Publications

Link out: Single nucleus RNAseq on developing mouse superior colliculi Link out: RNAseq web portal for Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

Erratum: Differential Effects of Unfolded Protein Response Pathways on Axon Injury-Induced Death of Retinal Ganglion Cells (Neuron (2012) 73(3) (445–452), (S089662731200030X), (10.1016/j.neuron.2011.11.026))

Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z 2024 Oct Neuron 112 3371

IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice

Yuan H, Chen S, Duncan MR, de Rivero Vaccari JP, Keane RW, Dalton Dietrich W, Chou TH, Benny M, Schmidt AF, Young K, Park KK, Porciatti V, Elizabeth Hartnett M, Wu S 2024 Aug Angiogenesis 27 423-440

Retrograde AAV-mediated gene modulation reveals chloride intracellular channel proteins as potent regulators of retinal ganglion cell death

Tapia M, Levay K, Tsoulfas P, Park KK 2024 Jul Experimental Neurology 377

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

Author Collaboration TR, Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV, Fouda AY, Ashok A, Moshiri A, Chedotal A, Reed AA, Askary A, Su AJ, La Torre A, Jalligampala A, Silva-Lepe A, Das A, Wirostko B, Frankfort BJ, Sivyer B, Alapure B, Young B, Clark B, Jones BW, Hellmer C, Mitchell C, Ufongene C, Goldman D, Feldheim D, Park KK, Varadarajan S 2023 Dec Molecular neurodegeneration 18

GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice

Sonny S, Yuan H, Chen S, Duncan MR, Chen P, Benny M, Young K, Park KK, Schmidt AF, Wu S 2023 Dec Scientific reports 13

Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly

Choi JS, Ayupe AC, Beckedorff F, Catanuto P, McCartan R, Levay K, Park KK 2023 Sep Cell Reports 42

Optic nerve diseases and regeneration: How far are we from the promised land?

Cen LP, Park KK, So KF 2023 Aug Clinical and Experimental Ophthalmology 51 627-641

Editorial: Promoting nervous system regeneration by treatments targeting neuron-glia interactions

De Lima S, Mietto BS, Ribas VT, Ribeiro-Resende VT, Oliveira AL, Park KK 2023 Frontiers in Cellular Neuroscience 17

Retinal ganglion cell expression of cytokine enhances occupancy of NG2 cell-derived astrocytes at the nerve injury site: Implication for axon regeneration

Ribeiro M, Ayupe AC, Beckedorff FC, Levay K, Rodriguez S, Tsoulfas P, Lee JK, Nascimento-dos-Santos G, Park KK 2022 Sep Experimental Neurology 355

Awakening dormant neurons long after spinal cord injury

Tapia ML, Park KK 2022 Sep PLoS biology 20

Subtype-specific survival and regeneration of retinal ganglion cells in response to injury

Tapia ML, Nascimento-dos-Santos G, Park KK 2022 Aug Frontiers in Cell and Developmental Biology 10

Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells

Ayupe AC, Beckedorff F, Levay K, Yon B, Salgueiro Y, Shiekhattar R, Park KK 2021 Dec BMC Genomics 22

Proteomics and systems biology in optic nerve regeneration

Meehan SD, Abdelrahman L, Arcuri J, Park KK, Samarah M, Bhattacharya SK 2021 Jan 249-270

Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing

Moses C, Hodgetts SI, Nugent F, Ben-Ary G, Park KK, Blancafort P, Harvey AR 2020 Dec Scientific reports 10

Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration

Chauhan MZ, Arcuri J, Park KK, Zafar MK, Fatmi R, Hackam AS, Yin Y, Benowitz L, Goldberg JL, Samarah M, Bhattacharya SK 2020 Feb iScience 23

1.38 - Regeneration of Retinal Ganglion Cell Axons

Park KK 2020 Jan 1 630-641

Neural cadherin plays distinct roles for neuronal survival and axon growth under different regenerative conditions

Ribeiro M, Levay K, Yon B, Ayupe AC, Salgueiro Y, Park KK 2020 eNeuro 7 1-18

Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

Bray ER, Yungher BJ, Levay K, Ribeiro M, Dvoryanchikov G, Ayupe AC, Thakor K, Marks V, Randolph M, Danzi MC, Schmidt TM, Chaudhari N, Lemmon VP, Hattar S, Park KK 2019 Aug Neuron 103 642-657.e7

Optic nerve regeneration in mammals: Regenerated or spared axons?

Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK 2017 Oct Experimental Neurology 296 83-88

3D visualization of individual regenerating retinal ganglion cell axons reveals surprisingly complex growth paths

Bray ER, Noga M, Thakor K, Wang Y, Lemmon VP, Park KK, Tsoulfas P 2017 Jul eNeuro 4

Regenerative responses and axon pathfinding of retinal ganglion cells in chronically injured mice

Yungher BJ, Ribeiro M, Park KK 2017 Mar Investigative Ophthalmology and Visual Science 58 1743-1750

Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse

Patel AK, Park KK, Hackam AS 2017 Feb Neuroscience 343 372-383

Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats

Park KK, Luo X, Mooney SJ, Yungher BJ, Belin S, Wang C, Holmes MM, He Z 2017 Feb Journal of Comparative Neurology 525 380-388

Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells

Dvoriantchikova G, Pappas S, Luo X, Ribeiro M, Danek D, Pelaez D, Park KK, Ivanov D 2016 Dec European Journal of Neuroscience 44 2935-2943

Hyperactivated Stat3 boosts axon regeneration in the CNS

Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP 2016 Jun Experimental Neurology 280 115-120

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK 2016 Apr Cell Reports 15 398-410

Viral vector-based improvement of optic nerve regeneration: Characterization of individual axons' growth patterns and synaptogenesis in a visual target

Yungher BJ, Luo X, Salgueiro Y, Blackmore MG, Park KK 2015 Oct Gene Therapy 22 811-821

3D imaging of axons in transparent spinal cords from rodents and nonhuman primates

Soderblom C, Lee DH, Dawood A, Carballosa M, Santamaria AJ, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, Lemmon VP, Lee JK, Tsoulfas P 2015 Mar eNeuro 2

Mammalian target of Rapamycin’s distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS

Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK 2014 Nov Journal of Neuroscience 34 15347-15355

Application of tissue clearing and light sheet fluorescence microscopy to assess optic nerve regeneration in unsectioned tissues

Luo X, Yungher B, Park KK 2014 Methods in Molecular Biology 1162 209-217

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration

Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H 2013 Oct Experimental Neurology 248 157-169

Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury

Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK 2013 Sep Experimental Neurology 247 653-662

Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells

Chou TH, Park KK, Luo X, Porciatti V 2013 Feb Investigative Ophthalmology and Visual Science 54 1236-1243

Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury

Soderblom C, Luo X, Blumenthal E, Bray E, Lyapichev K, Ramos J, Krishnan V, Lai-Hsu C, Park KK, Tsoulfas P, Lee JK 2013 Journal of Neuroscience 33 13882-13887

Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells

Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z 2012 Feb Neuron 73 445-452

Neuron-Intrinsic Inhibitors of Axon Regeneration: PTEN and SOCS3

Luo X, Park KK 2012 141-173

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z 2011 Dec Nature 480 372-375

Neuronal intrinsic mechanisms of axon regeneration

Liu K, Tedeschi A, Park KK, He Z 2011 Jul Annual Review of Neuroscience 34 131-152

The life, death and regenerative ability of immature and mature rat retinal ganglion cells are influenced by their birthdate

Dallimore EJ, Park KK, Pollett MA, Taylor JS, Harvey AR 2010 Oct Experimental Neurology 225 353-365

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z 2010 Sep Nature neuroscience 13 1075-1081

PTEN/mTOR and axon regeneration

Park KK, Liu K, Hu Y, Kanter JL, He Z 2010 May Experimental Neurology 223 45-50

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z 2009 Dec Neuron 64 617-623

Cytokine-induced SOCS expression is inhibited by cAMP analogue: Impact on regeneration in injured retina

Park KK, Hu Y, Muhling J, Pollett MA, Dallimore EJ, Turnley AM, Cui Q, Harvey AR 2009 Jun Molecular and Cellular Neuroscience 41 313-324

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z 2008 Nov Science 322 963-966

Gene therapy and transplantation in CNS repair: The visual system

Harvey AR, Hu Y, Leaver SG, Mellough CB, Park K, Verhaagen J, Plant GW, Cui Q 2006 Sep Progress in Retinal and Eye Research 25 449-489

Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells

Park K, Luo JM, Hisheh S, Harvey AR, Cui Q 2004 Dec Journal of Neuroscience 24 10806-10815