Kurtenbach S, Zhang S
2024 Oct
Journal of Clinical Oncology
42
3319-3329
Do Short Delays in Treatment Affect Uveal Melanoma Prognosis?
Harbour JW, Correa ZM, Stacey AW 2024 Sep Ophthalmology 131 1105-1106
Schneider S, Anderson JB, Bradley RP, Beigel K, Wright CM, Maguire BA, Yan G, Taylor DM, Harbour JW, Heuckeroth RO
2024 May
Journal of Clinical Investigation
134
Kurtenbach S, Sanchez MI, Kuznetsoff J, Rodriguez DA, Weich N, Dollar JJ, Cruz A, Kurtenbach S, Field MG, Durante MA, Decatur C, Sorouri M, Lai F, Yenisehirli G, Fang B, Shiekhattar R, Pelaez D, Correa ZM, Verdun RE, Harbour JW
2024 Feb
Oncogene
43
555-565
Vitreous metastasis from cutaneous melanoma: diagnosis and management
Ashkenazy N, Harbour JW, Dubovy SR, Albini TA, Sridhar J, Patel N, Hansen ED, Uchiyama E, Rubsamen PE, Correa ZM 2024 Arquivos Brasileiros de Oftalmologia 87
Richards JR, Shin D, Pryor R, Sorensen LK, Sun Z, So WM, Park G, Wolff R, Truong A, McMahon M, Grossmann AH, Harbour JW, Zhu W, Odelberg SJ, Yoo JH
2023 Sep
Oncogene
42
3015
Richards JR, Shin D, Pryor R, Sorensen LK, Sun Z, So WM, Park G, Wolff R, Truong A, McMahon M, Grossmann AH, Harbour JW, Zhu W, Odelberg SJ, Yoo JH
2023 Sep
Oncogene
42
3015
Richards JR, Shin D, Pryor R, Sorensen LK, Sun Z, So WM, Park G, Wolff R, Truong A, McMahon M, Grossmann AH, Harbour JW, Zhu W, Odelberg SJ, Yoo JH
2023 Aug
Oncogene
42
2629-2640
Han A, Mukha D, Chua V, Purwin TJ, Tiago M, Modasia B, Baqai U, Aumiller JL, Bechtel N, Hunter E, Danielson M, Terai M, Wedegaertner PB, Sato T, Landreville S, Davies MA, Kurtenbach S, Harbour JW, Schug ZT, Aplin AE
2023 Jul
Cancers
15
IRIS METASTASIS from BREAST CANCER SUCCESSFULLY TREATED with ABEMACICLIB and LETROZOLE
Goduni L, Ashkenazy N, Hansen E, Soyano-Muller A, Correa ZM, Harbour JW 2023 Mar Retinal Cases and Brief Reports 17 123-125
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
2023 Feb
Nature Reviews Clinical Oncology
20
99-115
Post-Radiation Cataract Management: Outcomes in Individuals with Uveal Melanoma
Sepulveda-Beltran PA, Levine H, Gibbons AG, Maharaj A, Choi DS, Martinez JD, Correa ZM, Amescua G, Harbour JW 2022 Dec Current Ophthalmology Reports 10 218-227HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma
Sriramareddy SN, Faião-Flores F, Emmons MF, Saha B, Chellappan S, Wyatt C, Smalley I, Licht JD, Durante MA, Harbour JW, Smalley KS 2022 Dec Cancer Gene Therapy 29 1840-1846
Gurayah AA, Peters VA, Jin W, Kalahasty K, Kwon D, Zhao W, Patel NV, Markoe AM, Correa ZM, Studenski MT, Harbour JW, Samuels SE
2022 Nov
Ocular Oncology and Pathology
8
175-180
Peters V, Gurayah A, Jin W, Kwon D, Zhao W, Patel NV, Markoe A, Correa Z, Studenski MT, Harbour JW, Samuels SE
2022 Nov
Brachytherapy
21
896-903
Zhang MG, Kuznetsoff JN, Owens DA, Gallo RA, Kalahasty K, Cruz AM, Kurtenbach S, Correa ZM, Pelaez D, Harbour JW
2022 Oct
Cancers
14
Goel N, Yadegarynia S, Kwon D, Kesmodel SB, Harbour JW, Kobetz E, Merchant N, Rodriguez DA
2022 Sep
Annals of surgery
276
430-440
Marquez MA, Fortun J, Iyer P, Harbour JW, Haddock LJ
2022 Sep
American Journal of Ophthalmology Case Reports
27
Russell JF, Villegas VM, Rosenfeld PJ, Harbour JW
2022 Sep
Retina Today
2022
21-61
Adjuvant crizotinib in high-risk uveal melanoma following definitive therapy
Khan S, Lutzky J, Shoushtari AN, Jeter J, Marr B, Olencki TE, Cebulla CM, Abdel-Rahman M, Harbour JW, Sender N, Nesson A, Singh-Kandah S, Hernandez S, King J, Katari MS, Dimapanat L, Izard S, Ambrosini G, Surriga O, Rai AJ, Chiuzan C, Schwartz GK, Carvajal RD 2022 Aug Frontiers in Oncology 12
Field MG, Kuznetsoff JN, Zhang MG, Dollar JJ, Durante MA, Sayegh Y, Decatur CL, Kurtenbach S, Pelaez D, Harbour JW
2022 Aug
Science Advances
8
Author Collaboration TG, Fabian ID, Abdallah E, Abdullahi SU, Abdulqader RA, Abdulrahaman AA, Abouelnaga S, Ademola-Popoola DS, Adio A, Afifi MA, Afshar AR, Aggarwal P, Aghaji AE, Ahmad A, Akib MN, Akinsete A, Al Harby L, Al Mesfer S, Al Ani MH, Alarcón Portabella S, Al-Badri SA, Alcasabas AP, Al-Dahmash SA, Alejos A, Alemany-Rubio E, Alfa Bio AI, Alfonso Carreras Y, Al-Haddad CE, Al-Hussaini HH, Ali AM, Alia DB, Al-Jadiry MF, Al-Jumaily U, Alkatan HM, All-Eriksson C, Al-Mafrachi AA, Almeida AA, Alsawidi KM, Al-Shaheen AA, Al-Shammary EH, Amankwaa-Frempong D, Amiruddin PO, Armytasari I, Astbury NJ, Atalay HT, Ataseven E, Atchaneeyasakul Lo, Atsiaya R, Autrata R, Balaguer J, Harbour JW
2022 Aug
The Lancet Global Health
10
e1128-e1140
Baqai U, Purwin TJ, Bechtel N, Chua V, Han A, Hartsough EJ, Kuznetsoff JN, Harbour JW, Aplin AE
2022 Aug
Molecular Cancer Research
20
1260-1271
Kaler CJ, Dollar JJ, Cruz AM, Kuznetsoff JN, Sanchez MI, Decatur CL, Licht JD, Smalley KS, Correa ZM, Kurtenbach S, Harbour JW
2022 Aug
Cancers
14
Sanati-Mehrizy A, Ghosh T, Peterson E, Starke RM, Harbour JW, Corrales-Medina FF
2022 May
Journal of Pediatric Hematology/Oncology
44
181-185
Stålhammar G, Yeung A, Mendoza P, Dubovy SR, William Harbour J, Grossniklaus HE
2022 Mar
Ophthalmology Science
2
Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma
