Featured Publications
Time cells in the human hippocampus and entorhinal cortex support episodic memory.
Umbach G, Kantak P, Jacobs J, Kahana M, Pfeiffer BE, Sperling M, Lega B, 2020 Oct Proc Natl Acad Sci U S A
Mohan UR, Watrous AJ, Miller JF, Lega BC, Sperling MR, Worrell GA, Gross RE, Zaghloul KA, Jobst BC, Davis KA, Sheth SA, Stein JM, Das SR, Gorniak R, Wanda PA, Rizzuto DS, Kahana MJ, Jacobs J,
2020 May
Brain Stimul
Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.
Nair DR, Laxer KD, Weber PB, Murro AM, Park YD, Barkley GL, Smith BJ, Gwinn RP, Doherty MJ, Noe KH, Zimmerman RS, Bergey GK, Anderson WS, Heck C, Liu CY, Lee RW, Sadler T, Duckrow RB, Hirsch LJ, Wharen RE, Tatum W, Srinivasan S, McKhann GM, Agostini MA, Alexopoulos AV, Jobst BC, Roberts DW, Salanova V, Witt TC, Cash SS, Cole AJ, Worrell GA, Lundstrom BN, Edwards JC, Halford JJ, Spencer DC, Ernst L, Skidmore CT, Sperling MR, Miller I, Geller EB, Berg MJ, Fessler AJ, Rutecki P, Goldman AM, Mizrahi EM, Gross RE, Shields DC, Schwartz TH, Labar DR, Fountain NB, Elias WJ, Olejniczak PW, Villemarette-Pittman NR, Eisenschenk S, Roper SN, Boggs JG, Courtney TA, Sun FT, Seale CG, Miller KL, Skarpaas TL, Morrell MJ, 2020 Jul NeurologyHippocampal Theta Oscillations Support Successful Associative Memory Formation.
Kota S, Rugg MD, Lega BC, 2020 12 J Neurosci 49 40 9507-9518
Tan RJ, Rugg MD, Lega BC,
2020 10
Neuropsychologia
147
107595
Kulkarni NJ, Lega BC,
2020 08
Neurosurgery
2
87
E138-E139
Functionally distinct high and low theta oscillations in the human hippocampus.
Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J, 2020 05 Nat Commun 1 11 2469
Hill PF, King DR, Lega BC, Rugg MD,
2020 02
Neuroimage
207
116397
Longitudinal Differences in Human Hippocampal Connectivity During Episodic Memory Processing.
Choi K, Bagen L, Robinson L, Umbach G, Rugg M, Lega B, 2020 Cereb Cortex Commun 1 1 tgaa010Seizures in glioma patients: An overview of incidence, etiology, and therapies.
Samudra N, Zacharias T, Plitt A, Lega B, Pan E, 2019 Sep J. Neurol. Sci. 404 80-85
Saboo KV, Varatharajah Y, Berry BM, Kremen V, Sperling MR, Davis KA, Jobst BC, Gross RE, Lega B, Sheth SA, Worrell GA, Iyer RK, Kucewicz MT,
2019 Nov
Sci Rep
1
9
17390
Auto-fluorescence Technology in Glioblastoma Resection: The Evolution of a New Tool and Approach.
El Ahmadieh TY, Aoun SG, Lega BC, 2019 Mar World NeurosurgHuman Verbal Memory Encoding Is Hierarchically Distributed in a Continuous Processing Stream.
Kucewicz MT, Saboo K, Berry BM, Kremen V, Miller LR, Khadjevand F, Inman CS, Wanda P, Sperling MR, Gorniak R, Davis KA, Jobst BC, Lega B, Sheth SA, Rizzuto DS, Iyer RK, Kahana MJ, Worrell GA, 2019 Jan-Feb eNeuro 1 6Neural activity reveals interactions between episodic and semantic memory systems during retrieval.
Weidemann CT, Kragel JE, Lega BC, Worrell GA, Sperling MR, Sharan AD, Jobst BC, Khadjevand F, Davis KA, Wanda PA, Kadel A, Rizzuto DS, Kahana MJ 2019 Jan J Exp Psychol Gen 1 148 1-12Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex.
Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs J, 2019 12 Nat Neurosci 12 22 2078-2086Hippocampal theta codes for distances in semantic and temporal spaces.
Solomon EA, Lega BC, Sperling MR, Kahana MJ, 2019 11 Proc Natl Acad Sci U S A 48 116 24343-24352Connectivity of the human insula: A cortico-cortical evoked potential (CCEP) study.
Dionisio S, Mayoglou L, Cho SM, Prime D, Flanigan PM, Lega B, Mosher J, Leahy R, Gonzalez-Martinez J, Nair D, 2019 11 Cortex 120 419-442Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions.
Goldstein HE, Smith EH, Gross RE, Jobst BC, Lega BC, Sperling MR, Worrell GA, Zaghloul KA, Wanda PA, Kahana MJ, Rizzuto DS, Schevon CA, McKhann GM, Sheth SA, 2019 11 J Neural Eng 6 16 066039Stimulation of the Posterior Cingulate Cortex Impairs Episodic Memory Encoding.
