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Dr. Chen

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    Dr. Smith's publications

    Featured Publications

    Genome-Wide Silencing Captures Obligate Apoptotic Components in Drosophila

    Chew, S.,Chen, P., Link, N., Galindo, K., Pogue, K. and Abrams, J.M. July 2009 Nature 460 123-127

    p53 Directs Focused Genomic Responses in Drosophila

    Akdemir, F., Christich, A., Sogame, N., Chapo, J., and Abrams, J.M February 2007 Oncogene

    The Apical Caspase, dronc, Governs Programmed and Unprogrammed Cell Death in Drosophila

    Chew, S., Akdemir, F.,Chen, P., Lu, W., Mills, K.,Daish, T.,Kumar, S.,Rodriguez,, A. and Abrams, J.M December 2004 Developmental Cell Volume 7 897-907

    A Collective Form of Cell Death Requires Homeodomain Interacting Protein Kinase

    Link, N., Chen, P., Lu, WJ, Pogue, K., Chuong, A., Mata, M., Checketts, J., Abrams, J.M August 2007 J. Cell Biol 4 (178) 567-74

    Distinct p53 isoforms code for opposing transcriptional outcomes.

    Wylie A, Jones AE, Das S, Lu WJ, Abrams JM, 2022 Jul Dev Cell

    p53 directly represses human LINE1 transposons.

    Tiwari B, Jones AE, Caillet CJ, Das S, Royer SK, Abrams JM, 2020 Oct Genes Dev

    Transposons, p53 and Genome Security.

    Tiwari B, Jones AE, Abrams JM 2018 Sep Trends Genet.

    Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance.

    Tiwari B, Kurtz P, Jones AE, Wylie A, Amatruda JF, Boggupalli DP, Gonsalvez GB, Abrams JM 2017 Oct Curr. Biol. 19 27 3010-3016.e3

    p53 in the game of transposons.

    Wylie A, Jones AE, Abrams JM 2016 Sep Bioessays

    A platform for interrogating cancer-associated p53 alleles.

    D'Brot A, Kurtz P, Regan E, Jakubowski B, Abrams JM 2016 Mar Oncogene

    A platform for interrogating cancer-associated p53 alleles.

    D'Brot A, Kurtz P, Regan E, Jakubowski B, Abrams JM 2016 Dec Oncogene

    p53 genes function to restrain mobile elements.

    Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM 2015 Dec Genes Dev.

    p53 activity is selectively licensed in the Drosophila stem cell compartment.

    Wylie A, Lu WJ, D'Brot A, Buszczak M, Abrams JM 2014 Elife 3 e01530

    A p53 enhancer region regulates target genes through chromatin conformations in cis and in trans.

    Link N, Kurtz P, O'Neal M, Garcia-Hughes G, Abrams JM 2013 Nov Genes Dev. 22 27 2433-8

    Tango7 directs cellular remodeling by the Drosophila apoptosome.

    D'Brot A, Chen P, Vaishnav M, Yuan S, Akey CW, Abrams JM 2013 Aug Genes Dev. 15 27 1650-5

    Meiotic recombination provokes functional activation of the p53 regulatory network.

    Lu WJ, Chapo J, Roig I, Abrams JM 2010 Jun Science 5983 328 1278-81

    Autophagy Occurs Upstream or Parallel to the Apoptosome During Histolytic Cell Death

    Akdemir, F., Farkas, R., Chen, P., Juhasz, G., Medvedova, L., Sass, M., Wang, L., Wang, X., Chittaranian, S., Gorski, SM., Rodriguez, A., Abrams, JM 2006 Development 133 1457-65

    Drosophila p53 preserves genomic stability by regulating cell death.

    Sogame N, Kim M, Abrams JM 2003 Apr Proc. Natl. Acad. Sci. U.S.A. 8 100 4696-701

    Unrestrained caspase-dependent cell death caused by loss of Diap1 function requires the Drosophila Apaf-1 homolog, Dark

    Rodriguez, A., Oliver, H. , and Abrams, J.M. 2002 EMBO J 21 (9) 2189-2197

    Drosophila p53 binds a damage response element at the reaper locus

    Brodsky, M, H. Nordstrom, W, Tsang, G., Kwan, E., Rubin, G.M. and Abrams, J.M. 2000 Cell 101 103-113

    Dark, is a Drosophila Homologue of Apaf-1/Ced-4 and Functions in an Evolutionary Conserved Death Pathway.

    Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X. and Abrams, J.M. 1999 Nature Cell Biology 1 272-279

    Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia.

    Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M, Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, Xu J, 2021 Apr Nat Genet
    Dr. Jones

    January 2025

    Dr. Jones joins the MAIA Lab

    Meet the newest member of the MAIA lab, Ben Jones, M.D., Ph.D.

    April 2024

    Behind the Scenes with MAIA Lab

    This is a wonderful article in Newsweek about how MAIA Lab operates.

    Read the MAIA Lab article

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      Doctors from Children's Hospital meet about childhood diseases

      A panel of 9 doctors from Children's Health Hospital met this week to discuss childhood diseases.

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