Han A, Chua V, Baqai U, Purwin TJ, Bechtel N, Hunter E, Tiago M, Seifert E, Speicher DW, Schug ZT, Harbour JW, Aplin AE 2022 Feb Oncogene 41 1129-1139
Wagley S, Belin PJ, Dollar JJ, Harbour JW, Maltry AC, Mruthyunjaya P, Schefler AC, Tang PH
2022 Feb
American journal of ophthalmology
234
1-5
Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia
Djulbegovic MB, Uversky VN, Karp CL, Harbour JW 2022 Jan International Journal of Biological Macromolecules 195 93-101Secondary Glaucoma Associated with Intraocular Metastatic Cutaneous Melanoma
Greenfield JA, Rowlands M, Harbour JW 2022 Jan Ophthalmology Glaucoma 5 119-120
Echegaray JJ, Harbour JW
2022 Jan
7783-7793
Alhumaid S, Harbour JW
2022 Jan
7795-7805
The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma
Chua V, Han A, Bechtel N, Purwin TJ, Hunter E, Liao C, Harbour JW, Aplin AE 2022 Jan Pigment Cell and Melanoma Research 35 78-87Analytical Validation and Performance of a 7-Gene Next-Generation Sequencing Panel in Uveal Melanoma
Alsina KM, Sholl LM, Covington KR, Arnal SM, Durante MA, Decatur CL, Stone JF, Oelschlager KM, Harbour JW, Monzon FA, Cook RW, Borman S 2021 Dec Ocular Oncology and Pathology 7 428-436Multiregional genetic evolution of metastatic uveal melanoma
Rodriguez DA, Yang J, Durante MA, Shoushtari AN, Moschos SJ, Wrzeszczynski KO, Harbour JW, Carvajal RD 2021 Dec npj Genomic Medicine 6Uphyloplot2: visualizing phylogenetic trees from single-cell RNA-seq data
Kurtenbach S, Cruz AM, Rodriguez DA, Durante MA, Harbour JW 2021 Dec BMC Genomics 22
Khine KT, Clark WM, Harbour JW
2021 Dec
JAMA Ophthalmology
139
1321-1322
Comprehensive assessment of the effect of eye plaque tilt on tumor dosimetry
Studenski MT, Markoe A, Samuels SE, Correa ZM, Bossart E, Harbour JW 2021 Nov Brachytherapy 20 1289-1295Structural protein analysis of driver gene mutations in conjunctival melanoma
Djulbegovic MB, Uversky VN, Harbour JW, Galor A, Karp CL 2021 Oct Genes 12
Ashkenazy N, Walter SD, Harbour JW
2021 Jul
JAMA Ophthalmology
139
802-803
Kinetic characterization of ASXL1/2-mediated allosteric regulation of the BAP1 deubiquitinase
Peng H, Cassel J, McCracken DS, Prokop JW, Sementino E, Cheung M, Collop PR, Polo A, Joshi S, Mandell JP, Ayyanathan K, Hinds D, Malkowicz SB, Harbour JW, Bowcock AM, Salvino J, Kennedy EJ, Testa JR, Rauscher FJ 2021 Jul Molecular Cancer Research 19 1099-1112
Harbour JW
2021 Jun
Clinical Cancer Research
27
2967-2969
Multimodal Imaging in the Diagnosis of Exophytic Juxtapapillary Retinal Capillary Hemangioblastoma
Russell JF, Villegas VM, Schwartz SG, Weng CY, Davis JL, Flynn HW, Harbour JW 2021 May American journal of ophthalmology 225 128-136PieParty: visualizing cells from scRNA-seq data as pie charts
Kurtenbach S, Dollar JJ, Cruz AM, Durante MA, Decatur CL, Harbour JW 2021 May Life Science Alliance 4
Han A, Purwin TJ, Bechtel N, Liao C, Chua V, Seifert E, Sato T, Schug ZT, Speicher DW, Harbour JW, Aplin AE
2021 Mar
Oncogene
40
1753
Han A, Purwin TJ, Bechtel N, Liao C, Chua V, Seifert E, Sato T, Schug ZT, Speicher DW, Harbour JW, Aplin AE
2021 Mar
Oncogene
40
1753
Kuznetsoff JN, Owens DA, Lopez A, Rodriguez DA, Chee NT, Kurtenbach S, Bilbao D, Roberts ER, Volmar CH, Wahlestedt C, Brothers SP, Harbour JW
2021 Feb
Molecular Cancer Research
19
215-222
Han A, Purwin TJ, Bechtel N, Liao C, Chua V, Seifert E, Sato T, Schug ZT, Speicher DW, William Harbour J, Aplin AE
2021 Jan
Oncogene
40
618-632
Molecular Basis of Uveal Melanoma and Emerging Therapeutic Targets
Harbour JW, Correa ZM 2021 Jan 3-12
Armitage AM, Kundra MA, Ghiam N, Atwal PS, Morel D, Hruska KS, Torene R, Harbour JW, Forghani I
2021 Jan
American Journal of Medical Genetics, Part A
185
208-212
Garoon RB, Medina CA, Scelfo C, Harbour JW
2021
Retinal Cases and Brief Reports
15
68-70
A novel cardiomyogenic role for Isl1+ neural crest cells in the inflow tract
Hatzistergos KE, Durante MA, Valasaki K, Wanschel AC, William Harbour J, Hare JM 2020 Dec Science Advances 6Single-cell analysis reveals new evolutionary complexity in uveal melanoma
Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW 2020 Dec Nature communications 11Impact of genetic ancestry on prognostic biomarkers in uveal melanoma
Rodriguez DA, Sanchez MI, Decatur CL, Correa ZM, Martin ER, Harbour JW 2020 Nov Cancers 12 1-13
Ashkenazy N, Orihuela G, Rodriguez LI, Negron CI, William Harbour J, Berrocal AM
2020 Nov
Ophthalmic Surgery Lasers and Imaging Retina
51
651-652
Bilateral uveitis associated with nivolumab therapy for metastatic non-small cell lung cancer
Dermarkarian CR, Patel NA, Villegas VM, Harbour JW 2020 Jun American Journal of Ophthalmology Case Reports 18Decitabine limits escape from MEK inhibition in uveal melanoma
Gonçalves J, Emmons MF, Faião-Flores F, Aplin AE, Harbour JW, Licht JD, Wink MR, Smalley KS 2020 May Pigment Cell and Melanoma Research 33 507-514Global Retinoblastoma Presentation and Analysis by National Income Level
