How do cells orchestrate complex changes to form a polarized tubule?

Tubule formation and regeneration

Mechanisms of tubule formation and regeneration

We study tubule formation and repair in the developing embryo and in regenerating tissue to understand their shared mechanisms at the cellular and molecular level.

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Stained tissue

Mechanisms of renal glomerular formation and function

We concentrate on the interaction of a specialized pericyte - the mesangial cell - with the glomerular basement membrane.

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Stained tissue

Principal Investigator

Denise Marciano

Denise Marciano, M.D., Ph.D.

Dr. Marcian studies the cellular and molecular mechanisms that drive kidney development and repair after injury. She uses a variety of cellular, genetic, and biochemical approaches to study these processes in renal tubules and the filtration units of the kidney, called glomeruli. Her grants include awards from the March of Dimes and the NIH.

Dr. Marciano earned her bachelor’s degree from Dartmouth College, her Ph.D. in cellular biophysics at the Rockefeller University and her medical degree at Cornell University. 

She completed her medical training at the University of California San Francisco, where she became drawn to caring for patients with kidney disease and a passion for research on how the kidney develops and functions.

In 2011, she joined UT Southwestern, where she melds her clinical and scientific interests. She is not only a PI but also an attending physician at Parkland Memorial Hospital, where she sees patients with renal disease.