Publications

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial.

Jha MK, Wilkinson ST, Krishnan K, Collins KA, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen SE, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew SJ, Anand A, 2024 Jun JAMA Netw Open 6 7 e2417786

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression.

Anand A, Mathew SJ, Sanacora G, Murrough JW, Goes FS, Altinay M, Aloysi AS, Asghar-Ali AA, Barnett BS, Chang LC, Collins KA, Costi S, Iqbal S, Jha MK, Krishnan K, Malone DA, Nikayin S, Nissen SE, Ostroff RB, Reti IM, Wilkinson ST, Wolski K, Hu B, 2023 May N Engl J Med

Pharmacotherapies for Treatment-Resistant Depression: How Antipsychotics Fit in the Rapidly Evolving Therapeutic Landscape.

Jha MK, Mathew SJ, 2023 Mar Am J Psychiatry 3 180 190-199

Accelerated Brain Aging in Adults with Major Depressive Disorder Predicts Poorer Outcome with Sertraline: Findings from the EMBARC Study.

Jha MK, Fatt CC, Minhajuddin A, Mayes T, Trivedi MH, 2022 Sep Biol Psychiatry Cogn Neurosci Neuroimaging

Smoking status links habenular volume to glycated hemoglobin: Findings from the Human Connectome Project-Young Adult.

Jha MK, Kim JW, Kenny PJ, Chin Fatt C, Minhajuddin A, Salas R, Ely BA, Klein M, Abdallah CG, Xu J, Trivedi MH, 2021 Sep Psychoneuroendocrinology 131 105321

Association between irritability and suicidal ideation in three clinical trials of adults with major depressive disorder.

Jha MK, Minhajuddin A, Chin Fatt C, Kircanski K, Stringaris A, Leibenluft E, Trivedi MH, 2020 Jul Neuropsychopharmacology

Irritability and Its Clinical Utility in Major Depressive Disorder: Prediction of Individual-Level Acute-Phase Outcomes Using Early Changes in Irritability and Depression Severity.

Jha MK, Minhajuddin A, South C, Rush AJ, Trivedi MH, 2019 May Am J Psychiatry 5 176 358-366

Screening and Management of Depression in Patients With Cardiovascular Disease: JACC State-of-the-Art Review.

Jha MK, Qamar A, Vaduganathan M, Charney DS, Murrough JW, 2019 04 J Am Coll Cardiol 14 73 1827-1845

Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial.

Jha MK, Minhajuddin A, Gadad BS, Greer T, Grannemann B, Soyombo A, Mayes TL, Rush AJ, Trivedi MH 2017 Jan Psychoneuroendocrinology 78 105-113

Early Improvement in Work Productivity Predicts Future Clinical Course in Depressed Outpatients: Findings From the CO-MED Trial.

Jha MK, Minhajuddin A, Greer TL, Carmody T, Rush AJ, Trivedi MH 2016 Aug Am J Psychiatry appiajp201616020176

Clinical and sociodemographic features of the Texas resilience against depression (T-RAD) study: Findings from the initial cohort.

Trivedi MH, Jha MK, Elmore JS, Carmody T, Chin Fatt C, Sethuram S, Wang T, Mayes TL, Foster JA, Minhajuddin A, 2024 Nov J Affect Disord 364 146-156

Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial.

Papakostas GI, Trivedi MH, Shelton RC, Iosifescu DV, Thase ME, Jha MK, Mathew SJ, DeBattista C, Dokucu ME, Brawman-Mintzer O, Currier GW, McCall WV, Modirrousta M, Macaluso M, Bystritsky A, Rodriguez FV, Nelson EB, Yeung AS, Feeney A, MacGregor LC, Carmody T, Fava M, 2024 Mar Mol Psychiatry

Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial.

Li MJ, Chau B, Belin T, Carmody T, Jha MK, Marino EN, Trivedi M, Shoptaw SJ, 2024 Jun Addiction

Problematic substance use in depressed adolescents: Prevalence and clinical correlates.