Fabian ID, Abdallah E, Abdullahi SU, Abdulqader RA, Adamou Boubacar S, Ademola-Popoola DS, Adio A, Afshar AR, Aggarwal P, Aghaji AE, Ahmad A, Akib MN, Al Harby L, Al Ani MH, Alakbarova A, Portabella SA, Al-Badri SA, Alcasabas AP, Al-Dahmash SA, Alejos A, Alemany-Rubio E, Alfa Bio AI, Alfonso Carreras Y, Al-Haddad C, Al-Hussaini HH, Ali AM, Alia DB, Al-Jadiry MF, Al-Jumaly U, Alkatan HM, All-Eriksson C, Al-Mafrachi AA, Almeida AA, Alsawidi KM, Al-Shaheen AA, Al-Shammary EH, Amiruddin PO, Antonino R, Astbury NJ, Atalay HT, Atchaneeyasakul LO, Atsiaya R, Attaseth T, Aung TH, Ayala S, Baizakova B, Balaguer J, Balayeva R, Balwierz W, Barranco H, Bascaran C, Beck Popovic M, Benavides R, Benmiloud S, Bennani Guebessi N, Berete RC, Berry JL, Bhaduri A, Bhat S, Biddulph SJ, Biewald EM, Bobrova N, Boehme M, Boldt HC, Bonanomi MT, Bornfeld N, Bouda GC, Bouguila H, Boumedane A, Brennan RC, Brichard BG, Buaboonnam J, Calderón-Sotelo P, Calle Jara DA, Camuglia JE, Cano MR, Capra M, Cassoux N, Castela G, Castillo L, Català-Mora J, Chantada GL, Chaudhry S, Chaugule SS, Chauhan A, Chawla B, Chernodrinska VS, Chiwanga FS, Chuluunbat T, Cieslik K, Cockcroft RL, Comsa C, Correa ZM, Correa Llano MG, Corson TW, Cowan-Lyn KE, Csóka M, Cui X, Da Gama IV, Dangboon W, Das A, Das S, Davanzo JM, Davidson A, De Potter P, Delgado KQ, Demirci H, Desjardins L, Diaz Coronado RY, Dimaras H, Dodgshun AJ, Donaldson C, Donato Macedo CR, Dragomir MD, Du Y, Du Bruyn M, Edison KS, Eka Sutyawan IW, El Kettani A, Elbahi AM, Elder JE, Elgalaly D, Elhaddad AM, Elhassan MM, Elzembely MM, Essuman VA, Evina TG, Fadoo Z, Fandiño AC, Faranoush M, Fasina O, Fernández DD, Fernández-Teijeiro A, Foster A, Frenkel S, Fu LD, Fuentes-Alabi SL, Gallie BL, Gandiwa M, Garcia JL, García Aldana D, Gassant PY, Geel JA, Ghassemi F, Girón AV, Gizachew Z, Goenz MA, Gold AS, Goldberg-Lavid M, Gole GA, Gomel N, Gonzalez E, Gonzalez Perez G, González-Rodríguez L, Garcia Pacheco HN, Graells J, Green L, Gregersen PA, Grigorovski ND, Guedenon KM, Gunasekera DS, Gündüz AK, Gupta H, Gupta S, Hadjistilianou T, Hamel P, Hamid SA, Hamzah N, Hansen ED, Harbour JW, Hartnett ME, Hasanreisoglu M, Hassan S, Hassan S, Hederova S, Hernandez J, Hernandez LM, Hessissen L, Hordofa DF, Huang LC, Hubbard GB, Hummlen M, Husakova K, Hussein Al-Janabi AN, Ida R, Ilic VR, Jairaj V, Jeeva I, Jenkinson H, Ji X, Jo DH, Johnson KP, Johnson WJ, Jones MM, Kabesha TB, Kabore RL, Kaliki S, Kalinaki A, Kantar M, Kao LY, Kardava T, Kebudi R, Kepak T, Keren-Froim N, Khan ZJ, Khaqan HA, Khauv P, Kheir WJ, Khetan V, Khodabande A, Khotenashvili Z, Kim JW, Kim JH, Kiratli H, Kivelä TT, Klett A, Komba Palet JE, Krivaitiene D, Kruger M, Kulvichit K, Kuntorini MW, Kyara A, Lachmann ES, Lam CP, Lam GC, Larson SA, Latinović S, Laurenti KD, Le BH, Lecuona K, Leverant AA, Li C, Limbu B, Long QB, López JP, Lukamba RM, Lumbroso L, Luna-Fineman S, Lutfi D, Lysytsia L, Magrath GN, Mahajan A, Majeed AR, Maka E, Makan M, Makimbetov EK, Manda C, Martín Begue N, Mason L, Mason JO, Matende IO, Materin M, Mattosinho CC, Matua M, Mayet I, Mbumba FB, McKenzie JD, Medina-Sanson A, Mehrvar A, Mengesha AA, Menon V, Mercado GJ, Mets MB, Midena E, Mishra DK, Mndeme FG, Mohamedani AA, Mohammad MT, Moll AC, Montero MM, Morales RA, Moreira C, Mruthyunjaya P, Msina MS, Msukwa G, Mudaliar SS, Muma KI, Munier FL, Murgoi G, Murray TG, Musa KO, Mushtaq A, Mustak H, Muyen OM, Naidu G, Nair AG, Naumenko L, Ndoye Roth PA, Nency YM, Neroev V, Ngo H, Nieves RM, Nikitovic M, Nkanga ED, Nkumbe H, Nuruddin M, Nyaywa M, Obono-Obiang G, Oguego NC, Olechowski A, Oliver SC, Osei-Bonsu P, Ossandon D, Paez-Escamilla MA, Pagarra H, Painter SL, Paintsil V, Paiva L, Pal BP, Palanivelu MS, Papyan R, Parrozzani R, Parulekar M, Pascual Morales CR, Paton KE, Pawinska-Wasikowska K, Pe'Er J, Peña A, Perić S, Pham CT, Philbert R, Plager DA, Pochop P, Polania RA, Polyakov VG, Pompe MT, Pons JJ, Prat D, Prom V, Purwanto I, Qadir AO, Qayyum S, Qian J, Rahman A, Rahman S, Rahmat J, Rajkarnikar P, Ramanjulu R, Ramasubramanian A, Ramirez-Ortiz MA, Raobela L, Rashid R, Reddy MA, Reich E, Renner LA, Reynders D, Ribadu D, Riheia MM, Ritter-Sovinz P, Rojanaporn D, Romero L, Roy SR, Saab RH, Saakyan S, Sabhan AH, Sagoo MS, Said AM, Saiju R, Salas B, San Román Pacheco S, Sánchez GL, Sayalith P, Scanlan TA, Schefler AC, Schoeman J, Sedaghat A, Seregard S, Seth R, Shah AS, Shakoor SA, Sharma MK, Sherief ST, Shetye NG, Shields CL, Siddiqui SN, Sidi Cheikh S, Silva S, Singh AD, Singh N, Singh U, Singha P, Sitorus RS, Skalet AH, Soebagjo HD, Sorochynska T, Ssali G, Stacey AW, Staffieri SE, Stahl ED, Stathopoulos C, Stirn Kranjc B, Stones DK, Strahlendorf C, Suarez ME, Sultana S, Sun X, Sundy M, Superstein R, Supriyadi E, Surukrattanaskul S, Suzuki S, Svojgr K, Sylla F, Tamamyan G, Tan D, Tandili A, Tarrillo Leiva FF, Tashvighi M, Tateshi B, Tehuteru ES, Teixeira LF, Teh KH, Theophile T, Toledano H, Trang DL, Traoré F, Trichaiyaporn S, Tuncer S, Tyau-Tyau H, Umar AB, Unal E, Uner OE, Urbak SF, Ushakova TL, Usmanov RH, Valeina S, Van Hoefen Wijsard M, Varadisai A, Vasquez L, Vaughan LO, Veleva-Krasteva NV, Verma N, Victor AA, Viksnins M, Villacís Chafla EG, Vishnevskia-Dai V, Vora T, Wachtel AE, Wackernagel W, Waddell K, Wade PD, Wali AH, Wang YZ, Weiss A, Wilson MW, Wime AD, Wiwatwongwana A, Wiwatwongwana D, Wolley Dod C, Wongwai P, Xiang D, Xiao Y, Yam JC, Yang H, Yanga JM, Yaqub MA, Yarovaya VA, Yarovoy AA, Ye H, Yousef YA, Yuliawati P, Zapata López AM, Zein E, Zhang C, Zhang Y, Zhao J, Zheng X, Zhilyaeva K, Zia N, Ziko OA, Zondervan M, Bowman R 2020 May JAMA Oncology 6 685-695Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ 2020 Mar Nature neuroscience 23 323-326Influence of tumor shape and location in eye plaque brachytherapy dosimetry
