Meet the Team
Masaki Mizuno, M.D.
Associate Professor
Dr. Mizuno earned his doctoral degree in 2005 from Waseda University in Tokyo, Japan. He completed a postdoctoral fellowship at UT Southwestern in 2009 and then joined the faculty in 2011. He is currently an active member of the American Physiological Society, the American College of Sports Medicine and the American Heart Association.
Lab Members
Rie Ishizawa, Ph.D., RD
Assistant Instructor
Juan Estrada, Ph.D.
Instructor
Ayumi Fukazawa, Ph.D.
Postdoctoral Fellow
Martha Romero, B.S.
Lab Manager
Lab Alumni
Norio Hotta, Ph.D.
Associate Professor
Chubu University
Nan Liang, Ph.D.
Associate Professor
Kyoto University
Research
Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, focusing on the mechanisms underlying alterations in circulatory control in type1 or type2 diabetes and Alzheimer’s disease. More specifically, the lab is actively investigating the central and peripheral mechanisms underpinning the abnormal alterations in sympathetic nerve activity that accompany the pathogenesis of these diseases.
Support
Pilot Synergy Grants for Collaborative Research, UTSW Circle of Friends
NIH NHLBI R01HL151632
SHP Interdisciplinary Research Grant Program
Featured Publications
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents
Hori A, Norio H, Fukazawa A, Estrada JA, Katanosaka K, Mizumura K, Sato J, Ishizawa R, Kim HK, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J Physiol 2021 Dec
The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes
Mizuno M, Hotta N, Ishizawa R, Kim HK, Iwamoto G, Vongpatanasin W, Mitchell JH, Smith SA, Exerc Sport Sci Rev 2021 May
TRPV1 (Transient Receptor Potential Vanilloid 1) Sensitization of Skeletal Muscle Afferents in Type 2 Diabetic Rats With Hyperglycemia
Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Mitchell JH, Smith SA, Vongpatanasin W, Mizuno M, Hypertension 2021 Mar HYPERTENSIONAHA12015672
Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in non-diabetic older adults
Hotta N, Hori A, Okamura Y, Baba R, Watanabe H, Sugawara J, Vongpatanasin W, Wang J, Kim HK, Ishizawa R, Iwamoto GA, Mitchell JH, Smith SA, Mizuno M. J Appl Physiol (1985). 2020 Jun 25.
Skeletal Muscle Reflex-Induced Sympathetic Dysregulation and Sensitization of Muscle Afferents in Type 1 Diabetic Rats
Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, Hypertension 2020 Feb HYPERTENSION AHA11914118
Insulin potentiates the response to mechanical stimuli in small dorsal root ganglion neurons and thin fibre muscle afferents in vitro
Hotta N, Katanosaka K, Mizumura K, Iwamoto GA, Ishizawa R, Kim HK, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J. Physiol. (Lond.) 2019 Aug
Exaggerated pressor and sympathetic responses to stimulation of the mesencephalic locomotor region and exercise pressor reflex in type II diabetic rats
Kim HK, Hotta N, Ishizawa R, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, Am. J. Physiol. Regul. Integr. Comp. Physiol. 2019 May
The Pressor Response to Concurrent Stimulation of the Mesencephalic Locomotor Region and Peripheral Sensory Afferents Is Attenuated in Normotensive but Not Hypertensive Rats
Liang N, Iwamoto GA, Downey RM, Mitchell JH, Smith SA, Mizuno M Front Physiol 2019 10 95
Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive rats
Liang N, Mitchell JH, Smith SA, Mizuno M Am. J. Physiol. Heart Circ. Physiol. 2015 Nov ajpheart.00479.2015
Mailing Address
UT Southwestern Medical Center
5323 Harry Hines Blvd,
Dallas, TX 75390-9174