Meet the Principal Investigator
Jaehyup Kim, M.D., Ph.D.
Assistant Professor of Pathology
During my postdoctoral training under Dr Chengcheng (Alec) Zhang (Department of Physiology), I used several techniques including flow cytometry, mass spectrometry and co-immunoprecipitation to study the biology of immune regulatory receptors. I helped identify the ligand of LILRB4 for the first time, which was published in the journal Nature with me as a co-first author (Mi et al, Nature 2018).
Following the completion of my clinical training and post-doctoral research training, I started my own independent lab with the support from NIH Mentored Clinical Scientist Research Career Development Award (5K08CA234544-04, The role of LILRB4 in AML progression and immune suppression).
My lab studies the mechanism of immune regulatory receptor regulation with a special focus on ligand identification and modulation. We have identified a novel class of ligands capable of activating various Ig-like domain containing receptors including PD-1 and TIM-3. Currently, my lab is working on clarifying the contribution of these ligands in various pathological processes including cancer and graft-versus-host disease.
- Discover novel ligands for Immune regulatory receptors
- Identify ligands with immune cell subset specific/preferential binding characteristics
- Leverage the difference in ligand binding affinity for clinical applications
Senior Research Associate
Reactive astrocytes expressing intense estrogen receptor-alpha immunoreactivities have much elongated cytoplasmic processes: an autopsy case of human cerebellar tissue with multiple genitourinary and gastrointestinal anomalies.Kim EJ, Oh CS, Kim J, Kim WH, Chung YH, Shin DH 2007 Oct J. Korean Med. Sci. 5 22 936-41