Studenski MT, Patel NV, Markoe A, Harbour JW, Samuels SE 2020 Mar Brachytherapy 19 249-254
Author Collaboration OO, Seider MI, Berry DE, Schefler AC, Materin M, Stinnett S, Mruthyunjaya P, Raufi NN, Harbour JW, Berry JL, Kim J, Skalet A, Miller A, Liu T, Demirci H, Ozkurt ZG, Hovland P, Aaberg T, Kim RS, Tann A
2020 Feb
Graefe's Archive for Clinical and Experimental Ophthalmology
258
427-435
Biological mechanisms and clinical signifi cance of BAP1 mutations in human cancer
Carbone M, Harbour JW, Brugarolas J, Bononi A, Pagano I, Dey A, Krausz T, Pass HI, Yang H, Gaudino G 2020 Cancer discovery 10 1103-1120Vitreoretinal lymphoma followed by systemic diffuse large B cell lymphoma
Fan KC, Tran KD, Harbour JW, Dubovy SA, Patel NA, Albini TA 2019 Dec Journal of Ophthalmic Inflammation and Infection 9
Durante MA, Walter SD, Paez-Escamilla M, Tokarev J, Decatur CL, Dubovy SR, Schefler AC, Harbour JW
2019 Dec
JAMA Ophthalmology
137
1434-1439
Kuznetsov JN, Aguero TH, Owens DA, Kurtenbach S, Field MG, Durante MA, Rodriguez DA, King ML, William Harbour J
2019 Sep
Science Advances
5
HDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma
Faião-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KS 2019 Sep Clinical Cancer Research 25 5686-5701
Field MG, Kuznetsov JN, Bussies PL, Cai LZ, Alawa KA, Decatur CL, Kurtenbach S, Harbour JW
2019 Sep
Clinical Cancer Research
25
5663-5673
Anbunathan H, Verstraten R, Singh AD, William Harbour J, Bowcock AM
2019 Aug
Clinical Cancer Research
25
5156-5166
Dean MK, Studenski MT, Paez-Escamilla MA, Walter SD, Kwon D, Markoe AM, Harbour JW, Samuels SE
2019 May
Brachytherapy
18
404-410
Husnain M, Mackrides N, Vega F, Paez-Escamilla M, Markoe AM, Harbour JW, Lossos IS
2019 Apr
Leukemia and Lymphoma
60
1308-1311
de la Fuente MI, Alderuccio JP, Reis IM, Omuro A, Markoe A, Echegaray JJ, Davis JL, Harbour JW, Lossos IS
2019 Apr
American Journal of Hematology
94
455-460
Persistent fetal vasculature presenting with axial elongation and platyphakia
Lin J, Paez-Escamilla M, Teira LE, Fallas B, Harbour JW 2019 Feb Journal of AAPOS 23 51-53ChIPprimersDB: A public repository of verified qPCR primers for chromatin immunoprecipitation (ChIP)
Kurtenbach S, Reddy R, Harbour JW 2019 Jan Nucleic acids research 47 D46-D49
Harbour JW, Paez-Escamilla M, Cai L, Walter SD, Augsburger JJ, Correa ZM
2019 Jan
American journal of ophthalmology
197
168-179
Follow the nevus: The cost-utility of monitoring for growth of choroidal nevi
Barsam AS, Gibbons A, McClellan AJ, Harbour JW, Smiddy WE 2019 International Journal of Ophthalmology 12 1456-1464
Jeng-Miller KW, Soomro T, Scott NL, Rao P, Marlow E, Chang EY, Ells A, Chau F, Nudleman E, Calvo CM, Patel N, Schwartz R, Cernichiaro-Espinosa LA, Montoya AG, Goldstein J, Harper CA, Baumal CR, Hartnett ME, Harbour JW, Besirli CG, Gupta MP, Chan RV, Drenser KA, Capone A, Murray TG, Mukai S, Trese MT, Berrocal AM, Wong SC, Yonekawa Y
2019
Ophthalmic Surgery Lasers and Imaging Retina
50
221-227
Genomic evolution of uveal melanoma arising in ocular melanocytosis
Durante MA, Field MG, Sanchez MI, Covington KR, Decatur CL, Dubovy SR, Harbour JW 2019 Cold Spring Harbor Molecular Case Studies 5An eight-year-old girl presents with two weeks of vision loss and nightly headaches
Scott NL, Tran KD, Cernichiaro-Espinosa LA, Russell JF, Hinkle JW, Harbour JW, Dubovy SR, Berrocal AM 2019 Ophthalmic Surgery Lasers and Imaging Retina 50 314-317
Paez-Escamilla M, Walter SD, Mohsenin A, Decatur CL, Harocopos GJ, Dubovy S, Harbour JW
2019
Ophthalmic Surgery Lasers and Imaging Retina
50
573-579
Drug and disease signature integration identifies synergistic combinations in glioblastoma
Stathias V, Jermakowicz AM, Maloof ME, Forlin M, Walters W, Suter RK, Durante MA, Williams SL, Harbour JW, Volmar CH, Lyons NJ, Wahlestedt C, Graham RM, Ivan ME, Komotar RJ, Sarkaria JN, Subramanian A, Golub TR, Schürer SC, Ayad NG 2018 Dec Nature communications 9Punctuated evolution of canonical genomic aberrations in uveal melanoma
Field MG, Durante MA, Anbunathan H, Cai LZ, Decatur CL, Bowcock AM, Kurtenbach S, Harbour JW 2018 Dec Nature communications 9Comprehensive study of the clinical phenotype of germline BAP1 variant-carrying families worldwide
