Publications

Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky DJ, Kroemer G, Liu J, Tang D, Kang R. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis. Autophagy. 2023 Jan;19(1): 54-74. doi:10.1080/15548627.2022.2059170. Epub 2022 Apr 10. PubMed PMID: 35403545; PubMed Central PMCID: PMC9809962

Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y. Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity. Sci Adv. 2023 Jan 6;9(1):eadd6626. doi: 10.1126/sciadv.add6626. Epub 2023 Jan 6. PMID: 36608132; PMCID: PMC9821867.

Song X, Zhou Z, Kang R, Tang D. Bispecific T cell engagers kill resistant cells during KRAS-G12C blockade therapy. Oncoimmunology. 2022;11(1):2141978. doi: 10.1080/2162402X.2022.2141978. PubMed PMID: 36338145; PubMed Central PMCID: PMC9629117.

Zhou Z, Song X, Kang R, Tang D. The emerging role of deubiquitinases in cell death. 2022 Dec 6;12(12):1825. doi: 10.3390/biom12121825. PMID: 36551253; PMCID: PMC9775562.

Song X, Liu J, Kuang F, Chen X, Zeh HJ 3rd, Kang R, Kroemer G, Xie Y, Tang D. PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis. Cell Rep. 2021 Feb 23;34(8):108767. doi: 10.1016/j.celrep.2021.108767. PubMed PMID: 33626342.

Song X, Zhou Z, Li H, Xue Y, Lu X, Bahar I, Kepp O, Hung MC, Kroemer G, Wan Y. Pharmacologic suppression of B7-H4 glycosylation restores antitumor immunity in immune-cold breast cancers. Cancer Discov. 2020 Dec;10(12):1872-1893. doi: 10.1158/2159-8290.CD-20-0402. Epub 2020 Sep 16. PubMed PMID: 32938586; PubMed Central PMCID: PMC7710601.

Liu J, Song X, Kuang F, Zhang Q, Xie Y, Kang R, Kroemer G, Tang D. NUPR1 is a critical repressor of ferroptosis. Nat Commun. 2021 Jan 28;12(1): 647. doi: 10.1038/s41467-021-20904-2. PubMed PMID: 33510144; PubMed Central PMCID: PMC7843652.

Lahiri V, Metur SP, Hu Z, Song X, Mari M, Hawkins WD, Bhattarai J, Delorme-Axford E, Reggiori F, Tang D, Dengjel J, Klionsky DJ. Post-transcriptional regulation of ATF1 is a critical node that modulates autophagy during distinct nutrient stresses. Autophagy. 2021 Nov 26:1-21. doi: 10.1080/15548627.2021.1997305. Epub ahead of print. PMID: 34836487.

Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D.  AMPK-medicated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc- activity. Curr Biol. 2018 Aug 6;28(15):2388-2399.e5. doi: 10.1016/j.cub.2018.05.094. Epub 2018 Jul 26. PubMed PMID: 30057310; PubMed Central PMCID: PMC6081251.

Lee DH, Kim D, Kim ST, Jeong S, Kim JL, Shim SM, Heo AJ, Song X, Guo ZS, Bartlett DL, Oh SC, Lee J, Saito Y, Kim BY, Kwon YT, Lee YJ.  PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5. Autophagy. 2018;14(11):1870-1885. doi: 10.1080/15548627.2018.1491212. Epub 2018 Jul 23. PubMed PMID: 29976090; PubMed Central PMCID: PMC6152518.

Song X, Lee DH, Dilly AK, Lee YS, Choudry HA, Kwon YT, Bartlett DL, Lee YJ. Crosstalk between apoptosis and autophagy is regulated by the arginylated BiP/Beclin-1/p62 complex. Mol Cancer Res. 2018 Jul;16(7):1077-1091. doi: 10.1158/1541-7786.MCR-17-0685. Epub 2018 Apr 18. PubMed PMID: 29669822; PubMed Central PMCID: PMC6030503.

Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, Wang P, Ma X, Kroemer G, Bartlett DL, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D. JTC801 induces pH-dependent death specifically in cancer cells and slows growth of tumors in mice. Gastroenterology. 2018 Apr;154(5):1480-1493. doi: 10.1053/j.gastro.2017.12.004. PubMed PMID: 29248440; PubMed Central PMCID: PMC5880694.

Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, Lotze MT, Zeh HJ 3rd, Kang R, Kroemer G, Tang D. The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep. 2017 Aug 15;20(7):1692-1704. doi: 10.1016/j.celrep.2017.07.055. PubMed PMID: 28813679.

Song X, Xie Y, Kang R, Hou W, Sun X, Epperly MW, Greenberger JS, Tang D. FANCD2 protects against bone marrow injury from ferroptosis. Biochem Biophys Res Commun. 2016 Nov 18;480(3):443-449. doi: 10.1016/j.bbrc.2016.10.068. Epub 2016 Oct 20. PubMed PMID: 27773819; PubMed Central PMCID: PMC6591579.

Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd, Kang R, Tang D. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy. 2016 Aug 2;12(8):1425-8. doi: 10.1080/15548627.2016.1187366. Epub 2016 May 31. PubMed PMID: 27245739; PubMed Central PMCID: PMC4968231.

Song X, Hong SH, Kwon WT, Bailey LM, Basse P, Bartlett DL, Kwon YT, Lee YJ. Secretory TRAIL-Armed natural killer cell-based therapy: in vitro and in vivo colorectal peritoneal carcinomatosis xenograft. Mol Cancer Ther. 2016 Jul;15(7):1591-601. doi: 10.1158/1535-7163.MCT-15-0937. Epub 2016 Apr 12. PubMed PMID: 27196776; PubMed Central PMCID: PMC4936937.

Xie Y, Song X, Sun X, Huang J, Zhong M, Lotze MT, Zeh HJ Rd, Kang R, Tang D. Identification of baicalein as a ferroptosis inhibitor by natural product library screening. Biochem Biophys Res Commun. 2016 May 13;473(4):775-780. doi: 10.1016/j.bbrc.2016.03.052. Epub 2016 Mar 30. PubMed PMID: 27037021.

Song X, Dilly AK, Choudry HA, Bartlett DL, Kwon YT, Lee YJ. Hypoxia promotes synergy between mitomycin c and bortezomib through a coordinated process of Bcl-xL phosphorylation and mitochondrial translocation of p53. Mol Cancer Res. 2015 Dec;13(12):1533-43. doi: 10.1158/1541-7786.MCR-15-0237. Epub 2015 Sep 9. PubMed PMID: 26354682; PubMed Central PMCID: PMC4684998.

Dilly AK, Song X, Zeh HJ, Guo ZS, Lee YJ, Bartlett DL, Choudry HA. Mitogen-activated protein kinase inhibition reduces mucin 2 production and mucinous tumor growth. Transl Res. 2015 Oct;166(4):344-54. doi: 10.1016/j.trsl.2015.03.004. Epub 2015 Mar 28. PubMed PMID: 25890193.

Kim SY, Lee DH, Song X, Bartlett DL, Kwon YT, Lee YJ. Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenobirus in combination with mitomycin C and hyperthermia on colon cancer cells. Apoptosis. 2014 Nov;19(11):1603-15. doi: 10.1007/s10495-014-1028-6. PubMed PMID: 25156145; PubMed Central PMCID: PMC4196052.

Song X, Kim SY, Zhang L, Tang D, Bartlett DL, Kwon YT, Lee YJ. Role of AMP-activated protein kinase in crosstalk between apoptosis and autophagy in human colon cancer. Cell Death Dis. 2014 Oct 30;5:e1504. doi: 10.1038/cddis.2014.463. PubMed PMID: 25356873; PubMed Central PMCID: PMC4649537.

