Publications

2023

Daniel Daou, Thomas G Gillette, Joseph A Hill; Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction; Physiology (Bethesda). 2023 Sep 1;38(5):0. DOI: 10.1152/physiol.00004.2023.

2022

Dan Tong, Gabriele G Schiattarella, Nan Jiang, Daniel Daou, Yuxuan Luo, Mark S Link, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Impaired AMP-Activated Protein Kinase Signaling in Heart Failure With Preserved Ejection Fraction-Associated Atrial Fibrillation; Circulation. 2022 Jul 5;146(1):73-76. doi: 10.1161/CIRCULATIONAHA.121.058301. Epub 2022 Jul 5.

Xiaoding Wang, Guangyu Zhang, Subhajit Dasgupta, Erica L Niewold, Chao Li, Qinfeng Li, Xiang Luo, Lin Tan, Anwarul Ferdous, Philip L Lorenzi, Beverly A Rothermel, Thomas G Gillette, Christopher M Adams, Philipp E Scherer, Joseph A Hill, Zhao V Wang; ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress; Circ Res. 2022 Jun 24;131(1):91-105. doi: 10.1161/CIRCRESAHA.122.321050. Epub 2022 May 16

2021

Anwarul Ferdous, Sarvjeet Singh, Yuxuan Luo, Md J Abedin, Nan Jiang, Cameron E Perry, Bret M Evers, Thomas G Gillette, Michael Kyba, Maria Trojanowska, Joseph A Hill; Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors; Circ Res. 2021 Oct 29;129(10):949-964. doi: 10.1161/CIRCRESAHA.121.318986. Epub 2021 Sep 21

Min Xie, Geoffrey W Cho, Yongli Kong, Dan L Li, Francisco Altamirano, Xiang Luo, Cyndi R Morales, Nan Jiang, Gabriele G Schiattarella, Herman I May, Jessica Medina, John M Shelton, Anwarul Ferdous, Thomas G Gillette, Joseph A Hill; Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury; Circ Res. 2021 May 28;128(11):1629-1641. doi: 10.1161/CIRCRESAHA.120.317046. Epub 2021 Apr 22

Yuxuan Luo, Nan Jiang, Herman I May, Xiang Luo, Anwarul Ferdous, Gabriele G Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy; Circulation. 2021 Jul 6;144(1):34-51. doi: 10.1161/CIRCULATIONAHA.120.052384. Epub 2021 Apr 6

Gabriele G Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine, Subhajit Dasgupta, Xuliang Wang, Kristin M French, Elisa Villalobos, Stephen B Spurgin, Maayan Waldman, Nan Jiang, Herman I May, Theodore M Hill, Yuxuan Luo, Heesoo Yoo, Vlad G Zaha, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction; Nat Commun. 2021 Mar 16;12(1):1684. doi: 10.1038/s41467-021-21931-9

2020

Soo Young Kim, Xin Zhang, Gabriele G Schiattarella, Francisco Altamirano, Thais A R Ramos, Kristin M French, Nan Jiang, Pamela A Szweda, Bret M Evers, Herman I May, Xiang Luo, Hongliang Li, Luke I Szweda, Vinicius Maracaja-Coutinho, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function; Circulation . 2020 Dec 15;142(24):2356-2370. doi: 10.1161/CIRCULATIONAHA.120.047239. Epub 2020 Oct 28

Guihao Chen, Chuansheng Xu, Thomas G Gillette, Tongyi Huang, Peisen Huang, Qing Li, Xiangdong Li, Qinfeng Li, Yu Ning, Ruijie Tang, Cunrong Huang, Yuyan Xiong, Xiaqiu Tian, Jun Xu, Junyan Xu, Liping Chang, Cong Wei, Chen Jin, Joseph A Hill, Yuejin Yang; Cardiomyocyte-derived small extracellular vesicles can signal eNOS activation in cardiac microvascular endothelial cells to protect against Ischemia/Reperfusion injury; Theranostics . 2020 Sep 23;10(25):11754-11774. doi: 10.7150/thno.43163. eCollection 2020

Anwarul Ferdous, Zhao V Wang, Yuxuan Luo, Dan L Li, Xiang Luo, Gabriele G Schiattarella, Francisco Altamirano, Herman I May, Pavan K Battiprolu, Annie Nguyen, Beverly A Rothermel, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth; Nat Commun. 2020 May 21;11(1):2551. doi: 10.1038/s41467-020-16345-y

Gabriele G Schiattarella, Dan Tong, Joseph A Hill; Can HFpEF and HFrEF Coexist?; Circulation. 2020 Mar 3;141(9):709-711. doi: 10.1161/CIRCULATIONAHA.119.045171. Epub 2020 Mar 2

2019

Dan Tong, Gabriele G Schiattarella, Nan Jiang, Herman I May, Sergio Lavandero, Thomas G Gillette,, Joseph A Hill; Female Sex Is Protective in a Preclinical Model of Heart Failure With Preserved Ejection Fraction; Circulation. 2019 Nov 19;140(21):1769-1771. doi: 10.1161/CIRCULATIONAHA.119.042267. Epub 2019 Nov 18

