Publications

Tran TA, Zhang QJ, Wang L, Gonzales C, Girard L, May H, Gillette T, Liu ZP, Martinez EDInhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival. J Biol Chem. 2022 Feb;298(2):101515. doi: 10.1016/j.jbc.2021.101515. Epub 2021 Dec 18. PubMed PMID: 34933013; PubMed Central PMCID: PMC8803621.

Son J, Huang S, Zeng Q, Bricker TL, Zhou JB, Zang R, Liu Z, Chang X, Harastani HH, Chen L, Castro MG, Zhao Y, Hou G, Fan B, Niu B, Guo R, Rothlauf PW, Bailey AL, Wang X, Shi PY, Martinez ED, Whelan SJ, Diamond MS, Boon AN, Li B, Ding S. JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis. mBio. 2022 January.

Bayo J, Fiore EJ, Dominguez LM, Cantero MJ, Ciarlantini MS, Malvicini M, Atorrasagasti C, Garcia MG, Rossi M, Cavasotto C, Martinez E, Comin J, Mazzolini GD. Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinoma. Gut. 2021 Jul;70(7):1362-1374. doi: 10.1136/gutjnl-2020-321454. Epub 2020 Oct 26. PubMed PMID: 33106353.

Khaliq M, Manikkam M, Martinez ED, Fallahi-Sichani M. Epigenetic modulation reveals differentiation state specificity of oncogene addiction. Nat Commun. 2021 Mar 9;12(1):1536. doi: 10.1038/s41467-021-21784-2. PubMed PMID: 33750776; PubMed Central PMCID: PMC7943789.

Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez, E.D.A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. PMID- 23792809

Hu, Y., Martinez, E.D. and MacMillan, J. Anthraquinones from a marine-derived Streptomyces spinoverrucosus. J Nat Prod. 2012 Oct 26;75(10):1759-64. PMID:23057874

Chang, J., Varghese, D.S., Gillam, M.C., Peyton, M., Modi, B., Schiltz, R.L., Girard, L., and Martinez, E.D. Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide, (2012), British Journal of Cancer, Jan 3;106(1):116-25. Epub 2011 Dec 8. PMCID: PMC Journal-In Process.

Best, A., Chang, J., Dull, A., Beutler, J. and Martinez, E.D. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell based assay, (2011), Journal of Biomedicine and Biotechnology, 2011:868095. Epub 2010 Dec 22. PMCID: PMC3014726

Holbeck, S., Chang, J., Best, A.M., Bookout, A.L., Mangelsdorf, D.J. and Martinez, E.D. Expression Profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions, (2010), Mol Endocrinol. 24(6):1287-96. PMID: 20375240. PMCID: PMC2875807.

Slack, M.D., Martinez, E.D., Wu, L.F. and Altschuler, S.J. Characterizing heterogeneous cellular responses to perturbations (2008), PNAS 105 (49):19306-11. PMID: 19052231. PMCID: PMC2614757.

Johnson, R.J., Huang, W., Jadhav, A., Austin, C.P., Inglese, J. and Martinez, E.D. A Quantitative High-Throughput Screen Identifies Potential Epigenetic Modulators of Gene Expression, (2008), Analytical Biochemistry 375(2):237-48. PMID: 18211814. PMCID: PMC2330280.

Martinez, E.D., Botos J., Dohoney K.M., Geiman T.M.,Kolla S.S., Olivera A., Qiu Y., Rayasam G.V., Stavreva D.A., Cohen-Fix O. Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition, (2007), EMBO Rep. 11:977-981.

Martinez, E.D., Dull, A., McMahon, J., Beutler, J. and Hager, G.L., High content fluorescence-based screening for epigenetic modulators, (2006), Methods in Enzymol. 414:21-36. PMID: 17110184.

Martinez, E.D. and Hager, G.L. Development of assays for nuclear receptor ligands using fluorescently tagged proteins, (2006), Methods in Enzymol. 414:37-50. PMID: 17110185.

Auld, D.S., Johnson, R.L., Zhang, Y.,  Veith, H., Jadhav, A., Yasgar, A.,  Simeonov, A., Zheng, W., Martinez, E.D., Westwick, J.K., Austin, C.P., and Inglese, J. Fluorescent protein-based cellular assays analyzed by laser scanning microplate cytometry in 1536-well plate format, (2006), Methods in Enzymol. 414:566-589. PMID: 17110211.

Qiu, Y., Zhao, Y., Becker, M., John, S., Parekh, B.S., Huang, S., Hendarwanto, A., Martinez, E.D., Chen, Y., Lu, H., Adkins, N.L., Stavreva, D.A., Wiench, M., Georgel, P.T., Schiltz, R.L., and Hager, G.L. HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription, (2006), Molecular Cell 22:669-679. PMID: 16762839.

Martinez, E.D., Rayasam, G., Dull, A., Walker, D. and Hager, G.L. An Estrogen Receptor Chimera Senses Ligands by Nuclear Translocation (2005), J Steroid Biochem Mol Biol 97(4):307-321. PMID: 16162406.

Martinez, E.D., Pattabiraman, N. and Danielsen, M. Analysis of the hormone binding domain of steroid receptors using chimeras generated by homologous recombination (2005), Exp. Cell Research 308(2):320-33. PMID: 15936754.

Nagaich, A.K., Rayasam, G.V., Martinez, E.D., Becker, M., Qiu, Y., Johnson, T.A., Elbi, C., Fletcher, T.M., John, S., and Hager, G.L. Subnuclear Trafficking and Gene Targeting by Steroid Receptors (2004), Ann N.Y. Acad. Sci. 1024:213-220. PMID: 15265783.

Tirado, O.M., Martinez, E.D., Rodriguez, O.C., Danielsen, M., Selva, D.M., Reventos, J., Munell, F. and Suarez-Quian, C.A. Short-term effects of Methoxyacetic Acid on Androgen Receptor and Androgen-Binding Protein Expression in Adult Rat Testis (2003), Biol Reprod 68(4):1437-1446.  PMID: 12606434.

Martinez, E.D. and Danielsen, M. Loss of androgen receptor transcriptional activity at the G1/S transition: involvement of acetylation pathways (2002), Journal of Biological Chemistry 277(33):29719-29729. PMID: 12055183.

List, H.J, Smith, C., Martinez, E.D., Harris, V., Danielsen, M. and Riegel, A. Effects of Antiandrogens on Chromatin Remodeling and Transcription of the Integrated Mouse Mammary Tumor Virus Promoter (2000), Exp. Cell Research 260:160-165. PMID: 11010820.

Martinez, E., Moore, D., Keller, E., Pearce, D., Vanden Heuvel, J.P., Robinson, V., Gottlieb, B., McDonald, P., Simons, S., Sanchez, E. and Danielsen, M. The Nuclear Receptor Resource: a growing family (1998), Nucleic Acids Res 26:239-241.  PMID: 9471621.

Martinez, E., Moore, D., Keller, E. Pearce, D., Robinson, V., McDonald, P., Simons, S., Sanchez, E., Danielsen, M. The Nuclear Receptor Resource Project (1997), Nucleic Acids Res 25:163-165. PMID: 9016529.

Danielsen, M. and Martinez, EThe glucocorticoid receptor resource (1996), Nucleic Acids Res 24:155-156. PMID: 8594567.