Walpole S, Pritchard AL, Cebulla CM, Pilarski R, Stautberg M, Davidorf FH, de la Fouchardière A, Cabaret O, Golmard L, Stoppa-Lyonnet D, Garfield E, Njauw CN, Cheung M, Turunen JA, Repo P, Järvinen RS, van Doorn R, Jager MJ, Luyten GP, Marinkovic M, Chau C, Potrony M, Höiom V, Helgadottir H, Pastorino L, Bruno W, Andreotti V, Dalmasso B, Ciccarese G, Queirolo P, Mastracci L, Wadt K, Kiilgaard JF, Speicher MR, van Poppelen N, Kilic E, Al-Jamal RT, Dianzani I, Betti M, Bergmann C, Santagata S, Dahiya S, Taibjee S, Burke J, Poplawski N, O’Shea SJ, Newton-Bishop J, Adlard J, Adams DJ, Lane AM, Kim I, Klebe S, Racher H, Harbour JW, Nickerson ML, Murali R, Palmer JM, Howlie M, Symmons J, Hamilton H, Warrier S, Glasson W, Johansson P, Robles-Espinoza CD, Ossio R, de Klein A, Puig S, Ghiorzo P, Nielsen M, Kivelä TT, Tsao H, Testa JR, Gerami P, Stern MH, Bressac-De Paillerets B, Abdel-Rahman MH, Hayward NK 2018 Dec Journal of the National Cancer Institute 110
Cai L, Paez-Escamilla M, Walter SD, Tarlan B, Decatur CL, Perez BM, Harbour JW
2018 Nov
American journal of ophthalmology
195
154-160
Paez-Escamilla M, Walter SD, Ramaiya KJ, Harbour JW
2018 Oct
Ophthalmic Surgery Lasers and Imaging Retina
49
812-814
Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo
Guo Y, Yang H, Chen S, Zhang P, Li R, Nimer SD, Harbour JW, Xu M, Yang FC 2018 Aug Leukemia 32 1834-1837
Harbour JW, Paez-Escamilla M
2018 May
JAMA Ophthalmology
136
597
William Harbour J, Paez-Escamilla M
2018 May
JAMA Ophthalmology
136
597
Garoon RB, William Harbour J
2018 Apr
Ophthalmic Surgery Lasers and Imaging Retina
49
276-277
Peng H, Prokop J, Karar J, Park K, Cao L, Harbour JW, Bowcock AM, Malkowicz SB, Cheung M, Testa JR, Rauscher FJ
2018 Mar
Cancer research
78
1200-1213
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies
Yang H, Kurtenbach S, Guo Y, Lohse I, Durante MA, Li J, Li Z, Al-Ali H, Li L, Chen Z, Field MG, Zhang P, Chen S, Yamamoto S, Li Z, Zhou Y, Nimer SD, William Harbour J, Wahlestedt C, Xu M, Yang FC 2018 Jan Blood 131 328-341
Paez-Escamilla M, Bagheri N, Harbour JW
2018 Jan
JAMA Ophthalmology
136
Intracameral topotecan hydrochloride for anterior chamber seeding of retinoblastoma
Paez-Escamilla M, Bagheri N, Teira LE, Corrales-Medina FF, Harbour JW 2017 Dec JAMA Ophthalmology 135 1453-1455Molecular characteristics of conjunctival melanoma using whole-exome sequencing
Swaminathan SS, Field MG, Sant D, Wang G, Galor A, Dubovy SR, Harbour JW, Karp CL 2017 Dec JAMA Ophthalmology 135 1434-1437
Harbour JW
2017 Nov
JAMA Ophthalmology
135
1231
Harbour JW, Paez-Escamilla M
2017 Oct
Investigative Ophthalmology and Visual Science
58
5444
Author Collaboration OO, Mruthyunjaya P, Seider MI, Stinnett S, Schefler A, Seider M, Raufi NN, Berry D, Stinnett S, Harbour JW, Berry J, Kim J, Skalet A, Miller A, Materin MA, Liu T, Demirci H, Ozkurt ZG, Hovland P, Aaberg T, Schefler A, Kim RS, Tann A
2017 Oct
Ophthalmology
124
1532-1539
Multimodal imaging of astrocytic hamartomas associated with tuberous sclerosis
Schwartz SG, Harbour JW 2017 Sep Ophthalmic Surgery Lasers and Imaging Retina 48 756-758
Fernandez MP, Al-Holou SN, Fischer O, Murray T, Harbour JW, Dubovy SR, Berrocal AM
2017 Aug
Journal of AAPOS
21
337-339.e2
Harbour JW
2017 Jul
JAMA Ophthalmology
135
819-820
An international survey of classification and treatment choices for group D retinoblastoma
Scelfo C, Francis JH, Khetan V, Jenkins T, Marr B, Abramson DH, Shields CL, Pe’er J, Munier F, Berry J, Harbour JW, Yarovoy A, Lucena E, Murray TG, Bhagia P, Paysse E, Tuncer S, Chantada GL, Moll AC, Ushakova T, Plager DA, Ziyovuddin I, Leal CA, Materin MA, Ji XD, Cursino JW, Polania R, Kiratli H, All-Ericsson C, Kebudi R, Honavar SG, Vishnevskia-Dai V, Epelman S, Daniels AB, Ling JD, Traore F, Ramirez-Ortiz MA 2017 Jun International Journal of Ophthalmology 10 961-967PRAME as a potential target for immunotherapy in metastatic uveal melanoma
Gezgin G, Luk SJ, Cao J, Dogrusöz M, Van Der Steen DM, Hagedoorn RS, Krijgsman D, Van Der Velden PA, Field MG, Luyten GP, Szuhai K, Harbour JW, Jordanova ES, Heemskerk MH, Jager MJ 2017 Jun JAMA Ophthalmology 135 541-549
Harbour JW
2017 Feb
JAMA Ophthalmology
135
175-176
Mohney BG, Elner VM, Smith AB, William Harbour J, Smith BD, Musch DC, Smith SJ
2017 Feb
Ophthalmic Surgery Lasers and Imaging Retina
48
151-159
Li Z, Zhang P, Yan A, Guo Z, Ban Y, Li J, Chen S, Yang H, He Y, Li J, Guo Y, Zhang W, Hajiramezanali E, An H, Fajardo D, William Harbour J, Ruan Y, Nimer SD, Yu P, Chen X, Xu M, Yang FC
2017 Jan
Science Advances
3
Rao RC, Harbour JW
2016 Sep
JAMA Ophthalmology
134
1063-1064
Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA
2016 Jul
Pigment Cell and Melanoma Research
29
404-416
Driver mutations in uveal melanoma associations with gene expression profile and patient outcomes
Decatur CL, Ong E, Garg N, Anbunathan H, Bowcock AM, Field MG, Harbour JW 2016 Jul JAMA Ophthalmology 134 728-733
Walter SD, Chao DL, Feuer W, Schiffman J, Char DH, Harbour JW
2016 Jul
JAMA Ophthalmology
134
734-740
ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma
Yoo JH, Shi DS, Grossmann AH, Sorensen LK, Tong ZZ, Mleynek TM, Rogers A, Zhu W, Richards JR, Winter JM, Zhu J, Dunn C, Bajji A, Shenderovich M, Mueller AL, Woodman SE, Harbour JW, Thomas KR, Odelberg SJ, Ostanin K, Li DY 2016 Jun Cancer Cell 29 889-904PRAME as an independent biomarker for metastasis in uveal melanoma
Field MG, Decatur CL, Kurtenbach S, Gezgin G, Van Der Velden PA, Jager MJ, Kozak KN, Harbour JW 2016 Mar Clinical Cancer Research 22 1234-1242
William Harbour J
2016 Jan
355-361