Marino EN, Jha MK, Minhajuddin A, Ayvaci ER, Levinson S, Pipes R, Emslie GJ, Trivedi MH, 2024 Jun Addict Behav Rep 19 100539

Treatment of Adolescent Depression: Comparison of Psychiatric and Pediatric Settings at an Academic Medical Center Using the VitalSign6 Application.

Ayvaci ER, Minhajuddin A, Elmore JS, Yagnik K, Jha MK, Emslie GJ, Mayes TL, Trivedi MH, 2024 Jan J Child Adolesc Psychopharmacol

Substance use patterns and mental health comorbidities in youth with a history of depression or suicidality: Findings from TX-YDSRN.

Clark SL, Dodd CG, Mitchell TB, Ingram SJ, Armstrong GM, Jha MK, Soares JC, Smith M, Minhajuddin A, Slater H, Wakefield SM, Trivedi MH, 2024 Aug J Affect Disord

Choosing Between Ketamine and Electroconvulsive Therapy for Outpatients With Treatment-Resistant Depression-Advantage Ketamine?

Mathew SJ, Jha MK, Anand A, 2023 Oct JAMA Psychiatry

Psychometric properties of Concise Associated Symptom Tracking (CAST) scale in youths and young adults: Findings from the Texas youth depression and suicide research network (TX-YDSRN).

Jha MK, Minhajuddin A, Slater H, Mayes TL, Blader J, Brown R, Garza C, Kennard BD, Riddle D, Storch EA, Shotwell J, Soutullo CA, Wakefield SM, Trivedi MH, 2023 May J Psychiatr Res 161 179-187

Characterizing inflammatory profiles of suicidal behavior in adolescents: Rationale and design.

Chin Fatt C, Ayvaci ER, Jha MK, Emslie G, Gibson S, Minhajuddin AT, Mayes TL, Farrar JD, Trivedi MH, 2023 Mar J Affect Disord 325 55-61

Early reduction in irritability is associated with improved outcomes among youth with depression: Findings from the AMOD study.

Mohamed AK, Croarkin PE, Jha MK, Vande Voort JL, 2023 Mar J Affect Disord 324 77-81

Treatment-Resistant Depression (TRD): Management Approaches in a Rapidly Evolving Therapeutic Landscape.

Jha MK, Trivedi MH, 2023 Jun Psychiatr Clin North Am 2 46 xiii-xiv

Approach to Diagnosis and Management of Treatment-Resistant Depression.

Rikhani K, Vas C, Jha MK, 2023 Jun Psychiatr Clin North Am 2 46 247-259

The Individual and Societal Burden of Treatment-Resistant Depression: An Overview.

Baig-Ward KM, Jha MK, Trivedi MH, 2023 Jun Psychiatr Clin North Am 2 46 211-226

Role of Psychedelics in Treatment-Resistant Depression.

Kamal S, Jha MK, Radhakrishnan R, 2023 Jun Psychiatr Clin North Am 2 46 291-305

Pharmacotherapy for Treatment-Resistant Depression: Antidepressants and Atypical Antipsychotics.

Vas C, Jain A, Trivedi M, Jha MK, Mathew SJ, 2023 Jun Psychiatr Clin North Am 2 46 261-275

The clinical, economic, and patient-centric burden of insomnia symptom severity in adults with major depressive disorder in the United States.

Joshi K, Cambron-Mellott MJ, Costantino H, Pfau A, Jha MK, 2023 Jul Brain Behav e3143

A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder.

Feder A, Costi S, Rutter SB, Collins AB, Govindarajulu U, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Bevilacqua L, Glasgow AM, Brallier J, Pietrzak RH, Murrough JW, Charney DS, 2023 Jul Focus (Am Psychiatr Publ) 3 21 296-305

Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial.

