Publications

Link out: Single nucleus RNAseq on developing mouse superior colliculi Link out: RNAseq web portal for Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly.

Choi JS, Ayupe AC, Beckedorff F, Catanuto P, McCartan R, Levay K, Park KK, 2023 Aug Cell Rep 9 42 113037

Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells.

Ayupe AC, Beckedorff F, Levay K, Yon B, Salgueiro Y, Shiekhattar R, Park KK, 2021 Oct BMC Genomics 1 22 741

Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells.

Bray ER, Yungher BJ, Levay K, Ribeiro M, Dvoryanchikov G, Ayupe AC, Thakor K, Marks V, Randolph M, Danzi MC, Schmidt TM, Chaudhari N, Lemmon VP, Hattar S, Park KK, 2019 Aug Neuron 4 103 642-657.e7

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System.

Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK 2016 Apr Cell Rep 2 15 398-410

Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury.

Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK 2013 Mar Exp. Neurol.

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.

Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z, 2008 Nov Science 5903 322 963-6

AAV2-Retro-Mediated Gene Transfer Selectively Targets Outer Retinal Cells Following Intravitreal Injection.

Kinane C, Panchal M, Tsoulfas P, Talla V, Park KK, 2026 Mar Invest Ophthalmol Vis Sci 3 67 54

Long non-coding RNAs: Emerging regulators of diverse programmed cell death pathways in neurons.

Mathew NC, Park KK, 2025 Sep Neural Regen Res

Enhancing neural stem cell integration in the injured spinal cord through targeted PTEN modulation.

Geniscan S, Park HH, Kim HS, Yoo S, Kim H, Jang BS, Hwang DH, Park KK, Kim BG, 2025 Jan Neural Regen Res

Concept of Normativity in Multi-Omics Analysis of Axon Regeneration.

Moceri I, Meehan S, Gonzalez E, Park KK, Hackam A, Lee RK, Bhattacharya S, 2024 Jun Biomolecules 7 14

Retrograde AAV-mediated gene modulation reveals chloride intracellular channel proteins as potent regulators of retinal ganglion cell death.

Tapia M, Levay K, Tsoulfas P, Park KK, 2024 Jul Exp Neurol 377 114810

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.

Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV, 2023 Sep Mol Neurodegener 1 18 64

GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice.

Sonny S, Yuan H, Chen S, Duncan MR, Chen P, Benny M, Young K, Park KK, Schmidt AF, Wu S, 2023 Jan Sci Rep 1 13 143

Optic nerve diseases and regeneration: How far are we from the promised land?

Cen LP, Park KK, So KF, 2023 Aug Clin Exp Ophthalmol 6 51 627-641

Awakening dormant neurons long after spinal cord injury.

Tapia ML, Park KK, 2022 Sep PLoS Biol 9 20 e3001830

Retinal ganglion cell expression of cytokine enhances occupancy of NG2 cell-derived astrocytes at the nerve injury site: Implication for axon regeneration.

Ribeiro M, Ayupe AC, Beckedorff FC, Levay K, Rodriguez S, Tsoulfas P, Lee JK, Nascimento-Dos-Santos G, Park KK, 2022 Sep Exp Neurol 355 114147

Subtype-specific survival and regeneration of retinal ganglion cells in response to injury.

Tapia ML, Nascimento-Dos-Santos G, Park KK, 2022 Front Cell Dev Biol 10 956279

Proteomics and systems biology in optic nerve regeneration.

Meehan SD, Abdelrahman L, Arcuri J, Park KK, Samarah M, Bhattacharya SK, 2021 Adv Protein Chem Struct Biol 127 249-270

Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing.

Moses C, Hodgetts SI, Nugent F, Ben-Ary G, Park KK, Blancafort P, Harvey AR, 2020 Jul Sci Rep 1 10 11393

Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration.

Chauhan MZ, Arcuri J, Park KK, Zafar MK, Fatmi R, Hackam AS, Yin Y, Benowitz L, Goldberg JL, Samarah M, Bhattacharya SK, 2020 Feb iScience 2 23 100836

Neural Cadherin Plays Distinct Roles for Neuronal Survival and Axon Growth under Different Regenerative Conditions.

Ribeiro M, Levay K, Yon B, Ayupe AC, Salgueiro Y, Park KK, 2020 eNeuro 6 7

Optic nerve regeneration in mammals: Regenerated or spared axons?

Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK, 2017 Oct Exp Neurol 296 83-88

Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice.