Uveal and Conjunctival Melanoma: Close Together-but Only Distantly Related
Harbour JW 2016 Jan Oncology (Williston Park, N.Y.) 30 44, 48
Fedorenko IV, Evernden B, Kenchappa RS, Sahebjam S, Ryzhova E, Puskas J, McIntosh L, Caceres G, Magliocco A, Etame A, Harbour JW, Smalley KS, Forsyth PA
2016
Melanoma research
26
481-486
Field MG, Durante MA, Decatur CL, Tarlan B, Oelschlager KM, Stone JF, Kuznetsov J, Bowcock AM, Kurtenbach S, Harbour JW
2016
Oncotarget
7
59209-59219
EMT-associated factors promote invasive properties of uveal melanoma cells
Asnaghi L, Gezgin G, Tripathy A, Handa JT, Merbs SL, van der Velden PA, Jager MJ, Harbour JW, Eberhart CG 2015 Aug Molecular Vision 21 919-929
Schwartz SG, Harbour JW
2015 May
Ophthalmic Surgery Lasers and Imaging Retina
46
586-588
Chao DL, Harbour JW
2015 Apr
Canadian Journal of Ophthalmology
50
151-154
Serous macular detachment following a systemic corticosteroid injection
Weng CY, William Harbour J 2015 Apr JAMA Ophthalmology 133 473-474Gene expression profiling and regression rate of irradiated uveal melanomas
Rao RC, Khan M, Badiyan SN, Harbour JW 2015 Mar Ophthalmic Surgery Lasers and Imaging Retina 46 333-337
Harbour JW, Mohsenin A
2015 Jan
37-41
Dyer MA, Dyer MA, Harbour JW, Harbour JW, Harbour JW
2015 Jan
61-68
Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma
Herlihy N, Dogrusöz M, Van Essen TH, William Harbour J, Van Der Velden PA, Van Eggermond MC, Haasnoot GW, Van Den Elsen PJ, Jager MJ 2015 Investigative Ophthalmology and Visual Science 56 1447-1458Epigenetic reprogramming of melanoma cells by vitamin C treatment
Gustafson CB, Yang C, Dickson KM, Shao H, Van Booven D, Harbour JW, Liu ZJ, Wang G 2015 Clinical Epigenetics 7
Walter SD, William Harbour J
2015
Clinical and Translational Oncology
10
1-13
Prognostic parameters in uveal melanoma and their association with bap1 expression
Van Essen TH, Van Pelt S, Versluis M, Bronkhorst IH, Van Duinen SG, Marinkovic M, Kroes WG, Ruivenkamp CA, Shukla S, De Klein A, Kiliç E, Harbour JW, Luyten GP, Van Der Velden PA, Verdijk RM, Jager MJ 2014 Dec British Journal of Ophthalmology 98 1738-1743
Chen RW, Harbour JW
2014 Dec
Graefe's Archive for Clinical and Experimental Ophthalmology
252
2021-2022
Combined PKC and MEK inhibition for treating metastatic uveal melanoma
Sagoo MS, Harbour JW, Stebbing J, Bowcock AM 2014 Sep Oncogene 33 4722-4723GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?
Field MG, Harbour JW 2014 Jun Cancer Cell 25 714-715A molecular revolution in uveal melanoma: Implications for patient care and targeted therapy
William Harbour J, Chao DL 2014 Jun Ophthalmology 121 1281-1288Recent developments in prognostic and predictive testing in uveal melanoma
Field MG, Harbour JW 2014 May Current Opinion in Ophthalmology 25 234-239
Badiyan SN, Rao RC, Apicelli AJ, Acharya S, Verma V, Garsa AA, Dewees T, Speirs CK, Garcia-Ramirez J, Esthappan J, Grigsby PW, Harbour JW
2014 Mar
International Journal of Radiation Oncology Biology Physics
88
801-805
William Harbour J, Chao DL
2014 Jan
63-68
Harbour JW
2014
427-440
Distinguishing torpedo maculopathy from similar lesions of the posterior segment
Villegas VM, Schwartz SG, Flynn HW, Capó H, Berrocal AM, Murray TG, Harbour JW 2014 Ophthalmic Surgery Lasers and Imaging Retina 45 222-226Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-Obstruction
Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO 2013 Dec Journal of Clinical Investigation 123 5152-5164BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma
Matatall KA, Agapova OA, Onken MD, Worley LA, Bowcock AM, Harbour JW 2013 Aug BMC Cancer 13
Harbour JW, Augsburger JJ, Char DH
2013 Jul
Ophthalmology
120
e51
Erratum: Gene expression profiling versus TNM classification (Ophthalmology (2013) 120 (1109))
Harbour JW, Augsburger JJ, Char DH 2013 Jul Ophthalmology 120 e52-e53Patient-derived xenografts recapitulate molecular features of human uveal melanomas
Laurent C, Gentien D, Piperno-Neumann S, Némati F, Nicolas A, Tesson B, Desjardins L, Mariani P, Rapinat A, Sastre-Garau X, Couturier J, Hupé P, de Koning L, Dubois T, Roman-Roman S, Stern MH, Barillot E, Harbour JW, Saule S, Decaudin D 2013 Jun Molecular oncology 7 625-636
Harbour JW, Chen R
2013 Apr
PLoS Currents
Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, Apte RS 2013 Apr Cell Metabolism 17 549-561Molecular testing prognostic of low risk in epithelioid uveal melanoma in a child
Dimaras H, Parulekar MV, Kwok G, Simpson ER, Ali A, Halliday W, Shago M, Harbour JW, Héon E, Gallie BL, Chan HS 2013 Mar British Journal of Ophthalmology 97 323-326Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma
Harbour JW, Roberson ED, Anbunathan H, Onken MD, Worley LA, Bowcock AM 2013 Feb Nature genetics 45 133-135
Harbour JW, Wilson D, Finger PT, Worley LA, Onken MD
2013 Jan
Ophthalmology
120
213-213.e3
A role for Jag2 in promoting uveal melanoma dissemination and growth
Asnaghi L, Handa JT, Merbs SL, Harbour JW, Eberhart CG 2013 Jan Investigative Ophthalmology and Visual Science 54 295-306Genomic, prognostic, and cell-signaling advances in uveal melanoma