Giles MA, Cooper CM, Jha MK, Chin Fatt CR, Pizzagalli DA, Mayes TL, Webb CA, Greer TL, Etkin A, Trombello JM, Chase HW, Phillips ML, McInnis MG, Carmody T, Adams P, Parsey RV, McGrath PJ, Weissman M, Kurian BT, Fava M, Trivedi MH, 2023 Jul Behav Sci (Basel) 8 13

A randomized pilot study of the prophylactic effect of ketamine on laboratory-induced stress in healthy adults.

Costi S, Evers A, Jha MK, Klein M, Overbey JR, Goosens KA, Burgess J, Alvarez K, Feder A, Charney DS, Murrough JW, 2023 Jan Neurobiol Stress 22 100505

Intranasal esketamine effectively treats treatment-resistant depression in adults regardless of baseline irritability.

Jha MK, Williamson DJ, Magharehabed G, Turkoz I, Daly EJ, Trivedi MH, 2023 Jan J Affect Disord 321 153-160

The real-world burden of adults with major depressive disorder with moderate or severe insomnia symptoms in the United States.

Joshi K, Cambron-Mellott MJ, Costantino H, Pfau A, Jha MK, 2023 Feb J Affect Disord 323 698-706

Data driven clusters derived from resting state functional connectivity: Findings from the EMBARC study.

Chin Fatt CR, Minhajuddin A, Jha MK, Mayes T, Rush AJ, Trivedi MH, 2023 Feb J Psychiatr Res 158 150-156

Features of immunometabolic depression as predictors of antidepressant treatment outcomes: pooled analysis of four clinical trials.

Vreijling SR, Chin Fatt CR, Williams LM, Schatzberg AF, Usherwood T, Nemeroff CB, Rush AJ, Uher R, Aitchison KJ, Köhler-Forsberg O, Rietschel M, Trivedi MH, Jha MK, Penninx BWJH, Beekman ATF, Jansen R, Lamers F, 2023 Dec Br J Psychiatry 1-9

Data-driven subgrouping of youths with depression reveals that resilience is associated with higher physical functioning despite high symptom burden in the Texas Youth Depression and Suicide Research Network (TX-YDSRN).

Minhajuddin A, Jha MK, Slater H, Mayes TL, Storch EA, Shotwell J, Soutullo C, Wakefield SM, Trivedi MH, 2023 Dec J Affect Disord

Predicting suicidal events: A comparison of the Concise Health Risk Tracking Self-Report (CHRT-SR) and the Columbia Suicide Severity Rating Scale (C-SSRS).

Mayes TL, Carmody T, Rush AJ, Nandy K, Emslie GJ, Kennard BD, Forbes K, Jha MK, Hughes JL, Heerschap JK, Trivedi MH, 2023 Aug Psychiatry Res 326 115306

Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study.

Chin Fatt CR, Asbury S, Jha MK, Minhajuddin A, Sethuram S, Mayes T, Kennedy SH, Foster JA, Trivedi MH, 2023 Apr Transl Psychiatry 1 13 139

Biomarkers in Psychiatric Drug Development: From Precision Medicine to Novel Therapeutics.

Carreon RL, Rivas-Grajales AM, Murphy N, Mathew SJ, Jha MK, 2023 Adv Neurobiol 30 287-297

Accelerated brain aging in individuals with diabetes: Association with poor glycemic control and increased all-cause mortality.

Jha MK, Chin Fatt CR, Minhajuddin A, Mayes TL, Berry JD, Trivedi MH, 2022 Sep Psychoneuroendocrinology 145 105921

Immune characterization of suicidal behavior in female adolescents.

Chin Fatt CR, Farrar JD, Jha MK, Minhajuddin A, Mayes T, Foster JA, Trivedi MH, 2022 Nov Brain Behav Immun Health 25 100499

Effect of Concomitant Benzodiazepines on the Antidepressant Effects of Ketamine: Findings From the RAPID Intravenous Ketamine Study.