Francisco Altamirano, Gabriele G Schiattarella, Kristin M French, Soo Young Kim, Felipe Engelberger, Sergii Kyrychenko, Elisa Villalobos, Dan Tong, Jay W Schneider, Cesar A Ramirez-Sarmiento, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Polycystin-1 Assembles With Kv Channels to Govern Cardiomyocyte Repolarization and Contractility; Circulation. 2019 Sep 10;140(11):921-936. doi: 10.1161/CIRCULATIONAHA.118.034731. Epub 2019 Jun 21

Gabriele G Schiattarella, Francisco Altamirano, Dan Tong, Kristin M French, Elisa Villalobos, Soo Young Kim, Xiang Luo, Nan Jiang, Herman I May, Zhao V Wang, Theodore M Hill, Pradeep P A Mammen, Jian Huang, Dong I Lee, Virginia S Hahn, Kavita Sharma, David A Kass, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Nitrosative stress drives heart failure with preserved ejection fractiony; Nature. 2019 Apr;568(7752):351-356. doi: 10.1038/s41586-019-1100-z. Epub 2019 Apr 10

Elisa Villalobos, Alfredo Criollo, Gabriele G Schiattarella, Francisco Altamirano, Kristin M French, Herman I May, Nan Jiang, Ngoc Uyen Nhi Nguyen, Diego Romero, Juan Carlos Roa, Lorena García, Guillermo Diaz-Araya, Eugenia Morselli, Anwarul Ferdous, Simon J Conway, Hesham A Sadek,Thomas G Gillette, Sergio Lavandero, Joseph A Hill; Fibroblast Primary Cilia Are Required for Cardiac Fibrosis; Circulation. 2019 May 14;139(20):2342-2357. doi: 10.1161/CIRCULATIONAHA.117.028752

2018

Gabriele G Schiattarella, Dan Tong, Joseph A Hill; Ventricular Phenotyping Reviews; Circulation. 2018 Aug 21;138(8):749-750. doi: 10.1161/CIRCULATIONAHA.118.036938

Gabriele G Schiattarella, Joseph A Hill; Epigenetic control of lipid metabolism: implications for lifespan and healthspan; Cardiovasc Res. 2018 May 1;114(6):e33-e35. doi: 10.1093/cvr/cvy048

Xukun Bi, Guangyu Zhang, Xiaoding Wang, Chau Nguyen, Herman I May, Xiaoting Li, Ali A Al-Hashimi, Richard C Austin, Thomas G Gillette, Guosheng Fu, Zhao V Wang, Joseph A Hill; Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation; Circ Res. 2018 May 25;122(11):1545-1554. doi: 10.1161/CIRCRESAHA.117.312641. Epub 2018 Apr 18

Alfredo Criollo, Francisco Altamirano, Zully Pedrozo, Gabriele G Schiattarella, Dan L Li, Pablo Rivera-Mejías, Cristian Sotomayor-Flores, Valentina Parra, Elisa Villalobos, Pavan K Battiprolu, Nan Jiang, Herman I May, Eugenia Morselli, Stefan Somlo, Humbert de Smedt, Thomas G Gillette, Sergio Lavandero, Joseph A Hill; Polycystin-2-dependent control of cardiomyocyte autophagy; J Mol Cell Cardiol. 2018 May;118:110-121. doi: 10.1016/j.yjmcc.2018.03.002. Epub 2018 Mar 63

Dian J Cao, Gabriele G Schiattarella, Elisa Villalobos, Nan Jiang, Herman I May, Tuo Li, Zhijian J Chen,Thomas G Gillette, Joseph A Hill; Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury; Circulation. 2018 Jun 12;137(24):2613-2634. doi: 10.1161/CIRCULATIONAHA.117.031046. Epub 2018 Feb 1

2017

Gabriele G Schiattarella, Joseph A Hill; Is Load-Induced Ventricular Hypertrophy Ever Compensatory?; Circulation. 2017 Oct 3;136(14):1273-1275. doi: 10.1161/CIRCULATIONAHA.117.030730

Gabriele G Schiattarella, Joseph A Hill; Metabolic control and oxidative stress in pathological cardiac remodelling; Eur Heart J. 2017 May 7;38(18):1399-1401. doi: 10.1093/eurheartj/ehw199

Dan Tong, Joseph A Hill; Spermidine Promotes Cardioprotective Autophagy; Circ Res. 2017 Apr 14;120(8):1229-1231. doi: 10.1161/CIRCRESAHA.117.310603

Dan L Li, Zhao V Wang, Ding G, Wei Tan, Xiang Luo, Alfredo Criollo, Min Xie, Jiang, Herman I May, Viktoriia Kyrychenko, Jay W Schneider,Thomas G Gillette, Joseph A Hill; Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification; Circulation. 2016 Apr 26;133(17):1668-87. doi: 10.1161/CIRCULATIONAHA.115.017443. Epub 2016 Mar 16

2016

Soo Young Kim, Cyndi R Morales, Thomas G Gillette, Joseph A Hill; Epigenetic regulation in heart failure; Curr Opin Cardiol. 2016 May;31(3):255-65. doi: 10.1097/HCO.0000000000000276