Harbour JW 2013 American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting 388-391
Modi YS, Epstein A, Bhaleeya S, Harbour JW, Albini T
2013
Journal of Ophthalmic Inflammation and Infection
3
1-4
High throughput mass spectrometry-based mutation profiling of primary uveal melanoma
Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, William Harbour J, Garraway LA, Kim IK 2012 Oct Investigative Ophthalmology and Visual Science 53 6991-6996Uveal melanoma: Molecular pattern, clinical features, and radiation response
Chappell MC, Char DH, Cole TB, Harbour JW, Mishra K, Weinberg VK, Phillips TL 2012 Aug American journal of ophthalmology 154 227-332.e2
Onken MD, Worley LA, Char DH, Augsburger JJ, Correa ZM, Nudleman E, Aaberg TM, Altaweel MM, Bardenstein DS, Finger PT, Gallie BL, Harocopos GJ, Hovland PG, McGowan HD, Milman T, Mruthyunjaya P, Simpson ER, Smith ME, Wilson DJ, Wirostko WJ, Harbour JW
2012 Aug
Ophthalmology
119
1596-1603
William Harbour J
2012 Jul
Clinical Advances in Hematology and Oncology
10
459-461
The genetics of uveal melanoma: An emerging framework for targeted therapy
Harbour JW 2012 Mar Pigment Cell and Melanoma Research 25 171-181Notch signaling promotes growth and invasion in uveal melanoma
Asnaghi L, Ebrahimi KB, Schreck KC, Bar EE, Coonfield ML, Bell WR, Handa J, Merbs SL, Harbour JW, Eberhart CG 2012 Feb Clinical Cancer Research 18 654-665Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, Bowcock AM, Harbour JW 2012 Jan Clinical Cancer Research 18 408-416
Lee TC, Gombos DS, William Harbour J, Mansfield NC, Linn Murphree A
2012 Jan
2104-2149
Harbour JW
2011 Dec
Pigment Cell and Melanoma Research
24
1081-1082
ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity
Landreville S, Agapova OA, Kneass ZT, Salesse C, William Harbour J 2011 Jun Pigment Cell and Melanoma Research 24 430-437Diagnostic testing and treatment choices in primary vitreoretinal lymphoma
Rajagopal R, Harbour JW 2011 Mar Retina 31 435-440
Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW
2011 Feb
Oncogene
30
588-599
Chan CC, Rubenstein JL, Coupland SE, Davis JL, Harbour JW, Johnston PB, Cassoux N, Touitou V, Smith JR, Batchelor TT, Pulido JS
2011
Oncologist
16
1589-1599
Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, Council ML, Matatall KA, Helms C, Bowcock AM
2010 Dec
Science
330
1410-1413
William Harbour J
2010 Nov
Retina Today
67-69
Association between gene expression profile, proliferation and metastasis in uveal melanoma
Onken MD, Worley LA, Harbour JW 2010 Sep Current Eye Research 35 857-863
Onken MD, Worley LA, Tuscan MD, Harbour JW
2010 Jul
Journal of Molecular Diagnostics
12
461-468
Woo KI, Harbour JW
2010 Jul
Archives of Ophthalmology
128
865-870
Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma
Landreville S, Ma D, Wu J, Harbour JW 2010 May Current Eye Research 35 435-439
Matatall K, Harbour JW
2010 Mar
377-382
A transformation in ocular oncology: From megacenter to multicenter
Harbour JW 2010 Mar Archives of Ophthalmology 128 367-368
Corrêa Zm, Harbour jW
2010 Feb
Expert Review of Ophthalmology
5
13-14
Id2 deficiency promotes metastasis in a mouse model of ocular cancer
Agapova OA, Person E, Harbour JW 2010 Feb Clinical and Experimental Metastasis 27 91-96
Matatall K, Harbour JW
2010
377-382
Corrêa ZM, Harbour JW
2010
362-368
Molecular Prognostic Testing and Individualized Patient Care in Uveal Melanoma
Harbour JW 2009 Dec American journal of ophthalmology 148 823-829.e1
Harbour JW, Corrêa ZM
2009 Jul
Retina Today
61-65
Dayani PN, Gould JE, Brown DB, Sharma KV, Linette GP, Harbour JW
2009 May
Archives of Ophthalmology
127
628-632
Harbour JW
2008 Aug
Cell Cycle
7
2276-2277
Onken MD, Worley LA, Harbour JW
2008 Jun
Clinical Cancer Research
14
3737-3745
Worley LA, Long MD, Onken MD, Harbour JW
2008 Jun
Melanoma research
18
184-190
Chang SH, Worley LA, Onken MD, Harbour JW
2008 Jun
Melanoma research
18
191-200
Integrative genomic analysis of aneuploidy in uveal melanoma
Ehlers JP, Worley L, Onken MD, Harbour JW 2008 Jan Clinical Cancer Research 14 115-122Hepatic arterial chemoembolization for management of metastatic melanoma
Sharma KV, Gould JE, Harbour JW, Linette GP, Pilgram TK, Dayani PN, Brown DB 2008 Jan American Journal of Roentgenology 190 99-104Tilting of radioactive plaques after initial accurate placement for treatment of uveal melanoma
Almony A, Breit S, Zhao H, Garcia-Ramirez J, Mansur DB, Harbour JW 2008 Jan Archives of Ophthalmology 126 65-70Correlation study of benign cytomorphology and final clinical diagnosis
Zhai J, Harbour JW, Smith ME, Dávila RM 2008 Acta Cytologica 52 196-200
Onken MD, Worley LA, Long MD, Duan S, Council ML, Bowcock AM, Harbour JW
2008
Investigative Ophthalmology and Visual Science
49
5230-5234
Ramaiya KJ, Harbour jW
2007 Dec
Expert Review of Ophthalmology
2
939-946
Treatment outcomes for primary intraocular lymphoma: Implications for external beam radiotherapy
Berenbom A, Davila RM, Lin HS, Harbour JW 2007 Sep Eye 21 1198-1201
Apte RS, Harbour JW
2007 Aug
Ophthalmic Research
39
188-190
Molecular prognostic testing in uveal melanoma: Has it finally come of age?