Feeney A, Hoeppner BB, Freeman MP, Flynn M, Iosifescu DV, Trivedi MH, Sanacora G, Mathew SJ, DeBattista C, Ionescu DF, Cusin C, Papakostas GI, Jha MK, Fava M, 2022 Nov J Clin Psychiatry 1 84

Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial.

Trombello JM, Cooper CM, Fatt CC, Grannemann BD, Carmody TJ, Jha MK, Mayes TL, Greer TL, Yezhuvath U, Aslan S, Pizzagalli DA, Weissman MM, Webb CA, Dillon DG, McGrath PJ, Fava M, Parsey RV, McInnis MG, Etkin A, Trivedi MH, 2022 Mar J Psychiatr Res 149 243-251

Antidepressant effect of prolonged twice-weekly intranasal esketamine treatments after nonresponse to electroconvulsive therapy in a patient with treatment-resistant depression.

Evers A, Klein M, Aloysi A, Murrough J, Jha MK, 2022 Feb Ann Clin Psychiatry 1 34 61-64

Rapidity of Symptom Improvement With Intranasal Esketamine for Major Depressive Disorder: A Systematic Review and Meta-Analysis.

Hock RS, Feeney A, Iovieno N, Murrough JW, Mathew SJ, Iosifescu DV, Fava M, Jha MK, Papakostas GI, 2022 Dec J Clin Psychiatry 1 84

Fibroblast growth factor 21 (FGF21) is increased in MDD and interacts with body mass index (BMI) to affect depression trajectory.

Mason BL, Minhajuddin A, Czysz AH, Jha MK, Gadad BS, Mayes TL, Trivedi MH, 2022 01 Transl Psychiatry 1 12 16

Patterns of Pretreatment Reward Task Brain Activation Predict Individual Antidepressant Response: Key Results From the EMBARC Randomized Clinical Trial.

Nguyen KP, Chin Fatt C, Treacher A, Mellema C, Cooper C, Jha MK, Kurian B, Fava M, McGrath PJ, Weissman M, Phillips ML, Trivedi MH, Montillo AA, 2021 Sep Biol Psychiatry

Dysfunction of default mode network is associated with active suicidal ideation in youths and young adults with depression: Findings from the T-RAD study.

Chin Fatt CR, Jha MK, Minhajuddin A, Mayes T, Ballard ED, Trivedi MH, 2021 Oct J Psychiatr Res 142 258-262

Gupta MD, Jha MK, Bansal A, Yadav R, Ramakrishanan S, Girish MP, Sarkar PG, Qamar A, Kumar S, Kumar S, Jain A, Saijpaul R, Gupta V, Kansal D, Garg S, Arora S, Biswas PS, Yusuf J, Malhotra RK, Batra V, Kathuria S, Mehta V, SafalShetty MK, Mukhopadhyay S, Tyagi S, Gupta A, 2021 Oct Indian Heart J

Vortioxetine Versus Placebo for Major Depressive Disorder: A Comprehensive Analysis of the Clinical Trial Dataset.

Iovieno N, Papakostas GI, Feeney A, Fava M, Mathew SJ, Iosifescu DI, Murrough JW, Macaluso M, Hock RS, Jha MK, 2021 Jun J Clin Psychiatry 4 82

Neuroimaging correlates and predictors of response to repeated-dose intravenous ketamine in PTSD: preliminary evidence.

Norbury A, Rutter SB, Collins AB, Costi S, Jha MK, Horn SR, Kautz M, Corniquel M, Collins KA, Glasgow AM, Brallier J, Shin LM, Charney DS, Murrough JW, Feder A, 2021 Jul Neuropsychopharmacology

Design and rationale of an intelligent algorithm to detect BuRnoUt in HeaLthcare workers in COVID era using ECG and artificiaL intelligence: The BRUCEE-LI study.

