Autonomic control of the cardiovascular system

Meet the Team

Masaki Mizuno

Masaki Mizuno, M.D.

Associate Professor

Dr. Mizuno earned his doctoral degree in 2005 from Waseda University in Tokyo, Japan. He completed a postdoctoral fellowship at UT Southwestern in 2009 and then joined the faculty in 2011. He is currently an active member of the American Physiological Society, the American College of Sports Medicine and the American Heart Association.

Lab Members

Rie Ishizawa, Ph.D., RD

Assistant Instructor

Rie Ishizawa

Juan Estrada, Ph.D.

Instructor

Juan Estrada

Ayumi Fukazawa, Ph.D.

Postdoctoral Fellow

Ayumi Fukazawa

Martha Romero, B.S.

Lab Manager

Martha Romero

Lab Alumni

Norio Hotta, Ph.D.

Associate Professor
Chubu University

Norio Hotta, Ph.D.

Nan Liang, Ph.D.

Associate Professor
Kyoto University

 
 
Nan Liang

Research

Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, focusing on the mechanisms underlying alterations in circulatory control in type1 or type2 diabetes and Alzheimer’s disease. More specifically, the lab is actively investigating the central and peripheral mechanisms underpinning the abnormal alterations in sympathetic nerve activity that accompany the pathogenesis of these diseases.

Support

Pilot Synergy Grants for Collaborative Research, UTSW Circle of Friends

NIH NHLBI R01HL151632

SHP Interdisciplinary Research Grant Program

Featured Publications

Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents
Hori A, Norio H, Fukazawa A, Estrada JA, Katanosaka K, Mizumura K, Sato J, Ishizawa R, Kim HK, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J Physiol 2021 Dec

The Impact of Insulin Resistance on Cardiovascular Control during Exercise in Diabetes
Mizuno M, Hotta N, Ishizawa R, Kim HK, Iwamoto G, Vongpatanasin W, Mitchell JH, Smith SA, Exerc Sport Sci Rev 2021 May

TRPV1 (Transient Receptor Potential Vanilloid 1) Sensitization of Skeletal Muscle Afferents in Type 2 Diabetic Rats With Hyperglycemia
Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Mitchell JH, Smith SA, Vongpatanasin W, Mizuno M, Hypertension 2021 Mar HYPERTENSIONAHA12015672

Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in non-diabetic older adults
Hotta N, Hori A, Okamura Y, Baba R, Watanabe H, Sugawara J, Vongpatanasin W, Wang J, Kim HK, Ishizawa R, Iwamoto GA, Mitchell JH, Smith SA, Mizuno M. J Appl Physiol (1985). 2020 Jun 25.

Skeletal Muscle Reflex-Induced Sympathetic Dysregulation and Sensitization of Muscle Afferents in Type 1 Diabetic Rats
Ishizawa R, Kim HK, Hotta N, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, Hypertension 2020 Feb HYPERTENSION AHA11914118

Insulin potentiates the response to mechanical stimuli in small dorsal root ganglion neurons and thin fibre muscle afferents in vitro
Hotta N, Katanosaka K, Mizumura K, Iwamoto GA, Ishizawa R, Kim HK, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, J. Physiol. (Lond.) 2019 Aug

Exaggerated pressor and sympathetic responses to stimulation of the mesencephalic locomotor region and exercise pressor reflex in type II diabetic rats
Kim HK, Hotta N, Ishizawa R, Iwamoto GA, Vongpatanasin W, Mitchell JH, Smith SA, Mizuno M, Am. J. Physiol. Regul. Integr. Comp. Physiol. 2019 May

The Pressor Response to Concurrent Stimulation of the Mesencephalic Locomotor Region and Peripheral Sensory Afferents Is Attenuated in Normotensive but Not Hypertensive Rats
Liang N, Iwamoto GA, Downey RM, Mitchell JH, Smith SA, Mizuno M Front Physiol 2019 10 95

Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive rats
Liang N, Mitchell JH, Smith SA, Mizuno M Am. J. Physiol. Heart Circ. Physiol. 2015 Nov ajpheart.00479.2015

Contact Us

Masaki Mizuno, PhD
Associate Professor

Email

Mailing Address

UT Southwestern Medical Center
5323 Harry Hines Blvd,
Dallas, TX 75390-9174