Harbour JW 2007 Aug Archives of Ophthalmology 125 1122-1123
Onken MD, Worley LA, Person E, Char DH, Bowcock AM, Harbour JW
2007 May
Clinical Cancer Research
13
2923-2927
Dyer MA, Harbour JW
2007 Mar
405-409
Harbour JW, Onken MD
2007 Mar
31-33
Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
Worley LA, Onken MD, Person E, Robirds D, Branson J, Char DH, Perry A, Harbour JW 2007 Mar Clinical Cancer Research 13 1466-1471
Harbour JW, Onken MD
2007
31-33
Ehlers JP, Harbour JW
2006 Dec
International ophthalmology clinics
46
167-180
Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens
Onken MD, Worley LA, Dávilla RM, Char DH, Harbour JW 2006 Nov Journal of Molecular Diagnostics 8 567-573Rb at the interface between cell cycle and apoptotic decisions
Delston RB, Harbour JW 2006 Nov Current molecular medicine 6 713-718Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas
Onken MD, Ehlers JP, Worley LA, Makita J, Yokota Y, Harbour JW 2006 May Cancer research 66 4602-4609Eye cancer: Unique insights into oncogenesis: The Cogan lecture
Harbour JW 2006 May Investigative Ophthalmology and Visual Science 47 1737-1745Lipid exudation following plaque radiotherapy for posterior uveal melanoma
Mills MD, Harbour JW 2006 Mar American journal of ophthalmology 141 594-595.e1
Onken MD, Lin AY, Worley LA, Folberg R, Harbour JW
2005 Oct
American journal of ophthalmology
140
748-749
Murphree AL, Samuel MA, Harbour JW, Mansfield NC
2005 Sep
1-3
557-607
DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma
Ehlers JP, Worley L, Onken MD, Harbour JW 2005 May Clinical Cancer Research 11 3609-3613
Lieman JH, Worley LA, Harbour JW
2005 Mar
Journal of Biological Chemistry
280
10484-10490
Ehlers JP, Harbour JW
2005 Mar
Clinical Cancer Research
11
1849-1853
Singh AD, Damato B, Howard P, Harbour JW
2005 Mar
Ophthalmology Clinics of North America
18
85-97
Loercher AE, Tank EM, Delston RB, Harbour JW
2005 Jan
Journal of Cell Biology
168
35-40
Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma
Sun Y, Tran BN, Worley LA, Delston RB, Harbour JW 2005 Investigative Ophthalmology and Visual Science 46 1561-1564Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management
Faulkner-Jones BE, Foster WJ, Harbour JW, Smith ME, Dávila RM 2005 Acta Cytologica 49 297-308
Onken MD, Worley LA, Ehlers JP, Harbour JW
2004 Oct
Cancer research
64
7205-7209
Harbour JW
2004 Sep
American journal of ophthalmology
138
471-473
Photodynamic therapy for choroidal metastasis from carcinoid tumor
Harbour JW 2004 Jun American journal of ophthalmology 137 1143-1145For whom the bell tolls: Susceptibility to common adult cancers in retinoblastoma survivors
Kay FJ, Harbour JW 2004 Mar Journal of the National Cancer Institute 96 342-343
Espinoza G, Rosenblatt B, Harbour JW
2004 Jan
American journal of ophthalmology
137
90-95
Association between choroidal pigmentation and posterior uveal melanoma in a white population
Harbour JW, Brantley MA, Hollingsworth H, Gordon M 2004 Jan British Journal of Ophthalmology 88 39-43Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi
Harbour JW, Brantley MA, Hollingsworth H, Gordon M 2004 Jan British Journal of Ophthalmology 88 36-38Cytologic diagnosis of intraocular lymphoma in vitreous aspirates
Farkas T, Harbour JW, Dávila RM 2004 Acta Cytologica 48 487-491Transpupillary Thermotherapy versus Plaque Radiotherapy for Suspected Choroidal Melanomas
Harbour JW, Meredith TA, Thompson PA, Gordon ME 2003 Nov Ophthalmology 110 2207-2214
Foster WJ, Fuller CE, Perry A, Harbour JW
2003 Sep
Archives of Ophthalmology
121
1311-1315
Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma
Foster WJ, Harbour JW, Holekamp NM, Shah GK, Thomas MA 2003 Sep American journal of ophthalmology 136 471-476
Loercher AE, Harbour JW
2003 Aug
Current Eye Research
27
69-74
Ocular melanoma: A review and the relationship to cutaneous melanoma
Hurst EA, Harbour JW, Cornelius LA 2003 Aug Archives of Dermatology 139 1067-1073Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb
Ma D, Zhou P, Harbour JW 2003 May Journal of Biological Chemistry 278 19358-19366Rate of resolution of exudative retinal detachment after plaque radiotherapy for uveal melanoma
Harbour JW, Ahmad S, El-Bash M 2002 Nov Archives of Ophthalmology 120 1463-1469Transducible peptide therapy for uveal melanoma and retinoblastoma
Harbour JW, Worley L, Ma D, Cohen M 2002 Oct Archives of Ophthalmology 120 1341-1346
Finger PT, Harbour JW, Karcioglu ZA
2002
Survey of Ophthalmology
47
1-16
Sheidow TG, Harbour JW
2002
Canadian Journal of Ophthalmology
37
314-317
Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy
Brantley MA, Worley L, Harbour JW 2002 American journal of ophthalmology 133 242-248
Gavin M, Zhang S, Dahiya A, Luo R, Postigo A, Ma D, Harbour W, Dean D
2001 Apr
Nature genetics
27
55
Brantley J, Harbour JW
2001
Ocular Immunology and Inflammation
9
1-8
Harbour JW
2001
Archives of Ophthalmology
119
1699-1704
Harbour JW, Dean DC
2000 Oct
Genes and Development
14
2393-2409
Brantley J, Harbour JW
2000 Aug
Cancer research
60
4320-4323
Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX, Harbour JW, Dean DC
2000 Mar
Cell
101
79-89
Harbour JW, Dean DC
2000
Current topics in microbiology and immunology
254
137-144
Harbour JW, Dean DC
2000
Current Opinion in Cell Biology
12
685-689
Harbour JW, Dean DC
2000
Nature cell biology
2
E65-E67
Brantley J, Harbour JW
2000
American Journal of Pathology
157
1795-1801
Harbour JW
1999 Nov
Survey of Ophthalmology
44
235-246
Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC
1999 Sep
Cell
98
859-869
Harbour JW
1998 Aug
Ophthalmology
105
1442-1447
Harbour JW, Char DH, Kroll S, Quivey JM, Castro J, Gragoudas ES, Egan KM
1997
Ophthalmology
104
1785-1793
Regulation of retinoblastoma protein activity by the c terminal domain
Harbour JW, Luo RX 1997 Investigative Ophthalmology and Visual Science 38 S384Langerhans cell histiocytosis diagnosed by fine needle biopsy
Harbour JW, Char DH, Ljung BM, Luna-Fineman S 1997 Archives of Ophthalmology 115 1212
Char D, Weidner N, Ahn J, Harbour JW
1997
Orbit
16
113-118
Pars plana vitrectomy in the management of phakic and pseudophakic malignant glaucoma
William Harbour J, Rubsamen PE, Palmberg P 1996 Sep Archives of Ophthalmology 114 1073-1078Local carboplatin therapy in transgenic murine retinoblastoma
Harbour JW, Murray TG, Hamasaki D, Cicciarelli N, Hernández E, Smith B, Windle J, O'Brien JM 1996 Aug Investigative Ophthalmology and Visual Science 37 1892-1898
William Harbour J, Murray TG, Byrne SF, Randall Hughes J, Kym Gendron E, Ehlies FJ, Markoe AM
1996
Retina
16
129-134
Harbour JW, Smiddy WE, Flynn HW, Rubsamen PE
1996
American journal of ophthalmology
121
405-413
Harbour JW, Augsburger JJ, Eagle RC
1995
Ophthalmology
102
1987-1993
Pars plana vitrectomy for chronic pseudophakic cystoid macular edema
Harbour JW, Smiddy WE, Rubsamen PE, Murray TG, Davis JL, Flynn HW 1995 American journal of ophthalmology 120 302-307Uveal Metastasis from Carcinoid Tumor: Clinical Observations in Nine Cases
Harbour JW, De Potter P, Shields CL, Shields JA 1994 Ophthalmology 101 1084-1090Expression in lung cancer of a transcribed sequence at the DNF15S2 locus at chromosome 3P21
Harbour JW, Lai SL, Gazdar AF, Minna JD, Kaye FJ 1990 Anticancer Research 10 23-27Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers
Leduc F, Brauch H, Hajj C, Dobrovic A, Kaye F, Gazdar A, Harbour JW, Pettengill OS, Sorenson GD, Van Den Berg A, Kok K, Campling B, Paquin F, Bradley WE, Zbar B, Minna J, Buys C, Ayoub J 1989 American Journal of Human Genetics 44 282-287Abnormalities in structure and expression of the human retinoblastoma gene in SCLC
Harbour JW, Lai SL, Whang-Peng J, Gazdar AF, Minna JD, Kaye FJ 1988 Science 241 353-357