Natu VS, Lin JJ, Burks A, Arora A, Rugg MD, Lega B, 2019 09 J Neurosci 36 39 7173-7182
Lin JJ, Umbach G, Rugg MD, Lega B,
2019 02
Hippocampus
2
29
68-72
Khambhati AN, Kahn AE, Costantini J, Ezzyat Y, Solomon EA, Gross RE, Jobst BC, Sheth SA, Zaghloul KA, Worrell G, Seger S, Lega BC, Weiss S, Sperling MR, Gorniak R, Das SR, Stein JM, Rizzuto DS, Kahana MJ, Lucas TH, Davis KA, Tracy JI, Bassett DS,
2019
Netw Neurosci
3
3
848-877
Waldman ZJ, Camarillo-Rodriguez L, Chervenova I, Berry B, Shimamoto S, Elahian B, Kucewicz M, Ganne C, He XS, Davis LA, Stein J, Das S, Gorniak R, Sharan AD, Gross R, Inman CS, Lega BC, Zaghloul K, Jobst BC, Davis KA, Wanda P, Khadjevand M, Tracy J, Rizzuto DS, Worrell G, Sperling M, Weiss SA
2018 Sep
Epilepsy Behav
88
33-40
Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W
2018 May
Nucleic Acids Res.
Miller J, Watrous AJ, Tsitsiklis M, Lee SA, Sheth SA, Schevon CA, Smith EH, Sperling MR, Sharan A, Asadi-Pooya AA, Worrell GA, Meisenhelter S, Inman CS, Davis KA, Lega B, Wanda PA, Das SR, Stein JM, Gorniak R, Jacobs J
2018 Jun
Nat Commun
1
9
2423
Electrical Stimulation Modulates High ? Activity and Human Memory Performance.
Kucewicz MT, Berry BM, Kremen V, Miller LR, Khadjevand F, Ezzyat Y, Stein JM, Wanda P, Sperling MR, Gorniak R, Davis KA, Jobst BC, Gross RE, Lega B, Stead SM, Rizzuto DS, Kahana MJ, Worrell GA 2018 Jan-Feb eNeuro 1 5
Kucewicz MT, Berry BM, Miller LR, Khadjevand F, Ezzyat Y, Stein JM, Kremen V, Brinkmann BH, Wanda P, Sperling MR, Gorniak R, Davis KA, Jobst BC, Gross RE, Lega B, Van Gompel J, Stead SM, Rizzuto DS, Kahana MJ, Worrell GA
2018 Jan
Brain
Electrophysiological signatures of spatial boundaries in the human subiculum.
Ah Lee S, Miller JF, Watrous AJ, Sperling MR, Sharan A, Worrell GA, Berry BM, Aronson JP, Davis KA, Gross RE, Lega B, Sheth S, Das SR, Stein JM, Gorniak R, Rizzuto DS, Jacobs J 2018 Feb J. Neurosci.Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.
Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ 2018 Feb Nat Commun 1 9 365Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory.
Goyal A, Miller J, Watrous AJ, Lee SA, Coffey T, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst B, Davis KA, Inman C, Sheth SA, Wanda PA, Ezzyat Y, Das SR, Stein J, Gorniak R, Jacobs J 2018 Apr J. Neurosci.
Arora A, Lin JJ, Gasperian A, Maldjian J, Stein J, Kahana M, Lega B,
2018 12
J Neural Eng
6
15
066028
Medial temporal lobe functional connectivity predicts stimulation-induced theta power.
Solomon EA, Kragel JE, Gross R, Lega B, Sperling MR, Worrell G, Sheth SA, Zaghloul KA, Jobst BC, Stein JM, Das S, Gorniak R, Inman CS, Seger S, Rizzuto DS, Kahana MJ, 2018 10 Nat Commun 1 9 4437Widespread theta synchrony and high-frequency desynchronization underlies enhanced cognition.
Solomon EA, Kragel JE, Sperling MR, Sharan A, Worrell G, Kucewicz M, Inman CS, Lega B, Davis KA, Stein JM, Jobst BC, Zaghloul KA, Sheth SA, Rizzuto DS, Kahana MJ 2017 Nov Nat Commun 1 8 1704Contextually Mediated Spontaneous Retrieval Is Specific to the Hippocampus.
Long NM, Sperling MR, Worrell GA, Davis KA, Gross RE, Lega BC, Jobst BC, Sheth SA, Zaghloul K, Stein JM, Kahana MJ 2017 Mar Curr. Biol.
Lin JJ, Rugg MD, Das S, Stein J, Rizzuto DS, Kahana MJ, Lega BC
2017 Jun
Hippocampus
Lega B, Germi J, Rugg M,
2017 Aug
J Cogn Neurosci
8
29
1415-1432
Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans.
Ezzyat Y, Kragel JE, Burke JF, Levy DF, Lyalenko A, Wanda P, O'Sullivan L, Hurley KB, Busygin S, Pedisich I, Sperling MR, Worrell GA, Kucewicz MT, Davis KA, Lucas TH, Inman CS, Lega BC, Jobst BC, Sheth SA, Zaghloul K, Jutras MJ, Stein JM, Das SR, Gorniak R, Rizzuto DS, Kahana MJ 2017 Apr Curr. Biol.Human Genomic Signatures of Brain Oscillations During Memory Encoding.