Cyndi R Morales, Dan L Li, Zully Pedrozo, Herman I May, Nan Jiang, Viktoriia Kyrychenko, Geoffrey W Cho, Soo Young Kim, Zhao V Wang, David Rotter, Beverly A Rothermel, Jay W Schneider, Sergio Lavandero, Thomas G Gillette, Joseph A Hill; Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression; Sci Signal. 2016 Apr 5;9(422):ra34. doi: 10.1126/scisignal.aad5736

Geoffrey W Cho, Francisco Altamirano, Joseph A Hill; Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death; Biochim Biophys Acta. 2016 Apr;1862(4):763-777. doi: 10.1016/j.bbadis.2016.01.011. Epub 2016 Jan 13

Jana S Burchfield, Ashley L Paul, Vishy Lanka, Wei Tan, Yongli Kong, Camille McCallister, Beverly A Rothermel, Jay W Schneider, Thomas G Gillette, Joseph A Hill; Pharmacological priming of adipose-derived stem cells promotes myocardial repair; J Investig Med. 2016 Jan;64(1):50-62. doi: 10.1136/jim-2015-000018

2015

Gabriele G Schiattarella, Joseph A Hill; Therapeutic targeting of autophagy in cardiovascular disease; J Mol Cell Cardiol. 2016 Jun;95:86-93. doi: 10.1016/j.yjmcc.2015.11.019. Epub 2015 Nov 18

Dian J Cao, Zhao V Wang, Joseph A Hill; Parkin Gone Wild: Unbridled Ubiquitination.; Circ Res. 2015 Jul 31;117(4):311-3. doi: 10.1161/CIRCRESAHA.115.307022

Francisco Altamirano, Zhao V Wang, Joseph A Hill; Cardioprotection in ischaemia-reperfusion injury: novel mechanisms and clinical translation; J Physiol. 2015 Sep 1;593(17):3773-88. doi: 10.1113/JP270953. Epub 2015 Aug 2

Zully Pedrozo, Alfredo Criollo, Pavan K Battiprolu, Cyndi R Morales, Ariel Contreras-Ferrat, Carolina Fernández, Nan Jiang, Xiang Luo, Michael J Caplan, Stefan Somlo, Beverly A Rothermel, Thomas G Gillette, Sergio Lavandero, Joseph A Hill; Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability; Circulation. 2015 Jun 16;131(24):2131-42. doi: 10.1161/CIRCULATIONAHA.114.013537. Epub 2015 Apr 17

Thomas G Gillette, Joseph A Hill; Readers, writers, and erasers: chromatin as the whiteboard of heart disease; Circ Res. 2015 Mar 27;116(7):1245-53. doi: 10.1161/CIRCRESAHA.116.303630

Zhao V Wang, Joseph A Hill; Diabetic cardiomyopathy: catabolism driving metabolism; Cell Metab. 2015 Feb 3;21(2):215-226. doi: 10.1016/j.cmet.2015.01.016

Xiang Luo, Joseph A Hill; Ca²⁺ in the cleft: fast and fluorescent; Circ Res. 2014 Jul 18;115(3):326-8. doi: 10.1161/CIRCRESAHA.114.304487. Epub 2015 Jan 2

Sergio Lavandero, Mario Chiong, Beverly A Rothermel, Joseph A Hill; Autophagy in cardiovascular biology.; J Clin Invest. 2015 Jan;125(1):55-64. doi: 10.1172/JCI73943. Epub 2015 Jan 2

2014

Zhao V Wang, Yingfeng Deng, Ningguo Gao, Zully Pedrozo, Dan L Li, Cyndi R Morales, Alfredo Criollo, Xiang Luo, Wei Tan, Nan Jiang, Mark A Lehrman, Beverly A Rothermel, Ann-Hwee Lee, Sergio Levandero, Pradeep P A Mammen, Anwarul Ferdous, Thomas G Gillette, Philipp E Sherer, Joseph A Hill; Spliced x-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway; Cell, 156(6):1179-1192, 2014

Min Xie, Yongli Kong, Wei Tan, Herman I May, Pavan K Battiprolu, Zully Pedrozo, Zhao V Wang, Cyndi Morales, Xiang Luo, Geoffrey Cho, Nan Jiang, Michael E Jessen, John J Warner, Sergio Lavandero, Thomas G Gillette, Aslan T Turer, Joseph A Hill; Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy; Circulation, 129(10):1139-1151, 2014

Cyndi R Morales, Zully Pedrozo, Sergio Lavandero, Joseph A Hill; Oxidative Stress and Autophagy in Cardiovascular Homeostasis; Antioxid Redox Signal, 20(3):507-518, 2014

Fangming Lin, Zhao V Wang, and Joseph A Hill; Seeing is believing: Dynamic changes in renal epithelial autophagy during injury and repair; Autophagy, 10(4), 2014 (ahead of print)

Ling Li, Zhao V Wang, Joseph A Hill, Fangming Lin; New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy; J Am Soc Nephrol, 25(2):305-315, 2014

Yanggan Wang, Samvit Tandan, Joseph A Hill; Calcineurin-dependent ion channel regulation in heart; Trends Cardiovasc Med, 24(1):14-22, 2014

2013

Zhao V Wang, Dan L Li, Joseph A Hill; Heart Failure and Loss of Metabolic Contro; J Cardiovasc Pharmacol, 2013

Dan L Li and Joseph A Hill; Cardiomyocyte autophagy and cancer chemotherapy; J Mol Cell Cardiol, 2013