Kim SY, Song X, Zhang L, Bartlett DL, Lee YJ. Role of Bcl-xL/Beclin-1 interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. Biochem Pharmacol. 2014 Mar 15;88(2):178-88. doi: 10.1016/j.bcp.2014.01.027. Epub 2014 Jan 31. PubMed PMID: 24486574; PubMed Central PMCID: PMC3969586.

Song X, Kim SY, Lee YJ. Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells. PLoS One. 2013;8(8):e73654. doi: 10.1371/journal.pone.0073654. eCollection 2013. PubMed PMID: 24013390; PubMed Central PMCID: PMC3754951.

Song X, Kim SY, Zhou Z, Lagasse E, Kwon YT, Lee YJ. Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells. Cell Death Dis. 2013 Apr 4;4:e577. doi: 10.1038/cddis.2013.104. PubMed PMID: 23559011; PubMed Central PMCID: PMC3641327.

Kim SY, Kang JW, Song X, Kim BK, Yoo YD, Kwon YT, Lee YJ. Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signal. 2013 Apr;25(4):961-9. doi: 10.1016/j.cellsig.2013.01.007. Epub 2013 Jan 16. PubMed PMID: 23333246; PubMed Central PMCID: PMC3595341.

Song X, Kim SY, Lee YJ. The role of Bcl-xL in synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia on human colon cancer. Mol Cancer Res. 2012 Dec;10(12):1567-79. doi: 10.1158/1541-7786.MCR-12-0209-T. Epub 2012 Oct 10. PubMed PMID: 23051936; PubMed Central PMCID: PMC3528808.

Kim SY, Rhee JG, Song X, Prochownik EV, Spitz DR, Lee YJ. Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM. PLoS One. 2012;7(11):e50423. doi: 10.1371/journal.pone.0050423. Epub 2012 Nov 21. PubMed PMID: 23185620; PubMed Central PMCID: PMC3503893.

Song X, Kim HC, Kim SY, Basse P, Park BH, Lee BC, Lee YJ. Hyperthermia-enhanced TRAIL- and mapatumumab-induced apoptotic death is mediated through mitochondria in human colon cancer cells. J Cell Biochem. 2012 May;113(5):1547-58. doi: 10.1002/jcb.24023. PubMed PMID: 22174016; PubMed Central PMCID: PMC3330147.

Song X, Guo W, Cui J, Qian X, Yi L, Chang M, Cai Q, Zhao Q. A tritherapy combination of a fusion protein vaccine with immune-modulating doses of sequential chemotherapies in an optimized regimen completely eradicates large tumors in mice. Int J Cancer. 2011 Mar 1;128(5):1129-38. doi: 10.1002/ijc.25451. PubMed PMID: 20473939.

Song X, Ye D, Liu B, Cui J, Zhao X, Yi L, Liang J, Song J, Zhang Z, Zhao Q. Combination of all-trans retinoic acid and a human papillomavirus therapeutic vaccine suppresses the number and function of immature myeloid cells and enhances antitumor immunity. Cancer Sci. 2009 Feb;100(2):334-40. doi: 10.1111/j.1349-7006.2008.01037.x. PubMed PMID: 19068090.

Liu B, Ye D, Song X, Zhao X, Yi L, Song J, Zhang Z, Zhao Q. A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis. Vaccine. 2008 Mar 4;26(10):1387-96. doi: 10.1016/j.vaccine.2007.12.034. Epub 2008 Jan 22. PubMed PMID: 18272260.

Lu Y, Zhang Z, Liu Q, Liu B, Song X, Wang M, Zhao X, Zhao Q. Immunological protection against HPV16 E7-expressing human esophageal cancer cell challenge by a novel HPV16-E6/E7 fusion protein based vaccine in a Hu-PBL-SCID mouse model. Biol Pharm Bull. 2007 Jan;30(1):150-6. doi: 10.1248/bpb.30.150. PubMed PMID: 17202676.