Berto S, Wang GZ, Germi J, Lega BC, Konopka G 2017 Apr Cereb. Cortex 1-16Maximizing the potential of social media and social networks in neurosurgery.
Ban VS, Lega B, Batjer HH 2016 Mar World NeurosurgStereo-Encephalography Versus Subdural Electrodes for Seizure Localization.
Podkorytova I, Hoes K, Lega B, 2016 Jan Neurosurg. Clin. N. Am. 1 27 97-109Direct Electrical Stimulation of the Human Entorhinal Region and Hippocampus Impairs Memory.
Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS 2016 Dec Neuron 5 92 983-990Interictal epileptiform discharges impair word recall in multiple brain areas.
Horak PC, Meisenhelter S, Song Y, Testorf ME, Kahana MJ, Viles WD, Bujarski KA, Connolly AC, Robbins AA, Sperling MR, Sharan AD, Worrell GA, Miller LR, Gross RE, Davis KA, Roberts DW, Lega B, Sheth SA, Zaghloul KA, Stein JM, Das SR, Rizzuto DS, Jobst BC 2016 Dec Epilepsia
Lega B, Dionisio S, Flanigan P, Bingaman W, Najm I, Nair D, Gonzalez-Martinez J,
2015 Sep
Epilepsy Res
115
17-29
Hatanpaa KJ, Fuda F, Koduru P, Young K, Lega B, Chen W
2015 Jul
JAMA Neurol
The gamma band effect for episodic memory encoding is absent in epileptogenic hippocampi.
Lega B, Dionisio S, Bingaman W, Najm I, Gonzalez-Martinez J 2014 Sep Clin Neurophysiol
Lega B, Burke J, Jacobs J, Kahana MJ
2014 Oct
Cereb. Cortex
Hemispheric malformations of cortical development: surgical indications and approach.
Lega B, Mullin J, Wyllie E, Bingaman W 2014 Nov Childs Nerv Syst 11 30 1831-7
Zaghloul KA, Weidemann CT, Lega BC, Jaggi JL, Baltuch GH, Kahana MJ
2012 Feb
J. Neurosci.
7
32
2453-60
Human hippocampal theta oscillations and the formation of episodic memories.
Lega BC, Jacobs J, Kahana M 2012 Apr Hippocampus 4 22 748-61Neuronal and oscillatory activity during reward processing in the human ventral striatum.
Lega BC, Kahana MJ, Jaggi J, Baltuch GH, Zaghloul K 2011 Nov Neuroreport 16 22 795-800
Lega BC, Kramer DR, Newman JG, Lee JY
2011 Jan
Skull Base
1
21
65-70
Whitmore RG, Williams BJ, Lega BC, Sanborn MR, Marcotte P
2011 Dec
J Clin Neurosci
12
18
1730-2
Brain-machine interfaces: electrophysiological challenges and limitations.
Lega BC, Serruya MD, Zaghloul KA 2011 Crit Rev Biomed Eng 1 39 5-28Choosing the best operation for chronic subdural hematoma: a decision analysis.
Lega BC, Danish SF, Malhotra NR, Sonnad SS, Stein SC 2010 Sep J. Neurosurg. 3 113 615-21
Lega BC, Halpern CH, Jaggi JL, Baltuch GH
2010 Jun
Neurobiol. Dis.
3
38
354-60
Lega BC, Bailey RL, Kramer DR, Heuer GG, Chen JY, Schuster JM
2010
Brain Inj
10
24
1231-5
Lega BC, Wilfong AA, Goldsmith IL, Verma A, Yoshor D
2009 Mar
Neurosurgery
3 Suppl
64
ons195-6; discussion ons196
Danish SF, Barone D, Lega BC, Stein SC
2009 Jun
Neurosurg Focus
6
26
E2
Dannenbaum M, Lega BC, Suki D, Harper RL, Yoshor D
2008 Sep
J. Neurosurg.
3
109
410-5
Yoshor D, Bosking WH, Lega BC, Sun P, Maunsell JH
2008 Jan
J. Neurosurg.
1
108
139-44
Recurrent hemifacial spasm following minor trauma: report of a case.
Lega BC, Harper RL, Dannenbaum MD, Yoshor D 2008 Stereotact Funct Neurosurg 6 86 394-6Postoperative dural sinus thrombosis in a patient in a hypercoagulable state. Case report.
Lega BC, Yoshor D 2006 Nov J. Neurosurg. 5 105 772-4
Lega BC
2006 Mar
Neurosurgery
3
58
567-76; discussion 567-76
Role of phospholipase A2 in the stimulation of sponge cell proliferation by homologous lectin.
Gramzow M, Schröder HC, Fritsche U, Kurelec B, Robitzki A, Zimmermann H, Friese K, Kreuter MH, Müller WE, 1989 Dec Cell 5 59 939-48