Gupta MD, Bansal A, Sarkar PG, Girish MP, Jha M, Yusuf J, Kumar S, Kumar S, Jain A, Kathuria S, Saijpaul R, Mishra A, Malhotra V, Yadav R, Ramakrishanan S, Malhotra RK, Batra V, Shetty MK, Sharma N, Mukhopadhyay S, Garg S, Gupta A, 2021 Jan-Feb Indian Heart J 1 73 109-113

Preliminary Evidence for Sociotropy and Autonomy in Relation to Antidepressant Treatment Outcome.

Cardinale R, Menkes MW, Andrews CM, Webb CA, Jha MK, Trombello JM, Trivedi MH, McInnis MG, Deldin PJ, 2021 Feb Psychiatr Q

Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project.

Jha MK, Schatzberg A, Minhajuddin A, Chin Fatt C, Mayes TL, Trivedi MH, 2021 Apr J Clin Psychiatry 3 82

Irritability as an independent predictor of concurrent and future suicidal ideation in adults with stimulant use disorder: Findings from the STRIDE study.

Jha MK, Minhajuddin A, Chin Fatt C, Shoptaw S, Kircanski K, Stringaris A, Leibenluft E, Trivedi M, 2021 09 J Affect Disord 292 108-113

Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial.

Costi S, Morris LS, Kirkwood KA, Hoch M, Corniquel M, Vo-Le B, Iqbal T, Chadha N, Pizzagalli DA, Whitton A, Bevilacqua L, Jha MK, Ursu S, Swann AC, Collins KA, Salas R, Bagiella E, Parides MK, Stern ER, Iosifescu DV, Han MH, Mathew SJ, Murrough JW, 2021 05 Am J Psychiatry 5 178 437-446

Dorsolateral Prefrontal Cortex and Subcallosal Cingulate Connectivity Show Preferential Antidepressant Response in Major Depressive Disorder.

Chin Fatt CR, Cooper C, Jha MK, Aslan S, Grannemann B, Kurian B, Greer TL, Fava M, Weissman M, McGrath PJ, Parsey RV, Etkin A, Phillips ML, Trivedi MH, 2021 01 Biol Psychiatry Cogn Neurosci Neuroimaging 1 6 20-28

Association of anger attacks with suicidal ideation in adults with major depressive disorder: Findings from the EMBARC study.

Jha MK, Fava M, Minhajuddin A, Chin Fatt C, Mischoulon D, Cusin C, Trivedi MH, 2021 01 Depress Anxiety 1 38 57-66

Quality of life after response to acute-phase cognitive therapy for recurrent depression.

Vittengl JR, Jha MK, Minhajuddin A, Thase ME, Jarrett RB, 2021 01 J Affect Disord 278 218-225

Effect of adjunctive pimavanserin on suicidal ideation in patients with major depression: Analysis of the CLARITY study.

Shelton RC, Fava M, Freeman MP, Thase ME, Papakostas GI, Jha MK, Trivedi MH, Dirks B, Liu K, Stankovic S, 2020 12 J Affect Disord 277 478-485

Association of Novel ALX4 Gene Polymorphisms with Antidepressant Treatment Response: Findings from the CO-MED Trial.

Gadad BS, Raj P, Jha MK, Carmody T, Dozmorov I, Mayes TL, Wakeland EK, Trivedi MH, 2018 Jun Mol Neuropsychiatry 1 4 7-19

Proteomics profiling reveals inflammatory biomarkers of antidepressant treatment response: Findings from the CO-MED trial.

Gadad BS, Jha MK, Grannemann BD, Mayes TL, Trivedi MH 2017 May J Psychiatr Res 94 1-6

A pilot program for implementing mental health screening, assessment, and navigation in a community-based cancer center.

Howe-Martin L, Jester B, Walker R, de la Garza N, Jha MK, Tovian C, Levinson S, Argenbright KE, Trivedi MH 2017 Mar Psychooncology

Is C-reactive protein ready for prime time in the selection of antidepressant medications?

Miller AH, Trivedi MH, Jha MK 2017 Apr Psychoneuroendocrinology

Daily activity level improvement with antidepressant medications predicts long-term clinical outcomes in outpatients with major depressive disorder.

