Personnel

Marek Napierala, Ph.D.

Associate Professor

Research Interests: I have more than 25 years of experience studying the molecular mechanisms associated with human diseases that are caused by the expansion of repeat sequences. Work in my group is focused on pathogenic GAA repeat sequences expanded in Friedreich’s ataxia. My laboratory is interested in both basic questions related to molecular mechanisms of FRDA as well as in the development of therapeutic strategies for this disease. My long-term research goal is to uncover pathways that are involved in the pathogenesis of FRDA in order to target them for therapeutic intervention. Our laboratory utilizes both cellular (induced pluripotent stem cell-derived) and mouse models of this disease. We also established the Friedreich’s Ataxia Cell Line Repository, the world’s largest bank of primary FRDA fibroblasts and induced pluripotent stem cell lines that currently holds more than 100 lines derived from different FRDA patients. My laboratory is also involved in the FRDA patient community, hosting interactive yearly meetings with FRDA patients and their caregivers. An essential part of our research program is mentoring the next generation of ataxia researchers, graduate students, postdoctoral fellows, and visiting scientists. Our laboratory always has openings for dedicated students and scientists.

Jill S. Napierala, Ph.D.

Assistant Professor

My research efforts are devoted to defining molecular mechanisms underlying the most commonly inherited ataxia in humans, Friedreich’s ataxia (FRDA). FRDA is a severe and progressive neurodegenerative disease that is caused by reduced expression of the Frataxin (FXN) gene. The majority of FRDA patients carry homozygous GAA repeat expansions in intron 1 of the FX N gene, while a fraction of patients are compound heterozygotes, carrying an expanded GAA repeat sequence in one allele and a missense or nonsense mutation in the other. The most common result of both types of lesions is lower levels of Frataxin, a mitochondrial protein involved in iron sulfur cluster synthesis. FRDA affects multiple organ systems and currently there is no cure for this disease nor are there approved drugs to treat the symptoms or prolong longevity for FRDA patients. My research areas include: specifying gene expression patterns unique to FRDA in order to identify novel therapeutic targets and disease biomarkers; modulating the expression and activity of mitochondrial aldehyde dehydrogenases to inhibit neurodegeneration in FRDA cell line and animal models; and defining pathogenic mechanisms of Frataxin missense mutations in FRDA.

Jixue Li, Ph.D.

Jixue Li, Ph.D.

Research Scientist

Education: Ph.D., Zhengzhou University, China

Research Interests: Mechanisms of repeat expansion in FRDA, modeling FRDA using iPSC-derived cells, genome editing and regulation of gene expression, developing therapeutic strategies for FRDA

Hobbies/Interests: Cooking, fishing

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Shibani Mukherjee, Ph.D.

Shibani Mukherjee, Ph.D.

Research Scientist

Education: Ph.D., India

Research Interests: Development of a system to check the potency of drugs developed against FRDA, role of frataxin in development of the nervous system

Hobbies/Interests: Reading, traveling, and gardening

Agnieszka Zimna, Ph.D.

Agnieszka Zimna, Ph.D.

Visiting Senior Researcher

Education: Ph.D., Institute of Human Genetics, Department of Reproductive Biology and Stem Cells, Poznan, Poland

Research Interests: iPSC differentiation for disease modelling, cardiomyocyte differentiation and culturing, electrophysiology of cardiomyocytes, regenerative medicine, cardiovascular research, cardiac studies in mice

Hobbies/Interests: bike, gym, ice-skating, long walks, restaurants and food, travel

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Terry Gemelli

Terry Gemelli

Research Scientist

Education: BS, the University of Texas at Arlington

Research Interests: use of antisense oligonucleotides to treat neurological diseases, understanding the impact of point mutations on frataxin protein maturation and stability in Friedreich’s ataxia

Hobbies/Interests: Running, lifting weights, gardening, crafts, and enjoying my cats and dogs

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Brandon Gerhart, M.S.

Brandon Gerhart, M.S.

Research Technician

Education: M.S., Mississippi State University

Research Interests: Molecular biology and genetics, animal models of human diseases

Hobbies/Interests: Fishing, hiking, and playing guitar

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Alumni

Research Scientists and Faculty

Yanjie Li, Ph.D.

Kevin Pawlik, Ph.D.

Jun Wang, M.D.

Larisa Pereboeva, M.D., Ph.D.

Helen (Guihua) Zhou, M.D., Ph.D.

Postdocs and Graduate Students

Angela Bhalla, Ph.D.

Daniel Fil, Ph.D.

Eunah Kim, Ph.D.

Kinga Linowiecka, Ph.D.

Ashlee Long, M.S.

Urszula Polak, Ph.D.

Natalia Rozwadowska, Ph.D.

Anna Schreiber, Ph.D.

Siyuan (Alice) Zhang, Ph.D.

Undergraduate and Rotation Students

Jordan Barham

Yu-Yun Chen

Amanda Clark

Matthew Lyons

Claudia Reyes

Randee Sedaka

Jiesen Zhang

Technicians

Barry Cochran

Robbie Conley

Cherlene Hardy

Elizabeth McIvor

Markia Robinson

Zachary Whaley

Opportunities

The Napierala Lab is looking for highly motivated graduate students and postdocs to join our group. Please email your CV to Marek Napierala, Ph.D. for consideration.

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