Min Xie, Jana S Burchfield, Joseph A Hill; Pathological ventricular remodeling: therapies; Circulation, 128(9):1021-1030, 2013

Min Xie and Joseph A Hill; HDAC-dependent ventricular remodeling; Trends Cardiovasc Med, 2013 (ahead of print)

Jana S Burchfield, Min Xie, Joseph A Hill; Pathological ventricular remodeling: mechanisms; Circulation, 128(4):388-400, 2013

Thomas G Gillette and Joseph A Hill; PKG Primes the Proteasome; Circulation, 128(4):325-327, 2013

Oktay F Rifki, Brian O Bodemann, Pavan K Battiprolu, Michael A White, and Joseph A Hill; RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy; J Mol Cell Cardiol, 59:128-138, 2013

Zully Pedrozo, Natalia Torrealba, Carolina Fernandez, Damian Gatica, Barbra Tror, Clara Quiroga, Andrea E Rodriguez, Gina Sanchez, Thomas G Gillette, Joseph A Hill, Paulina Donoso, Sergio Lavandero; Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy; Cardiovascular Research, 98(2):277-285, 2013 (ahead of print)

Young-Jae Nam, Kunhua Song, Xiang Luo, Edward Daniel, Kaleb Lambeth, Katherine West, Joseph A Hill, J Michael DiMaio, Linda A Baker, Rhonda Bassel-Duby, and Eric N Olson; Reprogramming of human fibroblasts toward a cardiac fate; PNAS, 110(14):5588-5593, 2013

Dian J Cao, Nan Jiang, Andrew Blagg, Janet L Johnstone, Raj Gondalia, Misook Oh, Xiang Luo, Kai-Chun Yang, John M Shelton, Beverly A Rothermel, Thomas G Gillette, Gerald W Dorn, Joseph A Hill; Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy; J Am Heart Assoc, 2(2):e000016, 2013

Zully Pedrozo, Natalia Torrealba, Carolina Fernández, Damian Gatica, Barbra Toro, Clara Quiroga, Andrea E Rodriguez, Gina Sanchez, Thomas G Gillette, Joseph A Hill, Paulina Donoso, and Sergio Lavandero; Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy; Cardiovascular Research, 2013 (ahead of print)

Yingfeng Deng, Zhao V Wang, Caroline Tao, Ningguo Gao, William L Holland, Anwarul Ferdous, Joyce J Repa, Guosheng Liang, Jin Ye, Mark A Lehrman, Joseph A Hill, Jay D Horton, and Philipp E Scherer; The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism; J Clin Invest, 123(1):455-468, 2013

Roberto Bravo, Valentina Parra, Damian Gatica, Andrea E Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao V Wang, Antonio Zorzano, Joseph A Hill, Enrique Jaimovich, Andrew F G Quest, and Sergio Lavandero; Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration; Int Rev Cell Mol Bio, 301:215-290, 2013

2012

Guo N Huang, Jeffrey E Thatcher, John McAnally, Yongli Kong, Xiaoxia Qi, Wei Tan, J Michael DiMaio, James F Amatruda, Robert D Gerard, Joseph A Hill, Rhonda Bassel-Duby, and Eric N Olson; C/EBP transcription factors mediate epicardial activation during heart development and injury; Science, 338(6114):1599-1603, 2012

Pavan K Battiprolu, Camila Lopez-Crisosto, Zhao V Wang, Andriy Nemchenko, Sergio Lavandero, and Joseph A Hill; Diabetic cardiomyopathy and metabolic remodeling of the heart; Life Sci, October 30, 2012

Berdymammet Hojayev, Beverly A Rothermel, Thomas G Gillette, and Joseph A Hill; FHL2 binds calcineurin and represses pathological cardiac growth; Mol Cell Biol, 32(19):4025-4034, 2012

Zhao V Wang, Anwarul Ferdous, and Joseph A Hill; Cardiomyocyte autophagy: metabolic profit and loss; Heart Fail Rev, September 30, 2012

Oktay F Rifki and Joseph A Hill; Cardiac autophagy: good with the bad; J Cardiovasc Pharmacol, 60(3):248-252, 2012

Anwarul Ferdous and Joseph A Hill; FoxO1 in Embryonic Development; Transcription, 3(5):221-224, 2012

Kunhua Song, Young-Jae Nam, Xiang Luo, Xiaoxia Qi, Wei Tan, Guo N Huang, Asha Acharya, Christopher L Smith, Michelle D Tallquist, Eric G Neilson, Joseph A Hill, Rhonda Bassel-Duby, and Eric N Olson; Heart repair by reprogramming non-myocytes with cardiac transcription factors; Nature, 485(7400):599-604, 2012

Arin B Aurora, Ahmed I Mahmoud, Xiang Luo, Brett A Johnson, Eva van Rooij, Satoshi Matsuzaki, Kenneth M Humphries, Joseph A Hill, Rhonda Bassel-Duby, Hesham A Sadek, and Eric N Olson; MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death; J Clin Invest, 122(4):1222-1232, 2012

Pavan K Battiprolu, Berdymammet Hojayev, Nan Jiang, Zhao V Wang, Xiang Luo, Myriam Iglewski, John M Shelton, Robert D Gerard, Beverly A Rothermel, Thomas G Gillette, Sergio Lavandero, and Joseph A Hill; Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice; J Clin Invest, 122(3):1109-1118, 2012

