Posaconazole, a second-generation triazole antifungal drug, inhibits the Hedgehog signaling pathway and progression of basal cell carcinoma
Chen B, Trang V, Lee A, Williams NS, Wilson AN, Epstein EH, Tang JY, Kim J Mol. Cancer Ther. 2016 Jan
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma
Kim DJ, Kim J, Spaunhurst K, Montoya J, Khodosh R, Chandra K, Fu T, Gilliam A, Molgo M, Beachy PA, Tang JY J. Clin. Oncol. 2014 Mar 32 8 745-51
Simultaneous measurement of smoothened entry into and exit from the primary cilium
Kim J, Hsia EY, Kim J, Sever N, Beachy PA, Zheng X PLoS ONE 2014 9 8 e104070
Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response
Myers BR, Sever N, Chong YC, Kim J, Belani JD, Rychnovsky S, Bazan JF, Beachy PA Dev. Cell 2013 Aug 26 4 346-57
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
Kim J, Aftab BT, Tang JY, Kim D, Lee AH, Rezaee M, Kim J, Chen B, King EM, Borodovsky A, Riggins GJ, Epstein EH, Beachy PA, Rudin CM Cancer Cell 2013 Jan 23 1 23-34
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy PA Proc Natl Acad Sci 2011 Mar 15 108 (11) 4453-8
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
Shin K, lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA Nature 2011 Apr 7 472 (7341) 110-4
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner Lee JJ, Kim J, Gardner D, Beachy PA Proc Natl Acad Sci 2010 Jul 27 107 (30) 13432-7
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, Reya T, Liu JO, Epstein EH, Stevens DA, Beachy PA Cancer Cell 2010 Apr 13 17 (4) 388-99
Thermodynamics of coaxially stacked helixes with GA and CC mismatches
Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner Walter AE, Turner DH Biochemistry 1996 Oct 29 35 (43) 13753-61