Qiao Lab
Meet the Principal Investigator
Jian Qiao M.D., Ph.D.
Assistant Professor of Pathology
Dr. Jian Qiao received her M.D. from China Medical University in medicine, and her Ph.D. from Chinese Academy of Science in Tumor Immunology. Before joining UT Southwestern Medical Center, Dr. Qiao has been working on the development of strategies for tumor-targeted delivery of therapeutics including cytokines, cytotoxic genes, and oncolytic viruses. Currently, Dr. Qiao' s lab focus on the development of novel tumor-targeted bispecific antibodies and cytokines to improve the therapeutic index by reducing systemic toxicity while enhancing antitumor immune responses.
Research Interest
- Antibody- and Cytokine- based immunotherapies
- Cancer and Autoimmune diseases
- Tumor Microenvironment
- Tumor-targeted delivery of immune therapeutics
Lab Members
Benjamin Moon
M.D., Ph.D. Student
Longchao Liu
Post-Doctoral Fellow
Casey Moore
M.D., Ph.D. Student
Xue Wang
Post-Doctoral Fellow
Joonbeom Bae
Post-Doctoral Fellow
Zhichen Sun
Post-Doctoral Fellow
Moore C, Bae J, Liu L, Li H, Fu YX, Qiao J,
2022 Sep
JCI Insight
Liu L, Chen J, Bae J, Li H, Sun Z, Moore C, Hsu E, Han C, Qiao J*, Fu YX*,
2021 Nov
Nat Biomed Eng.
Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling.
Han C, Liu Z, Zhang Y, Shen A, Dong C, Zhang A, Moore C, Ren Z, Lu C, Cao X, Zhang CL, Qiao J* Fu YX*, 2020 May Nat Immunol.
Qiao J*, Fu YX,
2020 Jul
Cell Mol Immunol.
Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8(+) T Cell Apoptosis.
Qiao J*, Liu Z, Dong C, Luan Y, Zhang A, Moore C, Fu K, Peng J, Wang Y, Ren Z, Han C, Xu T, Fu YX*, 2019 Jun Cancer Cell
Qiao J, Tang H, Fu YX,
2017 Apr
Curr Opin Immunol.
Qiao J, Liu Z, Fu YX,
2016 May
J Mol Med.
Qiao J, Dey M, Chang AL, Kim JW, Miska J, Ling A, Nettlebeck DM, Han Y, Zhang L, Lesniak MS.
2015 Apr
Oncoimmunology
Qiao J, Wang H, Kottke T, White C, Twigger K, Diaz RM, Thompson J, Selby P, de Bo-no J, Melcher A, Pandha H, Coffey M, Vile R, Harrington K
2008 Jan
Clin Cancer Res
Qiao J, Kottke T, Willmon C, Galivo F, Wongthida P, Diaz RM, Thompson J, Ryno P, Barber GN, Chester J, Selby P, Harrington K, Melcher A, Vile RG,
2008 Jan
Nat Med.
VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment.
Qiao J, Moreno, J, Sanchez-Perez, L, Kottke T, Thompson J, Caruso M, Diaz, RM, Vile R 2006 Oct Gene Ther.
Tang H, Qiao J, Fu YX
2916 Jan
Cancer Lett.
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
Lu C, Guan J, Lu S, Jin Q, Rousseau B, Lu T, Stephens D, Zhang H, Zhu J, Yang M, Ren Z, Liang Y, Liu Z, Han C, Liu L, Cao X, Zhang A, Qiao J, Batten K, Chen M, Cas-trillon DH, Wang T, Li B, Diaz LA, Jr., Li GM, Fu YX, 2021 Jan Cancer Cell
Deng S, Sun Z, Qiao J, Liang Y, Liu L, Dong C, Shen A, Wang Y, Tang H, Fu YX, Peng H,
2020 Apr
JCI Insight.
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
Li X, Liu Z, Zhang A, Han C, Shen A, Jiang L, Boothman DA, Qiao J, Wang Y, Huang X, Fu YX, 2019 Jul Nat Commun.
Liu Z, Han C, Dong C, Shen A, Hsu E, Ren Z, Lu C, Liu L, Zhang A, Timmerman C, Pu Y, Wang Y, Chen M, Qiao J, Fu YX,
2019 Aug
Sci Immunol.
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX, 2018 Feb J Clin Invest.Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy
Tang H, Zhu M, Qiao J, Fu YX, 2017 Oct Cell Mol Immunol.
Wainwright DA, Chang AL, Dey M, Balyasnikova IV, Kim C, Tobias A, Cheng Y, Kim JW, Qiao J, Zhang L, Han Y, Lesniak MS,
2014 Oct
Clin Cancer Res
Contact Us
Lab Phone: 214-648-6538 (Office)
Lab location: ND 6.310
Email
Mailing Address
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75390-9072
Physical Address
Department of Pathology, ND 6.310D (Office)
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, Texas 75390-9072