Congcong He, Michael C Bassik, Viviana Moresi, Kai Sun, Yongjie Wei, Zhongju Zou, Zhenyi An, Joy Loh, Jill Fisher, Qihua Sun, Stanley Korsmeyer, Milton Packer, Herman I May, Joseph A Hill, Herbert W Virgin, Christopher Gilpin, Guanghua Xiao, Rhonda Bassel-Duby, Philipp E Scherer, and Beth Levine; Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis; Nature, 481(7382):511-515, 2012

Xiang Luo, Berdymammet Hojayev, Nan Jiang, Zhao V Wang, Samvit Tandan, Andrey Rakalin, Beverly A Rothermel, Thomas G Gillette, and Joseph A Hill; STIM1-dependent store-operated Ca²⁺ entry is required for pathological cardiac hypertrophy; J Mol Cell Cardiol, 52(1):136-147, 2012

2011

Andriy Nemchenko, Mario Chiong, Aslan Turer, Sergio Lavandero, and Joseph A Hill; Autophagy as a therapeutic target in cardiovascular disease; J Mol Cell Cardiol, 51(4):584-593, 2011

Anwarul Ferdous, Jesse Morris, Mohammad Joynal Abedin, Shandon Collins, James A Richardson, and Joseph A Hill; Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo; PNAS, 108(39):16307-16312, 2011

Dian J Cao and Joseph A Hill; Titrating autophagy in cardiac plasticity; Autophagy, 7(9):1078-1079, 2011

Jeff M Berry, Vien Le, David Rotter, Pavan K Battiprolu, Bennett Grinsfelder, Paul Tannous, Jana S Burchfield, Michael Czubryt, Johannes Backs, Eric N Olson, Beverly A Rothermel, and Joseph A Hill; Reversibility of adverse, calcineurin-dependent cardiac remodeling; Circ Res, 109(4):407-417, 2011

Berdymammet Hojayev and Joseph A Hill; HDACs and hypertrophy, kinases and cancer; Circulation, 123(21):2341-2343, 2011

Min Xie, Cyndi R Morales, Sergio Lavandero, and Joseph A Hill; Tuning flux: autophagy as a target of heart disease therapy; Curr Opin Cardiol, 26(3):216-222, 2011

Dian J Cao, Zhao V Wang, Pavan K Battiprolu, Nan Jiang, Cyndi R Morales, Yongli Kong, Beverly A Rothermel, Thomas G Gillette, and Joseph A Hill; Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy; PNAS, 108(10):4123-4128, 2011

Joseph A Hill; Autophagy in cardiac plasticity and disease; Pediatr Cardiol, 32(3):282-289, 2011

Enzo R Porrello, Ahmed I Mahmoud, Emma Simpson, Joseph A Hill, James A Richardson, Eric N Olson, and Hesham A Sadek; Transient regenerative potential of the neonatal mouse heart; Science, 331(6020):1078-1080, 2011

Nita Sachan, Asim Dey, David Rotter, D Bennett Grinsfelder, Pavan K Battiprolu, Devanjan Sikder, Victoria Copeland, Misook Oh, Erik Bush, John M Shelton, James A Bibb, Joseph A Hill, and Beverly A Rothermel; Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart; Circ Res, 108(4):437-445, 2011

2010

Pavan K Battiprolu, Thomas G Gillette, Zhao V Wang, Sergio Lavandero, and Joseph A Hill; Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets; Drug Discov Today Dis Mech, 7(2):e135-e143, 2010

Myriam Iglewski, Joseph A Hill, Sergio Lavandero, Beverly A Rothermel; Mitochondrial fission and autophagy in the normal and diseased heart; Curr Hypertens Rep, 12(6):418-25, 2010

Jamie L Russell, Sean C Goetsch, Nicholas R Gaiano, Joseph A Hill, Eric N Olson, Jay W Schneider; A Dynamic Notch Injury Response Activates Epicardium and Contributes to Fibrosis Repair; Circ Res, 2010 (in press)

Hui Xu, Kenneth S Ginsburg, Duane D Hall, Maike Zimmermann, Ivar S Stein, Mingxu Zhang, Samvit Tandan, Joseph A Hill, Mary C Horne, Donald Bers, Johannes W Hell; Targeting of Protein Phosphatases PP2A and PP2B to the C-Terminus of the L-Type Calcium Channel Ca(v)1.2; Biochemistry, 2010 (in press)

David M Patrick, Rusty L Montgomery, Xiaoxia Qi, Susanna Obad, Sakari Kauppinen, Joseph A Hill, Eva van Rooij, Eric N Olson; Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice; J Clin Invest, 120(11):3912-6, 2010

Vassilis Dimas, Colby Ayers, James Daniels, Jose A Joglar, Joseph A Hill, R Haris Naseem; Spironolactone Therapy is Associated with Reduced Ventricular Tachycardia Rate in Patients with Cardiomyopathy; Pacing and Clinical Electrophysiology, 2010 (in press)

Peiguo Ding, Jian Huang, Pavan K Battiprolu, Joseph A Hill, Kristine E Kamm, James T Stull; Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo; J Biol Chem, 2010 (in press)

