Engineering light-based solutions for biomedical challenges.
We are focused on the development and translation of new tools for non-invasive characterization of physiology and disease. By working with multidisciplinary teams spanning engineering and medicine, our aim is to bring new technological solutions to the bedside, to address major challenges in medical care, and to improve patient outcomes and quality of life.
Raman scattering is an optical interaction that can be used for non-destructive physicochemical characterization of samples without the use of exogenous contrast or sample preparation. We apply spontaneous and coherent Raman microscopy approaches to visualize and quantify spatial and compositional properties of biomedical samples.
Using portable system components and versatile designs for light delivery and collection, we develop devices that directly interface with patients in a clinical setting. Non-invasive tool development enables the measurement of pathological changes and treatment response to augment screening, diagnosis, monitoring, and prediction across multiple tissues and diseases.
Data acquisition across over time in 3D space with encoded spectral information provides rich, multidimensional signals for complex analysis. Spanning multivariate statistical modeling and machine learning techniques, we develop new analytical methods to extract and represent biomedical data for medical decision making.
High spatial and spectral resolution analysis, rapid measurements, and sensitive detection tools enable the characterization of disease markers. By looking at the heterogeneity of biomarkers in tissue and patient-derived samples, improved detection approaches can be created to quantify disease processes amid the natural variation of human physiology.
Meet the PI
Dr. Isaac Pence is an Assistant Professor of Biomedical Engineering and Assistant Professor of Internal Medicine. The Pence lab develops and applies translational biophotonics technologies to address outstanding challenges in medicine and biology with an initial focus on cutaneous manifestations of systemic disease.
Department of Biomedical Engineering
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75390-9397
The laboratory and department are located on the South Campus of UT Southwestern, on the second floor of the Jonsson (K) and Moss (J) Buildings.
Looking for non-invasive and label-free tools for imaging and analysis? Interested in our imaging research? Get in touch to learn more or find out ways to collaborate.
The Pence Lab @ UT Southwestern is hiring! Come join the team.
The lab is seeking highly motivated students, postdocs, and clinical fellows with an interest in Biophotonics who are excited to develop and translate new optical spectroscopic and imaging tools to the bedside to expand our understanding of disease, monitor therapy response, and predict patient outcomes.
Prospective postdocs – The Pence Lab is seeking new colleagues with diverse training experiences in:
- Translational biophotonics
- Biomedical instrumentation
- Computational analysis
Prospective graduate students – Contact Isaac Pence to discuss possible rotation projects. We are a part of the UT Southwestern Biomedical Engineering Department and BME Graduate Program.
Information for prospective BME students interested in imaging research at UT Southwestern.