Hernandez Lab

The Hernandez Lab explores structural, cellular, and mechanobiological aspects of sexual dimorphism and sex hormones in cartilage health and osteoarthritis. Working in close collaboration with engineers and orthopedic surgeons, our research examines how sex-specific differences in the knee joint may contribute to higher incidence and severity of osteoarthritis in women later in life. Our research team also investigates the role hormones play in the production of cartilage extracellular and pericellular matrices throughout the lifespan. We use atomic force microscopy to measure the nanomechanical properties of cells and tissues, and bioreactors to investigate chondrocyte mechanotransduction.