Aslan T Turer, Joseph A Hill; Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy; Am J Cardiol, 106(3):360-8, 2010

Anwarul Ferdous, Pavan K Battiprolu, Yan G Ni, Beverly A Rothermel, Joseph A Hill; FoxO, autophagy, and cardiac remodeling; J Cardiovasc Transl Res, 3(4):355-64, 2010

Misook Oh, Asim Dey, Robert D Gerard, Joseph A Hill, Beverly A Rothermel; The CCAAT/enhancer binding protein beta (C/EBPß) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4; J Bio Chem, 285(22):16623-31, 2010

David W Markham, Joseph A Hill; MicroRNAs and heart failure diagnosis: MiR-acle or MiR-age?; Circ Res, 106(6):1011-3, 2010

Zhao V Wang, Beverly A Rothermel, Joseph A Hill; Autophagy in hypertensive heart disease; J Biol Chem, 285(12):8509-14, 2010

Jorge Massare, Jeff M Berry, Xiang Luo, Farhana Rob, Janet L Johnstone, John M Shelton, Rhonda Bassel-Duby, Joseph A Hill, R Haris Naseem; Diminished Cardiac Fibrosis in Heart Failure is Associated with Altered Ventricular Arrhythmia Phenotype; J Cardiovasc Electrophysiol, 21(9):1031-7, 2010

Yanggan Wang, Joseph A Hill; Electrophysiological Remodeling in Heart Failure; J Mol Cell Cardiol, 48(4):619-32, 2010

Andriy Nemchenko, Joseph A Hill; NEMO nuances NF-kappaB; Circ Res, 106(1):10-2, 2010

2009

Dian J. Cao, Thomas G. Gillette, Joseph A. Hill; Cardiomyocyte autophagy: remodeling, repairing, and reconstructing the heart; Curr Hypertens Rep, 11(6):406-11, 2009

Eva van Rooij, Jens Fielitz, Lillian B. Sutherland, Victor L. Thijssen, Harry J. Crijns, Michael J. Dimaio, John Shelton, Leon J. De Windt, Joseph A. Hill and Eric N. Olson; Myocyte Enhancer Factor 2 and Class II Histone Deacetylases Control a Gender-Specific Pathway of Cardioprotection Mediated by the Estrogen Receptor; Circ Res, 2009

Nikhil V. Munshi, John McAnally, Svetlana Bezprozvannaya, Jeff M. Berry, James A. Richardson, Joseph A. Hill, Eric N. Olson; Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay; Development, 136(15):26665-74, 2009

Erin E. Yund, Joseph A. Hill, Rebecca S. Keller; Hic-5 is required for fetal gene expression and cytoskeletal organization of neonatal cardiac myocytes; J Mol Cell Cardiol, 47(4):520-27, 2009

Samvit Tandan, Yanggan Wang, Thomas T. Wang, Nan Jiang, Duane D. Hall, Johannes W. Hell, Xian Luo, Beverly A. Rothermel, Joseph A. Hill; Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca2+ Channel; Circ Res, 105(1):51-60, 2009

Johannes Backs, Thea Backs, Stefan Neef, Michael M. Kreusser, Lorenz H. Lehmann, David M. Patrick, Chad E. Grueter, Xiaoxia Qi, James A. Richardson, Joseph A. Hill, Hugo A. Katus, Rhonda Bassel-Duby, Lars S. Maier, Eric N. Olson; The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload; Proc Natl Acad Sci, 106(7):2342-7, 2009

Hongxin Zhu, Beverly A. Rothermel, Joseph A. Hill; Autophagy in load-induced heart disease; Meth Enzymol, 453:343-63, 2009

2008

Beverly A Rothermel, Joseph A Hill; Autophagy in load-induced heart disease; Circ Res, 103(12):1363-1369, 2008

Beverly A Rothermel, Joseph A Hill; Adenosine A3 receptor and cardioprotection: enticing, enigmatic, elusive; Circulation, 118(17):1691-1693, 2008

Beverly A Rothermel, Joseph A Hill; The heart of autophagy: deconstructing cardiac proteotoxicity; Autophagy, 4(7):932-935, 2008

Yanggan Wang, Samvit Tandan, Jun Cheng, Chunmei Yang, Lan Nguyen, Jessica Sugianto, Janet L Johnstone, Yuyang Sun, Joseph A Hill; Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure; J Biol Chem, 283(37):25524-25532, 2008

Eva van Rooij, Lillian B Sutherland, Jeffrey E Thatcher, J Michael DiMaio, R Haris Naseem, William S Marshall, Joseph A Hill, Eric N Olson; Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis; Proc Natl Acad Sci USA, 105(35):13027-13032, 2008

Shusheng Wang, Arin B Aurora, Brett A Johnson, Xiaoxia Qi, John McAnally, Joseph A Hill, James A Richardson, Rhonda Bassel-Duby, Eric N Olson; The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis; Dev Cell, 15(2):261-271, 2008

Paul Tannous, Hongxin Zhu, Janet L Johnstone, John M Shelton, Namakkal S Rajasekaran, Ivor J Benjamin, Lan Nguyen, Robert D Gerard, Beth Levine, Beverly A Rothermel, Joseph A Hill; Autophagy is an adaptive response in desmin-related cardiomyopathy; Proc Natl Acad Sci USA, 105(28):9745-9750, 2008