Jha MK, Teer RB, Minhajuddin A, Greer TL, Rush AJ, Trivedi MH 2017 Neuropsychiatr Dis Treat 13 803-813

IMPROVEMENTS IN PSYCHOSOCIAL FUNCTIONING AND HEALTH-RELATED QUALITY OF LIFE FOLLOWING EXERCISE AUGMENTATION IN PATIENTS WITH TREATMENT RESPONSE BUT NONREMITTED MAJOR DEPRESSIVE DISORDER: RESULTS FROM THE TREAD STUDY.

Greer TL, Trombello JM, Rethorst CD, Carmody TJ, Jha MK, Liao A, Grannemann BD, Chambliss HO, Church TS, Trivedi MH 2016 May Depress Anxiety

COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.

Shukla AA, Jha M, Birchfield T, Mukherjee S, Gleason K, Abdisalaam S, Asaithamby A, Adams-Huet B, Tamminga CA, Ghose S 2016 Mar Schizophr. Res.

Attitudes Towards Substance Use Disorders and Association with Motivational Interviewing Education: A Survey of Psychiatry Chief Residents.

Jha MK, Abele MK, Brown JA, Ibrahim H, Wakhlu S 2016 Mar Acad Psychiatry

Early normalization of Quality of Life predicts later remission in depression: Findings from the CO-MED trial.

Jha MK, Greer TL, Grannemann BD, Carmody T, Rush AJ, Trivedi MH 2016 Jul J Affect Disord 206 17-22

Altered GABA neurotransmission in major depressive disorder: Re-analyzing publicly available data.

Jha MK, Sachdeva S 2016 Jan Eur Neuropsychopharmacol

Affect Following First Exercise Session as a Predictor of Treatment Response in Depression.

Suterwala AM, Rethorst CD, Carmody TJ, Greer TL, Grannemann BD, Jha M, Trivedi MH 2016 Aug J Clin Psychiatry 8 77 1036-42

Early Improvement in Psychosocial Function Predicts Longer-Term Symptomatic Remission in Depressed Patients.

Jha MK, Minhajuddin A, Greer TL, Carmody T, Rush AJ, Trivedi MH 2016 PLoS ONE 12 11 e0167901

Commentary: Clinical Approach to the Differential Diagnosis between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders.

Jha MK, Ivleva E 2016 Front Psychiatry 7 23

A Case of Frontotemporal Dementia Presenting With Treatment-Refractory Psychosis and Extreme Violence: Response to Combination of Clozapine, Medroxyprogesterone, and Sertraline.

Jha MK, Lambert ES, Beadles BA, Spradling B, Martinez R, Renfro N, Byerly M 2015 Oct J Clin Psychopharmacol

Training psychiatry residents at correctional facilities.

Jha MK, Fuehrlein BS, North CS, Brenner AM 2015 Feb Acad Psychiatry 1 39 123-4

Teaching Motivational Interviewing Skills to Psychiatry Trainees: Findings of a National Survey.

Abele M, Brown J, Ibrahim H, Jha MK 2014 May Acad Psychiatry

Availability and attitudes toward correctional psychiatry training: results of a national survey of training directors.

Fuehrlein BS, Jha MK, Brenner AM, North CS 2014 Apr J Behav Health Serv Res 2 41 244-50

Improvement in self-reported quality of life with cognitive therapy for recurrent major depressive disorder.

Jha MK, Minhajuddin A, Thase ME, Jarrett RB 2014 J Affect Disord 167 37-43

Can we address the shortage of psychiatrists in the correctional setting with exposure during residency training?

Fuehrlein BS, Jha MK, Brenner AM, North CS 2012 Dec Community Ment Health J 6 48 756-60

Post adoption depression.

Fields ES, Meuchel JM, Jaffe CJ, Jha M, Payne JL 2010 Apr Arch Womens Ment Health 2 13 147-51