Publications

Convergence of coronary artery disease genes onto endothelial cell programs.

Schnitzler GR, Kang H, Fang S, Angom RS, Lee-Kim VS, Ma XR, Zhou R, Zeng T, Guo K, Taylor MS, Vellarikkal SK, Barry AE, Sias-Garcia O, Bloemendal A, Munson G, Guckelberger P, Nguyen TH, Bergman DT, Hinshaw S, Cheng N, Cleary B, Aragam K, Lander ES, Finucane HK, Mukhopadhyay D, Gupta RM, Engreitz JM, 2024 Feb Nature 8000 626 799-807

Multiomic Analysis and CRISPR Perturbation Screens Identify Endothelial Cell Programs and Novel Therapeutic Targets for Coronary Artery Disease.

Gupta RM, Schnitzler GR, Fang S, Lee-Kim VS, Barry A, 2023 May Arterioscler Thromb Vasc Biol 5 43 600-608

Increases in hydraulic conductance and solute permeability in a mouse model of ascending thoracic aortic aneurysm.

Crandall CL, Kim SY, Rother J, Lee VS, Mecham RP, Wagenseil JE, 2022 Dec J Biomech 145 111360

Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.

Wang M, Lee-Kim VS, Atri DS, Elowe NH, Yu J, Garvie CW, Won HH, Hadaya JE, MacDonald BT, Trindade K, Melander O, Rader DJ, Natarajan P, Kathiresan S, Kaushik VK, Khera AV, Gupta RM, 2021 Oct Circ Genom Precis Med 5 14 e003399

CRISPR-Cas9 Genome Editing of Primary Human Vascular Cells In Vitro.

Atri DS, Lee-Kim VS, Vellarikkal SK, Sias-Garcia O, Yanamandala M, Schniztler GR, Gupta RM, 2021 Nov Curr Protoc 11 1 e291

The March of Monocytes in Atherosclerosis: One Cell at a Time.

Gupta RM, Lee-Kim VS, Libby P, 2020 May Circ Res 10 126 1324-1326

Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.

Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP, 2019 Jun JCI Insight 15 5

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.

Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP 2017 May Sci Adv 5 3 e1602532

Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis.

Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P, 2016 Aug Am J Respir Crit Care Med 3 194 333-44

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans.

Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D, Mecham RP, Frank NY, Stitziel NO, 2016 Aug Proc Natl Acad Sci U S A 31 113 8759-64

Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages.

Lee V, McMahan RS, Hu X, Gao X, Faustman EM, Griffith WC, Kavanagh TJ, Eaton DL, McGuire JK, Parks WC, 2015 May Nanotoxicology 3 9 336-43

In vitro approaches to assessing the toxicity of quantum dots.

McMahan RS, Lee V, Parks WC, Kavanagh TJ, Eaton DL, 2014 Methods Mol Biol 1199 155-63

MMP7 Coordinates Airway Epithelial Injury Response and Differentiation of Ciliated Cells.

Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P 2012 Dec Am. J. Respir. Cell Mol. Biol.