Paul Tannous, Hongxin Zhu, Andriy Nemchenko, Jeff M Berry, Janet L Johnstone, John M Shelton, Francis J Miller, Beverly A Rothermel, Joseph A Hill; Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy; Circulation, 117(24):3070-3078, 2008

Joseph A Hill, Eric N Olson; Cardiac plasticity; N Engl J Med, 358(13):1370-1380, 2008

Mounir Errami, Cristi L Galindo, Amina T Tassa, John M Dimaio, Joseph A Hill, Harold R Garner; Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice; J Pharmacol Exp Ther, 324(3):1196-1203, 2008

Jens Fielitz, Mi-Sung Kim, John M Shelton, Xiaoxia Qi, Joseph A Hill, James A Richardson, Rhonda Bassel-Duby, Eric N Olson; Requirement of protein kinase D1 for pathological cardiac remodeling; Proc Natl Acad Sci, 105(8):3059-3063, 2008

Beverly A Rothermel, Joseph A Hill, et. al.; Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes; Autophagy, 4(2):151-175, 2008

Yuri Kim, Dillon Phan, Eva van Rooij, Da-Zhi Wang, John McAnally, Xiaoxia Qi, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson; The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice; J Clin Invest, 118(1):124-132, 2008

Jeff M Berry, Dian J Cao, Beverly A Rothermel, Joseph A Hill; Histone deacetylase inhibition in the treatment of heart disease; Expert Opinion on Drug Safety, 7(1):53-67, 2008

2007

Hongxin Zhu, Paul Tannous, Janet L Johnstone, Yongli Kong, John M Shelton, James A Richardson, Vien Le, Beth Levine, Beverly A Rothermel, Joseph A Hill; Cardiac autophagy is a maladaptive response to hemodynamic stress; J Clin Invest, 117:1782-93, 2007

Yanggan Wang, Jun Cheng, Guohua Chen, Farhana Rob, R. Haris Naseem, Lan Nguyen, Janet L. Johnstone, Joseph A. Hill; Remodeling of Outward K(+) Currents in Pressure-Overload Heart Failure; J Cardiovasc Electrophysiol, 2007

Koichiro Kuwahara, Gordon C Teg Pipes, John McAnally, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson; Modulation of Adverse Cardiac Remodeling by STARS, a Mediator of MEF2 Signaling and SRF Activity; J Clin Invest, 117:1324-34, 2007

Chengcheng Shen, Mei-Jung Lin, Alp Yarandanakul, Vincenzo Lariccia, Joseph A. Hill, Donald W. Hilgemann; Dual Control of Cardiac Na/Ca Exchange by PIP2: Analysis of the Surface Membrane Fraction by Extracellular Cysteine PEGylation; J Physiol, 2007

2006

Koichiro Kuwahara, Yanggan Wang, John McAnally, James A Richardson, Rhonda Bassel-Duby, Joseph A Hill, Eric N Olson; TRPC6 Fulfills a Calcineurin Signaling Circuit During Pathologic Cardiac Remodeling; J Clin Invest, 116;3114-26, 2006

Yanggan Wang, Jun Cheng, Samvit Tandan, Minjie Jiang, Diana T McCloskey, Joseph A Hill; Transient-outward K+ Channel Inhibition Facilitates L-type Ca2+ Current in Heart; J Cardiovasc Electrophysiol, 17:298-304, 2006

Kunhua Song, Johannes Backs, John McAnally, Xiaoxia Qi, Robert D Gerard, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson; The Transcriptional Coactivator CAMTA2 Stimulates Cardiac Growth by Opposing Class II Histone Deacetylases; Cell, 125:453-66, 2006

Yongli Kong, Paul Tannous, Guangrong Lu, Kambeez Berenji, Beverly A Rothermel, Eric N Olson, Joseph A Hill; Suppression of Class I and II Distone Deacetylases Blunts Pressure-overload Cardiac Hypertrophy; Circulation, 113:2579-88, 2006

Yanggan Wang, Jun Cheng, Ronald W Joyner, Mary B Wagner, Joseph A Hill; Remodeling of Early-phase Repolarization: A Mechanism of Abnormal Impulse Conduction in Heart Failure; Circulation, 113:1849-56, 2006

Yanggan Wang, Joseph A Hill; Human atrial chloride channels: swelling with pride; J Cardiovasc Electrophysiol, 17;69-71, 2006

Yan G Ni, Kambeez Berenji, Na Wang, Misook Oh, Nita Sachan, Asim Dey, Jun Cheng, Guangrong Lu, David J Morris, Diego H Castrillon, Robert D Gerard, Beverly A Rothermel, Joseph A Hill; Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling; Circulation, 114:1159-68, 2006

2005

Joseph A Hill; In Vino Veritas: Alcohol and Heart Disease; Am J Med Sci, 329:124-35, 2005

Kenneth E Richardson, Paul Tannous, Kambeez Berenji, Bridgid Nolan, Kayla J Bayless, George E Davis, Beverly A Rothermel, Joseph A Hill; Guanosine Triphosphatase Activation Occurs Downstream of Calcineurin in Cardiac Hypertrophy; J Investig Med, 53:414-24, 2005