Yungher BJ, Ribeiro M, Park KK, 2017 Mar Invest Ophthalmol Vis Sci 3 58 1743-1750

Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse.

Patel AK, Park KK, Hackam AS, 2017 Feb Neuroscience 343 372-383

3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths.

Bray ER, Noga M, Thakor K, Wang Y, Lemmon VP, Park KK, Tsoulfas P, 2017 eNeuro 4 4

Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats.

Park KK, Luo X, Mooney SJ, Yungher BJ, Belin S, Wang C, Holmes MM, He Z 2016 Jun J. Comp. Neurol.

Virally delivered, constitutively active NF?B improves survival of injured retinal ganglion cells.

Dvoriantchikova G, Pappas S, Luo X, Ribeiro M, Danek D, Pelaez D, Park KK, Ivanov D 2016 Aug Eur. J. Neurosci.

Hyperactivated Stat3 boosts axon regeneration in the CNS.

Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP 2016 Apr Exp. Neurol. 280 115-120

Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target.

Yungher BJ, Luo X, Salgueiro Y, Blackmore MG, Park KK 2015 May Gene Ther.

3D Imaging of Axons in Transparent Spinal Cords from Rodents and Nonhuman Primates.

Soderblom C, Lee DH, Dawood A, Carballosa M, Jimena Santamaria A, Benavides FD, Jergova S, Grumbles RM, Thomas CK, Park KK, Guest JD, Lemmon VP, Lee JK, Tsoulfas P, 2015 eNeuro 2 2

Mammalian Target of Rapamycin's Distinct Roles and Effectiveness in Promoting Compensatory Axonal Sprouting in the Injured CNS.

Lee DH, Luo X, Yungher BJ, Bray E, Lee JK, Park KK 2014 Nov J. Neurosci. 46 34 15347-55

Application of tissue clearing and light sheet fluorescence microscopy to assess optic nerve regeneration in unsectioned tissues.

Luo X, Yungher B, Park KK 2014 Methods Mol. Biol. 1162 209-17

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.

Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H 2013 Jun Exp. Neurol.

Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury.

Soderblom C, Luo X, Blumenthal E, Bray E, Lyapichev K, Ramos J, Krishnan V, Lai-Hsu C, Park KK, Tsoulfas P, Lee JK 2013 Aug J. Neurosci. 34 33 13882-7

Retrograde signaling in the optic nerve is necessary for electrical responsiveness of retinal ganglion cells.

Chou TH, Park KK, Luo X, Porciatti V 2013 Invest. Ophthalmol. Vis. Sci. 2 54 1236-43

Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells.

Hu Y, Park KK, Yang L, Wei X, Yang Q, Cho KS, Thielen P, Lee AH, Cartoni R, Glimcher LH, Chen DF, He Z, 2012 Feb Neuron 3 73 445-52

Neuron-intrinsic inhibitors of axon regeneration: PTEN and SOCS3.

Luo X, Park KK, 2012 Int Rev Neurobiol 105 141-73

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.

Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z, 2011 Nov Nature 7377 480 372-5

Neuronal intrinsic mechanisms of axon regeneration.

Liu K, Tedeschi A, Park KK, He Z, 2011 Annu Rev Neurosci 34 131-52

PTEN deletion enhances the regenerative ability of adult corticospinal neurons.

Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z, 2010 Sep Nat Neurosci 9 13 1075-81

The life, death and regenerative ability of immature and mature rat retinal ganglion cells are influenced by their birthdate.

Dallimore EJ, Park KK, Pollett MA, Taylor JS, Harvey AR, 2010 Oct Exp Neurol 2 225 353-65

PTEN/mTOR and axon regeneration.

Park KK, Liu K, Hu Y, Kanter JL, He Z, 2010 May Exp Neurol 1 223 45-50

Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retina.

Park KK, Hu Y, Muhling J, Pollett MA, Dallimore EJ, Turnley AM, Cui Q, Harvey AR, 2009 Jul Mol Cell Neurosci 3 41 313-24

SOCS3 deletion promotes optic nerve regeneration in vivo.

Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z, 2009 Dec Neuron 5 64 617-23

Gene therapy and transplantation in CNS repair: the visual system.

Harvey AR, Hu Y, Leaver SG, Mellough CB, Park K, Verhaagen J, Plant GW, Cui Q, 2006 Sep Prog Retin Eye Res 5 25 449-89

Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.

Park K, Luo JM, Hisheh S, Harvey AR, Cui Q, 2004 Dec J Neurosci 48 24 10806-15