Kambeez Berenji, Mark H Drazner, Beverly A Rothermel, Joseph A Hill; Does Load-induced Ventricular Hypertrophy Progress to Systolic Heart Failure?; Am J Physiol Heart Circ Physiol, 289:H8-H16, 2005

Beverly A Rothermel, Kambeez Berenji, Paul Tannous, William Kutschke, Asim Dey, Bridgid Nolan, Ki-Dong Yoo, Elaine Demetroulis, Michael Gimbel, Barry Cabuay, Mohsen Karimi, Joseph A Hill; Differential Activation of Stress-Response Signaling in Load-Induced Cardiac Hypertrophy and Failure ; Physiol Genomics, 23:18-27, 2005

Misook Oh, Igor I Rybkin, Victoria Copeland, Michael P Czubryt, John M Shelton, Eva van Rooij, James A Richardson, Joseph A Hill, Leon J De Windt, Rhonda Bassel-Duby, Eric N Olson, Beverly A Rothermel; Calcineurin is Necessary for the Maintenance but not Embryonic Development of Slow Muscle Fibers ; Mol Cell Biol, 25:6629-38, 2005

2004

Norbert Frey, Tomasa Barrientos, John M Shelton, Derk Frank, Hartmut Rütten, Doris Gehring, Christian Kuhn, Matthias Lutz, Beverly Rothermel, Rhonda Bassel-Duby, James A Richardson, Hugo A Katus, Joseph A Hill, Eric N Olson; Mice Lacking Calsarcin-1 Are Sensitized to Calcineurin Signaling and Show Accelerated Cardiomyopathy in Response to Pathological Biomechanical Stress; Nat Med, 10:1336-43, 2004

Norbert Frey, Hugo A Katus, Eric N Olson, Joseph A Hill; Hypertrophy of the Heart: a New Therapeutic Target?; Circulation, 109:1580-9, 2004

Shurong Chang, Timothy A McKinsey, Chun Li Zhang, James A Richardson, Joseph A Hill, Eric N Olson; Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development; Mol Cell Biol, 24:8467-76, 2004

2003

Joseph A Hill; Electrical Remodeling in Cardiac Hypertrophy; Trends Cardiovasc Med, 13:316-22, 2003

Brian Palen, William Stanford, Thomas Fagan, Joseph A Hill; Atypical Chest Pain and Atypical Coronary Artery Disease; Am J Cardiol, 92:120, 2003

Chien-Chang Chen, Kathryn G Lamping, Daniel W Nuno, Rita Barresi, Sally J Prouty, Julie L Lavoie, Leanne L Cribbs, Sarah K England, Curt D Sigmund, Robert M Weiss, Roger A Williamson, Joseph A Hill, Kevin P Campbell; Abnormal Coronary Function in Mice Deficient in Alpha1H T-Type Ca2+ Channels; Science, 302:1416-8, 2003

2002

Joseph A Hill, Beverly Rothermel, Ki-Dong Yoo, Barry Cabuay, Elaine Demetroulis, Robert M Weiss, William Kutschke, Rhonda Bassel-Duby, R Sanders Williams; Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy; J Biol Chem, 277:10251-5, 2002

Francisco J Naya, Brian L Black, Hai Wu, Rhonda Bassel-Duby, James A Richardson, Joseph A Hill, Eric N Olson; Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor; Nat Med, 8:1303-9, 2002

Chun Li Zhang, Timothy A McKinsey, Shurong Chang, Christopher L Antos, Joseph A Hill, Eric N Olson; Class II Histone Deacetylases Act as Signal- Responsive Repressors of Cardiac Hypertrophy; Cell, 110:479-88, 2002

Christopher L Antos, Timothy A McKinsey, Norbert Frey, William Kutschke, John McAnally, John M Shelton, James A Richardson, Joseph A Hill, Eric N Olson; Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo; Proc Natl Acad Sci USA, 99:907-12, 2002

2001

B London, W Guo, Pan Xh, J S Lee, V Shusterman, C J Rocco, D A Logothetis, J M Nerbonne, J A Hill; Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine–Sensitive Component of Ik,slow and Resistance to Drug-Induced QT Prolongation; Circ Res, 88:940-6, 2001

Z Wang, B Nolan, W Kutschke, J A Hill; Sodium-Calcium Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy; J Biol Chem, 276:17706-11, 2001

Z Wang, W Kutschke, K E Richardson, M Karimi, J A Hill; Electrical Remodeling in Pressure-Overload Cardiac Hypertrophy (Role of Calcineurin); Circulation, 104:1657-63, 2001

2000

J A Hill, R E Kerber; Quo Vadis? How Should We Train Cardiologists at the Turn of the Century?; Circulation, 102:932-936, 2000

Joseph A Hill; Deconstructing cardiac hypertrophy: signaling pathways involved in structural, functional and electrical remodeling; Current Opinion in Cardiovascular, Pulmonary & Renal Investigational Drugs, 2:25-9, 2000

J A Hill, M Karimi, W Kutschke, R L Davisson, K Zimmerman, Z Wang, R E Kerber, R M Weiss; Cardiac Hypertrophy Is Not a Required Compensatory Response to Short-Term Pressure Overload; Circulation, 101:2863-9, 2000